Significance of physical activity on the clinical course of bronchial asthma: a literature review

2021 ◽  
Vol 29 (1) ◽  
pp. 161-170
Author(s):  
Ludmila V. Tribuntceva ◽  
Andrey V. Budnevsky ◽  
Yanina S. Shkatova ◽  
Yuliya S. Ivanchuk ◽  
Roman E. Tokmachev
Keyword(s):  
Physical Activity ◽  
Literature Review ◽  
Physical Exercise ◽  
Bronchial Asthma ◽  
Clinical Course ◽  
Interleukin 10 ◽  
Moderate Intensity ◽  
P2x7 Receptors ◽  
High Prevalence

This article contains a literature review of the results of experimental and clinical studies of the influence of physical exercise on the clinical course of bronchial asthma (BA) and presents the pathophysiological mechanisms of this influence. A high prevalence of sedentary lifestyle among patients with BA, its cause, and consequences are considered. Some studies have shown that patients with BA more rarely perform physical activity, and their physical exercises are less intensive and/or take shorter time. Effects of different variants of physical exercise on patients with BA are also discussed. Regular aerobic and mixed exercises of moderate intensity reliably lead to an improvement of the quality of life, reduction of exacerbations, use of inhalators on demand, nocturnal symptoms, and sleep; to a reduction of the hyperresponsiveness of the bronchi, eosinophil count in the sputum, levels of interleukin-6, and monocyte chemotactic factor-1; and to an increase in the level of interleukin-10. SOCS-JAK-STAT plays a role in the mechanism underlying the influence of aerobic exercises on inflammation, remodeling, and hyperresponsiveness of the airways by decreasing the expression of Th2 cytokines, chemokines, adhesion molecules, growth factors, NF-kB, and P2X7 receptors by the epithelium of the airways and by an increase in interleukin-10 level. Conclusion. Data available in the literature are obtained on small cohorts of foreign patients. Clinical data devoted to the influence of aerobic exercises on control of BA and parameters of the respiratory functions are contradictory. Further investigations are required in this field.

Symptoms of lower urinary tract in women who practice physical exercise regularly.

2014 ◽  
Vol 12 ◽  
pp. 212
Author(s):  
Eliana Barreto ◽  
Eduardo Filoni ◽  
Fátima Faní Fitz
Keyword(s):  
Physical Activity ◽  
Physical Exercise ◽  
Short Form ◽  
Urinary Symptoms ◽  
Highly Active ◽  
International Consultation ◽  
High Prevalence ◽  
Study Participants ◽  
Activity Questionnaire

Introduction: The practice of regular physical exercise provides benefits to health and quality of life. However, these are seen as promoters of dysfunctions of the pelvic floor muscles (PFMs). Objective: Evaluate the level of physical activity and the presence of urinary symptoms in women who perform exercise regularly and check the relation between then. Method: Forty-seven women who practice regularly physical exercise were evaluated in two gyms in the State of São Paulo/Brazil. The participants were characterized in accordance with the age, number of pregnancies, parity, body mass index, waist circumference, duration of physical exercise, weekly frequency of exercise and time spent in physical exercise. The level of physical activity was assessed by the "International Physical Activity Questionnaire" (IPAQ) long, and the presence of urinary symptoms and their severity were assessed by the International Consultation on Incontinence Questionnaire - Short Form (ICIQ-SF). Results: Approximately 51.9% of women were considered active (greater than 600 METs value) and 49.1% were considered highly active (more than 1500's MET value). It was observed the presence UI in 72.3% of study participants. Approximately 52% of women showed a moderate UI according to the ICIQ-SF. Conclusion: Women were considered active or very active according to the recommendations of the IPAQ. It was observed a high prevalence of urinary symptoms in women on efforts in women who perform any physical activity regulary. The severity of the incontinence was classified as moderate according the ICIQ-SF. No significant relation it was observed between the severity of the UI and the level of physical activity.

A Systematic Review of the Relationships Between Physical Activity and Sleep in Early Childhood

2021 ◽  
pp. 1-17
Author(s):  
Christine W. St. Laurent ◽  
Katrina Rodheim ◽  
Rebecca M.C. Spencer
Keyword(s):  
Physical Activity ◽  
Systematic Review ◽  
Evaluation Framework ◽  
Outcome Studies ◽  
Study Quality ◽  
Assessment Development ◽  
High Prevalence ◽  
Study Characteristics ◽  
Study Designs

The aim of this systematic review was to examine the associations between physical activity and sleep in children aged less than 6 years. Articles were included if participants were primarily aged less than 6 years and study designs were observational or experimental. Study characteristics were extracted, and the Grading Recommendations Assessment, Development and Evaluation framework was used to assess study quality. Thirty-six studies (16 sleep, 16 physical activity, and three fitness outcomes) from 18 countries reported in 29 articles were included. The majority of sleep and physical activity outcome studies reported mixed effects with very low to low quality of evidence. Fitness outcome studies were limited, and therefore, evidence was insufficient. The high prevalence of mixed and null results could be related to study limitations. Importantly, this review points to the critical need for higher quality studies of sleep and physical activity in young children, which would support health recommendations and intervention strategies for healthier child development.

