The Pharmacological Importance of Nigellasativaas Radioprotective Agent

2019 ◽  
Vol 4 (04) ◽  
Author(s):  
A. A. Kompiang Martini ◽  
I Dewa Made Sukrama
Keyword(s):  
Oxidative Stress ◽  
Nigella Sativa ◽  
Seed Extract ◽  
Pharmacological Effects ◽  
Omega 3 ◽  
Black Cumin ◽  
Natural Remedy ◽  
Markers Of Oxidative Stress ◽  
Black Cumin Seed ◽  
Radioprotective Agent

Background: Many studies have showed that Nigella sativa is used as a natural remedy in treating various diseases across the globe. Indonesia is famous for its rich spices, one of which is the "Black Cumin" seed extract (Nigella Sativa N.S). Purpose: To analyze the effects of Nigella sativa as an antioxidant to inhibit oxidative stress caused by ionizing-free radiation. Result: Nigella sativa is widely used to diagnose, treat disease, and decrease the level of malondialdehyde (MDA) as one of the final markers of oxidative stress. Nigella sativa has been used as a treatment for various types of diseases in the world. Through the components contained in Nigella sativa it is believed to have uses as an antimicrobial, anti-inflammatory, antibacterial, antiviral, and as an antioxidant. Th[e mechanism of action of Nigella sativa depends on the type of disease. The contents of Nigella sativa are essential oils and thymoquionoe, dithymoquinone, thymol, carvacrol, nigellicine, nigellidine, nigellimine-N-oxide and alpha-hedrine. As well as some vitamins and omega 3 contained in it. The content of Nigella sativa will work together by inhibiting the okidasin reaction. Conclusion: Nigella Sativa can be used in herbal medicine because it has pharmacological effects; antibacterial, antifungal, antiviral and antioxidant. Nigella sativa has many health benefits. Nigella sativa contains thymoquinone which can reduce lipid peroxidation and increase antioxidant enzymes. The effectiveness of Nigella sativa as a radioprotector can prevent the occurrence of free radicals caused by ionizing radiation.

scholarly journals EFFECTIVENESS TEST OF BLACK CUMIN SEEDS (NIGELLA SATIVA) EXTRACT ON THE GROWTH OF KLEBSIELLA PNEUMONIAE AND PSEUDOMONAS AERUGINOSA BACTERIA

2021 ◽  
Vol 7 (2) ◽  
pp. 130-138
Author(s):  
Nadya Nazimuddin Putri ◽  
Linda Chiuman ◽  
Chrismis Novalinda Ginting ◽  
Ermi Girsang
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Klebsiella Pneumoniae ◽  
Nigella Sativa ◽  
Ethanol Extract ◽  
Inhibition Zone ◽  
Seed Extract ◽  
Diffusion Method ◽  
Black Cumin ◽  
Black Cumin Seed ◽  
Cumin Seed

Black cumin seeds are known to have beneficial contents as antibacterial. This study aimed to determine the effectiveness of black cumin seed extract (Nigella sativa) on the growth of Klebsiella pneumoniae and Pseudomonas aeruginosa. The method used was the disc diffusion method. The ethanol extract of black cumin seeds gain by maceration method and was made into various concentration (5, 7.5, 10, 12.5, and 15)%. For positive control, ciprofloxacin disc were used and negative control used distilled water. The research model used was in vitro experimental research. The results showed that ethanol extract of black cumin seeds have antibacterial activity against Klebsiella pneumoniae with inhibition zone diameters (4.5, 6.7, 10.1, 11, 12.8) mm, Pseudomonas aeruginosa with inhibition zone diameters (7.5, 12, 12.6, 13.4, 15.6) mm, positive controls respectively (24.3 and 20.7) mm and negative controls (0). It can be concluded that black cumin seed extract has an inhibiting effect on the growth of Klebsiella pneumoniae and Pseudomonas aeruginosa.

scholarly journals Nigella sativa (Black Cumin) Seed Extract Alleviates Symptoms of Allergic Diarrhea in Mice, Involving Opioid Receptors

PLoS ONE ◽  
2012 ◽  
Vol 7 (6) ◽  
pp. e39841 ◽  
Author(s):  
Swantje C. Duncker ◽  
David Philippe ◽  
Christine Martin-Paschoud ◽  
Mireille Moser ◽  
Annick Mercenier ◽  
...  
Keyword(s):  
Opioid Receptors ◽  
Nigella Sativa ◽  
Seed Extract ◽  
Black Cumin ◽  
Black Cumin Seed ◽  
Cumin Seed

scholarly journals THE EFFECT OF NIGELLA SATIVA (BLACK CUMIN) SEED EXTRACT ON CANDIDA ALBICANS VIABILITY

2019 ◽  
pp. 88-91
Author(s):  
WULAN DARMAWAN ◽  
RATNA FARIDA ◽  
SRI REDJEKI
Keyword(s):  
Candida Albicans ◽  
Nigella Sativa ◽  
Artificial Saliva ◽  
Oral Candidiasis ◽  
Positive Control ◽  
Seed Extract ◽  
Black Cumin ◽  
Microtiter Plates ◽  
Common Opportunistic Infection ◽  
Black Cumin Seed

