scholarly journals Investigation of relationship between the level of cytokines and clinical parameters of patients with generalized periodontitis under the influence of Zinaxin

2014 ◽  
Vol 18 (3 (71)) ◽  
Author(s):  
S. S. Romanyshyn ◽  
V. I. Gereluk ◽  
O. P. Kobryn ◽  
N. I. Kukurudz ◽  
L. I. Kurbatova ◽  
...  
Keyword(s):  
Oral Fluid ◽  
Pathological Process ◽  
Laboratory Research ◽  
Clinical Parameters ◽  
Clinical Indicators ◽  
Periodontal Tissues ◽  
Process Formation ◽  
Cytokine Imbalance ◽  
Pro Inflammatory Cytokines

As a result of a comprehensive clinical and laboratory research the pathogenetic role of cytokine imbalance in the pathological process formation in the periodontal tissues was established. Correlation analysis of cytokines’ content in gingival and oral fluid of patients with generalized periodontitis and data of clinical indicators of periodontal tissues showed that there is a strong direct connection between pro-inflammatory cytokines and clinical parameters.

scholarly journals Особливості клінічних проявів ураження тканин пародонта у підлітків на тлі аліментарно-конституціонального ожиріння

2017 ◽  
Author(s):  
O. I. Lebid ◽  
K. M. Duda
Keyword(s):  
Body Weight ◽  
Statistical Processing ◽  
Pathological Process ◽  
The State ◽  
Index Score ◽  
The Body ◽  
Control Group ◽  
Excess Body Weight ◽  
Clinical Indicators ◽  
Periodontal Tissues

The article presents the results of clinical examination of periodontal tissues in adolescents against the background of alimentary-constitutional obesity.The aim of the study – to investigate the features of the course of diseases of the periodontal tissue according to clinical indices in persons with alimentary-constitutional obesity.Materials and Methods. As a result of the survey, 95 adolescents aged 16–18 years old were included to study the features of the course of infl ammatory diseases of periodontal tissues in adolescents with alimentary-constitutional obesity 76 adolescents and 19 adolescents with harmonious physical development. To clarify the diagnosis, «excessive body weight» was determined by weight and height of the patient, and measured the circumference of the waist and hips. In the future, the body mass index (BMI) was calculated as the ratio of body weight in kg to square of growth in m2. Diagnosis of excess body weight was confi rmed with BMI less than 30kg/m2. The evaluation of the condition of periodontal tissues was carried out according to subjective and objective criteria (clinical parameters, index score). For the verifi cation of the pathological process in the periodontium, the classifi cation of M. F. Danilevskyi (1994) was used. The state of periodontal tissues was described using a traditional index score. Statistical processing of the results was carried out using commonly used methods of variation statistics with a help of personal computer using a statistical software package «Statistica 8.0» («Statsoft», USA). The probability level was estimated at 95 % (p<0.05) using Student’s t criterion.Conclusions. Consequently, the clinical indicators of the state of periodontal tissues in the context of alimentaryconstitutional obesity (Fedorov-Volodkin’s index, Green-Vermillion index, Sillness-Loe index, CPITN index) signifi cantly deteriorate compared with the corresponding indicators in the control group of adolescents without AKO, indicating the effect of alimentary-constitutional obesity on the clinical course, the severity and severity of theinfl ammatory process and the feasibility of timely and effective pharmacotherapy.

scholarly journals Cytokine status in patients with generalized periodontitis in the settings of type II diabetes mellitus

2020 ◽  
Vol 103 (4) ◽  
pp. 22-25
Author(s):  
S. Riznyk ◽  
◽  
Yu. Riznyk ◽  
Keyword(s):  
Diabetes Mellitus ◽  
Proinflammatory Cytokines ◽  
Type Ii Diabetes ◽  
Oral Fluid ◽  
Pathological Process ◽  
Immunological Methods ◽  
Immunological Study ◽  
Type Ii ◽  
Periodontal Tissues ◽  
Tnf Α

Introduction. The problem of generalized periodontitis is taking on particular significance due to the data concerning its close connection with somatic diseases, among which diabetes mellitus is particularly important. In studying the pathogenesis of generalized periodontitis in the settings of diabetes mellitus, it is important to determine the synergistic effect of proinflammatory cytokines, which can be markers of local changes and a diagnostic criterion for the severity and activity of the pathological process in the periodontal tissues. The aim of the study was to determine the cytokine profile of oral fluid in patients with generalized periodontitis in the settings of type II diabetes depending on the severity and course of the dystrophic-inflammatory process in periodontal tissues. Materials and methods. To study this issue, a comprehensive clinical and immunological study of 41 patients with generalized periodontitis in the settings of type II diabetes and 10 people with clinically intact periodontal tissues was performed. Results. The development of the pathological process in patients with generalized periodontitis in the settings of diabetes mellitus is accompanied by an increase in the concentration of proinflammatory cytokines in the oral fluid, namely TNF-α, IL-1β, IL-6, which contribute to the progression of dystrophic inflammation in periodontal tissues. The mechanism of pathogenetic correlations substantiates the scientific approach to the choice and application of immunological methods for the study of patients with generalized periodontitis. Conclusions. Level detection of TNF-α, IL-1β, IL-6 pro-inflammatory cytokines in the oral fluid can be a diagnostically important factor in determining the severity of the pathological process and the effectiveness of treatment of patients with generalized periodontitis.

