Molecular imprinted polymer and its applications in Agriculture Science: a review

Contamination of environment due to indiscriminate use of herbicides poses severe risks to soil, water and air as well as human health. Therefore, need of easy, rapid and of low cost detection methods triggered the researcher to find out new technology. Molecularly imprinted polymers (MIPs), the synthetic materials are very useful in these circumstances. It offers several advantages to the environmental scientist, chemist, pharmaceutical, and agro food industry for analysis, sensoring, extraction, or preconcentration of analytes. The high toxicity of herbicides and their large use in modern agriculture practices has increased public concerns. In this review paper, imprinting and detection of herbicide, the recognition and transport properties of molecularly imprinted polymer (MIP) membranes prepared for herbicides such as Isoproturon and 2,4-D in particular have been discussed.

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Recent Advances and Perspectives of Molecularly Imprinted Polymer-Based Fluorescent Sensors in Food and Environment Analysis

Nanomaterials ◽

10.3390/nano9071030 ◽

2019 ◽

Vol 9 (7) ◽

pp. 1030 ◽

Cited By ~ 7

Author(s):

Guangyang Liu ◽

Xiaodong Huang ◽

Lingyun Li ◽

Xiaomin Xu ◽

Yanguo Zhang ◽

...

Keyword(s):

Molecularly Imprinted Polymer ◽

New Technology ◽

Three Dimensional ◽

High Sensitivity ◽

Detection Methods ◽

Fluorescent Nanoparticles ◽

Imprinted Polymer ◽

Recognition Mechanism ◽

Molecularly Imprinted ◽

Wide Range

Molecular imprinting technology (MIT), also known as molecular template technology, is a new technology involving material chemistry, polymer chemistry, biochemistry, and other multi-disciplinary approaches. This technology is used to realize the unique recognition ability of three-dimensional crosslinked polymers, called the molecularly imprinted polymers (MIPs). MIPs demonstrate a wide range of applicability, good plasticity, stability, and high selectivity, and their internal recognition sites can be selectively combined with template molecules to achieve selective recognition. A molecularly imprinted fluorescence sensor (MIFs) incorporates fluorescent materials (fluorescein or fluorescent nanoparticles) into a molecularly imprinted polymer synthesis system and transforms the binding sites between target molecules and molecularly imprinted materials into readable fluorescence signals. This sensor demonstrates the advantages of high sensitivity and selectivity of fluorescence detection. Molecularly imprinted materials demonstrate considerable research significance and broad application prospects. They are a research hotspot in the field of food and environment safety sensing analysis. In this study, the progress in the construction and application of MIFs was reviewed with emphasis on the preparation principle, detection methods, and molecular recognition mechanism. The applications of MIFs in food and environment safety detection in recent years were summarized, and the research trends and development prospects of MIFs were discussed.

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Sensing of Furfural by Molecularly Imprinted Polymers on Plasmonic and Electrochemical Platforms

Proceedings ◽

10.3390/proceedings2019015048 ◽

2019 ◽

Vol 15 (1) ◽

pp. 48

Author(s):

Pesavento ◽

Cennamo ◽

Alberti ◽

Marchetti ◽

Zeni

Keyword(s):

Molecularly Imprinted Polymers ◽

Low Cost ◽

Human Beings ◽

Imprinted Polymer ◽

Molecularly Imprinted ◽

Detectable Concentration ◽

Carcinogenic Effects ◽

Furanic Compounds ◽

Safety Applications

The goal of this work is to test the possibility of selective detection of furfural (2-FAL) in aqueous solutions, with a molecularly imprinted polymer (MIP) receptor exploiting two different transduction methods, for food safety applications. In particular, sensors with electrochemical and surface plasmon resonance (SPR) transduction are considered. Two concentration ranges could be investigated by the different sensing approaches since the detectable concentration level depends on the sensitivity of the detection technique employed. The determination of 2-FAL at different concentration levels in the aqueous medium of interest, as for example beverages, is becoming a very crucial task not only for the relevance of furanic compounds in affecting the flavor but also for their possible toxic and carcinogenic effects on the human beings. For these reasons, their determination by a fast, easy and low-cost method is of interest. The sensor methods here proposed appears to be particularly suitable, since, although together and not individually, they allow the determination in a wide concentration range.

