scholarly journals Antimicrobial and anticancer activities of copolymers of tri-O-acetyl-D-glucal and itaconic anhydride

2021 ◽  
pp. 108-108
Author(s):  
Chetana Deoghare ◽  
Shruti Balaji ◽  
Savitha Dhandapani ◽  
Honey Srivastava ◽  
Anasuya Ganguly ◽  
...  
Keyword(s):  
Antimicrobial Agents ◽  
Gel Permeation Chromatography ◽  
Thermal Characterization ◽  
Radical Copolymerization ◽  
Dilution Method ◽  
Anticancer Activities ◽  
Scanning Calorimetry ◽  
Free Radical Copolymerization ◽  
Itaconic Anhydride ◽  
Ferrier Rearrangement

This paper reports the synthesis and characterization of monomers itaconic anhydride (IA) and tri-O-acetyl-D-glucal (TAG) as well as 4,6-di-O-acetyl-D-glucal (PSG). The homopolymers and copolymers of IA and TAG were synthesized via free radical copolymerization in bulk using azobisiso-butyronitrile as an initiator using different feed ratios of monomers. Their structural, molecular, and thermal characterization was done using 1H-NMR spectroscopy, gel permeation chromatography, and differential scanning calorimetry, respectively. The glass transition temperature (Tg) of copolymers was found in the range of 139-145 ?C. The highest Tg was found for IA-TAG2 copolymers, whereas IA-TAG4 copolymer showed lowest Tg. The molecular weight of the copolymers was in the range 5157-5499 g mol-1. The monomer TAG undergoes Ferrier rearrangement in water to give PSG. The antimicrobial activity of IA, TAG, PSG and IA-TAG copolymers was studied using the minimum microbicidal concentration-broth dilution method. TAG, IA, and PSG, as well as homopolymer and copolymers of IA and TAG are excellent antimicrobial agents.

scholarly journals Strong Antimicrobial Activity of Highly Stable Nanocomposite Containing AgNPs Based on Water-Soluble Triazole-Sulfonate Copolymer

Pharmaceutics ◽  
2022 ◽  
Vol 14 (1) ◽  
pp. 206
Author(s):  
Alexander Pozdnyakov ◽  
Artem Emel’yanov ◽  
Anastasiya Ivanova ◽  
Nadezhda Kuznetsova ◽  
Tat’yana Semenova ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Chemical Reduction ◽  
Gel Permeation Chromatography ◽  
Radical Copolymerization ◽  
Water Soluble ◽  
Morphological Properties ◽  
Hydrodynamic Diameter ◽  
Scanning Calorimetry ◽  
Free Radical Copolymerization ◽  
Strong Antimicrobial Activity

A new hydrophilic polymeric nanocomposite containing AgNPs was synthesized by chemical reduction of metal ions in an aqueous medium in the presence of the copolymer. A new water-soluble copolymer of 1-vinyl-1,2,4-triazole and vinylsulfonic acid sodium salt (poly(VT-co-Na-VSA)) was obtained by free-radical copolymerization and was used as a stabilizing precursor agent. The structural, dimensional, and morphological properties of the nanocomposite were studied by UV–Vis, FTIR, X-ray diffraction, atomic absorption, transmission and scanning electron microscopy, dynamic and electrophoretic light scattering, gel permeation chromatography, thermogravimetric analysis, and differential scanning calorimetry. Hydrodynamic diameter of macroclubs for the copolymer was 171 nm, and for the nanocomposite it was 694 nm. Zeta potential for the copolymer was −63.8 mV, and for the nanocomposite it was −70.4 mV. The nanocomposite had strong antimicrobial activity towards Gram-negative and Gram-positive microorganisms: MIC and MBC values were in the range of 0.25–4.0 and 0.5–8.0 μg/mL, respectively.

scholarly journals P(N-Phenylmaleimide-Alt-Styrene) Introduced with 4-Carboxyl and Its Effect on the Heat Deflection Temperature of Nylon 6

