scholarly journals Optimization Carbopol And Glycerol As Basis Of Hand Gel Antiseptics Extract Ethanol Ceremai Leaf (Phyllantus Acidus (L.) Skeels) With Simplex Lattice Design

2017 ◽  
Vol 2 (01) ◽  
pp. 35 ◽  
Author(s):  
Dwi Saryanti ◽  
Izzatun Ni'mah Zulfa
Keyword(s):  
Physical Properties ◽  
Ethanol Extract ◽  
Gelling Agent ◽  
Test Results ◽  
Lattice Design ◽  
Simplex Lattice Design ◽  
Carbopol 940 ◽  
Phyllanthus Acidus ◽  
Simplex Lattice ◽  
The One

Ceremai leaf (<em>Phyllanthus acidus </em>(L.) Skeels) is the one of the potential plant which contain flavonoid that had antibacterial activity. Carbopol is a gelling agent that is easily dispersible in water and provide consistency to the gel, while the glycerin is a humectant that can improve the softness of the gel. Carbopol can provide viscosity / hardness in the gel it is necessary to combine with glycerin to soften the gel and the increase of the spread The aims of this research to know the optimum composition from carbopol and gliserol in antiseptic gel formulation of ceremai leaf ethanol extract by Simplex Lattice Design (SLD). The method of extraction used maseration method with ethanol 70 % solvent. extract made of gel with components carbopol 940(0-100%) and glycerin(0-100%) with respond criteria physical properties such as pH, spreadability, sticking and protection power. The optimum formulated based on Simplex Lattice Design<em> </em>was the combination of carbopol 50 % : glycerol 50 %. Optimum results are obtained gel has a good physical properties. The test results showed that the effectiveness of antiseptic hand gels have generated a good antiseptic. Acceptability test results showed that the gel can be accepted by society.

scholarly journals Optimasi Formula Krim Ekstrak Daun Katuk (Sauropus Androgynus) Variasi Konsentrasi Asam Stearat, Trietanolamin, dan Gliserin

2020 ◽  
pp. 110-119
Author(s):  
Febia Arien Lestari ◽  
Wahida Hajrin ◽  
Nisa Isneni Hanifa
Keyword(s):  
Stearic Acid ◽  
Physical Properties ◽  
Secondary Metabolite ◽  
Test Results ◽  
Design Expert ◽  
Lattice Design ◽  
Simplex Lattice Design ◽  
Simplex Lattice ◽  
Optimum Formula ◽  
Selection Of

Sauropus androgynus (L.) Merr.) contain secondary metabolite compounds: flavonoids and polyphenols which has bioactivity as antioxidants. Antioxidants act as photoprotector, so it can be formulated into sun protection product. The selection of cream base is very important due to it’s not only as vehicle of active ingredients but also affecting cream’s physical properties and effectiveness. This study aims to determine the composition of the optimum base formula and evaluation formula cream of extract katuk leaves with variations concentration of stearic acid, TEA, and glycerin. Formula optimization was conducted through the Simplex Lattice Design methode with 13 formulas. The results of evaluation were processed with Design Expert software. The optimum formula was respectively at 13.16% stearic acid, 12% glycerin, and 3.84% TEA. The optimum formula cream evaluation was spreadability in 4.89 cm, 0.56 s stickiness power, and pH 6,1. Acceptability test results showed that the cream could accepted by society very well.

scholarly journals Optimasi Formula Nanoemulsi Gel Ekstrak Buah Bakau Hitam (Rhizophora Mucronatalamk.) Dengan Variasi Gelling Agent Hpmc, Carbopol 940 Dan Viscolam Mac 10

2021 ◽  
Vol 2 (02) ◽  
pp. 50-61
Author(s):  
Meliana Inda Setiawati ◽  
Elisa Issusilaningtyas ◽  
Lulu Setiyabudi
Keyword(s):  
Gelling Agent ◽  
Rhizophora Mucronata ◽  
Design Expert ◽  
Freeze Thaw ◽  
Lattice Design ◽  
Simplex Lattice Design ◽  
Carbopol 940 ◽  
Simplex Design ◽  
Simplex Lattice