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A simple approach to prepare fluorescent molecularly imprinted nanoparticles

RSC Advances ◽

10.1039/d0ra10618f ◽

2021 ◽

Vol 11 (13) ◽

pp. 7732-7737

Author(s):

Fenying Wang ◽

Dan Wang ◽

Tingting Wang ◽

Yu Jin ◽

Baoping Ling ◽

...

Keyword(s):

High Performance ◽

Low Cost ◽

Sol Gel ◽

Silica Sol ◽

Simple Approach ◽

Imprinted Polymer ◽

Molecularly Imprinted ◽

Low Toxicity ◽

Good Biocompatibility ◽

Molecularly Imprinted Nanoparticles

Fluorescent molecularly imprinted polymer (FMIP) gains great attention in many fields due to their low cost, good biocompatibility and low toxicity. Here, a high-performance FMIP was prepared based on the autocatalytic silica sol–gel reaction.

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Molecularly Imprinted Polymers Combined with Electrochemical Sensors for Food Contaminants Analysis

Molecules ◽

10.3390/molecules26154607 ◽

2021 ◽

Vol 26 (15) ◽

pp. 4607

Author(s):

Dounia Elfadil ◽

Abderrahman Lamaoui ◽

Flavio Della Pelle ◽

Aziz Amine ◽

Dario Compagnone

Keyword(s):

Food Safety ◽

Molecularly Imprinted Polymers ◽

Electrochemical Sensors ◽

Low Cost ◽

Electrochemical Analysis ◽

Ease Of Use ◽

Electrochemical Sensing ◽

Food Contaminants ◽

Molecularly Imprinted ◽

Imprinted Polymers

Detection of relevant contaminants using screening approaches is a key issue to ensure food safety and respect for the regulatory limits established. Electrochemical sensors present several advantages such as rapidity; ease of use; possibility of on-site analysis and low cost. The lack of selectivity for electrochemical sensors working in complex samples as food may be overcome by coupling them with molecularly imprinted polymers (MIPs). MIPs are synthetic materials that mimic biological receptors and are produced by the polymerization of functional monomers in presence of a target analyte. This paper critically reviews and discusses the recent progress in MIP-based electrochemical sensors for food safety. A brief introduction on MIPs and electrochemical sensors is given; followed by a discussion of the recent achievements for various MIPs-based electrochemical sensors for food contaminants analysis. Both electropolymerization and chemical synthesis of MIP-based electrochemical sensing are discussed as well as the relevant applications of MIPs used in sample preparation and then coupled to electrochemical analysis. Future perspectives and challenges have been eventually given.

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Application progress of magnetic molecularly imprinted polymer chemical sensors in the detection of biomarkers

The Analyst ◽

10.1039/d1an01112j ◽

2022 ◽

Author(s):

Ying Wang ◽

Xiaomin Yang ◽

Lin Pang ◽

Pengfei Geng ◽

Fang Mi ◽

...

Keyword(s):

Chemical Sensors ◽

Molecularly Imprinted Polymers ◽

Essential Role ◽

Imprinted Polymer ◽

Molecularly Imprinted ◽

Magnetic Molecularly Imprinted Polymer ◽

Magnetic Molecularly Imprinted Polymers ◽

Highly Sensitive ◽

Detection Of Biomarkers ◽

Highly Sensitive Detection

Specific recognition and highly sensitive detection of biomarkers play an essential role in identifying, early diagnosis and prevention of many diseases. Magnetic molecularly imprinted polymers (MMIP) have been widely used...

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Preparation of carbon-based metal organic frameworks modified molecularly imprinted polymers for selective recognition of bovine hemoglobin in biological samples

New Journal of Chemistry ◽

10.1039/d1nj05522d ◽

2022 ◽

Author(s):

Xue Chen ◽

Jinyue Chai ◽

Baodong Sun ◽

Xue Yang ◽

Feng Zhang ◽

...

Keyword(s):

Molecularly Imprinted Polymers ◽

Metal Organic Framework ◽

Selective Recognition ◽

Template Molecule ◽

Bovine Hemoglobin ◽

Carbon Spheres ◽

Imprinted Polymer ◽

Molecularly Imprinted ◽

Metal Organic ◽

Carbon Based

In this study, the carbon-based Cu2+-immobilized metal-organic framework modified molecularly imprinted polymer (C@GI@Cu-MOFs@MIPs) adsorbent was prepared using bovine hemoglobin (BHb) as a template molecule with carbon spheres as carriers for...

