scholarly journals Clinical Evaluation of Acanthosis Nigricans and Its Correlation with Endocrine, Metabolic and Nutritional Factors in Gujarat, India

2021 ◽  
Vol 11 (6) ◽  
pp. 1-7
Author(s):  
Patel Sohan A ◽  
Dave Jayant B ◽  
Mehta Timir Y
Keyword(s):  
Vitamin B12 ◽  
Lipid Profile ◽  
Acanthosis Nigricans ◽  
Serum Insulin ◽  
Control Group ◽  
Physical Parameters ◽  
Common Denominator ◽  
Nutritional Factors ◽  
The Mean ◽  
Level Of Significance

Acanthosis nigricans (AN) refers to the velvety, black hyperpigmentation in flexures usually on the neck and axillae. AN is associated with multiple endocrinopathies and insulin resistance is reported to be a common denominator among them. The aim of the study was to identify the correlation of metabolic factors (Serum glucose, lipid profile), endocrine factors (TSH, serum insulin), and nutritional factors (vitamin B12, Ferritin) in AN patients in Aravalli district of Gujarat state. A total of Seventeen Patients (11 male and 6 female) were included in the study History, clinical observations, physical parameters, and biochemical tests were noted in AN patients and correlation of some likely factors with AN was explored. The age was 28.41±15.09 years for AN group and 35.45±8.74 years for the control group. The mean BMI was found to be higher in AN at 1 % level of significance (P = 0.007) implying that overweight/obesity is associated with AN. The mean TSH value was found to be higher in AN than control group at 5 % level of significance (P = 0.0115) implying that hypothyroidism (elevated TSH value) is associated with AN. The 45.45 % patients had higher blood glucose levels and some of the patients had higher level of insulin. The mean lipid profile, vitamin B12 and serum ferritin were found to be at non-significance level. All statistical tests were performed using graph pad prism software (version 5.0). Positive correlations were observed between higher fasting glucose and hyperinsulinemia with AN and others factors such as metabolic and endocrine like overweight/obesity, hypothyroidism, higher glucose and serum insulin with AN. This implies that AN can serve as a marker for detecting hyperinsulinemia and hypothyroidism. Some of the parameters like, Serum lipid profile, vitamin B12 and ferritin levels could not be correlated to AN. Thus, patients with AN can be targeted for lifestyle and behavioral modifications at an early stage to avoid the serious consequences of AN.

Effects of epigallocatechin-3-gallate of Camellia sinensis leaves on blood pressure, lipid profile, atherogenic index of plasma and some inflammatory and antioxidant markers in type 2 diabetes mellitus patients: a clinical trial

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Hadi Bazyar ◽  
Seyed Ahmad Hosseini ◽  
Sirous Saradar ◽  
Delsa Mombaini ◽  
Mohammad Allivand ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Lipid Profile ◽  
Atherogenic Index ◽  
Control Group ◽  
Atherogenic Index Of Plasma ◽  
The Mean

Abstract Background In patients with type 2 diabetes mellitus (T2DM) the inflammatory and metabolic responses to epigallocatechin-3-gallate (EGCG) are unknown. Objectives Evaluate the impacts of EGCG on metabolic factors and some biomarkers of stress oxidative in patients with T2DM. Methods In this randomized, double-blind, placebo-controlled trial, 50 patients with T2DM consumed either 2 tablets (300 mg) EGCG (n=25) or wheat flour as placebo (n=25) for 2 months. The total antioxidant capacity (TAC), interleukin-6 (IL-6), lipid profile, mean arterial pressure (MAP), atherogenic index of plasma (AIP) were evaluated before and after the intervention. Results The finding of present study exhibited a significant increase in the serum levels of TAC after the EGCG supplementation (p=0.001). Also, in compare with control group, the mean changes of TAC were significantly higher in supplement group (p=0.01). In intervention group, a significant decrease was observed in the mean levels of triglyceride, total cholesterol, diastolic blood pressure (DBP), AIP, and MAP (p<0.05). Taking EGCG resulted in the mean changes of total cholesterol, MAP and DBP were significantly lower in compare with control group (p<0.05). Conclusions This study recommended that EGCG supplementation may be improved blood pressure, lipid profile, AIP, and oxidative status in patients with T2DM.

