Yeast the Present and Future Cell Facture

Author(s):  
Waill A Elkhateeb

Yeasts are eukaryotic microorganisms that are existing in a wide range of habitats, thanks to their ability to adapt even in extreme locations and conditions. Moreover, the unicellular nature of yeasts makes them better suited for deep liquid substrates or moist and uneven surfaces. Till now, about 1500 species of yeasts are described, and the genus Saccharomyces is the well-studied genus of all the yeasts in terms of physiology and genetics. In this review, we elucidate the role of yeasts as biotechnological tool and their current and potential applications. We also highlighted the features, and industrial application of some marine yeasts. Furthermore, describing rarely basidiomycetous yeast involved in different applications. Contributions of yeasts and their enzymes in food, industrial, and pharmaceuticals fields were also discussed. Finally, employment of yeasts in biotransformation process was show.

Author(s):  
Pravin Shende ◽  
Nikita P. Devlekar

: Stem cells (SCs) show a wide range of applications in the treatment of numerous diseases including neurodegenerative diseases, diabetes, cardiovascular diseases, cancer, etc. SC related research has gained popularity owing to the unique characteristics of self-renewal and differentiation. Artificial intelligence (AI), an emerging field of computer science and engineering has shown potential applications in different fields like robotics, agriculture, home automation, healthcare, banking, and transportation since its invention. This review aims to describe the various applications of AI in SC biology including understanding the behavior of SCs, recognizing individual cell type before undergoing differentiation, characterization of SCs using mathematical models and prediction of mortality risk associated with SC transplantation. This review emphasizes the role of neural networks in SC biology and further elucidates the concepts of machine learning and deep learning and their applications in SC research.


2016 ◽  
Vol 12 ◽  
pp. 1428-1433 ◽  
Author(s):  
Bernardas Morkunas ◽  
Balint Gal ◽  
Warren R J D Galloway ◽  
James T Hodgkinson ◽  
Brett M Ibbeson ◽  
...  

Pyocyanin is a small molecule produced by Pseudomonas aeruginosa that plays a crucial role in the pathogenesis of infections by this notorious opportunistic pathogen. The inhibition of pyocyanin production has been identified as an attractive antivirulence strategy for the treatment of P. aeruginosa infections. Herein, we report the discovery of an inhibitor of pyocyanin production in cultures of wild-type P. aeruginosa which is based around a 4-alkylquinolin-2(1H)-one scaffold. To the best of our knowledge, this is the first reported example of pyocyanin inhibition by a compound based around this molecular framework. The compound may therefore be representative of a new structural sub-class of pyocyanin inhibitors, which could potentially be exploited in in a therapeutic context for the development of critically needed new antipseudomonal agents. In this context, the use of wild-type cells in this study is notable, since the data obtained are of direct relevance to native situations. The compound could also be of value in better elucidating the role of pyocyanin in P. aeruginosa infections. Evidence suggests that the active compound reduces the level of pyocyanin production by inhibiting the cell–cell signalling mechanism known as quorum sensing. This could have interesting implications; quorum sensing regulates a range of additional elements associated with the pathogenicity of P. aeruginosa and there is a wide range of other potential applications where the inhibition of quorum sensing is desirable.


2020 ◽  
Vol 7 (3) ◽  
pp. 262-266
Author(s):  
Nuno Moura-Coelho

Social media have played an increasing role in medicine with potential applications for both physicians and patients. This trend has also impacted clinical and surgical practice in ophthalmology in a wide range of subspecialties to promote scientific research findings, provide further tools for teaching, and ease communication between ophthalmologists across the globe improving patient care. However, social media have certain limitations that need to be overcome to ensure their reliability and quality for physicians and patients. This article provides a review of the current applications and pitfalls of social media in ophthalmology.


