scholarly journals Compliance with treatment of patients with glaucoma

2014 ◽  
Vol 61 (4) ◽  
pp. 47-53
Author(s):  
Nevena Bjelovic ◽  
Ivan Sencanic ◽  
Goran Trajkovic
Keyword(s):  
Side Effects ◽  
Treatment Satisfaction ◽  
Treatment Effectiveness ◽  
Study Objective ◽  
Satisfaction Questionnaire ◽  
Level Of Satisfaction ◽  
Significant Difference ◽  
Patient Reported ◽  
Satisfaction With Treatment ◽  
High Level

Introduction: Glaucoma is progressive, chronic optic neuropathy, causing visual field damage and progressive loss of sight. This is a leading cause of preventable blindness and most often asymptomatic disease. Recommended management of glaucoma typically includes the use of medication(s). Compliance rates vary between 25 and 59%. Patient reported outcomes (PRO's) are an umbrella term, covering a broad range of health data reported by patients. PRO's self reported questionnaires are developed to assess several aspects of patient health status, including treatment satisfaction and adherence. Study objective: To assess patient satisfaction with medication effectiveness, medication side effects, convenience and overall treatment satisfaction. Material and method: Using a crosssectional study design, glaucoma patients had been recruited, and examined at the Centre for Sight "Oftalmika" in Belgrade, Serbia in the period between May 15th and June 15th 2011. The questionnaire used in research was the Treatment Satisfaction Questionnaire for Medication Version ii (TSQM). Results: Total of 73 glaucoma patients filled out the Treatment Satisfaction Questionnaire. The mean age was 62.8 years. Satisfaction score for TSQM subscales: Effectiveness, Side Effects, and Convenience and Overall Satisfaction have not showed statistically significant difference between the subscales. The participants are satisfied with the treatment effectiveness, independently on gender, age, level of the education, and the difference within the family life style. Participants from the secondary educational level (iSCED levels) showed significantly lower satisfaction with the side effects than others. Also, there is a significantly higher level of satisfaction with treatment, for the people who live alone. Overall, the study determined that there is a statistically significant positive linear correlation between overall satisfaction with treatment and its determinants. Conclusion: Our respondents showed a high level of satisfaction with therapy. Patients' satisfaction with treatment was higher in patients who believe that the therapy is effective, who are not bothered with the influence of side effects and are satisfied with the therapeutic schemes.

scholarly journals Treatment satisfaction in 5q-spinal muscular atrophy under nusinersen therapy

2021 ◽  
Vol 14 ◽  
pp. 175628642199890 ◽  
Author(s):  
Alma Osmanovic ◽  
Gresa Ranxha ◽  
Mareike Kumpe ◽  
Claudia D. Wurster ◽  
Benjamin Stolte ◽  
...  
Keyword(s):  
Side Effects ◽  
Spinal Muscular Atrophy ◽  
Outcome Measures ◽  
Treatment Satisfaction ◽  
Treatment Duration ◽  
Treatment Effectiveness ◽  
Muscular Atrophy ◽  
Patients Satisfaction ◽  
Motor Outcome ◽  
Ambulatory Patients