scholarly journals Effect of Whole Quail (Coturnix japonica) Egg Consumption on some Reproductive Parameters and Lipid Profile of Male Albino Rat (Rattus norvegicus)

2017 ◽  
Vol 9 (3) ◽  
pp. 315-320 ◽  
Author(s):  
Chidozie N. OKOYE ◽  
Samuel O. EKERE ◽  
Onyinyechukwu A. AGINA ◽  
Ikechukwu J. UDEANI ◽  
Chukwunonso K. EZEASOR
Keyword(s):  
Lipid Profile ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Control Group ◽  
Low Density ◽  
Epididymal Sperm ◽  
Treatment Groups ◽  
Egg Consumption ◽  
Group A ◽  
The Mean

The present study evaluated the effect of whole egg consumption on the liver, testes, cauda epididymal sperm reserve and lipid profile of male rats. These evaluations were carried out on adult twenty (20) male albino rats, which were randomly selected into four groups of 5 rats each, designated groups A, B, C and D. Group A was the control group and received only equivalent volume of distilled water, while groups B, C and D received 0.25mg/kg, 0.5mg/kg; and 1.0mg/kg body weight of the quail egg respectively. Standard procedures were carried out in the tissue processing, cauda epididymal sperm reserve and in lipid profile determinations. On days 35 and 49, the mean serum total cholesterol value of group D was significantly lower than that of the control group. On day 35, the mean serum low density lipoprotein and high density lipoprotein (LDL and HDL cholesterol) values of all the treatment groups were significantly lower and higher than that of the control group, respectively. However, on days 49 and 63, the mean serum very low density lipoprotein (VLDL cholesterol) and triglyceride values of all the treatment groups were significantly higher than that of the control group. A significant increase in cadual epididymal sperm count (CESR) was recorded on day 63 at the mid and high doses. No obvious pathological lesions were observed in the histomorphology of the testes and liver when compared to the control. Therefore, whole quail egg consumption caused an increase in serum triglyceride and very low density lipoprotein concentration, and also improved fertility. In other words, prolonged consumption of quail egg should be done with caution as it may predispose one to cardiovascular disease.

scholarly journals The Effect of Smoking on the Lipid Profile of Inhabitant Smokers of Hasilpur, District Bahawalpur, Pakistan

2020 ◽  
Vol 10 (2) ◽  
pp. 82-86
Author(s):  
Mushtaq Hussain Lashari ◽  
Sumbel Sumera ◽  
Umer Farooq ◽  
Zia Ur Rehman ◽  
Nuzhat Sial ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Serum Triglyceride ◽  
Mean Value ◽  
Heavy Smoker ◽  
Control Group ◽  
Mean Values ◽  
Significant Difference ◽  
The Mean ◽  
Control Light ◽  
Heavy Smokers

Background: Health problem are culturally associated with smoking in developing countries. Many hazardous chemicals are taken up by direct or passive smoking causing lipid peroxidation resulting in oxidative stress. Objectives: To estimate the occurrence of smoking and its effects on the lipid profile in populations of Hasilpur, Pakistan. Methodology: The current study was conducted from April - August 2014. Out of 247 apparently healthy subjects of both genders (male=220; female=27), 134 were smokers and 113 were non-smokers. In order to analyze lipid profile, blood samples were collected in early morning hours from the selected members who were asked to fast all night. By using Chem-100 chemistry analyzer, cholesterol, triglyceride, HDL, LDL and VLDL were analyzed. Results: The overall prevalence of smokers was 54.25%. The results showed 60.9% prevalence in males and 0% in females. The mean value of serum triglyceride in control, light smokers and heavy smokers was 147.4±11.7mg/dl, 190.8±41.4 and 205.3±29.7mg/dl, respectively. The results of cholesterol in control, light smokers and heavy smokers were 147.38±7.99mg/dl, 136.8 ±12. 8mg/dl and 173.44±8.63mg/dl, respectively. There was a considerable distinction in the mean level of serum triglyceride and cholesterol between the control group, light smokers and heavy smoker groups (P<00.5). The mean value of HDL of control, light smokers and heavy smokers was 30.93±1.30mg/dl, 31.10±2.45 and 34.58±1.55mg/dl, respectively. The mean values of LDL and VLDL of control, light smokers and heavy smokers were 110.46±3.63mg/dl, 106.00±4.52mg/dl, 117.19±3.48mg/dl and 33.54±3.11mg/dl, 49±9.02mg/dl, 41.06±5.34mg/dl, respectively. There was significant difference in the mean level of HDL, LDL and VLDL between the control group, light smokers and heavy smoker groups (P<0.05). Conclusion: This study concluded that smoking is the reasons of variation in the lipid profile. Elevated period of smoking and the number of smoked cigarettes/day reason the alteration in serum lipid levels and is probably related with increased danger for coronary artery disease.