PENGARUH LATIHAN FISIK AEROBIK DENGAN INTENSITAS SEDANG TERHADAP KONDISI MAKROSKOPIK DAN GAMBARAN HISTOPATOLOGI MIOKARD MENCIT BALB/C

2019 ◽  
Vol 1 (2) ◽  
pp. 30
Author(s):  
Niswan Helja Batubara ◽  
Nova Sylviana ◽  
Hasrayati Agustina ◽  
Hadaral Hudanul Qolbi
Keyword(s):  
Physical Activity ◽  
Cardiovascular Diseases ◽  
Physical Exercise ◽  
Aerobic Exercise ◽  
Pathological Condition ◽  
Moderate Intensity ◽  
Control Group ◽  
Intensity Increase ◽  
Pathological Features ◽  
Histopathologic Features

Cardiovascular diseases is one of the non-communicable diseases that has been the leading cause of death compared to other causes. Actually, cardiovascular diseases can be prevented with avoiding the risk factors and lifestyle improvements such as doing physical exercise. Useful physical exercise according to according to The American College of Cardiology/American Heart Association (ACC/AHA) is a moderate intensity aerobic exercise conducted 30 minutes in time for 5 days a week. This research aims to study the effects of moderate intensity aerobic exercise on macroscopic conditions, histopathologic features of the myocardium of mice. This research using 35 male balb/c mice devided to 3 groups (control, physical activity, exercise). Variables in this research included duration of physical activity and exercise, macroscopic conditions, histopathologic features of the myocardium of balb/c mice. After 10 and 28 days of exposure, the heart were harvested. The macroscopic conditions, histopathologic features of the myocardium were examined. The weight of heart in physical activity group was greater than control group (p=0.009). Similarly, the weight of heart exercise group was also greater compared to control group (p=0.013). The histopathologic features in physical activity and physical exercise groups showed pathological features of myocardial infarction (p=0.242). While in the control group did not show pathological features. Aerobic physical activity moderate intensity increase the risk of pathological condition of heart in the form of myocardial infarct through the macroscopic conditions and histological features of myocardium. Meanwhile, exercise with moderate intensity affect the physiological hypertrophy of the myocardium.

Physical Exercise and Quality of Life of Patients Diagnosed with Colorectal Cancer: Systematic Literature Review

2020 ◽  
Author(s):  
Kleber Henrique da Silva Bezerra ◽  
Marcelo Vaughan Lima de Oliveira ◽  
Israel Junior Borges do Nascimento ◽  
Letícia de Barros Rocha ◽  
Luiz Euclides Coelho de Souza Filho ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Colorectal Cancer ◽  
Literature Review ◽  
Physical Exercise ◽  
Systematic Literature Review

scholarly journals Feasibility and efficacy of a supervised home-based physical exercise program for metastatic cancer patients receiving oral targeted therapy: study protocol for the phase II/III - UNICANCER SdS 01 QUALIOR trial

BMC Cancer ◽  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Florence Joly ◽  
Claudia Lefeuvre-Plesse ◽  
Claire Garnier-Tixidre ◽  
Carole Helissey ◽  
Nathalie Menneveau ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Targeted Therapy ◽  
Physical Exercise ◽  
Cancer Patients ◽  
Phase Ii ◽  
Metastatic Cancer ◽  
Activity Program ◽  
Home Based