Background: Nusinersen was the first approved disease-modifying therapy for all 5q-spinal muscular atrophy (SMA) patients regardless of age or disease severity. Its efficacy in adults has recently been demonstrated in a large cohort by motor outcome measures, which were only partially suitable to detect changes in very mildly or severely affected patients. Patient-reported outcome measures (PROs) have been suggested as a valuable addition. Here, we aimed to assess treatment satisfaction and investigate whether it may be a useful PRO to monitor SMA patients. Methods: We enrolled 91 mainly adult 5q-SMA patients treated with nusinersen in a national, multicenter, cross-sectional observational study. 21 patients underwent longitudinal follow up. Patients’ satisfaction with treatment in four dimensions (global, effectiveness, convenience, side effects) was assessed by the Treatment Satisfaction Questionnaire for Medication German version 1.4 (TSQM-1.4©) and related to clinical parameters, motor scores, and treatment duration. Results: More than 90% of SMA patients were consistently satisfied over a median treatment duration of 10 months. Highest mean scores were observed in the dimensions ‘side effects,’ ‘global satisfaction,’ and ‘effectiveness’ (93.5 ± 14.8 versus 73.1 ± 21.0 and 64.8 ± 20.6, respectively). Patients’ satisfaction with the convenience of treatment was considerably lower (43.6 ± 20.2). Interestingly, satisfaction with the effectiveness was higher in ambulatory ( p = 0.014) compared with non-ambulatory patients and directly correlated to motor outcome measures. Five non-ambulatory patients withdrew from therapy. All of them presented with a deterioration of motor outcome measures and reported dissatisfaction with treatment effectiveness and convenience. Conclusion: Most patients were satisfied with nusinersen treatment effectiveness. Less severely affected patients indicated higher satisfaction. The TSQM-1.4© helped to identify therapy non-responders, who mainly addressed dissatisfaction with effectiveness and convenience. We suggest introducing the TSQM-1.4© as an additional PRO in SMA into clinical practice.

scholarly journals Short Practical Regimen of Acupuncture for Melasma: A Prospective Cohort Study in a Tertiary Hospital in Thailand

2021 ◽  
Vol 9 ◽  
Author(s):  
Thanan Supasiri ◽  
Nuntida Salakshna ◽  
Krit Pongpirul
Keyword(s):  
Side Effects ◽  
Adverse Events ◽  
Severity Index ◽  
Tertiary Hospital ◽  
Optimal Number ◽  
Significant Difference ◽  
Patient Reported ◽  
Group A ◽  
The Mean ◽  
Group B

Background: Acupuncture shows benefits for patients with melasma, although no optimal number of sessions have been determined.Methods: The prospective observational study was conducted in melasma patients who were treated with acupuncture procedures two times a week and were evaluated after the 5th and the 10th sessions of acupuncture, with a 1-week follow-up after the last session. Participants Groups A and B received five and 10 acupuncture sessions, respectively. Melasma was assessed by using the melanin index (MI), melasma area and severity index (MASI), patient-reported improvement scores, and acupuncture-related adverse events.Results: Out of 113 participants, 67 received five sessions of acupuncture treatment while 39 received 10 sessions. At 1 week after five sessions of acupuncture in Group A, the mean MI decreased by 28.7 (95% CI −38.5 to −18.8, p < 0.001), whereas the median MASI decreased by 3.4 (95% CI −6.9 to −1.2, p < 0.001) points. At 1 week after ten sessions of acupuncture in Group B, the mean MI decreased by 31.3 (95% CI −45 to −17.6, p < 0.001), whereas the median MASI decreased by 5.4 (95%CI −9.9 to −3, p < 0.001) points. The first five sessions of acupuncture had a higher incremental effect than the last five sessions, although there was no statistically significant difference. Twenty-nine participants reported minor side effects. Group B had a risk ratio (RR) of having adverse events 1.8 times (95% CI 1.0–3.4, p = 0.05) compared with Group A.Conclusion: Short acupuncture regimens of 5–10 sessions in melasma seem to be effective and practical with minor side effects.

scholarly journals Global Pathology Training in Residency and Fellowship: A Mutually Beneficial Intervention

2020 ◽  
Author(s):  
Lianna Goetz ◽  
Khadija Huggins ◽  
Wesley Greaves ◽  
Tricia Peters ◽  
Melanie Johncilla
Keyword(s):  
Global Health ◽  
Turnaround Time ◽  
Middle Income ◽  
Middle Income Countries ◽  
Level Of Satisfaction ◽  
Significant Difference ◽  
The Us ◽  
Clinician Satisfaction ◽  
High Level ◽  
Pathology Training

