Optimasi Formula Krim Ekstrak Daun Katuk (Sauropus Androgynus) Variasi Konsentrasi Asam Stearat, Trietanolamin, dan Gliserin

Sauropus androgynus (L.) Merr.) contain secondary metabolite compounds: flavonoids and polyphenols which has bioactivity as antioxidants. Antioxidants act as photoprotector, so it can be formulated into sun protection product. The selection of cream base is very important due to it’s not only as vehicle of active ingredients but also affecting cream’s physical properties and effectiveness. This study aims to determine the composition of the optimum base formula and evaluation formula cream of extract katuk leaves with variations concentration of stearic acid, TEA, and glycerin. Formula optimization was conducted through the Simplex Lattice Design methode with 13 formulas. The results of evaluation were processed with Design Expert software. The optimum formula was respectively at 13.16% stearic acid, 12% glycerin, and 3.84% TEA. The optimum formula cream evaluation was spreadability in 4.89 cm, 0.56 s stickiness power, and pH 6,1. Acceptability test results showed that the cream could accepted by society very well.

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Optimasi Formula Tablet Piroksikam Menggunakan Eksipien Laktosa, Avicel pH-101, dan Amprotab dengan Metode Simplex Lattice Design

Pharmacon Jurnal Farmasi Indonesia ◽

10.23917/pharmacon.v17i1.9176 ◽

2020 ◽

Vol 17 (1) ◽

pp. 31-44

Author(s):

Ikhwan Yuda Kusuma ◽

Rani Prabandari

Keyword(s):

Physical Properties ◽

Design Method ◽

Dominant Factor ◽

Content Uniformity ◽

Compression Tests ◽

Lattice Design ◽

Simplex Lattice Design ◽

Contour Plots ◽

Simplex Lattice ◽

Optimum Formula

Piroxicam solubility in water is very small this cause problem in the process of absorption so that it’s required an optimal formula to establish the physical properties of tablet quality for piroxicam tablets. The purpose of this research was creating formulas with the optimal combination of excipients lactose, Avicel pH 101, and piroxicam amprotab to obtain tablets with good physical properties and disolution. Seven piroxicam tablet formulas were made with a combination of lactose, avicel PH-101, and Amprotab on 2 batches. Method for making tablets piroxicam was established by direct compression. Tests included were the physical properties of piroxicam tablets tablets weight uniformity, uniformity of size, hardness, brittleness, disintegration test, as well as dissolution test, and content uniformity. Based on the simplex lattice design method, lactose is a dominant factor to improved the uniformity of tablet’s concentartions. Interaction of two components avicel PH-101 and amprotab is a dominant factor to reduced vulnerability. Interaction of three components lactose, avicel PH-101 and amprotab is a dominant factor to lowered the value coefisien variation of weight uniformity, increased hardness, decreased the disintegration, and improved dissolution of tablets. Selection of the optimum formula was determined by the method of simplex lattice design through diagrams superimposed contour plots and contour plots for obtaining the optimal proportions of each ingredient as follows: lactose (85,154–100%), avicel PH-101 (0–12,437%), and amprotab (0–5,425%).

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Optimasi Formula Sediaan Losion Tabir Surya dari Ekstrak Etanol Terpurifikasi Kulit Buah Manggis (Garcinia mangostana L) Dengan Metode Simplex Lattice Design

Jurnal Sains Farmasi & Klinis ◽

10.25077/jsfk.8.2.145-156.2021 ◽

2021 ◽

Vol 8 (2) ◽

pp. 145

Author(s):

Yeyen Dwi Iryani ◽

Ika Yuni Astuti ◽

Diniatik Diniatik

Keyword(s):