Abstract Background Currently, oral targeted therapies are known to be effective and are frequently used to treat metastatic cancer patients, but fatigue is a frequently reported early side effect of these treatments. This fatigue may impact the patient’s treatment adherence and result in a negative impact on quality of life. Physical exercise significantly improved the general well-being and quality of life of advanced cancer patients. However, there is no specific physical activity program adapted for patients with advanced disease. Methods QUALIOR is a two-part, randomized, open-label, and multicenter with two arms phase II/III trial. Patients (phase II: n = 120; phase III: n = 312) with metastatic cancer (breast cancer, kidney cancer, lung cancer, and other cancers [including but not limited to colon cancer, melanoma, sarcoma, or hepatocarcinoma]) treated with a first- or second-line oral targeted therapy without chemotherapy will be included. Patients will be randomized (2:1) to a 3-month supervised home-based standardized physical activity program or to a recommended adapted physical activity (via a booklet). The primary objective of the phase II is to evaluate the feasibility of the supervised program. The primary objective of the phase III is the evaluation of the benefit of the supervised home-based program compare to the recommended program in terms of fatigue and quality of life at 3 months. The secondary objectives aim to evaluate the impact of the supervised program on fatigue over time, pain, physical capacities, psychosocial and cognitive functions, general quality of life, frequency of dose reduction and patients’ adherence to the targeted therapy, overall survival, and progression-free survival. This study will also evaluate the medico-economic impact of supervised program compared to the recommended adapted physical activity program. Discussion The aim of this study is to evaluate home-based physical exercise program for metastatic cancer patients treated with oral targeted therapies to help patients to cope with fatigue and improve quality of life. Trial registration This trial was registered in ClinicalTrials.gov since May 2017 (NCT03169075).

Review: Multiple sclerosis and physical exercise: recommendations for the application of resistance-, endurance- and combined training

2008 ◽  
Vol 14 (1) ◽  
pp. 35-53 ◽  
Author(s):  
U. Dalgas ◽  
E. Stenager ◽  
T. Ingemann-Hansen
Keyword(s):  
Multiple Sclerosis ◽  
Physical Exercise ◽  
Endurance Training ◽  
Exercise Prescription ◽  
Moderate Intensity ◽  
Physiological Profile ◽  
Combined Training ◽  
Beneficial Effects ◽  
Training Modality

This review summarizes the existing knowledge regarding the effects of physical exercise in patients suffering from multiple sclerosis (MS). Furthermore, recommendations are given regarding exercise prescription for MS patients and for future study directions. Previously, MS patients were advised not to participate in physical exercise. During recent years, it has been increasingly acknowledged that exercise benefits MS patients. The requirement for exercise in MS patients is emphasized by their physiological profile, which probably reflects both the effects of the disease per se and the reversible effects of an inactive lifestyle. To date the effects of exercise have only been studied in moderately impaired MS patients with an EDSS score of less than 7. Evidence exists for recommending participation in endurance training at low to moderate intensity, as the existing literature demonstrates that MS patients can both tolerate and benefit from this training modality. Also, resistance training of moderate intensity seems to be well tolerated and to have beneficial effects on MS patients, but the methodological quality of the existing evidence is in general low and the number of studies is limited. Only two studies have evaluated the effects of combined resistance- and endurance training, making solid conclusions regarding this training modality impossible. Multiple Sclerosis 2008; 14: 35—53. http://msj.sagepub.com

scholarly journals EPIDEMIOLOGIC ASPECTS IN PREVENTION OF THE NEW CORONAVIRUS INFECTION (COVID-19): LITERATURE REVIEW

2021 ◽  
pp. 167-176
Author(s):  
T.M. Butaev ◽  
◽  
A.S. Tsirikhova ◽  
D.V. Kabaloeva ◽  
D.O. Kudukhova ◽  
...  
Keyword(s):  
Literature Review ◽  
Clinical Course ◽  
Public Healthcare ◽  
Resident Physicians ◽  
Rapid Spread ◽  
The World ◽  
History Of ◽  
Coronavirus Infection ◽  
The Moment

At the end of 2019 the mankind had to face a new coronavirus infection with higher virulence which resulted in its rapid spread all over the world and in an ultimate pandemic. Initially a new virus which causes COVID-19 was called 2019-nCoV but it soon acquired its well-known name, SARS-CoV-2. We can positively state that this new coronavirus infec- tion will remain in the history of world public healthcare as a disease that caused a collapse in rendering medical aid. Un- doubtedly, this new coronavirus infection has changed customary lifestyle of the overall world population.This review can be considered problematic in its essence and focuses on examining contemporary trends in the official epidemiologic situation in the world regarding the new coronavirus infection (SARS-CoV-2). Having analyzed several for- eign and domestic documents, the authors revealed a necessity to enhance levels and quality of COVID-19 epidemiologic diagnostics. There is a suggestion being considered at the moment on including additional clinical and diagnostic activities aimed at preventing further spread of the new coronavirus infection. We should note that data on COVID-19-related mortal- ity and morbidity are renewed every day and every hour. Given that, it seems rather difficult to keep in line with the latest trends in COVID-19 prevention and epidemiologic diagnostics. However, the authors made an attempt to possibly collect all the latest data on epidemiological peculiarities related to clinical course of the new coronavirus infection. The authors have a hope that this review will be useful for epidemiologists when they detect new cases of the diseases as well as for lecturers at medical higher educational establishments when they train students and resident physicians.

