scholarly journals ANGKA BANDING NETROFIL/LIMFOSIT APENDISITIS AKUT

2016 ◽  
Vol 19 (1) ◽  
pp. 30
Author(s):  
Yanty Tandirogang ◽  
Uleng Bahrun ◽  
Mutmainnah Mutmainnah
Keyword(s):  
Acute Appendicitis ◽  
Acute Inflammation ◽  
Diagnostic Marker ◽  
Perforated Appendicitis ◽  
Laboratory Examination ◽  
Inflammatory Immune Response ◽  
Immediate Surgery ◽  
Almost All ◽  
One Way Anova ◽  
Sensitive Marker

Acute appendicitis is one of the acute abdominal conditions encountered in almost all hospitals in Indonesia. Acute inflammation of the appendix requiring immediate surgery to prevent complications, so it should takes several particular checking’s to support the diagnosis quickly. These are leukocytes count, especially neutrophils and lymphocytes as the sensitive marker of the inflammatory process which belong to the simple laboratory examination and can be used as a diagnostic marker of acute appendicitis as well. The inflammatory immune response can be described of the percentage of neutrophils to the lymphocytes ratio in the circulation. A retrospective study was performed on patients whom suspected for acute appendicitis those undergoing appendectomy from January 2010−May 2011. The data were grouped according to post appendectomy diagnosis and the ratio of neutrophils/lymphocytes (NLR) compared with other parameter. The NLR in each group was compaed by one way ANOVA analyzing. A total of 59 patients were identified: 19 catarrhally, 19 phlegmonous, 10 gangrenous and 11 with perforation. Compared with other markers, NLR is much better in predicting acute appendicitis. NLR increased in all groups (mean>7), specifically on the perforated appendicitis that is greatly increased (mean=12.273). But this was not significantly different NLR from the group (p=0.098). Based on this study it can be concluded, that NLR is the better marker for diagnosis rather than leukocyte and USG. But unfortunately, it can not be used to differentiate the grading in acute appendicitis.

scholarly journals ANGKA KEJADIAN APENDISITIS DI RSUP PROF. DR. R. D. KANDOU MANADO PERIODE OKTOBER 2012 – SEPTEMBER 2015

e-CliniC ◽  
2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Gloria A. Thomas ◽  
Ishak Lahunduitan ◽  
Adrian Tangkilisan
Keyword(s):  
Acute Appendicitis ◽  
Acute Inflammation ◽  
Perforated Appendicitis ◽  
Vermiform Appendix ◽  
Clinical Decision ◽  
Chronic Appendicitis ◽  
Suspected Appendicitis ◽  
Male Patients ◽  
Using Data ◽  
Age Range

Abstract: Appendicitis is an inflammation of vermiform appendix. Acute inflammation of the appendix needs to be treated immediately to prevent fatal complications. The incidence among females and males is slightly comparable, however, the incidence is higher among males than females in the age range between 20-30 years. The fundamental clinical decision in the diagnosis of a patient with suspected appendicitis is whether to do an operation or not. The meaningful evaluation of acute appendicitis balances early operative intervention to prevent operative risks. This study aimed to obtain the incidence of appendicitis at Prof. Dr. R.D Kandou Hosiptal Manado from October 2012 to September 2015. This was a  retrospective descriptive study using data of the Department of Medical Record Prof. Dr. R.D Kandou Manado Hospital. The results showed that there were 650 patients. Most patients had acute appendicitis as many as 412 patients (63%) meanwhile chronic appendicitis was found in 38 patients (6%). Of 650 patients, 200 patients had complications; 193 patients (30%) with perforated appendicitis and 7 patients (1%) with appendicular mass. The most frequent age group to develop appendicitis was 20-29 years. The number of male patients was higher than the females. Keywords: appendicitis, incidence  Abstrak: Apendisitis adalah adanya peradangan pada apendiks vermiformis. Peradangan akut pada apendiks memerlukan tindak bedah segera untuk mencegah komplikasi yang umumnya berbahaya. Insidens pada perempuan dan laki-laki umumnya sebanding, kecuali pada umur 20-30 tahun insidens pada laki-laki lebih tinggi. Keputusan klinis mendasar dalam mendiagnosis pasien dengan dugaan apendisitis ialah apakah perlu dilakukannya operasi atau tidak.  Evaluasi yang baik dari kasus apendisitis akut dapat mengurangi intervensi untuk operasi awal, dengan harapan dapat mengurangi risiko operasi yang tidak diperlukan. Penelitian ini bertujuan untuk mengetahui angka kejadian apendisitis di RSUP Prof. Dr. R. D, Kandou Manado periode Oktober 2012 – September 2015. Metode penelitian yang digunakan ialah deskriptif retrospektif dengan menggunakan data di Bagian Rekam Medik RSUP Prof. Dr. R. D. Kandou Manado. Hasil penelitian menunjukkan bahwa selama periode Oktober 2012 – September 2015 terdapat 650 pasien. Jumlah pasien terbanyak ialah apendisitis akut yaitu 412 pasien (63%) sedangkan apendisitis kronik sebanyak 38 pasien (6%). Dari 650 pasien, yang mengalami komplikasi sebanyak 200 pasien yang terdiri dari 193 pasien (30%) dengan komplikasi apendisitis perforasi dan 7 pasien (1%) dengan periapendikuler infiltrat. Kelompok umur tersering yang menderita apendisitis ialah 20-29 tahun. Jumlah pasien laki-laki lebih banyak daripada perempuan. Kata kunci: apendisitis, angka kejadian  