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Magnetic molecularly imprinted polymers–silver nanoparticle based micro-solid phase extraction for the determination of polycyclic aromatic hydrocarbons in water samples

RSC Advances ◽

10.1039/c6ra08499k ◽

2016 ◽

Vol 6 (60) ◽

pp. 54702-54708 ◽

Cited By ~ 11

Author(s):

Mostafa Khajeh ◽

Marzieh Sharifirad ◽

Mousa Bohlooli ◽

Mansour Ghaffari-Moghaddam

Keyword(s):

Silver Nanoparticle ◽

Aromatic Hydrocarbons ◽

Molecularly Imprinted Polymers ◽

Solid Phase ◽

Imprinted Polymer ◽

Molecularly Imprinted ◽

Magnetic Molecularly Imprinted Polymer ◽

Magnetic Molecularly Imprinted Polymers ◽

Polycyclic Aromatic

In this study, an efficient and sensitive magnetic molecularly imprinted polymer–silver nanoparticle (MMIPS) system was successfully synthesized.

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Molecularly Imprinted Polymer Based Sensors for Medical Applications

Sensors ◽

10.3390/s19061279 ◽

2019 ◽

Vol 19 (6) ◽

pp. 1279 ◽

Cited By ~ 41

Author(s):

Yeşeren Saylan ◽

Semra Akgönüllü ◽

Handan Yavuz ◽

Serhat Ünal ◽

Adil Denizli

Keyword(s):

Surface Modification ◽

Homeland Security ◽

Molecular Imprinting ◽

Molecularly Imprinted Polymer ◽

Structural Changes ◽

Low Cost ◽

Dimensional Structure ◽

Imprinted Polymer ◽

Molecularly Imprinted ◽

Physical And Chemical

Sensors have been extensively used owing to multiple advantages, including exceptional sensing performance, user-friendly operation, fast response, high sensitivity and specificity, portability, and real-time analysis. In recent years, efforts in sensor realm have expanded promptly, and it has already presented a broad range of applications in the fields of medical, pharmaceutical and environmental applications, food safety, and homeland security. In particular, molecularly imprinted polymer based sensors have created a fascinating horizon for surface modification techniques by forming specific recognition cavities for template molecules in the polymeric matrix. This method ensures a broad range of versatility to imprint a variety of biomolecules with different size, three dimensional structure, physical and chemical features. In contrast to complex and time-consuming laboratory surface modification methods, molecular imprinting offers a rapid, sensitive, inexpensive, easy-to-use, and highly selective approaches for sensing, and especially for the applications of diagnosis, screening, and theranostics. Due to its physical and chemical robustness, high stability, low-cost, and reusability features, molecularly imprinted polymer based sensors have become very attractive modalities for such applications with a sensitivity of minute structural changes in the structure of biomolecules. This review aims at discussing the principle of molecular imprinting method, the integration of molecularly imprinted polymers with sensing tools, the recent advances and strategies in molecular imprinting methodologies, their applications in medical, and future outlook on this concept.

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Molecularly imprinted polymers in biological applications

BioTechniques ◽

10.2144/btn-2020-0091 ◽

2020 ◽

Vol 69 (6) ◽

pp. 406-419

Author(s):

Zahra El-Schich ◽

Yuecheng Zhang ◽

Marek Feith ◽

Sarah Beyer ◽

Louise Sternbæk ◽

...

Keyword(s):

Amino Acids ◽

Molecularly Imprinted Polymers ◽

Low Cost ◽

Cancer Diagnostics ◽

Biological Applications ◽

Molecularly Imprinted ◽

Imprinted Polymers ◽

Recognition Elements ◽

Synthesis Procedure

Molecularly imprinted polymers (MIPs) are currently widely used and further developed for biological applications. The MIP synthesis procedure is a key process, and a wide variety of protocols exist. The templates that are used for imprinting vary from the smallest glycosylated glycan structures or even amino acids to whole proteins or bacteria. The low cost, quick preparation, stability and reproducibility have been highlighted as advantages of MIPs. The biological applications utilizing MIPs discussed here include enzyme-linked assays, sensors, in vivo applications, drug delivery, cancer diagnostics and more. Indeed, there are numerous examples of how MIPs can be used as recognition elements similar to natural antibodies.

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