Objective: Nigella sativa has antifungal effects against Candida albicans. The antifungal activity of N. sativa is due to the components of thymoquinone,thymol, and carvacrol. Oral candidiasis is a common opportunistic infection of the human oral cavity typically caused by the infection of C. albicans.The aim of this study was to assess the antifungal effectiveness of N. sativa seed extract (SE) on the viability of C. albicans.Methods: C. albicans was added to the wells of 96-well microtiter plates that were coated with artificial saliva and exposed to N. sativa SE atconcentrations of 6.25%–50% or 1 μl of amphotericin B (250 mg/μl) as a positive control. The viability of C. albicans was determined with the3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay.Results: The optical density of C. albicans incrementally decreased on exposure to increasing concentrations of N. sativa SE.Conclusion: N. sativa SE concentration is inversely correlated to the viability of C. albicans.

scholarly journals Pengaruh Pemberian Ekstrak Biji Jintan Hitam terhadap Kadar Kolesterol HDL dan LDL Rattus Norvegicus Jantan Galur Wistar yang Diberi Diet Tinggi Lemak

2021 ◽  
Vol 18 (2) ◽  
pp. 204
Author(s):  
RETNO SETYA KEMALA ◽  
CHOESNAN EFFENDI ◽  
ASAMI RIETA KUMALA
Keyword(s):  
Rattus Norvegicus ◽  
Ldl Cholesterol ◽  
Nigella Sativa ◽  
Seed Extract ◽  
Control Group ◽  
Black Cumin ◽  
Cholesterol Levels ◽  
White Rats ◽  
Black Cumin Seed ◽  
Cumin Seed

<p>There are a lot of various kinds of plants such as Black Cumin <em>(Nigella sativa L.)</em> which is believed by the people to increase HDL and decrease LDL levels in the blood.</p><p>The purpose of this experiment<strong> </strong>to know the effect of extract black cumin seeds <em>(Nigella sativa L.)</em>can increase HDL and decrease LDL cholesterol levels of white rats <em>(Rattus norvegicus)</em>.</p><p>This experiment using 24 of rats which divided into 4 groups, namely the negative control group, positive control group, the treatment group one dosage 126 mg/KgBWand the treatment group two dosage 252 mg/KgBW. This research was carried out for 28 days and continued by termination.</p><p>In the One way ANOVA test, HDL levels obtained significant values of 0.134 and LDL levels of 0.070 which means p&gt; 0.05 and showed that black cumin seed extract (Nigella sativa L.) there’s no different.</p><p>The conclusion of the experiment is giving black cumin seed extract <em>(Nigella sativa L.) </em>had no effect for increasing HDL and decreasing LDL cholesterol levels of white rats <em>(Rattus norvegicus)</em>.</p><p><strong>Keywords: </strong> black cumin seed extract, HDL cholesterol levels, LDL cholesterol level, <em>(Nigella sativa L.)</em>.</p><p><strong> </strong></p>

scholarly journals BLACK CUMIN (NIGELLA SATIVA) EFFECT ON EXPRESSION OF TNF-α, IL-2, DANsFlt-1IN PREECLAMPTIC MODEL RATS

2020 ◽  
pp. 78-86
Author(s):  
JOHNY MARPAUNG ◽  
M. F. G. SIREGAR ◽  
MAKMUR SITEPU ◽  
ADANG BACHTIAR
Keyword(s):  
Analytical Study ◽  
Nigella Sativa ◽  
Seed Extract ◽  
Control Group ◽  
Control Group Design ◽  
Black Cumin ◽  
Tnf Α ◽  
Black Cumin Seed ◽  
Cumin Seed ◽  
Normally Distributed

Objective: To prove the effect of giving black cumin seed extract (Nigella sativa) to decrease levels of TNF-α, IL-2, sFlt-1, and in PE model mice. Methods: This study is an analytical study with true experimental research design in laboratory mice (Rattus norvegicus) pregnant female has given black cumin seed extract (Nigella sativa) at a dose of 500 mg/kg/day and 2000 mg/kg/day. The treatment of all samples was carried out simultaneously and during the treatment was observed using the type of Postest Only Control Group Design. To assess whether the sample is normally distributed or not the Shapiro-Wilk test was carried out because the sample was ≤50. To assess the comparison of parameters (differences in expression of IL-2, sFlt-1, and TNF-α) between groups, the ANOVA test was used if the data were normally distributed and the Kruskal Wallis test if the data were not normally distributed. Results: From these results, it can be seen that there are significant differences in the administration of black cumin extract on TNF-α, IL-2, andsFlt-1 expression (p<0.001); the administration of black cumin extract can reduce TNF-α, IL-2, and sFlt-1 expression in preeclampsia mice. The administration of 2000 mg black cumin extract can reduce TNF-α and IL-2 expression more significantly. Conclusion: Black cumin can reduce levels of TNF-α, IL-2, sFlt-1 in models mice with preeclampsia (p<0.001).