Software Design ◽

Garcinia Mangostana ◽

Design Expert ◽

Lattice Design ◽

Simplex Lattice Design ◽

Simplex Lattice ◽

Optimum Formula

Ekstrak kulit buah manggis (Garcinia mangostana L) mengandung senyawa xanton yang memiliki aktivitas farmakologis dimana salah satu turunan xanton α-mangostin bekerja sebagai antioksidan. Penelitian ini bertujuan untuk mengetahui etanol yang menghasilkan ekstrak dengan jumlah xanton tertinggi, menguji aktivitas antioksidan dan tabir surya dari ekstrak terpurifikasi serta mengoptimasi formula sediaan losion tabir surya dari ekstrak terpurifikasi kulit manggis.Optimasi formula losion dilakukan menggunakan software Design Expert® versi 11 dengan kombinasi ekstrak terpurifikasi, asam stearat dan trietanolamin. 14 formula losion dievaluasi nilai SPF, pH dan viskositasnya untuk penentuan formula optimum. Formula optimum selanjutnya diuji nilai SPF, ph dan viskositas untuk membandingkan prediksi software dan hasil percobaan. Selain itu dilakukan uji daya sebar, daya lekat serta stabilitas mekanis terhadap formula optimum. Hasil penelitian menunjukkan kandungan xanton dalam ekstrak etanol 50% sebesar 20,42%, ekstrak etanol 70 % sebesar 29,88% dan ekstrak etanol 96% sebesar 64,57%. Ekstrak terpurifikasi kulit buah manggis memiliki aktivitas antioksidan dengan nilai IC50 sebesar 5,53 dan nilai AAI 14,46 serta memiliki nilai SPF 8,94 pada konsentrasi 50 µg/ml. Formula optimum yang diperoleh memiliki nilai SPF 7,49 ± 0,0297, kekentalan 21.166,666 cp ± 10,41 serta pH 6,490 ± 0,0404, daya sebar 7,833333 ± 0,15, daya lekat 2,03 ± 0,01.

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OPTIMASI ASAM STEARAT DAN TEA PADA FORMULA SEDIAAN KRIM EKSTRAK KULIT PISANG KEPOK (Musa paradisiaca L.)

Jurnal Riset Kefarmasian Indonesia ◽

10.33759/jrki.v1i3.44 ◽

2019 ◽

Vol 1 (3) ◽

pp. 225-237

Author(s):

Dwi Saryanti ◽

Iwan Setiawan ◽

Romadona Ayu Safitri

Keyword(s):

Stearic Acid ◽

Maximum Concentration ◽

Design Method ◽

Minimum Concentration ◽

Lattice Design ◽

Simplex Lattice Design ◽

Significant Difference ◽

Simplex Lattice ◽

Optimum Formula ◽

Optimal Formula

Banana kepok peel has flavonoid compounds used as antioxidants. The aim of this research is to get optimum formula of cream by combination of stearic acid and trietanolamin on good physical propertie of cream. Cream was made with stearic acid 15% minimum concentration and maximum concentration 17%, triethanolamine with minimum concentration 2% and maximum concentration 4%. The optimization of the formula was using the simplex lattice design method with parameters are pH, viscosity, spreadability, adhesion and protection. The optimum cream formula on the combination of stearic acid 16.7 grams and triethanolamine 2.3 grams. Verification results of optimal formula cream for pH got 6.1, viscosity 237.47, adhesion 12.32, power spread 18.11, protection 14.98 which showed no significant difference in the test, and has good stability.

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OPTIMASI GEL HAND SANITIZER OLEUM CITRI DENGAN KOMBINASI CARBOPOL, LIDAH BUAYA DAN TEA MENGGUNAKAN SIMPLEX LATTICE DESIGN

Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan ◽

10.36387/jiis.v6i1.569 ◽

2021 ◽

Vol 6 (1) ◽

pp. 21-28

Author(s):

Joko Santoso ◽

◽

Heru Nurcahyo

Keyword(s):

Physical Properties ◽

Design Method ◽

Aloe Vera ◽

Homogeneity Test ◽

Stabilizing Agents ◽

Hand Sanitizer ◽

Lattice Design ◽

Simplex Lattice Design ◽

Simplex Lattice ◽

Optimum Formula

Handsanitizer gel is composed of various additives such as geling agents, humectants and neutralizing / stabilizing agents. This material is certainly a basic ingredient that will affect the shape and quality of the preparation. Carbopol is very good when used, so that low levels can provide a significant viscosity response. Eleven hand sanitizer gel formulas with variations of carbomer, aloe vera and TEA were tested for their physical properties including organoleptic, homogeneity test, pH test, spreadability and adhesion test . The optimum formula is obtained by using the Simplex Lattice Design method, then the results are analyzed using an expert design software. The optimum formula for oleum citri hand sanitizer gel contains 0.944 with carbomer 0 (0.5%), aloe vera 0.471 (5.239%) and TEA 0.529 (0.576%). The t test results obtained showed insignificant differences between the response of the physical properties of the experiment results and the prediction software.

