PHENOLOGICAL CYCLE AND DIURNAL VARIATION EFFECTS ON THE VOLATILE OIL CHARACTERISTICS OF SAGE (Salvia officinalis L.)

The agronomic and chemical characteristics of aromatic plants are affected by nutritional sources. Salvia officinalis (common sage) is an aromatic plant extensively used in food, popular medicine, and many pharmacological research studies. In this study, the effects of NPK, vermicompost and two types of microbiological fertilizer were investigated on the agronomic parameters and volatile oil characteristics of S. officinalis grown in the greenhouse. The plants were harvested two times (1st and 2nd cuttings) during the growing season. The consumption of NPK has the highest effect on stem number (54 no plant-1), fresh and dry herb weight (96.8 and 27.2 g p-1), fresh and dry leaf weight (74.6 and 19.6 g p-1), and volatile oil percentage (1.64%). While the herb weight at the 1st cutting (74.3 g p-1) was higher than the 2nd cutting (70.2 g p-1), the fresh (58.2 g p-1) and dry (16.6 g p-1) leaf weights and the leaf ratio (80.5 %) at the 2nd cutting were higher than the 1st cutting. Moreover, the volatile oil contents at the 1st cutting (1.44%) were higher than the 2nd cutting (1.18%). In total, 31 compounds were identified in the volatile oils by using GC/FID-MS. The percentages of α-Thujone (22.4-31.4%) and Camphor (21.0-25.4%) were found higher than other compounds. The content of α-Thujone was higher in NPK and vermicompost treatments. Based on the results, the application of different nutritional sources improved the yield and chemical properties of S. officinalis. Among the non-chemical nutrient sources, vermicompost had high efficiency.

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The Effect of Fertilization and Mycorrhiza Inoculation on Yield Variables and Essential Oil Characteristics of Salvia officinalis L. Growing in the Greenhouse and at the Field

Indian Journal of Pharmaceutical Education and Research ◽

10.5530/ijper.51.3s.44 ◽

2017 ◽

Vol 51 (3s2) ◽

pp. s341-s348

Author(s):

Reyhan Bahtiyarca Bagdat ◽

Lyle Eugene Craker ◽

Kadriye Yuksel

Keyword(s):

Essential Oil ◽

Salvia Officinalis ◽

Oil Characteristics ◽

Salvia Officinalis L

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Effects of Beech Bark Extract in the Sage (Salvia Officinalis L.) Plant Growth and Volatile Oil Profile

Agronomy ◽

10.3390/agronomy10050676 ◽

2020 ◽

Vol 10 (5) ◽

pp. 676 ◽

Cited By ~ 1

Author(s):

Corneliu Tanase ◽

Ruxandra Ștefănescu ◽

Diana Gabriela Gheorghieș ◽

Loredana Dandu ◽

Adrian Nisca ◽

...

Keyword(s):

Vascular Tissue ◽

Biomass Accumulation ◽

Growth Stimulation ◽

Volatile Oil ◽

Salvia Officinalis ◽

Bark Extract ◽

Experimental Variant ◽

Treated Plant ◽

Salvia Officinalis L ◽

Pigment Accumulation

The use of bioactive compounds can act in growth stimulation and also influence the biosynthesis of the metabolites in plants. The aim of this paper is to assess the influence of the beech (Fagus sylvatica L.) bark crude extract (BBCE) on the growth and development of sage (Salvia officinalis L.) plants. Special attention was given to the analysis of volatile oil obtained from the sage treated plant. Thus, the biological activity of BBCE was assessed by determining the germination capacity, biomass accumulation, histo-anatomical aspects, and photoassimilatory pigment accumulation, quantitative, and qualitative sage volatile oil analysis. The results show stimulation of the biomass and photoassimilatory pigment accumulation. The mesophyll thickness and the vascular tissue surface are smaller in the treated variants, compared to the control. On the other hand, the amount of volatile oil was significantly higher in the treated plants. In the experimental variants, an increase in the quantity of eucalyptol, camphor, camphene, and α-caryophyllene is observed. The amount of eucalyptol increased in the experimental variant, with about 82%, compared to the control. BBCE could be properly used as natural bioregulators because according to our results seems to improve the yield of the sage crop. The results of this research have the potential to contribute greatly to ecological agricultural production.