Buah bakau hitam (Rhizophora mucronata Lamk.) mempunyai aktivitas antioksidan dengan komponen aktifnya adalah alkaloid, flavonoid, steroid, fenol hidroquinon, dan tanin. Dalam penelitian ini dipilih sediaan nanoemulgel sebagai kosmetik untuk antioksidan. Tujuan dari penelitian ini yaitu untuk mengetahui komposisi optimum campuran gelling agent untuk menghasilkan nanoemulgel ekstrak buah bakau hitam yang memenuhi sifat fisik dan stabilitas yang baik. Optimasi menggunakan metode Simplex Lattice Design (SLD) dengan variasi gelling agent menggunakan HPMC, Carbopol 940 dan Viscolam MAC 10 yang diperoleh sebanyak empat belas formula, dengan karakteristik fisik organoleptis, pH, homogenitas, daya sebar, viskositas dan stabilitas fisik perubahan viskositas dengan metode freeze thaw. Data dinalisis menggunakan simplex design expert 10.0.1 dan uji t serta deskriptif. Hasil formulasi optimum campuran gelling agent untuk menghasilkan nanoemulgel ekstrak buah bakau hitam yang memenuhi sifat fisik dan stabilitas yang baik adalah nanoemulgel pada formula VI, dan pada hasil penentuan formula optimum nanoemulgel ekstrak buah bakau hitam diperoleh dengan campuran HPMC 0,024%, carbopol 940 0,38% dan viscolam MAC 10 0,59%. Dengan nilai respon yang diperoleh untuk evaluasi dengan daya sebar 2,21 cm, viskositas 49043,2 Cps dan perubahan viskositas 579,3 Cps.

OPTIMASI FORMULA EKSTRAK JAHE MERAH (Zingiber officinale) DENGAN METODE KEMPA LANGSUNG MENGGUNAKAN ANALISIS SIMPLEX LATTICE DESIGN

2017 ◽  
Vol 1 (1) ◽  
pp. 47
Author(s):  
Hayatus Sa'adah
Keyword(s):  
Dosage Form ◽  
Ethanol Extract ◽  
Zingiber Officinale ◽  
Disintegration Time ◽  
Lattice Design ◽  
Simplex Lattice Design ◽  
Optimum Proportion ◽  
Simplex Lattice ◽  
Red Ginger ◽  
Tablet Hardness

Processing of medicinal plants into the appropriate dosage form can ensure security during use. It is a motivation in making acceptable dosage form which is easy and convenient to use, especially the manufacture of ethanol extract red ginger tablets using a combination of starch 1500 and amprotab.The study begins with the manufacture of dry extract of red ginger. Optimization of making tablets using a combination of starch 1500 and disintegrator with simplex lattice design using three formulas is done by direct compaction method. Further testing on the tablet hardness, friability and disintegration time.The results showed starch 1500 has a greater influence increase hardness and disintegration time of tablets, as well as lowering the fragility of the tablet. While the interaction of starch 1500 and disintegrator has no effect on the physical tablet. The optimum proportion of the combination of starch 1500 and disintegrator meet the physical requirements of tablets with a ratio of 4: 6 with 7.99 kg hardness, the friability of 0.32% and disintegration time of 2.42 minutes

scholarly journals Optimasi Formula Tablet Piroksikam Menggunakan Eksipien Laktosa, Avicel pH-101, dan Amprotab dengan Metode Simplex Lattice Design

2020 ◽  
Vol 17 (1) ◽  
pp. 31-44
Author(s):  
Ikhwan Yuda Kusuma ◽  
Rani Prabandari
Keyword(s):  
Physical Properties ◽  
Design Method ◽  
Dominant Factor ◽  
Content Uniformity ◽  
Compression Tests ◽  
Lattice Design ◽  
Simplex Lattice Design ◽  
Contour Plots ◽  
Simplex Lattice ◽  
Optimum Formula