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Optimasi Campuran Manitol-Sukrosa Untuk Tablet Hisap Ekstrak Daun Dewa (Gynura Procumbens (Lour) Merr)) Secara Granulasi Basah Dengan Metode Simplex Lattice Design

Jurnal Kebidanan dan Kesehatan Tradisional ◽

10.37341/jkkt.v1i1.30 ◽

2016 ◽

Vol 1 (1) ◽

Author(s):

Youstiana Dwi Rusita

Keyword(s):

Physical Properties ◽

Flow Rate ◽

Leaf Extract ◽

T Test ◽

Wet Granulation ◽

Response Characteristics ◽

Lattice Design ◽

Simplex Lattice Design ◽

Simplex Lattice ◽

Optimum Formula

Abstract: Dewa Leaves, Lozenges, Simplex Lattice Design. Dewa is an Indonesian traditional medicinal plants are efficacious among others to the tonsils. Dewa leaf extract can be prepared as lozenges because it is more practical and effective than the traditional way in the form of infusion. This study aimed to get the optimum formula mannitol - sucrose using the simplex lattice design that has more value than triall error. Dewa leaf aqueous extract obtained by maceration leaf powder dewa with 70% ethanol and then evaporated to obtain a thick extract is dried with aerosil. This study is based on the method simplex lattice design with two components, namely FI (100% mannitol), F II (100% sucrose), F III (50% mannitol: 50% sucrose). The method used in the manufacture of leaf extract lozenges Dewa was wet granulation using the binder PVP. The granules tested flow rate, compactibility and granules ditablet to test the taste responses. Of the value of the response characteristics of the granules obtained the largest total selected as the optimum formula. Furthermore ditablet and tested physical properties which include uniformity of weight, hardness and friability of tablets. Data of physical properties of the granules suction of the optimum formula theoretically and statistically tested using the t test (T-test). The results showed that the optimum formula derived from a mixture of mannitol 70% - sucrosa 30%. From the results of the t test (T-test) and compactibility flow rate did not different significantly betwen theoretical experiment. To test the taste responses acceptable 98% of respondents. Dewa leaf extract lozenges optimum formula produced meets the physical properties of the tablet.

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PENGARUH PENGGUNAAN VARIASI KONSENTRASI AVICEL PH-101 PADA FORMULA TABLET PREDNISOLONE

Viva Medika: Jurnal Kesehatan, Kebidanan dan Keperawatan ◽

10.35960/vm.v10i3.447 ◽

2019 ◽

Vol 10 (3) ◽

pp. 21-43

Author(s):

Hilda Suherman

Keyword(s):

Physical Properties ◽

Dissolution Test ◽

Absorption Process ◽

Disintegration Time ◽

Direct Printing ◽

Lattice Design ◽

Inflammatory Conditions ◽

Simplex Lattice Design ◽

Simplex Lattice ◽

Optimum Formula

Abstract Prednisolone is a steroid class drug that is used to treat certain types of allergies, inflammatory conditions, autoimmune disorders and cancer. Solubility of prednisolone is very difficult to dissolve in water causing problems in the absorption process so that the optimum formula is needed to form Prednisolone tablets that meet the requirements of the physical properties of tablets. The purpose of this study was to make the optimum formula with a combination of lactose excipients, avicel pH-101, and amprotab to obtain prednisolone tablets with good physical properties and dissolution. Prednisolone tablets made 7 formulas with a combination of lactose (A) Avicel PH-101 (B), and Amprotab (C), Formula I (100% A); Formula II (100% B); Formula III (100% C); Formula IV (50% A + 50% B); Formula V (50% A + 50% C); Formula VI (50% B + 50% C); Formula VII (33.33% A + 33.33% B + 33.33% C) in 2 batches. The method of making prednisolone tablets by direct printing. Testing of prednisolone tablets included the physical properties of tablets, weight uniformity, uniformity in size, hardness, friability, disintegration time, and dissolution test, and content determination. Keywords: optimization of formulas, tablets, Prednisolone, Simplex Lattice Design.