Materials ◽  
2018 ◽  
Vol 11 (11) ◽  
pp. 2330 ◽  
Author(s):  
Yufei Liu ◽  
Min He ◽  
Daohai Zhang ◽  
Qian Zhao ◽  
Yang Li ◽  
...  
Keyword(s):  
Dynamic Viscosity ◽  
Gel Permeation Chromatography ◽  
Nylon 6 ◽  
Mechanical Analysis ◽  
Radical Copolymerization ◽  
Resonance Spectroscopy ◽  
Scanning Calorimetry ◽  
Free Radical Copolymerization ◽  
Ft Ir ◽  
Heat Deflection Temperature

P(N-phenylmaleimide-alt-styrene) (P(NPMI-alt-St)) and P(N-(4-carboxyphenyl)maleimide-alt-styrene) (P(CPMI-alt-St)) were designed and synthesized via free radical copolymerization. Fourier transform infrared spectroscopy (FT-IR), nuclear magnetic resonance spectroscopy (1H NMR and 13C NMR), gel permeation chromatography (GPC), and differential scanning calorimetry (DSC) were used to confirm the structure of P(NPMI-alt-St) and P(CPMI-alt-St). Next, the effect of P(CPMI-alt-St) on the heat deflection temperature (HDT) of nylon 6 was studied. In comparison to the PA6/P(NPMI-alt-St) blend, with the addition of 10 wt %, the HDT value of the PA6/P(CPMI-alt-St) blend increased by 15.7 °C, and the glass transition temperature (Tg) by Dynamic mechanical analysis (DMA) increased 2.3 °C. According to the analysis of DMA, dynamic viscosity, and the SEM of PA6 and its blends, P(CPMI-alt-St) promoted its compatibility with PA6, and promoted the storage modulus and dynamic viscosity of the blends. Thus, the introduction of 4-carboxyl can significantly improve the effect of P(CPMI-alt-St) on the heat resistance modification of nylon 6.

scholarly journals Synthesis and Characterization of a Multifunctional Conjugated Polymer

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Emerson C. G. Campos ◽  
Cristiano Zanlorenzi ◽  
Bruno F. Nowacki ◽  
Gabriela M. Miranda ◽  
Denis A. Turchetti ◽  
...  
Keyword(s):  
Conjugated Polymer ◽  
Molar Mass ◽  
Photophysical Properties ◽  
Gel Permeation Chromatography ◽  
Thermal Characterization ◽  
Polymer Structure ◽  
Synthesis And Characterization ◽  
Metallic Ions ◽  
Scanning Calorimetry

This work reports the synthesis and characterization of a conjugated polymer based on fluorene and terpyridine, namely, poly[(9,9-bis(3-((S)-2-methylbutylpropanoate))fluorene-alt-6,6′-(2,2′:6′,2′′-terpyridin-6-yl)] (LaPPS71). The structure was characterized by 1H and 13C nuclear magnetic resonance (NMR) and Fourier-transform infrared (FTIR) spectroscopy. The molar mass was measured by gel permeation chromatography (GPC). As thermal characterization, the glass transition temperature (Tg) was measured by differential scanning calorimetry (DSC). The polymer structure contains two sites capable of complexation with metallic ions, affording the possibility of obtainment of independent or electronically coupled properties, depending on the complexation site. The photophysical properties were fully explored in solution and solid state, presenting ideal results for the preparation of various metallopolymers, in addition to potential application as a metamaterial, due to the presence of the chiral center in the side chains of the polymer.

Free Radical Copolymerization of Acrylamide and Linalool with Functional Group as a Pendant

2003 ◽  
Vol 15 (3) ◽  
pp. 243-257 ◽  
Author(s):  
Anjali Shukla ◽  
A. K. Srivastava
Keyword(s):  
Functional Group ◽  
Gel Permeation Chromatography ◽  
Radical Copolymerization ◽  
Amide Group ◽  
Gravimetric Analysis ◽  
Free Radical Copolymerization ◽  
Alternating Copolymer ◽  
Analysis Technique ◽  
The Fourier Transform ◽  
The Ideal