Context.— Most cancers occur in lower and middle income countries, where pathologists are scarce. Despite this, few pathology training programs offer global health electives, and trainees are not exposed to challenges associated with practicing in resource-restricted settings. Objective.— To implement a global health elective model aimed at exposing trainees to global health while alleviating overburdened pathologists in resource-restricted settings. Design.— For 1 year, trainees at 2 US institutions reviewed cases shipped weekly from a pathology lab serving Trinidad and Tobago and Guyana. Turnaround time, specimen type, and trainee and clinician satisfaction were assessed. Results.— Trainees reviewed an average of 16 cases per week. Average turnaround time was 6 days. There was no significant difference between the turnaround time for the US trainees and the pathologist based in the lab in Trinidad. Trainees and clinicians reported a high level of satisfaction, and the collaboration was fruitful, resulting in the publication of a case report. Conclusions.— We demonstrate that collaboration between US trainees and laboratories in resource-restricted settings, in the form of a global health elective, is mutually beneficial.

scholarly journals Efficacy comparison of cetirizine and loratadine for allergic rhinitis in children

2012 ◽  
Vol 52 (2) ◽  
pp. 61
Author(s):  
Juliana Juliana ◽  
Rita Evalina ◽  
Lily Irsa ◽  
M. Sjabaroeddin Loebis
Keyword(s):  
Allergic Rhinitis ◽  
High Schools ◽  
Side Effects ◽  
Global Health ◽  
Treatment Effectiveness ◽  
Junior High Schools ◽  
Double Blind ◽  
Once Daily ◽  
Significant Difference ◽  
Therapeutic Responses

Background Allergic rhinitis represents a global health problemaffecting 10% to more than 40% of the population worldwide.Several studies in recent years have described the efficacy ofsecond-generation antihistamines in younger children. It isnot well established whether cetirizine is more effective thanloratadine in reducing symptoms of allergic rhinitis.Objective The objective of this study was to compare the efficacyof loratadine with cetirizine for treatment of allergic rhinitis.Methods We conducted a randomized, double-blind, controlledtrial of 100 children, aged 13 to 16 years, from October toNovember 2009 at two junior high schools in Medan. GroupI received 10 mg of cetirizine and group II received 10 mg ofloratadine, each once daily in the morning for 14 days. Drugefficacy was assessed by changes from baseline symptom scoresand evaluation of therapeutic responses after 3 days, 7 days and14 days of treatment.Results The efficacy of cetirizine compared to that of loratadinewas not statistically significant in diminishing nasal symptomsafter 3 days, 7 days and 14 days of treatment (P=0.40, P=0.07,and P=0.057, respectively). Evaluation of side effects, however,revealed significantly fewer headaches in the cetirizine group after3 days and 7 days of treatment (P=0.01 and P=0.03, respectively)than in the loratidine group. In addition, the loratadine grouphad significantly more instances of palpitations after 7 days oftreatment (P=0.04) compared to the cetirizine group.Conclusion There was no significant difference in cetirizine andloratadine treatment effectiveness on allergic rhinitis. However,loratadine was found to cause more headaches and palpitationsthan cetirizine. [Paediatr lndones. 2012;52:61-6].

Plantarflexion Torque Following Reconstruction of Achilles Tendinosis or Rupture with Flexor Hallucis Longus Augmentation

2000 ◽  
Vol 21 (4) ◽  
pp. 324-329 ◽  
Author(s):  
Michael T. Monroe ◽  
David J. Dixon ◽  
Timothy C. Beals ◽  
Gregory Pomeroy ◽  
David L. Crowley ◽  
...  
Keyword(s):  
Primary Repair ◽  
Subjective Evaluation ◽  
Achilles Tendon Rupture ◽  
Peak Torque ◽  
Flexor Hallucis Longus ◽  
Ankle Motion ◽  
Achilles Tendinosis ◽  
Level Of Satisfaction ◽  
Significant Difference ◽  
High Level