2015 ◽  
Vol 788 ◽  
pp. 5-41 ◽  
Author(s):  
Jörn Callies ◽  
Glenn Flierl ◽  
Raffaele Ferrari ◽  
Baylor Fox-Kemper

Upper-ocean turbulence at scales smaller than the mesoscale is believed to exchange surface and thermocline waters, which plays an important role in both physical and biogeochemical budgets. But what energizes this submesoscale turbulence remains a topic of debate. Two mechanisms have been proposed: mesoscale-driven surface frontogenesis and baroclinic mixed-layer instabilities. The goal here is to understand the differences between the dynamics of these two mechanisms, using a simple quasi-geostrophic model. The essence of mesoscale-driven surface frontogenesis is captured by the well-known surface quasi-geostrophic model, which describes the sharpening of surface buoyancy gradients and the subsequent breakup in secondary roll-up instabilities. We formulate a similarly archetypical Eady-like model of submesoscale turbulence induced by mixed-layer instabilities. The model captures the scale and structure of this baroclinic instability in the mixed layer. A wide range of scales are energized through a turbulent inverse cascade of kinetic energy that is fuelled by the submesoscale mixed-layer instability. Major differences to mesoscale-driven surface frontogenesis are that mixed-layer instabilities energize the entire depth of the mixed layer and produce larger vertical velocities. The distribution of energy across scales and in the vertical produced by our simple model of mixed-layer instabilities compares favourably to observations of energetic wintertime submesoscale flows, suggesting that it captures the leading-order balanced dynamics of these flows. The dynamics described here in an oceanographic context have potential applications to other geophysical fluids with layers of different stratifications.


2008 ◽  
pp. 61-76
Author(s):  
A. Porshakov ◽  
A. Ponomarenko

The role of monetary factor in generating inflationary processes in Russia has stimulated various debates in social and scientific circles for a relatively long time. The authors show that identification of the specificity of relationship between money and inflation requires a complex approach based on statistical modeling and involving a wide range of indicators relevant for the price changes in the economy. As a result a model of inflation for Russia implying the decomposition of inflation dynamics into demand-side and supply-side factors is suggested. The main conclusion drawn is that during the recent years the volume of inflationary pressures in the Russian economy has been determined by the deviation of money supply from money demand, rather than by money supply alone. At the same time, monetary factor has a long-run spread over time impact on inflation.


2018 ◽  
Vol 7 (2) ◽  
pp. 117-128 ◽  
Author(s):  
Erin Sullivan ◽  
Marie Louise Herzfeld-Schild

This introduction surveys the rise of the history of emotions as a field and the role of the arts in such developments. Reflecting on the foundational role of the arts in the early emotion-oriented histories of Johan Huizinga and Jacob Burkhardt, as well as the concerns about methodological impressionism that have sometimes arisen in response to such studies, the introduction considers how intensive engagements with the arts can open up new insights into past emotions while still being historically and theoretically rigorous. Drawing on a wide range of emotionally charged art works from different times and places—including the novels of Carson McCullers and Harriet Beecher-Stowe, the private poetry of neo-Confucian Chinese civil servants, the photojournalism of twentieth-century war correspondents, and music from Igor Stravinsky to the Beatles—the introduction proposes five ways in which art in all its forms contributes to emotional life and consequently to emotional histories: first, by incubating deep emotional experiences that contribute to formations of identity; second, by acting as a place for the expression of private or deviant emotions; third, by functioning as a barometer of wider cultural and attitudinal change; fourth, by serving as an engine of momentous historical change; and fifth, by working as a tool for emotional connection across communities, both within specific time periods but also across them. The introduction finishes by outlining how the special issue's five articles and review section address each of these categories, while also illustrating new methodological possibilities for the field.