Linalool (LIN) and acrylamide (AM) have been copolymerized by benzoyl peroxide (BPO) in xylene at 75°C for 40 min. The system follows the ideal kinetics with bimolecular termination and results in the formation of nearly alternating copolymer as evidenced from the reactivity ratios, r1(AM) = 0.3 and r2(LIN) = 0.05, which have been calculated by the Kelen-Tudos method. The overall activation energy of copolymerization is 40 kJ mol−1. The Fourier transform infrared spectrum of the copolymer shows the presence of the band at 3395 cm−1 due to the alcoholic group of LIN and at 1453 cm−1 due to the amide group of AM. The 1HNMR spectrum shows peaks at 7.0-7.7δ due to the alcoholic group of LIN and at 6.3-7.0δ due to the amide group of AM. The Alfrey-Price Q- e parameters for LIN have been calculated as Q2 = 0:274 and e2 = −0.749. The mechanism of copolymerization has been elucidated. In this paper we also report on the measurement of Mark-Houwink constants in tetrahydrofuran (THF) at 25°C by means of gel permeation chromatography (GPC) as α = 0.50 and K = 7.5 × 10−4 dl g−1. The thermal decompositions of the copolymer are established with the help of the thermal gravimetric analysis technique.

scholarly journals Synthesis, Characterization and Copolymerization of N-(phenylamino)maleimide with MMA

2007 ◽  
Vol 4 (2) ◽  
pp. 265-271
Author(s):  
B. L. Hiran ◽  
S. N. Paliwal ◽  
Jyoti Choudhary ◽  
P. R. Choudhary
Keyword(s):  
Thermal Stability ◽  
Molecular Weight ◽  
Density Measurement ◽  
Gel Permeation Chromatography ◽  
Radical Copolymerization ◽  
Free Radical Copolymerization ◽  
H Nmr ◽  
Gel Permeation ◽  
Ft Ir ◽  
Thermal Stability Of

The free radical copolymerization of N-(phenylamino)maleimide (N-PAMI) was carried. The copolymerization with methyl methacrylate (MMA) was performed at 65°C with AIBN as the initiator in THF solvent. Resulting copolymer was characterized by density measurement, intrinsic viscosity, solubility, FT-IR &1H NMR spectroscopy. Effect of the solvent and time on copolymer yield was also investigated. The molecular weight of copolymer was determined by gel permeation chromatography (GPC). The thermal stability of copolymer was determined by Thermogravimetric analysis (TGA).

scholarly journals Facile Synthesis, Characterization, and In Vitro Antimicrobial and Anticancer Activities of Biscoumarin Copolyester Bearing Pendant 3-(Trifluoromethyl)Styrene

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Narendran Kandaswamy ◽  
Nanthini Raveendiran
Keyword(s):  
Gel Permeation Chromatography ◽  
Inherent Viscosity ◽  
Proton Nuclear Magnetic Resonance ◽  
Diffusion Method ◽  
X Ray Diffraction ◽  
Anticancer Activities ◽  
Scanning Calorimetry ◽  
H Nmr ◽  
Agar Disc

Synthesis of random biscoumarin copolyester bearing pendant 3-(trifluoromethyl)styrene was prepared by the reaction of biscoumarin monomer 3 and hydroquinone 5 with azeloyl chloride. The influence of pendant 3-(trifluoromethyl)styrene unit on the properties of copolyester such as inherent viscosity, solubility, and thermal stability was investigated and compared in detail. The inherent viscosity and polydispersity index of the copolyester were found to be 0.15 dL/g and 1.36, respectively. The chemical structure of the copolyester was investigated by Fourier-transform infrared spectroscopy (FTIR) and proton nuclear magnetic resonance (1H-NMR) spectroscopy. The physical properties of copolyester were characterized by thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), gel permeation chromatography (GPC), and X-ray diffraction (XRD) technique. Agar disc diffusion method was employed to study the antimicrobial activity of the random copolyester. In vitro anticancer activity against lung cancer (Hep-2) cell line was also investigated.

scholarly journals Microwave-Assisted Synthesis of Cross-Linked Co-poly(itaconic anhydride-methyl methacrylate): The Effects of the Molar Ratio and Cross-Linking Agent on the Thermal Stability