Piroxicam solubility in water is very small this cause problem in the process of absorption so that it’s required an optimal formula to establish the physical properties of tablet quality for piroxicam tablets. The purpose of this research was creating formulas with the optimal combination of excipients lactose, Avicel pH 101, and piroxicam amprotab to obtain tablets with good physical properties and disolution. Seven piroxicam tablet formulas were made with a combination of lactose, avicel PH-101, and Amprotab on 2 batches. Method for making tablets piroxicam was established by direct compression. Tests included were the physical properties of piroxicam tablets tablets weight uniformity, uniformity of size, hardness, brittleness, disintegration test, as well as dissolution test, and content uniformity. Based on the simplex lattice design method, lactose is a dominant factor to improved the uniformity of tablet’s concentartions. Interaction of two components avicel PH-101 and amprotab is a dominant factor to reduced vulnerability. Interaction of three components lactose, avicel PH-101 and amprotab is a dominant factor to lowered the value coefisien variation of weight uniformity, increased hardness, decreased the disintegration, and improved dissolution of tablets. Selection of the optimum formula was determined by the method of simplex lattice design through diagrams superimposed contour plots and contour plots for obtaining the optimal proportions of each ingredient as follows: lactose (85,154–100%), avicel PH-101 (0–12,437%), and amprotab (0–5,425%).

scholarly journals Tablet Formula Optimization From Helminthostachys Zaylanica Extract Using A Simplex Lattice Design

2021 ◽  
Vol 6 (3) ◽  
pp. 131-136
Author(s):  
Fitrya Fitrya ◽  
Najma Annuria Fithri ◽  
Budi Untari ◽  
Aprililianti
Keyword(s):  
Physical Properties ◽  
Toxicity Tests ◽  
Dissolution Time ◽  
Wet Granulation ◽  
Disintegration Time ◽  
Lattice Design ◽  
Simplex Lattice Design ◽  
Weight Variation ◽  
Simplex Lattice ◽  
Helminthostachys Zeylanica

Helminthostachys zeylanica extract has pharmacological activities such as antioxidant, antiinflamatory, and antihyerucemia. This extract is nontoxic substance from the acute and subchronic toxicity tests. This extract has a potency to be formulated into tablet dosage forms. This study aims to optimize a tablet formula from Helminthostachys zeylanica extract. Disintegrant and binder concentrations were independent variables, while physical properties and dissolution time of the tablets were dependent variables. The tablet was prepared by a wet granulation method. Formula was optimized by Simplex Lattice Design. Physicochemical propertiesof granule, physical properties and dissolution of tablet were then analyzed with One Way ANOVA (p = 0.05). Based on granule analysis, specification of physicochemical parameters, such as hausner’s ratio, compressibility index, flowability, repose angle, and water content, met standard British Pharmacopeia. In addition, the starch and PVA concentrations influenced thickness, weight variation, hardness, friability, disintegration time and dissolution of the tablets (p <0.05), except for friability (p> 0.05). Based on this study, the starch and PVA concentrations for the optimum tablet formula were 19.5% and 1.05%, respectively.

scholarly journals OPTIMIZATION OF CARBOPOL 940 AND PROPYLENE GLYCOL CONCENTRATION ON THE CHARACTERISTIC AND INHIBITORY EFFECT OF ETHANOL EXTRACT GEL OF PAPAYA (Carica papaya L.) SEEDS AGAINST Staphylococcus aureus

2021 ◽  
Vol 18 (1) ◽  
pp. 15-25
Author(s):  
Octavianus Yandri ◽  
Wahyuning Setyani
Keyword(s):  
Staphylococcus Aureus ◽  
Physical Properties ◽  
Propylene Glycol ◽  
Inhibitory Activity ◽  
Carica Papaya ◽  
Ethanol Extract ◽  
Gelling Agent ◽  
Activity Test ◽  
Carbopol 940 ◽  
Papaya Seed

Papaya (Carica papaya L.) seeds contain alkaloids, flavonoids, tannins, phenolic compounds and saponins have been proven its synergistic effect in inhibiting the growth of Staphylococcus aureus. In this research, ethanol extract of papaya seeds was formulated in gel preparations. Optimization of the composition of the gelling agent and humectant was carried out to obtain the gel preparation of papaya seed ethanol extract with good physical properties and stability. The parameters used to determine the stability of the preparation are Physical properties which include viscosity, spreadability, and percentage of viscosity shift. Data analysis was performed using Design-Expert software version 12 and SPSS. The inhibitory activity test was carried out by the disk-diffusion agar method with Staphylococcus aureus ATCC 25923 as the test bacteria. The results of the inhibitory activity test of papaya seed ethanol extract at a concentration of 20% had moderate activity and at concentrations of 40%, 60%, 80% and 100% classified as strong against the Staphylococcus aureus. Carbopol 940 is dominant factor in influencing the response of viscosity (92.504%) and spreadability (59.539%). Preparations with good physical properties and stability were obtained on the use of carbopol 940 and propylene glycol as much as 1.06604 grams and 13.2146 grams respectively.