scholarly journals Association Between Meeting Physical Activity Guidelines with Ambulation and Quality of Life in Claudication

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 681-681
Author(s):  
Andrew Gardner ◽  
Polly Montgomery ◽  
Ming Wang ◽  
Biyi Shen ◽  
Shangming Zhang ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Moderate Intensity ◽  
Health Related Quality ◽  
Physical Activity Guidelines ◽  
Related Quality ◽  
Health Related ◽  
Group 2 ◽  
Group 1

Abstract We determined if meeting the 2018 physical activity guidelines was associated with better ambulatory function, health-related quality of life, and inflammation than failing to meet the guidelines in patients with peripheral artery disease and claudication. Secondly, we determined the optimal number of total daily steps that are needed to meet the physical activity guidelines. Five hundred seventy-two patients were assessed on their daily ambulatory activity for one week with a step activity monitor, and were grouped according to whether they achieved less than 150 minutes of moderate intensity physical activity per week (Group 1=Do Not Meet Guidelines; n=397), or whether they were above this threshold (Group 2=Meet Guidelines; n=175). Treadmill peak walking time (mean±SD) was significantly higher (p<0.001) in Group 2 (709±359 sec) than in Group 1 (427±281 sec). The health-related quality of life score for physical function was significantly higher (p<0.001) in Group 2 (61±22%) than in Group 1 (44±21%). High sensitivity C-reactive protein was significantly lower (p<0.001) in Group 2 (3.6±4.5 mg/L) than in Group 1 (5.9±6.1 mg/L). Finally, 7,675 daily steps was the optimal threshold associated with meeting the physical activity guidelines, with a sensitivity of 82.9% and a specificity of 88.4%. In conclusion, patients with claudication who meet the 2018 physical activity guidelines for US adults had better ambulation, HRQoL, and inflammation outcomes than those who failed to meet the guidelines. From a practical standpoint, patients with claudication best achieved the physical activity guidelines by taking a total of 7,675 daily steps.

scholarly journals Impact of a Tailored Nutritional and Physical Exercise Programme on Efficacy and Functional Outcomes in Older Patients with Hematological Malignancies Classified By Frailty Profile

Blood ◽  
2019 ◽  
Vol 134 (Supplement_1) ◽  
pp. 3424-3424
Author(s):  
Maite Antonio ◽  
Montserrat Arnan Sangerman ◽  
Eva Domingo-Domenech ◽  
Eva González-Barca ◽  
Casimiro Javierre ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Physical Exercise ◽  
Older Patients ◽  
Nutritional Support ◽  
Hematological Malignancies ◽  
Moderate Intensity ◽  
Control Group ◽  
Chi Square ◽  
Before And After