2020 ◽  
Vol 2020 ◽  
pp. 1-11
Author(s):  
Ali Aldalbahi ◽  
Mostafizur Rahaman ◽  
Ayman El-Faham
Keyword(s):  
Methyl Methacrylate ◽  
Radical Copolymerization ◽  
Polymerization Process ◽  
Molar Ratio ◽  
Cross Linking ◽  
Microwave Assisted Synthesis ◽  
Free Radical Copolymerization ◽  
Itaconic Anhydride ◽  
Stiffness Properties ◽  
Ethylene Dimethacrylate

In the present work, a new series of cross-linked copolymers based on itaconic anhydride and methyl methacrylate were prepared employing free radical copolymerization in the presence of azobisisobutyronitrile as an initiator and 2-butanone as a solvent under microwave irradiation. The copolymers containing itaconic anhydride (ITA) and methyl methacrylate (MMA) were chosen due to the formation of long-term stable anhydride moieties, which might be useful to attach enzymes covalently with numerous applications in water treatment. The copolymerization process was carried out in the presence of two types of cross-linking agent, namely, ethylene dimethacrylate (EDMA) and divinylbenzene (DVB) in a range of 0-20% (w/w) to explore their effect on the thermal and stiffness properties of the obtained cross-linked copolymers. Increasing the ratio of the cross-linking agent, the copolymers prefer to precipitate rather than form a gel during the polymerization process. While using ethylene dimethacrylate as a cross-linking agent, the copolymers change from porous to stiffness structures depending on the molar ratio of the monomers used during the polymerization. On the other hand, using divinylbenzene as a cross-linking agent, the stiffness structure was obtained in all cases and there is no effect observed for the monomer’s ratio or the percentage of cross-linking agent on the morphology of the prepared copolymers.

scholarly journals Sulfur/Organic Copolymers as Curing Agents for Rubber

Polymers ◽  
2018 ◽  
Vol 10 (8) ◽  
pp. 870 ◽  
Author(s):  
Jakub Wręczycki ◽  
Dariusz Bieliński ◽  
Rafał Anyszka
Keyword(s):  
Mechanical Properties ◽  
Crosslink Density ◽  
Elemental Sulfur ◽  
Freezing Point ◽  
Petroleum Industry ◽  
Polymeric Materials ◽  
Mechanical Analysis ◽  
Radical Copolymerization ◽  
Scanning Calorimetry ◽  
Free Radical Copolymerization

It is widely acknowledged that waste sulfur generated from the petroleum industry creates huge storage and ecological problems. Therefore, the various methods of utilization are becoming increasingly attractive research topics worldwide. The thermal ability of elemental sulfur to homolytic cleavage of S8 rings enables its free radical copolymerization with unsaturated organic species and the obtaining of chemically stable polymeric materials. Here we report a novel possibility to use sulfur/organic copolymers obtained via “inverse vulcanization” as curatives for rubber. For this purpose, several various sulfur/organic copolymers were synthesized and analyzed from the point of view of their performance as rubber crosslinking agents. Solvent extraction was used to purify sulfur/organic copolymers from unreacted (elemental) sulfur. Thermal properties of the prepared copolymers were characterized by thermogravimetric analysis and differential scanning calorimetry (TGA–DSC). Crosslink density and structure of cured elastomers was studied by equilibrium swelling, thiol-amine analysis and freezing point depression. Mechanical properties of the vulcanizates were determined under static and dynamic conditions (DMA—dynamic mechanical analysis). It is proved that the utilization of sulfur/organic copolymers as curatives enables an effective crosslinking process of rubbers. Taking into account the results of a crosslink density analysis and mechanical properties of the vulcanizates cured with purified copolymers, it is evident that relatively long copolymer macromolecules are also involved in the formation of chemical bonds between unsaturated rubber macromolecules.