scholarly journals State of collagenolysis in experimental periodontitis of bacterial-immune genesis and its correction with flavonol

2021 ◽  
Vol 26 (2) ◽  
pp. 26-32
Author(s):  
A.Ye. Demkovych ◽  
Yu.I. Bondarenko ◽  
O.O. Fastovets ◽  
A.O. Hrad ◽  
P.A. Hasiuk ◽  
...  
Keyword(s):  
Inflammatory Process ◽  
Soft Tissues ◽  
Pathological Process ◽  
Calibration Graph ◽  
The State ◽  
Experimental Animals ◽  
Periodontal Tissues ◽  
Tissue Homogenates ◽  
Experimental Periodontitis

The article presents an assessment of the dynamics of changes in the content of the marker of collagenolysis – free oxyproline in the homogeniate of soft tissues and bone in experimental bacterial-immune periodontitis and elucidation of the effect of flavonol quercetin on these indicators. The aim of this study was to determine the role of cytokinogenesis and the effect of flavonol on it in the pathogenesis, development and course of experimental periodontitis. During the experiment, a fragment of the mandible was taken from the animals, from which the soft tissues and bone were carefully separated. The state of collagen was determined by the content of free oxyproline in the soft and bone tissues. The concentration was determined according to the calibration graph and expressed in μmol/g. The results of studies of the indicators of the state of biopolymers of connective tissue structures of periodontium on the 7th, 14th and 30th day of experimental bacterial-immune periodontitis and after its correction with flavonol (from the 7th to the 14th day of the experiment) are presented. The data on the nature of changes in the content of collagen monomers in the process of formation of the inflammatory focus in the periodontal complex are given. During the acute phase of the inflammatory process in rats there was revealed a slight increase in blood free oxyproline in bone homogenate and homogenate of soft periodontal tissues, on the 14th day the dynamics continued to increase, at a later stage of the experiment, namely on the 30th day, increase in bone resorption continued  as compared to the 7th and 14th day. During the correction of disorders resulted from  the development of this pathological process there was a decrease in the level of free oxyproline in the bone homogenate and homogenate of soft tissues of mandibular periodontium, as compared to the same indicators of animals who did not receive quercetin on the 14th day. The use of flavonol quercetin, which, by affecting immune processes, limited the inflammatory response in periodontal tissues and stabilized collagenolysis processes in periodontal tissues was manifested by a decrease in free oxyproline in bone and soft tissue homogenates of experimental animals.

The Role of Distress Disclosure Tendencies in the Experience and Expression of Laboratory-Induced Sadness

2017 ◽  
Vol 38 (1) ◽  
pp. 55-62 ◽  
Author(s):  
Jeffrey H. Kahn ◽  
Daniel W. Cox ◽  
A. Myfanwy Bakker ◽  
Julia I. O’Loughlin ◽  
Agnieszka M. Kotlarczyk
Keyword(s):  
Individual Differences ◽  
Emotional Reactivity ◽  
Subjective Experience ◽  
Negative Emotion ◽  
Theoretical Models ◽  
Laboratory Research ◽  
Emotion Words ◽  
Distress Disclosure ◽  
Computerized Text Analysis

Abstract. The benefits of talking with others about unpleasant emotions have been thoroughly investigated, but individual differences in distress disclosure tendencies have not been adequately integrated within theoretical models of emotion. The purpose of this laboratory research was to determine whether distress disclosure tendencies stem from differences in emotional reactivity or differences in emotion regulation. After completing measures of distress disclosure tendencies, social desirability, and positive and negative affect, 84 participants (74% women) were video recorded while viewing a sadness-inducing film clip. Participants completed post-film measures of affect and were then interviewed about their reactions to the film; these interviews were audio recorded for later coding and computerized text analysis. Distress disclosure tendencies were not predictive of the subjective experience of emotion, but they were positively related to facial expressions of sadness and happiness. Distress disclosure tendencies also predicted judges’ ratings of the verbal disclosure of emotion during the interview, but self-reported disclosure and use of positive and negative emotion words were not associated with distress disclosure tendencies. The authors present implications of this research for integrating individual differences in distress disclosure with models of emotion.