scholarly journals PENGARUH MODEL PROBLEM BASED LEARNING BERBASIS LINGKUNGAN TERHADAP HASIL BELAJAR SISWA KELAS X AP PADA MATA AJAR SANITASI, HYGIENE DAN KESELAMATAN KERJA DI SMK PARIWISATA TRIATMA JAYA SINGARAJA TAHUN AJARAN 2018/2019

2019 ◽  
Vol 10 (2) ◽  
pp. 74
Author(s):  
Yulianitias Yulianitias ◽  
Cokorda Istri Raka Marsiti ◽  
Luh Masdarini
Keyword(s):  
Random Sampling ◽  
Model Problem ◽  
Problem Based Learning ◽  
Workplace Safety ◽  
Control Group ◽  
Control Group Design ◽  
The Mean ◽  
The Difference ◽  
Level Of Significance ◽  
Academic Year

ABSTRAK Tujuan dari penelitian ini adalah untuk mengetahui perbedaan dari penggunaan model Problem Based Learning berbasis lingkungan terhadap hasil belajar siswa kelas X-AP mata ajar Sanitasi, Hygiene dan Keselamatan kerja di SMK Pariwisata Triatma Jaya Singaraja Tahun Ajaran 2018/2019. Desain penelitian yang digunakan adalah Non equivalent Only Control Group Design. Objek dalam penelitian ini terdiri dari dua kelas sampel, yaitu kelas eksperimen dan kelas kontrol. Metode pemilihan sampel penelitian adalah dengan teknik random sampling. Proses pengumpulan data menggunakan instrumen tes untuk mengetahui hasil belajar siswa, kemudian melakukan pengujian hipotesis dengan menggunakan teknik uji-t. Berdasarkan hasil analisis data, diperoleh thitung 7,641 dan ttabel (pada taraf signifikansi 5%) = 3,460. Hal ini berarti bahwa thitung> ttabel, sehingga dapat diinterpretasikan bahwa terdapat pengaruh yang signifikan terhadap hasil belajar siswa X AP Di SMK Pariwisata Triatma Jaya Singaraja antara kelompok siswa yang dibelajarkan dengan Problem Based Learning berbasis lingkungan lebih tinggi dibandingkan kelompok siswa yang dibelajarkan dengan metode konvensional. Dilihat dari hasil perhitungan rata-rata hasil belajar Sanitasi, Hygiene dan Keselamatan kerja kelompok eksperimen adalah 81 lebih besar dari rata-rata hasil belajar Sanitasi, Hygiene dan Keselamatan kerja kelompok kontrol yaitu 76 Kata kunci: Hasil belajar Sanitasi, Hygiene dan Keselamatan Kerja, Model Problem Based Learning (PBL) Berbasis Lingkungan ABSTRACT The study aimed at finding out the difference of implementation of problem based learning model with environmental basis towards the achievement of class XAP students on the subjects of sanitation, hygiene, and workplace safety at SMK Pariwisata Triatma Jaya Singaraja on the academic year 2018/2019. The research was designed with non equivalent only group control. The objects were two classes of samples, namely controlled and sample classes. Random sampling method was apllied to determine the sample of the research. The data were gathered by using test to find out the achievement of the students , then examining the hypothesis was done by implementing t-examiner technique. The results show that tvalue is 7,641 and ttable (at level of significance 5%) = 3,460. It means that tvalue> ttable. It can be interpreted that there is a significant effect towards the students’ahievement of class X AP at SMK Pariwisata Triatma Jaya Singaraja. The group of students that were treated with Problem Based Learning with the environmental basis got the mean score 81 for sanitation, hygiene, and workplace safety, it is higher than those who were treated with conventional method (controlled group).Key words : achievement, sanitation, hygiene, and workplace safety Model