scholarly journals PENGARUH KRIM EKSTRAK JINTAN HITAM (Nigella sativa) TERHADAP KADAR KOLAGEN DAN HIDRASI KULIT PADA TIKUS (Rattus norvegicus) GALUR WISTAR JANTAN YANG DIPAPAR SINAR ULTRAVIOLET-B

2020 ◽  
Vol 19 (3A) ◽  
Author(s):  
Winda Sari ◽  
Linda Chiuman ◽  
Sahna Ferdinand Ginting ◽  
Chrismis Novalinda Ginting
Keyword(s):  
Rattus Norvegicus ◽  
Nigella Sativa ◽  
Seed Extract ◽  
Ultraviolet B ◽  
Oxygen Species ◽  
Black Cumin ◽  
Wistar Strain ◽  
Before And After ◽  
Black Cumin Seed ◽  
Cumin Seed

Photoaging is caused by exposure to sunlight and ultraviolet radiation (UV-B) through the reactive oxygen species (ROS) molecules formation, resulting in decreased levels of collagen. It is characterized by wrinkles, sagging and rough surfaces. Black cumin has been used in medicine due to its high antioxidant potential. The aim of this study is to identify the effect of black cumin cream on collagen levels and hydration of the skin of Rattus norvegicus exposed to ultraviolet-B rays. This is experimental study in which 30 male Wistar strain rats were classified into 6 sub-groups, namely the KN group (without treatment), KP (getting Nivea cream moisturizer), P1 (basic cream ), P2 (black cumin seed extract cream 0.25%), P3 (cream 0.5%) and P4 (cream 0.75%). P4 rat collagen levels increased significantly before and after the intervention (24 ± 2.23 vs 42.6 ± 14.6, p <0.05).Cream with lower concentrations did not provide a significant increase (p> 0.05). P4 rats also showed increased skin hydration (38.6 ± 19.3 to 63.0 ± 4.47 (p <0.05)), and this was not found in other groups. The administration of topical black cumin seed extract 0.75% can inhibit decreased levels of collagen and increase skin tissue hydration.   

scholarly journals Assessment the Antioxidant and Hypolipidmic Effect of Black Cumin (Nigella sativa L.) Flavonoids in Induced Oxidative Stressed Male Rabbits

2012 ◽  
Vol 36 (2) ◽  
pp. 163-173
Author(s):  
Kahtan A. Al-Mzaien
Keyword(s):  
Oxidative Stress ◽  
Drinking Water ◽  
Nigella Sativa ◽  
Tap Water ◽  
Scavenging Activity ◽  
Black Cumin ◽  
Sugar Moiety ◽  
Black Cumin Seed ◽  
Cumin Seed

Qualitative and quantitative assessment of flavonoids, sugar moiety and antioxidant scavenging activity (in vitro and vivo) of black cumin seed ( Nigella sativa L.) as well as serum lipid profile inhydrogen peroxide (H2O2) induced oxidative stress and flavonoids treated adult male rabbits were the main aim of the current study. The results showed that black cumin seeds contained 4.50gmcrude flavonoids per kg crushed seeds and the high performance liquid chromatography indicated the existence of 22 flavonoids, only seven of which were identified flavonoids represented nearly 2.751gm/kg of the total flavonoids. The concentration of kaempferol was the highest whereas quercetin the lowest. Glucose, fructose and sucrose were the sugar moiety of flavonoids with an average concentration of 3.22, 2.21 and 3.31 g/kg crushed seeds respectively. Assessment the antioxidant scavenging activity of the extracted flavonoids and its effect on lipid profile in H2O2 treated rabbits were carried out as follows; eighteen adult male rabbits were randomly divided into three equal groups. Rabbits in the first group were received tap water and served as control (C), whereas animals in 2nd group received 0.5% H2O2 in drinking tap water (T1), animals in the 3rd group were received 0.5% H2O2 in drinking water with 27.5mg/kg B.W. of black cuminseeds flavonoids.Fasting blood samples were collected at 0, 4, 8 and 12 weeks of the experiment. The results clarified that 0.5% H2O2 in drinking water caused significant elevation in serum malondialdehyde (MDA) and reduction in glutathione (GSH) concentration of treated animals respectively.The incidence of antioxidant scavenging activity in vitro was more pronounced than that recorded in vivo particularly at the early stages of administration and extracted flavonoids ameliorate to a great extent the incidence of hydrogen peroxide induced oxidative stress in male rabbits. The results revealed that administration of 0.5% H2O2 in drinking water for 12 weeks to male rabbits caused significant p<0.05 elevation in TC, TAG, LDL-C and VLDL-C concentration, with significant p<0.05 reduction in serum HDL-C concentration as compared with the control where as Black Cumin seed flavonoids caused significant reduction in the serum concentration of TC, TAG, LDL-C, and VLDL-C and significantly p<0.05 elevation in HDL-C concentration comparing to H2O2 treated group.Conclusion: This study clarified the significant role of black cumin flavonoids in modulation of glutathion (GSH) content and malondialdehyde( MDA) equivalent and exhibited highly hypolipidmic effect.

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