Nine patients treated surgically for Achilles tendon rupture (7 patients) or tendinosis (2 patients) with primary repair or debridement and augmentation with the flexor hallucis longus muscle-tendon unit were evaluated at a mean of 19 months postoperative. Subjective evaluation revealed a high level of satisfaction. All patients returned to work and only two patients reported limitation in their recreational activities. The mean post-operative AOFAS Ankle-Hindfoot Score was 90 points. Four patients reported mild occasional pain and one patient complained of moderate daily pain. Motion assessment showed a 20% increase in the hallux MTP dorsiflexion compared to the non-operative side (p = 0.045). No difference in ankle motion was noted. Cybex II+ dynamic evaluation of plantarflexion peak torque was complete on both extremities. The torque deficit on the reconstructed extremity was 20% (p = 0.01) at 120 degrees per second and 26% (p = 0.003) at 30 degrees per second. There is no significant difference between the torque deficit recorded for patients with Achilles rupture and those with Achilles tendinosis. A trend toward improved torque production with longer follow up was observed.

scholarly journals Pain Management in Post-Craniotomy Patients: A Survey of Canadian Neurosurgeons

2011 ◽  
Vol 38 (3) ◽  
pp. 456-460 ◽  
Author(s):  
Basil Hassouneh ◽  
John E. Centofanti ◽  
Kesava Reddy
Keyword(s):  
Side Effects ◽  
Evidence Based ◽  
First Line ◽  
Rescue Analgesia ◽  
Beliefs And Practices ◽  
Level Of Satisfaction ◽  
Gastrointestinal Side Effects ◽  
High Level ◽  
Neurological Surgery ◽  
Weak Opioid

Introduction:Despite the growing recognition for analgesic needs in post-craniotomy patients, this remains a poorly studied area in neurological surgery. The class and regimen of analgesia that is most suitable for these patients remains controversial. The objective of this study is to examine the current beliefs and practices of Canadian neurosurgeons when managing post-craniotomy pain.Methods:A survey was sent to all practicing Canadian neurosurgeons to examine the following aspects of analgesia in craniotomy patients: type of analgesics used, common side effects encountered, satisfaction with current regimen and the rationale for their practice.Results:Of 156 potential respondents, 103 neurosurgeons (66%) completed the survey. Codeine (59%) was the most prescribed firstline analgesic followed by morphine (38%). The use of a second-line opioid was significantly higher among codeine prescribers compared to morphine, 53% compared to 28% (p < 0.001). Nausea, constipation and neurologic depression were reported as common side effects by 76%, 66% and 27% of respondents respectively. Of the respondents, 90% reported a high level of satisfaction with their current choice of analgesia; nonetheless, they predominantly described their practice as personal preference or protocol driven rather than evidence-based.Conclusions:Codeine - a weak opioid - is the most common first-line analgesic prescribed to craniotomy patients. This practice is associated with substantially increased reliance on potent opioids for rescue analgesia. Whether novel regimens can provide optimal pain control while minimizing neurologic and gastrointestinal side effects remains to be addressed by future trials.

scholarly journals Supportive Infusions in Integrative Breast and Gynecological Oncology – Report on Patientsʼ Satisfaction and Self-reported Effects and Side Effects

2018 ◽  
Vol 78 (11) ◽  
pp. 1129-1137 ◽  
Author(s):  
Carolin Hack ◽  
Sophia Antoniadis ◽  
Matthias Beckmann ◽  
Anna Brandl ◽  
Peter Fasching ◽  
...  
Keyword(s):  
Side Effects ◽  
Gynecological Cancer ◽  
Nutritional Therapy ◽  
Cross Sectional Study ◽  
University Hospital ◽  
Infusion Therapy ◽  
Cross Sectional ◽  
Level Of Satisfaction ◽  
High Level