Author(s):  
C. Claire Thomson

The first book-length study in English of a national corpus of state-sponsored informational film, this book traces how Danish shorts on topics including social welfare, industry, art and architecture were commissioned, funded, produced and reviewed from the inter-war period to the 1960s. For three decades, state-sponsored short filmmaking educated Danish citizens, promoted Denmark to the world, and shaped the careers of renowned directors like Carl Th. Dreyer. Examining the life cycle of a representative selection of films, and discussing their preservation and mediation in the digital age, this book presents a detailed case study of how informational cinema is shaped by, and indeed shapes, its cultural, political and technological contexts.The book combines close textual analysis of a broad range of films with detailed accounts of their commissioning, production, distribution and reception in Denmark and abroad, drawing on Actor-Network Theory to emphasise the role of a wide range of entities in these processes. It considers a broad range of genres and sub-genres, including industrial process films, public information films, art films, the city symphony, the essay film, and many more. It also maps international networks of informational and documentary films in the post-war period, and explores the role of informational film in Danish cultural and political history.


2020 ◽  
pp. 102-109
Author(s):  
Svetlana Alekseevna Raschetina ◽  

Relevance and problem statement. Modern unstable society is characterized by narrowing the boundaries of controlled socialization and expanding the boundaries of spontaneous socialization of a teenager based on his immersion in the question arises about the importance of the family in the process of socialization of a teenager in the conditions of expanding the space of socialization. There is a need to study the role of the family in this process, to search, develop and test research methods that allow us to reveal the phenomenon of socialization from the side of its value characteristics. The purpose and methodology of the study: to identify the possibilities of a systematic and anthropological methodology for studying the role of the family in the process of socialization of adolescents in modern conditions, testing research methods: photo research on the topic “Ego – I” (author of the German sociologist H. Abels), profile update reflexive processes (by S. A. Raschetina). Materials and results of the study. The study showed that for all the problems that exist in the family of the perestroika era and in the modern family, it acts for a teenager as a value and the first (main) support in the processes of socialization. The positions well known in psychology about the importance of interpersonal relations in adolescence for the formation of attitudes towards oneself as the basis of socialization are confirmed. Today, the frontiers of making friends have expanded enormously on the basis of Internet communication. The types of activities of interest to a teenager (traditional and new ones related to digitalization) are the third pillar of socialization. Conclusion. The “Ego – I” method of photo research has a wide range of possibilities for quantitative and qualitative analysis of the socialization process to identify the value Pillars of this process.


Author(s):  
Simon Goldhill

How did the Victorians engage with the ancient world? This book is an exploration of how ancient Greece and Rome influenced Victorian culture. Through Victorian art, opera, and novels, the book examines how sexuality and desire, the politics of culture, and the role of religion in society were considered and debated through the Victorian obsession with antiquity. Looking at Victorian art, it demonstrates how desire and sexuality, particularly anxieties about male desire, were represented and communicated through classical imagery. Probing into operas of the period, the book addresses ideas of citizenship, nationalism, and cultural politics. And through fiction—specifically nineteenth-century novels about the Roman Empire—it discusses religion and the fierce battles over the church as Christianity began to lose dominance over the progressive stance of Victorian science and investigation. Rediscovering some great forgotten works and reframing some more familiar ones, the book offers extraordinary insights into how the Victorian sense of antiquity and our sense of the Victorians came into being. With a wide range of examples and stories, it demonstrates how interest in the classical past shaped nineteenth-century self-expression, giving antiquity a unique place in Victorian culture.


2016 ◽  
Vol 1 (1) ◽  
pp. 4
Author(s):  
Marymol Koshy ◽  
Bushra Johari ◽  
Mohd Farhan Hamdan ◽  
Mohammad Hanafiah

Hypertrophic cardiomyopathy (HCM) is a global disease affecting people of various ethnic origins and both genders. HCM is a genetic disorder with a wide range of symptoms, including the catastrophic presentation of sudden cardiac death. Proper diagnosis and treatment of this disorder can relieve symptoms and prolong life. Non-invasive imaging is essential in diagnosing HCM. We present a review to deliberate the potential use of cardiac magnetic resonance (CMR) imaging in HCM assessment and also identify the risk factors entailed with risk stratification of HCM based on Magnetic Resonance Imaging (MRI).


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