scholarly journals The effects of Anethum graveolens (dill) powder supplementation on clinical and metabolic status in patients with type 2 diabetes

2020 ◽  
Author(s):  
Fatemeh Haidari ◽  
Mehrnoosh Zakerkish ◽  
Fatemeh Borazjani ◽  
Kambiz Ahmadi Angali ◽  
Golnaz Amoochi
Keyword(s):  
Type 2 Diabetes ◽  
Lipid Profile ◽  
Intervention Group ◽  
Gastrointestinal Symptoms ◽  
Control Group ◽  
Diabetic Patients ◽  
Anethum Graveolens ◽  
Type 2 Diabetic Patients ◽  
The Mean

Abstract Background: The objective of this study was to investigate the effects of anethum graveolens (dill) powder supplementation on glycemic control, lipid profile, some antioxidants and inflammatory markers, and gastrointestinal symptoms in type 2 diabetic patients. Material and methods: In this study, 42 patients with type 2 diabetes were randomly allocated to intervention and control groups and received either 3g/day dill powder or placebo (3 capsules/day, 1 g each). Fasting blood sugar (FBS), insulin, homeostatic model assessment of insulin resistance (HOMA- IR), lipid profile, hs-C-reactive protein (hs-CRP), total antioxidant capacity (TAC), malondialdehyde (MDA), and gastrointestinal symptoms were measured in all of the subjects at baseline and post-intervention. Results: The dill powder supplementation significantly decreased the mean serum levels of insulin, HOMA-IR, LDL-C, TC, and MDA in the intervention group in comparison with the baseline measurements (p < 0.05). Also, the mean serum levels of HDL and TAC were significantly increased in the intervention group in comparison with the baseline measurement (p < 0.05). Colonic motility disorder was the only gastrointestinal symptom whose frequency was significantly reduced by supplementation (P = 0.01). The mean changes of insulin, LDL-C , TC, and MDA were significantly lower in the intervention group than in the control group (p < 0.05). In addition, the mean changes in HDL were significantly higher in the intervention group than in the control group (p < 0.05). Conclusion: Dill powder supplementation can be effective in controlling the glycemic, lipid, stress oxidative, and gastrointestinal symptoms in type 2 diabetic patients. Keywords: Type 2 diabetes; Dill powder; Glycemic control; Lipid profile; Stress oxidative status

Resistant Starch Supplementation Improves Bifidobacteria Colonization and Lipid Profile in Adult Obese Subjects Residing in Urban Vadodara

2018 ◽  
Vol 55 (4) ◽  
pp. 432
Author(s):  
Mini Sheth ◽  
Aanchal Johari ◽  
Isha Shah
Keyword(s):  
Lipid Profile ◽  
Resistant Starch ◽  
Age Groups ◽  
Randomised Control Trial ◽  
Control Group ◽  
Obese Adults ◽  
Obese Subjects ◽  
The Mean ◽  
The Impact ◽  
Experimental Group