The role of inflammatory cytokines in the pathogenesis of premature labor in multiple pregnancy as a result of ART

2016 ◽  
pp. 73-76
Author(s):  
B.M. Ventskivskiy ◽  
◽  
I.V. Poladych ◽  
S.O. Avramenko ◽  
◽  
...  
Keyword(s):  
Assisted Reproductive Technology ◽  
Inflammatory Cytokines ◽  
Proinflammatory Cytokines ◽  
Local Level ◽  
Multiple Pregnancy ◽  
Reproductive Technology ◽  
System Level ◽  
Premature Labor ◽  
Pro Inflammatory Cytokines

In recent years there has been an increase in the frequency of multiple pregnancies and the associated perinatal losses. It is a result of multiple pregnancy in ART refers to a high-risk gestation, at which premature births occur in 2 times more often than in singleton pregnancies. The objective: to determine the role of pro-inflammatory cytokines in the pathogenesis of premature labor in multiple pregnancy, as a result of assisted reproductive technology. Patients and methods. to determine the pro-inflammatory cytokines that all pregnant with bagtopliddyam held immunosorbent assay, defined concentrations of interleukin (IL) in serum and cervical mucus. Results. The analysis of the levels of pro-inflammatory cytokines (IL-1, IL-8) in the test environment, found high concentrations in the surveyed women with multiple pregnancy, due to the use of ART, compared with spontaneous multiple and singleton pregnancy. Increased concentration of proinflammatory cytokines in patients with multiple pregnancy by ART is associated with their synthesis at the system level, it stimulated foci of inflammation in the female genitals and extragenital localization. This correlates with the clinical data and statistical analysis, patients with multiple pregnancy as a result of ART had weighed infectious-inflammatory history. Conclusion. The study showed that elevated levels of proinflammatory cytokines in the systemic and local level in patients with multiple pregnancy due to ART, typical for women with miscarriage, because of the physiological course of pregnancy characterized by the predominance of anti-inflammatory cytokines that prevent rejection of the fetus as a foreign factor. Based on the data obtained proved the role of systemic inflammatory factors in the genesis of preterm labor in women with a multiple pregnancy, as a result of assisted reproductive technology. Key words: multiple pregnancy, assisted reproductive technology, premature birth, interleukine-1, interleukine-8.

Use of riboflavinum and magnesium citrate in obstetrics and gynecology

GYNECOLOGY ◽  
2018 ◽  
Vol 20 (6) ◽  
pp. 60-66
Author(s):  
O A Gromova ◽  
I Yu Torshin ◽  
N K Tetruashvili
Keyword(s):  
Thrombus Formation ◽  
Sirtuin 1 ◽  
Obstetrics And Gynecology ◽  
Inflammatory Factor ◽  
Vitamin B2 ◽  
Magnesium Citrate ◽  
Fetal Malformations ◽  
Folate Cycle ◽  
Pro Inflammatory Cytokines

Low provision of cells with vitamin B2 and magnesium leads to a decrease in the activity of the sirtuin-1 deacetylase and an increase in the activity of the pro-inflammatory factor NF-kB, a decrease in the levels of glutathione, an increase in the levels of homocysteine, thrombus formation, the activity of mitochondria, the development of migraine, convulsions and miscarriage. The role of riboflavin in the regulation of the folate cycle in the genotype MTHFR 677TT for the prevention of folatresistant fetal malformations, the advantages of an aqueous solution of riboflavin and magnesium citrate is considered. The data on titanium dioxide, which increases the level of pro-inflammatory cytokines IL-1b, IL-4, IL-5, IL-6, G-CSF, CCL-2, CCL-3, CCL-4, are presented.

Understanding the role of Inflammasome in Angina Pectoris

2020 ◽  
Vol 21 ◽  
Author(s):  
Ishita Sharma ◽  
Tapan Behl ◽  
Simona Bungau ◽  
Monika Sachdeva ◽  
Arun Kumar ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Angina Pectoris ◽  
Nlrp3 Inflammasome ◽  
Vital Role ◽  
Death Process ◽  
Cell Death Process ◽  
Artery Disease ◽  
Species Production ◽  
Pro Inflammatory Cytokines

Abstract:: Angina pectoris, associated with coronary artery disease, a cardiovascular disease where, pain is caused by adverse oxygen supply in myocardium, resulting in contractility and discomfort in chest. Inflammasomes, triggered by stimuli due to infection and cellular stress have identified to play a vital role in the progression of cardiovascular disorders and thus, causing various symptoms like angina pectoris. Nlrp3 inflammasome, a key contributor in the pathogenesis of angina pectoris, requires activation and primary signaling for the commencement of inflammation. Nlrp3 inflammasome elicit out an inflammatory response by emission of pro inflammatory cytokines by ROS (reactive oxygen species) production, mobilization of K+ efflux and Ca2+ and by activation of lysosome destabilization that eventually causes pyroptosis, a programmed cell death process. Thus, inflammasome are considered to be one of the factors involved in the progression of coronary artery diseases and have an intricate role in development of angina pectoris.

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