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Examination of the changes in components of the volatile oil from Abyssinian sage, Musk sage and Medical sage [Salvia aethiopis L., Salvia sclarea L. and Salvia officinalis L. (hybrid)] growing in different locations

Grasas y Aceites ◽

10.3989/gya.0715182 ◽

2019 ◽

Vol 70 (3) ◽

pp. 319 ◽

Cited By ~ 1

Author(s):

H. B. Karayel ◽

M. Akçura

Keyword(s):

Field Experiments ◽

Oil Quality ◽

Volatile Oil ◽

Salvia Officinalis ◽

Volatile Oils ◽

Salvia Sclarea ◽

Germacrene D ◽

Oil Components ◽

Salvia Officinalis L ◽

Main Components

This study was conducted simultaneously in different locations in Çanakkale, Balıkesir and Kütahya in order to determine the effect of location on the volatile oil components, volatile oil rate and volatile oil quality of Abyssinian sage, Musk sage and Medical sage (Salvia aethiopis L., Salvia sclarea L. and Salvia officinalis L. (hybrid)) plants from the 2015 growing season. Field experiments were carried out in 3 replicates according to the randomized block design. These plants’ volatile oils were obtained by the hydrodistillation method (GC-MS/FID) and the volatile oil rates in three different locations were measured as 0.53%, 0.21%, 0.20%, respectively. The basic components of the volatile oil were determined as follows: β-caryophyllene 36.22%, 30.46%, 35.96%, α-copaene 15.06%, 16.46%, 16.58%, germacrene-D 13.23%, 20.01%, 15.20%, β-cubebene 5.62%, 7.04%, 6.93%, α–humulene 8.68%, 7.40%, 8.54%, caryophylleneoxide 7.40%, 1.82%, 3.53%. No volatile oil was acquired from Salvia sclarea L. except for the Çanakkale location which was only 0.02% and the main components in this volatile oil were measured as germacrene-D 20.78%, and phytol 17.81%. The best volatile oil contents from Abyssinian sage and Musk sage were obtained from the Çanakkale location with 0.53% and 0.02%, respectively. The rates of volatile oils from Medical sage (Salvia officinalis L. (hybrid)) were 1.00%, 1.40% and 0.96%, respectively, in the three locations. The main components in this volatile oil were measured as α-thujone 46,00%, 44.53%, 35.78%, β-thujone 5.05%, 6.31%, 8.61%, camphor 10.73%, 19.15%, 18.68%, 1.8-cineole 8.99%, 7.23%, 5.06%, viridiflorol 1.85%, 2.28%, 4.23%. The highest volatile oil rate in Medical sage was reached at the Balıkesir location at a rate of 1.40%. As a result of this study it was found that volatile oil components are comparatively richer in terpenes and the amount of volatile oil differs according to ecological factors.

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Chemical composition of essential oils from leaves and twigs with leaves of two new varieties of common sage (Salvia officinalis L.)

Planta Medica ◽

10.1055/s-0030-1264353 ◽

2010 ◽

Vol 76 (12) ◽

Author(s):

A Aprotosoaie ◽

E Gille ◽

A Spac ◽

M Gonceariuc ◽

M Hancianu ◽

...

Keyword(s):

Chemical Composition ◽

Essential Oils ◽

Salvia Officinalis ◽

New Varieties ◽

Salvia Officinalis L

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Contribution to the Optimization of a Gas Chromatographic Method by QbD Approach used for Analysis of Essential Oils from Salvia officinalis

Revista de Chimie ◽

10.37358/rc.19.6.7266 ◽

2019 ◽

Vol 70 (6) ◽

pp. 2015-2020

Author(s):

Silvia Robu ◽

Aurelia Romila ◽

Olimpia Dumitriu Buzia ◽

Adrian Florin Spac ◽

Camelia Diaconu ◽

...

Keyword(s):

Essential Oil ◽

Essential Oils ◽

Plant Material ◽

Mobile Phase ◽

Chromatographic Method ◽

Salvia Officinalis ◽

Salvia Officinalis L ◽

Gas Chromatographic Method

Numerous articles on Salvia officinalis L. have been published regarding the composition of their essential oil. The considerable variation found may be due to the quality of the plant material as well as to the methods used for analysis. A simple GC-MS method was developed and optimized in the QbD approach, for the determination of sage essential oils. The optimization of GC-MS analysis was performed using different mobile phase flows, injection volumes, split ratios and temperature programs. The optimized method proved to be simple and can be successfully applied for the determination of sage essential oils.

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Comparative Study of a and b- pinene Content in Volatile Oils of Abies alba, Pinus sylvestris, Juniperus communis, Rosmarinus officinalis, Salvia officinalis and Coriandrum sativum

Revista de Chimie ◽

10.37358/rc.18.9.6529 ◽

2018 ◽

Vol 69 (9) ◽

pp. 2338-2342

Author(s):

Mariana Popescu ◽

Diana Puiu ◽

Anca Daniela Raiciu

Keyword(s):

Pinus Sylvestris ◽

Raw Materials ◽

Abies Alba ◽

Volatile Oil ◽

Rosmarinus Officinalis ◽

Salvia Officinalis ◽

Coriandrum Sativum ◽

Volatile Oils ◽

Juniperus Communis ◽

Chromatographic Profile

The study describes the composition of volatile oils obtained by steam distillation of water fir (Abies alba), pine (Pinus sylvestris), juniper (Juniperus communis), rosemary (Rosmarinus officinalis), sage (Salvia officinalis), and coriander (Coriandrum sativum) using the gas chromatography technique coupled with mass spectrometry (GC-MS). Chromatographic profile revealed the presence of specific components for each studied volatile oil. It noted the presence of a and b- pinene in all volatile oils studied at different concentrations. Volatile oils studied, from green sources and rich in a, b-pinene will be used as raw materials for creating products with anti-inflammatory, antiseptic, bronchodilators properties.