Obesity continues to be a growing problem globally among all age groups, further associated with life threatening co-morbidities. Resistant Starch (RS) as a dietary component has been recently recognized as a prebiotic with potential role in improving the bacterial ecology of human gut. The present study was undertaken to evaluate the impact of resistant starch supplementation by the obese adults in urban Vadodara on microbial changes in gut flora with respect to Bifidobacteria and Enterobacteria. Using a non randomised control trial study design, 60 obese adults were enrolled from the free living population of urban Vadodara. Baseline information was collected and subjects were classified into control (n=30) and experimental group (n=30). Experimental group was supplemented with 10 g of RS daily for the period of two months (60 days). The control group were not given anything during this period. Blood and stool samples were analysed for lipid profile and the presence of Bifidobacteria and pathogenic Enterobacteria, respectively both at baseline and after the intervention period. Results revealed a significant increase in the mean log counts of Bifidobacteria by 11.7% with no significant reduction in the mean log counts of enteric pathogens and lipid profile of subjects. Hence study concludes that a daily supplementation of 10 grams of RS for 60 days to the obese subjects improved colonization of beneficial gut microbiota in terms of Bifidobacteria, but had little effect on obesity.

scholarly journals Efek ekstrak daun sirsak (Annona muricata Linn) terhadap profil lipid tikus putih jantan (Rattus Norvegicus)

2014 ◽  
Vol 3 (1) ◽  
pp. 7-12 ◽  
Author(s):  
Indrawati Wurdianing ◽  
SA Nugraheni ◽  
Zen Rahfiludin
Keyword(s):  
Treatment Group ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Cholesterol Level ◽  
Ldl Cholesterol ◽  
Total Cholesterol Level ◽  
Wilcoxon Test ◽  
Control Group ◽  
Annona Muricata ◽  
The Mean

Background: Lipid profile effects is a risk factor for Coronary Heart Disease. Soursop leaves (Annona muricata L) isa traditional medicine plant containing metabolic compounds that contribute to the improvement of the lipid profile.Objective: To determine the effects of soursop leaves extract on lipid profile (total cholesterol, LDL cholesterol, HDLcholesterol and triglyceride).Methods: An experimental study using randomized pre-posttest with control group design. Sample consisted of 28 maleWistar rats, were divided into four groups. The control group (K) was only given High Fat High Cholesterol (HFHC)diet and treatment groups (P1, P2, P3) were given a HFHC diet plus Annona muricata L extract with doses of 100, 200and 300 mg/kgBB per day for 28 days respectively. Data were analyzed by Wilcoxon test, Kruskal-Wallis and MannWhitney.Results: The mean total cholesterol level significantly decreased in the treatment group P1 (p = 0.028) from 60.7 mg/dl(47.6-75.3) to 45.5 mg/dl (38.4-62.4). Mean HDL cholesterol level significantly increased in the treatment group P2(p=0.043) from 26.0 mg/dl (19.7-35.3) to 27.9 mg/dl (18.8-38.0). The mean levels of LDL cholesterol and triglyceridedecreased but not significantly.Conclusion: The administration of Annona muricata L extract can decrease total cholesterol and increase HDLcholesterol significantly.

Pentachlorophenol Residues in Porcine Tissue Following Preslaughter Exposure to Treated Wood Shavings

1991 ◽  
Vol 54 (6) ◽  
pp. 448-450 ◽  
Author(s):  
KELLY M. BUTLER ◽  
RICHARD FRANK
Keyword(s):  
Degrees Of Freedom ◽  
Treated Wood ◽  
Test Group ◽  
Liver Fat ◽  
Control Group ◽  
Porcine Tissue ◽  
Wood Shavings ◽  
Significant Difference ◽  
The Mean ◽  
Level Of Significance

Sixty market hogs originating from one producer and finished in a concrete and steel facility were divided into two groups of 30 and housed for approximately 60 h on either straw (control group) or pentachlorophenol (PCP) treated wood shavings (test group). Feed, straw, and shavings were analyzed for PCP residues. Both feed and straw yielded nondetectable levels of PCP residues, while shavings ranged from 0.03 to 12.0 ppm. The hogs were shipped to slaughter without bedding, and liver, fat and muscle (muscle from the test group only) samples were collected postmortem. The mean level of PCP residue in control (straw) hog livers was 0.037 ppm, while that of livers of hogs bedded with contaminated shavings was 0.342 ppm, a highly significant difference. The t-value using Welch's approximation equalled 9.77 using 28.5 degrees of freedom, indicating the mean PCP residue level was higher for the treated than the control group at a 0.01% level of significance.