Abstract Background During cancer therapy, many patients suffer from malnutrition or vitamin deficiency. Treatment for nutrition-related deficiencies should therefore include nutritional therapy and possibly oral or intravenous substitution of micronutrients. Little information exists on multinutrient infusion therapies. The aim of this study was to develop standardized infusion protocols for integrative medicine infusions with micronutrients (IMed infusions) and to report on side effects of the treatment and patientsʼ satisfaction with it. Methods For the IMed consultancy service, four special formulas for intravenous use were developed in cooperation with the pharmacy at Erlangen University Hospital. A retrospective cross-sectional study was conducted between October 2015 and January 2018 in which 45 patients with gynecological or breast cancer (BC) and IMed infusion therapy were included. Follow-up data were obtained from 20 patients using a standardized questionnaire on IMed infusions. Results A total of 280 IMed infusions were administered in the study period. The majority of the patients received an IMed regeneration infusion (78%). The majority of the patients had BC and were receiving chemotherapy. Most patients reported a high or very high level of satisfaction with the organization (60%), general treatment (65%) and counseling (85%). Subjective improvement in their disease-related and therapy-induced symptoms, such as fatigue, polyneuropathy and physical efficiency, was reported by 70% of the patients, while 75% reported a subjective increase in quality of life. Side effects were rare and minor. Conclusions Therapy with IMed infusions in women with BC or gynecological cancer requires the same standards set for drug therapy. Although vitamins represent dietary supplements, appropriate assessment of the patientʼs medical history is needed and patients must receive appropriate information. For this purpose, standardized processes, as in the context of an IMed consultancy service, are helpful.

OP141 A Patient-Reported Outcome Measure For Hemorrhoidal Disease

2018 ◽  
Vol 34 (S1) ◽  
pp. 51-52
Author(s):  
Robin van Tol ◽  
Merel Kimman ◽  
Jarno Melenhorst ◽  
Laurents Stassen ◽  
Stephanie Breukink ◽  
...  
Keyword(s):  
Health Professionals ◽  
Treatment Satisfaction ◽  
Outcome Measure ◽  
Treatment Effectiveness ◽  
Daily Life ◽  
Treatment Options ◽  
Patient Reported Outcome ◽  
Hemorrhoidal Disease ◽  
Patient Reported Outcome Measure ◽  
Patient Reported

Introduction:Treatment options for hemorrhoidal disease (HD) include conservative treatment (e.g. laxatives), rubber band ligation, and more invasive surgical treatment options. Outcomes reported in clinical trials evaluating treatment effectiveness are heterogeneous, making comparisons difficult. Moreover, clinical outcomes, such as recurrence, complications and symptoms, do not fully represent the relevant benefits and harms of treatment to the patient. We therefore developed (i) a core outcome set (COS) for HD treatment, and (ii) a patient-reported outcome measure (PROM) evaluating symptoms and impact on daily life.Methods:Literature review established outcomes most commonly used in studies evaluating HD treatment. A Delphi study with health professionals and patients was conducted to rank and discuss the outcomes in terms of importance and completeness, and reach consensus on a COS. In addition, individual patient interviews (n=15) were held to gain insight into patient experiences with HD and treatment. A panel of experts subsequently developed a PROM that focused on the core outcomes. Face and content validity were assessed (n=10) using a retrospective verbal probing technique.Results:Recurrent symptoms, complications and treatment satisfaction were the primary focus for health professionals, while patients were more concerned with overall impact on daily life. Patients ranked blood loss, pain and itching as the most bothersome symptoms. A PROM was developed, consisting of seven items covering three domains: severity of symptoms, impact on daily life, and treatment satisfaction (if applicable). The questions and response options were clear to patients and content validity was good. The questionnaire took approximately three minutes to complete.Conclusions:We developed a COS and a PROM for HD treatment. The PROM can be used in clinical trials as the primary outcome measure evaluating treatment effectiveness from the patient's perspective. It can also support shared decision-making regarding individual treatment pathways in clinical practice. A psychometric validation study is currently underway.

scholarly journals Assessment of motivation, expectations and satisfaction of adult patients submitted to orthodontic treatment

2013 ◽  
Vol 18 (2) ◽  
pp. 81-87 ◽  
Author(s):  
Patrícia Gomide de Souza Andrade Oliveira ◽  
Rubens Rodrigues Tavares ◽  
Jairo Curado de Freitas
Keyword(s):  
Orthodontic Treatment ◽  
Psychological Aspects ◽  
Adult Patients ◽  
The Other ◽  
Treatment Results ◽  
High Interest ◽  
Other Hand ◽  
Level Of Satisfaction ◽  
Satisfaction With Treatment ◽  
High Level

