25-Hydroxyvitamin D Concentrations and In Vivo Insulin Sensitivity and  -Cell Function Relative to Insulin Sensitivity in Black and White Youth

Serum 25-hydroxyvitamin D (25(OH)D) concentrations have been reported to increase following weight loss. Moreover, both weight loss and higher serum 25(OH)D concentrations have been associated with a lower risk of developing type 2 diabetes. The objective of the present study was to determine whether the increase in serum 25(OH)D concentration following weight loss is associated with improved insulin sensitivity, insulin secretion and disposition index (β-cell function). Data from two prospective lifestyle modification studies had been combined. Following a lifestyle-modifying weight loss intervention for 1 year, eighty-four men and women with prediabetes and a BMI ≥ 27 kg/m2 were divided based on weight loss at 1 year: < 5 % (non-responders, n 56) and ≥ 5 % (responders, n 28). The association between the change in serum 25(OH)D concentration and changes in insulin sensitivity (homeostasis model assessment of insulin sensitivity (HOMA%S) and Matsuda), insulin secretion (AUC of C-peptide) and disposition index after adjustment for weight loss was examined. Participants in the responders' group lost on average 9·5 % of their weight when compared with non-responders who lost only 0·8 % of weight. Weight loss in responders resulted in improved insulin sensitivity (HOMA%S, P= 0·0003) and disposition index (P= 0·02); however, insulin secretion remained unchanged. The rise in serum 25(OH)D concentration following weight loss in responders was significantly higher than that in non-responders (8·9 (sd 12·5) v. 3·6 (sd 10·7) nmol/l, P= 0·05). However, it had not been associated with amelioration of insulin sensitivity and β-cell function, even after adjustment for weight loss and several confounders. In conclusion, the increase in serum 25(OH)D concentration following weight loss does not contribute to the improvement in insulin sensitivity or β-cell function.

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Associations Between Serum 25-Hydroxyvitamin D, Insulin Sensitivity, Insulin Secretion, and β-Cell Function According to Glucose Tolerance Status

Metabolic Syndrome and Related Disorders ◽

10.1089/met.2014.0159 ◽

2015 ◽

Vol 13 (5) ◽

pp. 208-213 ◽

Cited By ~ 5

Author(s):

Anne-Sophie Morisset ◽

Vanessa Tardio ◽

John Weisnagel ◽

Simone Lemieux ◽

Jean Bergeron ◽

...

Keyword(s):

Insulin Secretion ◽

Insulin Sensitivity ◽

Glucose Tolerance ◽

Cell Function ◽

Β Cell ◽

Hydroxyvitamin D ◽

Β Cell Function ◽

25 Hydroxyvitamin D ◽

Glucose Tolerance Status

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Increased Circulatory Extrarenal 1α,25-Dihydroxyvitamin D3 in Bilaterally Nephrectomized Rats

Endocrine Metabolic & Immune Disorders - Drug Targets ◽

10.2174/1871530320666200530222426 ◽

2020 ◽

Vol 20 (9) ◽

pp. 1523-1530

Author(s):

Murat Dabak ◽

Durrin O. Dabak ◽

Tuncay Kuloglu ◽

Ersoy Baydar ◽

Hakan Bulut ◽

...

Keyword(s):

Immune Cells ◽

Low Dose ◽

Systemic Circulation ◽

Bilateral Nephrectomy ◽

Dihydroxyvitamin D3 ◽

Hydroxyvitamin D ◽

Inflammatory Conditions ◽

Calcium Phosphorus ◽

25 Hydroxyvitamin D

Background: Extrarenal 1α,25-dihydroxyvitamin D3 (1,25-D) locally produced by immune cells plays crucial roles in the regulation of the immune system. However, in vivo status of extrarenal 1,25-D and 25-hydroxyvitamin D (25-D) in acute inflammatory conditions are unknown. Objective: The aim of this study was to determine the extrarenal 1,25-D level in circulation in bilaterally nephrectomized rats, induced by low-dose lipopolysaccharide (LPS). Methods: Renal 1,25-D synthesis was terminated through bilateral nephrectomy in rats. The rats received intraperitoneal LPS (50 μg/kg BW) three times and the experiment was ended 24 hours after nephrectomy. Serum 1,25-D, 25-D, calcium, phosphorus, intact parathyroid hormone, and calcitonin levels were measured and immunohistochemistry was applied to detect the sources of extrarenal 1,25- D synthesis. Results: Circulatory 1,25-D concentration remarkably increased in both LPS-treated and non-treated bilaterally nephrectomized rats. Elevated circulatory 1,25-D did not have hypercalcemic endocrinal effects. The increased 1,25-D level also resulted in a concurrent rapid and dramatic depletion of circulatory 25-D. Conclusions: Extrarenal 1,25-D could enter into the systemic circulation and, therefore, might have systemic effects besides its autocrine and paracrine functions.