Optimasi Carbopol 940 dan Gliserin dalam Formula Gel Lendir Bekicot (Achatina fulica Ferr) sebagai Antibakteri Staphylococcus aureus dengan Metode Simplex Lattice Design

2020 ◽  
Vol 17 (1) ◽  
pp. 108
Author(s):  
Arsiaty Sumule ◽  
Ilham Kuncahyo ◽  
Fransiska Leviana
Keyword(s):  
Staphylococcus Aureus ◽  
Program Design ◽  
Achatina Fulica ◽  
Design Expert ◽  
Lattice Design ◽  
Simplex Lattice Design ◽  
Carbopol 940 ◽  
Simplex Lattice

Lendir bekicot (Achatina fulica Ferr) mengandung protein achasin, suatu senyawa dengan aktivitas antibakteri yang mendukung proses penyembuhan luka. Selain itu, peptida mytimacin-AF pada lender bekicot diketahui menghambat pertumbuhan Staphylococcus aureus ATCC 25923. Lendir bekicot kurang praktis jika digunakan secara langsung sehingga perlu dikembangkan menjadi bentuk sediaan gel. Penelitian ini bertujuan untuk mengetahui proporsi optimum campuran carbopol 940 dengan gliserin dalam formula gel dan mengevaluasi aktivitas antibakteri formula optimum terhadap S. aureus ATCC 25923. Gel lendir bekicot dibuat tiga formula dengan komposisi carbopol 940 dan gliserin masing-masing sebesar 1; 1,5; dan 2%, serta 15; 14,5; dan 14%. Semua formula diuji sifat fisiknya selama empat minggu, meliputi organoleptis, homogenitas, viskositas, daya sebar, daya lekat, dan pergeseran viskositas. Hasil uji dioptimasi dengan metode simplex lattice design menggunakan program Design Expert 8.0.6.1. Formula optimum yang diperoleh dievaluasi sifat fisiknya selama empat minggu, sedangkan aktivitas antibakterinya diuji dengan menggunakan metode difusi sumuran. Hasil penelitian menunjukkan formula optimum gel lendir bekicot dengan proporsi campuran carbopol 940 dan gliserin masing-masing 1,123 dan 14,877%. Formula optimum memiliki aktivitas antibakteri terhadap S. aureus dengan diameter zona hambat sebesar 1,73 cm.

scholarly journals OPTIMASI GEL HAND SANITIZER OLEUM CITRI DENGAN KOMBINASI CARBOPOL, LIDAH BUAYA DAN TEA MENGGUNAKAN SIMPLEX LATTICE DESIGN

2021 ◽  
Vol 6 (1) ◽  
pp. 21-28
Author(s):  
Joko Santoso ◽  
◽  
Heru Nurcahyo
Keyword(s):  
Physical Properties ◽  
Design Method ◽  
Aloe Vera ◽  
Homogeneity Test ◽  
Stabilizing Agents ◽  
Hand Sanitizer ◽  
Lattice Design ◽  
Simplex Lattice Design ◽  
Simplex Lattice ◽  
Optimum Formula

Handsanitizer gel is composed of various additives such as geling agents, humectants and neutralizing / stabilizing agents. This material is certainly a basic ingredient that will affect the shape and quality of the preparation. Carbopol is very good when used, so that low levels can provide a significant viscosity response. Eleven hand sanitizer gel formulas with variations of carbomer, aloe vera and TEA were tested for their physical properties including organoleptic, homogeneity test, pH test, spreadability and adhesion test . The optimum formula is obtained by using the Simplex Lattice Design method, then the results are analyzed using an expert design software. The optimum formula for oleum citri hand sanitizer gel contains 0.944 with carbomer 0 (0.5%), aloe vera 0.471 (5.239%) and TEA 0.529 (0.576%). The t test results obtained showed insignificant differences between the response of the physical properties of the experiment results and the prediction software.