High Percentage of Regulatory T Cells before and after Vitamin B12 Treatment in Patients with Pernicious Anemia

2014 ◽  
Vol 133 (1) ◽  
pp. 83-88 ◽  
Author(s):  
Satoru Watanabe ◽  
Norifumi Ide ◽  
Hatsue Ogawara ◽  
Akihiko Yokohama ◽  
Takeki Mitsui ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Vitamin B12 ◽  
Pernicious Anemia ◽  
Vitamin B12 Deficiency ◽  
T Cell Subsets ◽  
Control Group ◽  
Significant Difference ◽  
Before And After ◽  
The Mean

Introduction: In some previous studies, vitamin B12 treatment showed immunomodulatory effects and restored the immunological abnormalities in patients with pernicious anemia (PA). In the present study, peripheral blood T cell subsets, including regulatory T cells (Tregs), were examined before and after vitamin B12 treatment in PA patients. Patients and Methods: The percentages of CD4, CD8, Th1, Th2 and Tregs were examined in 23 PA patients before vitamin B12 treatment, in 23 other PA patients after vitamin B12 treatment and in 28 healthy controls. Results: The mean percentage of CD8+ T cells was significantly higher in the control group (23.0%; 95% CI, 20.4-25.6%) than in the pre- (16.0%; 95% CI, 12.1-20.0%) and posttreatment groups (15.2%; 95% CI, 11.8-18.6%; p < 0.05). The CD4/CD8 ratio was significantly lower in the control group (2.01; 95% CI, 1.66-2.34) than in the pre- (3.45; 95% CI, 2.55-7.80) and posttreatment groups (2.97; 95% CI, 2.22-3.72; p < 0.05). There was no significant difference in the mean Th1/Th2 ratio among these groups. There were significant increases in the mean percentage of Tregs in the pre- (6.29%; 95% CI, 5.04-7.54%) and posttreatment groups (7.77%; 95% CI, 6.34-9.20%) compared with the control group (4.18%; 95% CI, 3.92-4.47%; p < 0.05). Conclusions: The percentage of Tregs was significantly higher in PA patients than in normal subjects, and this high Treg percentage was not different before and after vitamin B12 treatment. Other immunological alterations also did not recover after vitamin B12 treatment, so that these immunological changes appear to be the cause of PA and are not induced by vitamin B12 deficiency.

scholarly journals Effect of Multiple Intelligences Instructional Strategy on Achievement and Retention in Mole Concept Among Chemistry Students in Abuja, Nigeria

2021 ◽  
Vol 2 (1) ◽  
Author(s):  
Ojiyi C. A ◽  
Agu P. A.
Keyword(s):  
Multiple Intelligences ◽  
Learning Style ◽  
Instructional Strategy ◽  
Research Question ◽  
Control Group ◽  
Chemistry Students ◽  
Significant Difference ◽  
Post Test ◽  
The Mean ◽  
Level Of Significance

This study examined the Effect of Multiple Intelligences Instructional Strategy (MIIS) on Achievement and Retention in Mole Concept among Chemistry Students in Abuja, Nigeria. Quasi experimental, pre-test, post-test, and post post-test control group design was adopted for this study. Two research questions guided the study and two hypotheses were tested at 0.05 level of significance. The population of the study was senior secondary school chemistry students in Abuja, Nigeria. The sample for the study was two co-educational schools. One served as the experimental group and the other served as the control group. Mole Concept Achievement Test (MCAT) (KR-21 = 0.70) was used for data collection. Descriptive statistics of mean and standard deviation was used to answer the research question, while null hypotheses were tested using ANCOVA at 0.05 level of significance. The result of the study reveals that, there was significant difference between the mean achievement scores of students taught the mole concept using multiple intelligences instructional strategy (MIIS) and those taught using lecture method. There was a significant difference between the mean retention scores of chemistry students taught the mole concept using MIIS and conventional method. Based on the findings of this study, the following recommendations have been made; there is a need for curriculum developers to develop appropriate curriculum that will make provision for the teacher to adopt various activities that will appeal to each students’ learning style or intelligence to enable them learn effectively

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