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Association of serum 25-hydroxyvitamin D with insulin resistance and β-cell function in a healthy Chinese female population

Acta Pharmacologica Sinica ◽

10.1038/aps.2013.13 ◽

2013 ◽

Vol 34 (8) ◽

pp. 1070-1074 ◽

Cited By ~ 12

Author(s):

Min-fang Tao ◽

Zeng Zhang ◽

Yao-hua Ke ◽

Jin-wei He ◽

Wen-zhen Fu ◽

...

Keyword(s):

Insulin Resistance ◽

Cell Function ◽

Β Cell ◽

Female Population ◽

Hydroxyvitamin D ◽

Β Cell Function ◽

25 Hydroxyvitamin D ◽

Healthy Chinese

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Follow-up of GK rats during prediabetes highlights increased insulin action and fat deposition despite low insulin secretion

AJP Endocrinology and Metabolism ◽

10.1152/ajpendo.00501.2007 ◽

2008 ◽

Vol 294 (1) ◽

pp. E168-E175 ◽

Cited By ~ 32

Author(s):

Jamileh Movassat ◽

Danièle Bailbé ◽

Cécile Lubrano-Berthelier ◽

Françoise Picarel-Blanchot ◽

Eric Bertin ◽

...

Keyword(s):

Body Composition ◽

Insulin Secretion ◽

Insulin Sensitivity ◽

Cell Function ◽

Cell Mass ◽

The Body ◽

Whole Body ◽

Β Cell ◽

Gk Rats

The adult Goto-Kakizaki (GK) rat is characterized by impaired glucose-induced insulin secretion in vivo and in vitro, decreased β-cell mass, decreased insulin sensitivity in the liver, and moderate insulin resistance in muscles and adipose tissue. GK rats do not exhibit basal hyperglycemia during the first 3 wk after birth and therefore could be considered prediabetic during this period. Our aim was to identify the initial pathophysiological changes occurring during the prediabetes period in this model of type 2 diabetes (T2DM). To address this, we investigated β-cell function, insulin sensitivity, and body composition in normoglycemic prediabetic GK rats. Our results revealed that the in vivo secretory response of GK β-cells to glucose is markedly reduced and the whole body insulin sensitivity is increased in the prediabetic GK rats in vivo. Moreover, the body composition of suckling GK rats is altered compared with age-matched Wistar rats, with an increase of the number of adipocytes before weaning despite a decreased body weight and lean mass in the GK rats. None of these changes appeared to be due to the postnatal nutritional environment of GK pups as demonstrated by cross-fostering GK pups with nondiabetic Wistar dams. In conclusion, in the GK model of T2DM, β-cell dysfunction associated with increased insulin sensitivity and the alteration of body composition are proximal events that might contribute to the establishment of overt diabetes in adult GK rats.

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Circulating 25-Hydroxyvitamin D Concentrations Are Correlated With Cardiometabolic Risk Among American Black and White Adolescents Living in a Year-Round Sunny Climate

Diabetes Care ◽

10.2337/dc11-1944 ◽

2012 ◽

Vol 35 (5) ◽

pp. 1133-1138 ◽

Cited By ~ 36

Author(s):

S. Parikh ◽

D.-h. Guo ◽

N. K. Pollock ◽

K. Petty ◽

J. Bhagatwala ◽

...

Keyword(s):

Cardiometabolic Risk ◽

White Adolescents ◽

Hydroxyvitamin D ◽

Black And White ◽

25 Hydroxyvitamin D ◽

American Black ◽

Black And White Adolescents

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Cardiometabolic Risk Factors in Men with Elevated Macroprolactin Content: A Pilot Study

Experimental and Clinical Endocrinology & Diabetes ◽

10.1055/a-0902-4439 ◽

2019 ◽

Vol 129 (01) ◽

pp. 7-13

Author(s):

Robert Krysiak ◽

Witold Szkróbka ◽

Bogusław Okopień

Keyword(s):