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PENGARUH PENGGUNAAN VARIASI KONSENTRASI AVICEL PH-101 PADA FORMULA TABLET PREDNISOLONE

Viva Medika: Jurnal Kesehatan, Kebidanan dan Keperawatan ◽

10.35960/vm.v10i3.446 ◽

2019 ◽

Vol 10 (3) ◽

pp. 44-65

Author(s):

Hilda Suherman

Keyword(s):

Physical Properties ◽

Dissolution Test ◽

Absorption Process ◽

Disintegration Time ◽

Direct Printing ◽

Lattice Design ◽

Inflammatory Conditions ◽

Simplex Lattice Design ◽

Simplex Lattice ◽

Optimum Formula

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Optimization Carbopol And Glycerol As Basis Of Hand Gel Antiseptics Extract Ethanol Ceremai Leaf (Phyllantus Acidus (L.) Skeels) With Simplex Lattice Design

JPSCR Journal of Pharmaceutical Science and Clinical Research ◽

10.20961/jpscr.v2i01.5238 ◽

2017 ◽

Vol 2 (01) ◽

pp. 35 ◽

Cited By ~ 1

Author(s):

Dwi Saryanti ◽

Izzatun Ni'mah Zulfa

Keyword(s):

Physical Properties ◽

Ethanol Extract ◽

Gelling Agent ◽

Test Results ◽

Lattice Design ◽

Simplex Lattice Design ◽

Carbopol 940 ◽

Phyllanthus Acidus ◽

Simplex Lattice ◽

The One

Ceremai leaf (Phyllanthus acidus (L.) Skeels) is the one of the potential plant which contain flavonoid that had antibacterial activity. Carbopol is a gelling agent that is easily dispersible in water and provide consistency to the gel, while the glycerin is a humectant that can improve the softness of the gel. Carbopol can provide viscosity / hardness in the gel it is necessary to combine with glycerin to soften the gel and the increase of the spread The aims of this research to know the optimum composition from carbopol and gliserol in antiseptic gel formulation of ceremai leaf ethanol extract by Simplex Lattice Design (SLD). The method of extraction used maseration method with ethanol 70 % solvent. extract made of gel with components carbopol 940(0-100%) and glycerin(0-100%) with respond criteria physical properties such as pH, spreadability, sticking and protection power. The optimum formulated based on Simplex Lattice Design was the combination of carbopol 50 % : glycerol 50 %. Optimum results are obtained gel has a good physical properties. The test results showed that the effectiveness of antiseptic hand gels have generated a good antiseptic. Acceptability test results showed that the gel can be accepted by society.

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Optimization Formula of Turmeric (Curcuma longa L.) Extract Chewable with Combination of Mannitol-Lactose as Filler Based on Simplex Lattice Design

JPSCR Journal of Pharmaceutical Science and Clinical Research ◽

10.20961/jpscr.v2i01.5284 ◽

2017 ◽

Vol 2 (01) ◽

pp. 53 ◽

Cited By ~ 2

Author(s):

Dian Eka Ermawati ◽

Saifullah Sulaiman ◽

Indah Purwantini

Keyword(s):