OBJECTIVE: The purpose of this study was to analyze the psychological aspects of adult patients who sought and underwent orthodontic treatment, evaluating their expectations and discomfort during treatment, as well as their satisfaction after completion of dental movement. RESULTS AND CONCLUSIONS: Data obtained from previous published papers, and also from questionnaires answered by 54 patients, showed that adult patients stood out for their attention to details and high interest in the esthetic improvements provided by treatment, and also for a greater perception of their initial malocclusion. On the other hand, the same data showed that adult patients, once informed about the limitations of their treatment and having confidence on the orthodontist, presented a high level of satisfaction with treatment results, revealing themselves as good patients for indication and execution of orthodontic procedures.

scholarly journals P355 Preferences and satisfaction of IBD patients in whom the adalimumab regimen was changed from 40 mg weekly to 80 mg every other week: the ADASCAL study

2021 ◽  
Vol 15 (Supplement_1) ◽  
pp. S374-S376
Author(s):  
C Taxonera Samso ◽  
P Martínez-Montiel ◽  
M Barreiro-De-Acosta ◽  
I Vera ◽  
R Lorente ◽  
...  
Keyword(s):  
Side Effects ◽  
Dose Escalation ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Global Satisfaction ◽  
Vas Score ◽  
Mayo Score ◽  
Level Of Satisfaction ◽  
High Level ◽  
Attending Physicians

Abstract Background Adalimumab (ADA) dose escalation from 40 mg SC every other week (EOW) to 40 mg weekly is approved for IBD patients with loss of response. A recently registered device containing 80 mg of ADA will allow an alternative dose escalation regimen with SC doses of 80 mg EOW. The ADASCAL study aimed to evaluate the preferences and satisfaction of patients with modifying the ADA regimen from 40 mg weekly to 80 mg EOW. Methods This multicentre cross-sectional study included patients with IBD in whom the ADA regimen was changed from 40 mg weekly to 80 mg EOW according to clinical practice. Patients who have received at least 4 doses of 80 mg EOW completed a 4-item self-questionnaire (a Likert-like 5-point scale for preferences, 2 closed questions for convenience, and a 100-point visual analogue scale [VAS] to evaluate patient’s preference for weekly or EOW ADA) (Figure 1); and the 14-item Treatment Satisfaction Questionnaire for medication (TSQM 1.4) that covers 4 domains: effectiveness, side effects, convenience, and overall satisfaction. Results Seventy-seven patients (64 CD, 13 UC; 67.5% men; mean age 48 years, SD 14.1) were included. The overall mean duration of exposure to ADA was 66 months (SD 34), with mean exposure to ADA 40 mg weekly of 40 months (SD 25), and mean exposure to ADA 80 mg EOW of 12 months (SD 5). At the time of the survey, 87.1% of CD patients and all UC patients were in clinical remission (Harvey-Bradshaw index ≤4 for CD, Partial Mayo score ≤1 for UC). According to the results of the questionnaires, 74% of the patients preferred the 80 mg EOW ADA regimen (59.7% had a strong preference and 14.3% had a slight preference) (Figure 1). Patients referred that ADA EOW regimen interferes less with daily activity and with travel plans. Most patients wanted to continue with ADA 80 mg EOW, as reflected by a mean VAS score of 84.7 (SD 24.1), where 0 indicated a choice for weekly ADA, 100 for ADA EOW, and 50 indifferent. Overall, 77% of patients preferred to continue with ADA EOW, 4% with ADA weekly, and 17% were indifferent. Attending physicians also reported a greater preference for the EOW ADA regimen (mean VAS score 93, SD 7.8). The mean global satisfaction according to the TSQM was 84.3% (SD 13.5), where 0 indicated extremely dissatisfied and 100 extremely satisfied. Patients reported very high TSQM scores for individual components: effectiveness 77.6% (SD 16.9), convenience 83.7% (SD 14.5), and side effects 86.1% (SD 23.4). Conclusion IBD patients in whom the ADA regimen was changed from 40 mg weekly to 80 mg EOW reported a higher preference for the EOW regimen. TSQM results indicated that patients had a high level of satisfaction with the current EOW regimen. Therefore, most patients wanted to continue with ADA 80 mg EOW.

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