Uric Acid ◽

Insulin Sensitivity ◽

Plasma Levels ◽

Cardiometabolic Risk ◽

Plasma Lipids ◽

Plasma Concentrations ◽

Hdl Cholesterol ◽

High Sensitivity ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D

Abstract Background Macroprolactinemia is a condition associated with the presence of large amounts of high molecular weight complexes of prolactin. Despite high prevalence, clinical significance of macroprolactin remains poorly understood. Objective The aim of this study was to assess cardiometabolic risk in men with isolated macroprolactinemia. Methods The study population included 11 men with isolated macroprolactinemia, 14 subjects with monomeric hyperprolactinemia and 14 men with prolactin levels within the reference range. Glucose homeostasis markers, plasma lipids, as well as plasma levels of uric acid, high-sensitivity C-reactive protein (hsCRP), fibrinogen, homocysteine and 25-hydroxyvitamin D were determined in all included patients. Results Compared to healthy counterparts, men with isolated macroprolactinemia had higher levels of 2-h postchallenge glucose, hsCRP and fibrinogen, lower levels of 25-hydroxyvitamin D and reduced insulin sensitivity. Patients with monomeric hyperprolactinemia were characterized by increased plasma levels of 2-h postchallenge glucose, triglycerides, uric acid, hsCRP, fibrinogen and homocysteine, reduced insulin sensitivity and decreased plasma concentrations of HDL cholesterol and 25-hydroxyvitamin D. Subjects with isolated macroprolactinemia differed from patients with monomeric hyperprolactinemia in postchallenge plasma glucose, insulin sensitivity, uric acid, hsCRP, fibrinogen, homocysteine and 25-hydroxyvitamin D. In men with monomeric hyperprolactinemia, uric acid, hsCRP, fibrinogen, homocysteine and 25-hydroxyvitamin D, while in men with elevated levels of macroprolactin, uric acid, hsCRP, fibrinogen and 25-hydroxyvitamin D correlated with a content of monomeric prolactin or macroprolactin, respectively, as well as with a degree of insulin sensitivity. Conclusions The obtained results suggest that macroprolactinemia may increase cardiometabolic risk but to a lesser extent than monomeric hyperprolactinemia.

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Serum 25-Hydroxyvitamin D Concentrations Are Associated with Mental Health and Psychosocial Stress in Young Adults

Nutrients ◽

10.3390/nu12071938 ◽

2020 ◽

Vol 12 (7) ◽

pp. 1938 ◽

Cited By ~ 1

Author(s):

Li Chen ◽

Haidong Zhu ◽

Gregory A. Harshfield ◽

Frank A. Treiber ◽

Jennifer S. Pollock ◽

...

Keyword(s):

Mental Health ◽

Young Adults ◽

Perceived Stress ◽

Trait Anxiety ◽

Life Stress ◽

Vitamin D Supplementation ◽

P Values ◽

Hydroxyvitamin D ◽

Black And White ◽

25 Hydroxyvitamin D

We aimed to test the hypothesis that serum 25-hydroxyvitamin D3 (25(OH)D) concentration is associated with mental health and life stress measures in young adults and investigate gender and racial disparities in these associations. This study comprised 327 black and white participants. Depression, trait anxiety, perceived stress, and hostility were measured by the following validated instruments: Beck Depression Inventory (BDI), State-Trait Anxiety Inventory (STAI), Perceived Stress Scale (PSS), and Cook–Medley Hostility Scale (CMHS). Linear regression was used to estimate correlations between serum 25(OH)D concentration and mental health measurements in the total population and in subgroups stratified by gender and race. In this sample (28.2 ± 3.1 years, 52% female, 53% black), serum 25(OH)D concentration was negatively related to BDI, STAI, PSS, total CMHS score, and the majority of CMHS subscale scores (p-values < 0.05). Stratified by gender, most of these associations remained significant only in women (p-values < 0.05). Stratified by race, higher 25(OH)D concentrations in white participants were significantly related to lower BDI, STAI, PSS, and CMHS-cynicism subscales (p-values < 0.05); 25(OH)D concentrations in the black participants were only inversely associated with CMHS and most CMHS subscales (p-values < 0.05) but not with BDI, STAI, and PSS. We present novel findings of consistent inverse relationships between serum 25(OH)D concentration and various measures of mental health and life stress. Long-term interventional studies are warranted in order to investigate the roles of vitamin D supplementation in the prevention and mitigation of depression, anxiety, and psychological stress in young adults.

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