Physical Properties ◽

Curcuma Longa ◽

Water Extract ◽

Hydroalcoholic Extract ◽

Lattice Design ◽

Simplex Lattice Design ◽

Simplex Lattice ◽

Student’S T ◽

Optimum Formula ◽

Prevention Of Atherosclerosis

<div class="WordSection1">Hydroalcoholic extract of turmeric (Curcuma longa L.) doses of 1.66 mg/kg containing 10% of curcuminoid was recommended as a supplement for prevention of atherosclerosis. This study aimed to formulate hydroalcoholic extract of turmeric into chewable which are more acceptable and practical. Mannitol-Lactose selected as a filler to make the chewable in this study. Optimum composition of filler of the mixture obtained by the Simplex Lattice Design method.Identification of turmeric rhizome has been done at Departemen of Plant Taxonomy, Faculty of Biology, Gadjah Mada University, Yogyakarta, Indonesia. The rhizome extraction carried out as re to research carried out by Quiles. The mixture between curcuminoid, ethanol and water extract made up to 25% level of curcuminoid level. Then, Extract was granulated with combination of filler mannitol-lactose to be five formulas, there are: FI (mannitol 100%), FII (mannitol-lactose 75%:25%), FIII (mannitol-lactose 50%:50%), FIV (mannitol-lactose 25%:75%), FV (lactose 100%). The granules then tested their physical properties such as flowability, compactibility, and water content. Furthermore, the granules tableted and physical tested including : weight uniformity, hardness, friability, absorption, flavor acceptance and soluble time. Determining the optimum formulation obtained from the physical properties of the granules and chewable physical properties based on SLD methods. Optimum formula of chewable then tested with kurkuminoid levels. The physical properties data of granules and chewable were analyzed statistically using student’s t-test.The result of this study was the optimum formula obtained from the mixture of mannitol-lactose fillers with a ratio of 90% mannitol: 10% lactose. The optimum formula of turmeric extract chewable produced meets the physical properties of the granules and chewable. Acceptance of flavor chewable optimum formula appreciation in the range of sweet and sour taste to sour. Percentage kurkuminoid levels in chewable after manufacture process was 76.42%.</div>

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Optimasi Formula Sediaan Krim o/w Kombinasi Oksibenzon dan Titanium Dioksida Serta Uji Aktivitas Tabir Suryanya Secara In Vivo

Majalah Farmaseutik ◽

10.22146/farmaseutik.v14i2.42596 ◽

2019 ◽

Vol 14 (2) ◽

pp. 63

Author(s):

Ribka Elcistia ◽

Abdul Karim Zulkarnain

Keyword(s):

New Zealand ◽

Software Design ◽

T Test ◽

Design Expert ◽

Lattice Design ◽

Simplex Lattice Design ◽

Design Software ◽

Simplex Lattice

Efek buruk dari sinar matahari dapat dikurangi dengan penggunaan tabir surya. Optimasi emulgator trietanolamin (TEA) stearat dan setil alkohol pada krim tabir surya kombinasi oksibenzon dan titanium dioksida diharapkan menghasilkan formula optimum krim dengan stabilitas fisik yang baik. Tujuan penelitian ini yaitu mengetahui proporsi TEA stearat dan setil alkohol formula optimum dan nilai SPF krim o/w kombinasi oksibenzon dan titanium dioksida. Penetapan formula optimum dilakukan pada data uji sifat fisik krim menggunakan metode Simplex Lattice Design design software Design Expert version 9.0.4. Uji one sample t-test dilakukan untuk mengetahui perbedaan nilai antara formula optimum yang dihasilkan software Design Expert version 9.0.4 dengan hasil percobaan. Perbandingan sifat fisik formula optimum krim o/w kombinasi oksibenzon dan titanium oksida selama penyimpanan 4 minggu dianalisis menggunakan uji ANOVA. Pengujian nilai SPF secara in vivo dilakukan pada kelinci betina galur New Zealand White terinduksi senyawa 8-metoksiprosalen. Hasil penelitian menunjukkan proporsi TEA stearat dan setil alkohol yang menghasilkan formula optimum krim o/w kombinasi oksibenzon dan titanium dioksida adalah 8.93% dan 2.07%. Sifat fisik viskositas dan daya lekat tidak berbeda signifikan, sedangkan daya sebar berbeda signifikan selama penyimpanan 4 minggu. Pengujian aktivitas tabir surya secara in vivo krim o/w kombinasi oksibenzon dan titanium dioksida menghasilkan nilai SPF 12.

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