Chemical and Thermal Characterization of Road Bitumen Ageing

2010 ◽  
Vol 636-637 ◽  
pp. 273-279 ◽  
Author(s):  
M. Sá da Costa ◽  
Fabienne Farcas ◽  
L.F. Santos ◽  
M.I. Eusébio ◽  
António Correia Diogo
Keyword(s):  
Gel Permeation Chromatography ◽  
Thermal Characterization ◽  
Chemical Modifications ◽  
Scanning Calorimetry ◽  
Relative Contribution ◽  
Physico Chemical ◽  
Relaxation Temperature ◽  
And Performance ◽  
Structural Indices ◽  
Oxygenated Functional Groups

Bitumen ageing stands for a number of physico-chemical modifications that occur in bitumen as a response to environmental conditions. Several tests have been proposed to simulate bitumen ageing. Two of the most common ones are: a) the Rolling Thin Film Oven Test (RTFOT), which simulates short term ageing; b) the Pressure Ageing Vessel (PAV) test, which accounts for long-term ageing and it is usually performed on the RTFOT residue. A study of the physico-chemical modifications of a 50/70 pavement grade bitumen caused by ageing is presented. Both RTFOT and PAV tests were used. A follow-up of bitumen modifications due to ageing was done by several methods. In particular: 1) Fourier transform infrared spectroscopy (FTIR), to follow bitumen oxidation by the increase of oxygenated functional groups, which were quantified by taking appropriate structural indices; 2) Iatroscan thin layer chromatography (TLC), to follow bitumen composition expressed by the generic SARA fractions (saturates, aromatics, resins and asphaltenes); 3) Gel permeation chromatography (GPC), under “ultra-fast” conditions, to follow the colloidal structure of bitumen; and 4) Differential scanning calorimetry (DSC), to evaluate the changes of the crystallized fractions (%FC) and the glass relaxation temperature (Tg). The results show that the PAV test causes more severe changes in bitumen than the RTFOT test. In particular, the evolution of the oxidation processes could be quantified by taking carbonyl and sulfoxide structural indices. Ageing also modified the SARA profile, namely, the relative contribution of aromatics, resins and asphaltenes fractions. On the other hand, DSC data remained almost unaffected after ageing tests, which may be indicative of the survival of most of the phases of the bitumen after these tests. Finally, a comparative analysis of the sensitivity and performance of all these methods is presented.

Synthesis and property studies of oligomer obtained from the reaction of 4-vinylbenzocyclobutene and styrene with divinyl tetramethyl disiloxane-bisbenzocyclobutene

e-Polymers ◽  
2010 ◽  
Vol 10 (1) ◽  
Author(s):  
Yewei Xu ◽  
Fanghua Zhu ◽  
Liqin Xie ◽  
Junxiao Yang ◽  
Lin Zhang ◽  
...  
Keyword(s):  
Low Cost ◽  
Gel Permeation Chromatography ◽  
Radical Copolymerization ◽  
Film Material ◽  
Scanning Calorimetry ◽  
Cure Reaction ◽  
Good Thermal Stability ◽  
Molecular Weights ◽  
H Nmr ◽  
Polymer Resin

AbstractRadical copolymerization of 4-vinylbenzocyclobutene (VBCB) with styrene (St) afforded the copolymer (4-vinylbenzocyclobutene-co-styrene) (VBCBSt). Reaction of VBCB-St and divinyl tetramethyl disiloxane-bisbenzocyclobutene (DVSBCB) gave the oligomer (VBCB-St-DVSBCB), which was subsequently subjected to the cure reaction. The structures of VBCB-St and oligomer (VBCB-St- DVSBCB) were characterized by FTIR and 1H NMR, which are in agreement with the proposed structures. Molecular weights of the synthesized polymers were estimated by gel permeation chromatography (GPC). Differential scanning calorimetry (DSC) showed that VBCB-St exhibited glass transition temperature (Tg > 95 °C) however it is not the case for the oligomers (VBCB-St-DVSBCB). TG measurements indicated that the polymers had the good thermal stability with decomposition temperatures (TD > 370 °C). The polymer resin possessed good film planarization in the AFM images and the process of oligomer curing on a wafer without fusion and flow. These results indicated that the oligomer (VBCB-St- DVSBCB) is a promising film material with a relatively low cost.

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