scholarly journals Optimasi Campuran Manitol-Sukrosa Untuk Tablet Hisap Ekstrak Daun Dewa (Gynura Procumbens (Lour) Merr)) Secara Granulasi Basah Dengan Metode Simplex Lattice Design

2016 ◽  
Vol 1 (1) ◽  
Author(s):  
Youstiana Dwi Rusita
Keyword(s):  
Physical Properties ◽  
Flow Rate ◽  
Leaf Extract ◽  
T Test ◽  
Wet Granulation ◽  
Response Characteristics ◽  
Lattice Design ◽  
Simplex Lattice Design ◽  
Simplex Lattice ◽  
Optimum Formula

Abstract: Dewa Leaves, Lozenges, Simplex Lattice Design. Dewa is an Indonesian traditional medicinal plants are efficacious among others to the tonsils. Dewa leaf extract can be prepared as lozenges because it is more practical and effective than the traditional way in the form of infusion. This study aimed to get the optimum formula mannitol - sucrose using the simplex lattice design that has more value than triall error. Dewa leaf aqueous extract obtained by maceration leaf powder dewa with 70% ethanol and then evaporated to obtain a thick extract is dried with aerosil. This study is based on the method simplex lattice design with two components, namely FI (100% mannitol), F II (100% sucrose), F III (50% mannitol: 50% sucrose). The method used in the manufacture of leaf extract lozenges Dewa was wet granulation using the binder PVP. The granules tested flow rate, compactibility and granules ditablet to test the taste responses. Of the value of the response characteristics of the granules obtained the largest total selected as the optimum formula. Furthermore ditablet and tested physical properties which include uniformity of weight, hardness and friability of tablets. Data of physical properties of the granules suction of the optimum formula theoretically and statistically tested using the t test (T-test). The results showed that the optimum formula derived from a mixture of mannitol 70% - sucrosa 30%. From the results of the t test (T-test) and compactibility flow rate did not different significantly betwen theoretical experiment. To test the taste responses acceptable 98% of respondents. Dewa leaf extract lozenges optimum formula produced meets the physical properties of the tablet.

Self-Nanoemulsifying Drug Delivery System (SNEDDS) with Enhanched Solubilization of Ethanol Extract from Mangosteen Peels (Garcinia Mangostana, L.) for Treatment of Topical Gangrene Foot: Design and Optimization

2017 ◽  
Vol 7 (04) ◽  
Author(s):  
Pratiwi L. ◽  
Sari R. ◽  
Apridamayanti P.
Keyword(s):  
Drug Delivery ◽  
Ph Value ◽  
Drug Loading ◽  
Coconut Oil ◽  
Ethanol Extract ◽  
Garcinia Mangostana ◽  
Lattice Design ◽  
Peg 400 ◽  
Simplex Lattice Design ◽  
Simplex Lattice

The aim of the present study is to develop and optimize self-nanoemulsifying drug delivery systems (SNEDDS) to improve the topical bioavailability of poorly soluble ethanol extract of mangosteen peels and to get optimum method of SNEDDS by simplex lattice design, using Design Expert software ®version 7. Solubility of ethanol extract of the mangosteen peels was estimated in various compositions to select proper components combinations. Virgin coconut oil/ VCO (oil), Tween® 80 (surfactants) as well as polietilenglikol 400 (PEG 400) (co-surfactants) were employed to construct pseudo-ternary phase diagrams. Transmittance and pH, droplet size, zeta potential, and thermodynamic stability were performed to optimize formulations from phase diagram. Fourteen formulations composed of VCO, Tween 80 and PEG 400 at simplex lattice design ratios were selected. The results showed that the ethanol extract of the mangosteen peels SNEDDS optimum consisting of Cremophor EL as the surfactant, PEG 400 as the co-surfactant, and VCO as the oil phase with a ratio of 5.27: 1: 1.72. Evaluation of SNEDDS with an optimum formulation with drug loading value of 125 mg/5 mL, emulsification time of 5,2 seconds, transmittance value of 74,6552 %, pH value 5,85 and has a particle size of 18,9 nm. Ethanol extract of the mangosteen peels loaded SNEDDS, with enhanced solubilization and nanosizing, and has potential to improve the absorption of drug and increase its topical antimicrobial activity against Staphylococcus aureus.

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