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Therapeutic Properties of Several Chemical Compounds from Salvia officinalis L. in Alzheimer’s Disease

Mini-Reviews in Medicinal Chemistry ◽

10.2174/1389557521999201230200209 ◽

2020 ◽

Vol 21 ◽

Author(s):

Georgiana Uță ◽

Denisa Ștefania Manolescu ◽

Speranța Avram

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Side Effects ◽

Chemical Compounds ◽

Natural Compounds ◽

Salvia Officinalis ◽

Chemical Structures ◽

In Silico Studies ◽

Wide Range ◽

Salvia Officinalis L

Background.: Currently, the pharmacological management in Alzheimer's disease is based on several chemical structures, represented by acetylcholinesterase and N-methyl-D-aspartate (NMDA) receptor ligands, with still unclear molecular mechanisms, but severe side effects. For this reason, a challenge for Alzheimer's disease treatment remains to identify new drugs with reduced side effects. Recently, the natural compounds, in particular certain chemical compounds identified in the essential oil of peppermint, sage, grapes, sea buckthorn, have increased interest as possible therapeutics. Objectives.: In this paper, we have summarized data from the recent literature, on several chemical compounds extracted from Salvia officinalis L., with therapeutic potential in Alzheimer's disease. Methods.: In addition to the wide range of experimental methods performed in vivo and in vitro, also we presented some in silico studies of medicinal compounds. Results. Through this mini-review, we present the latest information regarding the therapeutic characteristics of natural compounds isolated from Salvia officinalis L. in Alzheimer's disease. Conclusion.: Thus, based on the information presented, we can say that phytotherapy is a reliable therapeutic method in a neurodegenerative disease.

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Identification and Determination of the Components of Garden Sage (Salvia officinalis L.) Essential Oil, Isolated by Different Extraction Methods

Journal of Analytical Chemistry ◽

10.1134/s1061934820110131 ◽

2020 ◽

Vol 75 (11) ◽

pp. 1451-1460

Author(s):

Z. A. Temerdashev ◽

V. V. Milevskaya ◽

L. P. Ryabokon’ ◽

N. N. Latin ◽

N. V. Kiseleva ◽

...

Keyword(s):

Essential Oil ◽

Extraction Methods ◽

Salvia Officinalis ◽

Salvia Officinalis L

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Modulation of Brain-Derived Neurotrophic Factor (BDNF) Signaling Pathway by Culinary Sage (Salvia officinalis L.)

International Journal of Molecular Sciences ◽

10.3390/ijms22147382 ◽

2021 ◽

Vol 22 (14) ◽

pp. 7382

Author(s):

Nancy Chiang ◽

Shahla Ray ◽

Jade Lomax ◽

Sydney Goertzen ◽

Slavko Komarnytsky ◽

...

Keyword(s):

Liquid Chromatography ◽

Neurotrophic Factor ◽

High Performance ◽

Memory Function ◽

Brain Derived Neurotrophic Factor ◽

Salvia Officinalis ◽

C6 Glioma Cells ◽

Medicinal Uses ◽

Bdnf Signaling ◽

Salvia Officinalis L

Culinary sage (Salvia officinalis L.) is a common spice plant in the mint family (Lamiaceae) well known for its distinctive culinary and traditional medicinal uses. Sage tea has been used traditionally as a brain-enhancing tonic and extracts from sage have been reported to have both cognitive and memory enhancing effects. Brain-derived neurotrophic factor (BDNF) is an endogenous signaling molecule involved in cognition and memory function. In this study, activity-guided fractionation employing preparative reverse-phase high performance liquid chromatography (RP-HPLC) of culinary sage extracts led to the discovery of benzyl 6-O-β-D-apiofuranosyl-β-D-glucoside (B6AG) as a natural product that upregulates transcription of neurotrophic factors in C6 glioma cells. Purified B6AG showed a moderate dose response, with upregulation of BDNF and with EC50 at 6.46 μM. To better understand the natural variation in culinary sage, B6AG was quantitated in the leaves of several commercial varieties by liquid chromatography-mass spectrometry (LC-MS). The level of B6AG in dried culinary sage was found to range from 334 ± 14 to 698 ± 65 μg/g. This study provided a foundation for future investigations, including quantitative inquiries on the distribution of B6AG within the different plant organs, explorations in optimizing post-harvest practices, and aid in the development of sage varieties with elevated levels of B6AG.

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