BACKGROUND As the result of population aging, hematologists increasingly face the challenge of effectively managing older adults with oncological diseases. The heterogeneity of the aging process means that chronological age does not serve as a pivotal variable on which the clinical or treatment decisions are based. To improve outcomes in older population it is critical to select treatment considering patients' frailty profile and patients' needs to ensure they complete the treatment proposedComprehensive geriatric assessment (CGA) is a gold-standard multidimensional tool to characterize older patients according to their biological frailty profile. CGA identifies patient- and condition-related factors that might be potentially reversible through subsequent clinical interventions Older patient may present some degree of physical decline during the treatment due to variables related to the disease itself and/or to the treatment. This can lead to an accelerated decline from aging, affect their functional independence, their quality of life, and their ability to complete the treatment There is evidence that nutritional support and physical exercise during and after oncological treatments provides benefits in muscular and aerobic condition, quality of life, fatigue and adherence to treatment. But data on hematological patient, usually treated with more intensive schemes associated with a higher incidence of cytopenia and fatigue is scarce ENDPOINT - PRIMARY To determine the impact of an individualized geriatric intervention program of physical exercise and nutritional support on adherence to planned oncological treatment in patients ≥ 70 years with hematological malignancies - SECONDARY Analyze the relation between CGA and aging biomarkersEvaluate adherence to the intervention programDetermine the rate of completion and causes for non-completion of treatmentMeasure at the beginning and end of intervention, and 6 months after treatment completion: The program's effect on physical condition parametersChanges in functional capacity: basic and instrumental activities of daily lifeLevels of fatigueQuality of lifeDetermine the incidence and degree of severity of toxicityDetermine treatment response parameters: time to treatment failure and to progression, disease-free, overall and cancer-specific survival METHODS DESIGN Prospective clinical trial, randomized, parallel and open groupsSETTING Comprehensive cancer centerINCLUSION CRITERIA Histopathological diagnosis of hematological malignancies: multiple myeloma, lymphoproliferative syndromes and myelodisplastic syndromesPatients who meet criteria for medical treatment: chemotherapy, radiotherapy, immunotherapy or targeted therapiesPatients in optimal conditions to perform moderate intensity physical exercise (responsible doctor's judgement)Signature of informed consentEXCLUSION CRITERIA Failure to meet any of the inclusion criteria.INTERVENTION All patients will be assessed through a CGA. The intervention group will received the standard treatment according to the clinical protocol of the institution and will participate in a program of personalized physical exercise and nutritional support. The control group will be treated in a standard manner according to the institution's clinical protocolRANDOMIZATION Subjects will be assigned a 1.1 ratio to one of the groups using a simple randomisation methodMAIN VARIABLE: rate of treatment compliance (relationship between the prescribed dose and the dose administered)SECONDARY VARIABLES: CGA scales, aging biomarkers, nutritional parameters and basal body composition before and after the intervention, quality of life before and after the intervention, toxicity and complications during treatment and response to treatment.STATISTICAL ANALYSIS The comparability of the components of the intervention and control group will be analyzed by Chi square test (qualitative variables) and Student's t test and Wilcoxson test (quantitative variables). The analysis of the intervention will be carried out according to the intention of treatment. The main variable will be analyzed by comparison test of chi-square proportions and confidence intervals will be calculated. The variable will be measured at the end of the intervention, according to the degree of compliance with the nutritional and physical exercise program. Disclosures Domingo-Domenech: Takeda: Consultancy, Membership on an entity's Board of Directors or advisory committees, Other: Travel expenses; Seattle Genetics: Research Funding; Bristol-Myers Squibb: Other: Travel expenses; Roche: Other: Travel expenses. González-Barca:Kiowa: Consultancy; Roche: Consultancy, Honoraria; Celgene: Consultancy; Celtrion: Consultancy; AbbVie: Consultancy, Honoraria; Janssen: Consultancy, Honoraria; Takeda: Honoraria. Sureda:Roche: Honoraria; BMS: Consultancy, Honoraria; Novartis: Consultancy, Honoraria; Janssen: Consultancy, Honoraria; Gilead: Consultancy; Sanofi: Consultancy, Honoraria; Takeda: Consultancy, Honoraria, Speakers Bureau.

scholarly journals The Role of Physical Activity in the Rehabilitation of Patients Suffering From Mild Persistent Bronchial Asthma

2017 ◽  
pp. 140-150
Author(s):  
Igor Grygus
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Bronchial Asthma ◽  
Persistent Asthma ◽  
Physical Rehabilitation ◽  
Outpatient Basis ◽  
Adequate Treatment ◽  
Mild Persistent Asthma

Bronchial asthma – a chronic relapsing disease that affects 1-18 % of the population in various countries worldwide, die annually around 250,000 people. Asthma worsens quality of life, reduced exercise tolerance, causing respiratory dysfunction and poor physical condition of patients. The aim of research is to study the role of physical activity for rehabilitation of patients suffered from mild persistent asthma during their treatment at hospital. The study involved 30 patients being in hospital due to the exacerbation of asthmatic disease. To compare the effectiveness of the proposed physical rehabilitation program was formed two control groups of 30 patients who used medication and only with traditional methods of exercise. The average age of patients was 35,41 ± 1,05 years. Groups were formed by randomization patients were compared by sex and age. Monitoring the rehabilitation process conducted by the current and landmark controls, which ensure adequate treatment expansion and intensification of physical activity each patient. The program of physical rehabilitation is based on the survey results of patients, paying attention to their functional state, rapid assessment of health and physical features of the disease. The basis of the program was a gradual expansion of physical activity of patients. When building sessions followed a certain sequence purpose of physical training, which consisted of three parts: introduction, main and final. Used have morning hygienic gymnastics and gymnastics, independent study, individually and in small groups. One of the popular methods of training both in-patient and outpatient basis, was walking up the stairs. The second half of the course of rehabilitation systems used cyclic exercises. The use of dosed physical activity while physical rehabilitation of patients suffered from mild persistent asthma has improved functional status of their cardiovascular and respiratory systems, physical performance, quality of life, helped to control the disease.

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