scholarly journals HUBUNGAN STATUS GIZI DENGAN BERAT RINGANNYA CAMPAK PADA ANAK

e-CliniC ◽  
2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Teressa S. Liwu ◽  
Novie H. Rampengan ◽  
Suryadi N. N. Tatura
Keyword(s):  
Acute Appendicitis ◽  
Acute Inflammation ◽  
Perforated Appendicitis ◽  
Vermiform Appendix ◽  
Clinical Decision ◽  
Chronic Appendicitis ◽  
Suspected Appendicitis ◽  
Male Patients ◽  
Using Data ◽  
Age Range

Abstract: Appendicitis is an inflammation of vermiform appendix. Acute inflammation of the appendix needs to be treated immediately to prevent fatal complications. The incidence among females and males is slightly comparable, however, the incidence is higher among males than females in the age range between 20-30 years. The fundamental clinical decision in the diagnosis of a patient with suspected appendicitis is whether to do an operation or not. The meaningful evaluation of acute appendicitis balances early operative intervention to prevent operative risks. This study aimed to obtain the incidence of appendicitis at Prof. Dr. R.D Kandou Hosiptal Manado from October 2012 to September 2015. This was a  retrospective descriptive study using data of the Department of Medical Record Prof. Dr. R.D Kandou Manado Hospital. The results showed that there were 650 patients. Most patients had acute appendicitis as many as 412 patients (63%) meanwhile chronic appendicitis was found in 38 patients (6%). Of 650 patients, 200 patients had complications; 193 patients (30%) with perforated appendicitis and 7 patients (1%) with appendicular mass. The most frequent age group to develop appendicitis was 20-29 years. The number of male patients was higher than the females. Keywords: appendicitis, incidence  Abstrak: Apendisitis adalah adanya peradangan pada apendiks vermiformis. Peradangan akut pada apendiks memerlukan tindak bedah segera untuk mencegah komplikasi yang umumnya berbahaya. Insidens pada perempuan dan laki-laki umumnya sebanding, kecuali pada umur 20-30 tahun insidens pada laki-laki lebih tinggi. Keputusan klinis mendasar dalam mendiagnosis pasien dengan dugaan apendisitis ialah apakah perlu dilakukannya operasi atau tidak.  Evaluasi yang baik dari kasus apendisitis akut dapat mengurangi intervensi untuk operasi awal, dengan harapan dapat mengurangi risiko operasi yang tidak diperlukan. Penelitian ini bertujuan untuk mengetahui angka kejadian apendisitis di RSUP Prof. Dr. R. D, Kandou Manado periode Oktober 2012 – September 2015. Metode penelitian yang digunakan ialah deskriptif retrospektif dengan menggunakan data di Bagian Rekam Medik RSUP Prof. Dr. R. D. Kandou Manado. Hasil penelitian menunjukkan bahwa selama periode Oktober 2012 – September 2015 terdapat 650 pasien. Jumlah pasien terbanyak ialah apendisitis akut yaitu 412 pasien (63%) sedangkan apendisitis kronik sebanyak 38 pasien (6%). Dari 650 pasien, yang mengalami komplikasi sebanyak 200 pasien yang terdiri dari 193 pasien (30%) dengan komplikasi apendisitis perforasi dan 7 pasien (1%) dengan periapendikuler infiltrat. Kelompok umur tersering yang menderita apendisitis ialah 20-29 tahun. Jumlah pasien laki-laki lebih banyak daripada perempuan. Kata kunci: apendisitis, angka kejadian

scholarly journals Hyperbilirubinemia: a new diagnostic marker for perpendicular perforation

2017 ◽  
Vol 4 (9) ◽  
pp. 3024
Author(s):  
Ramaswami Y. B. ◽  
Prakash H. S. ◽  
Raghavendra Prabhu T. C. ◽  
Faiyaz Abdul Jabbar
Keyword(s):  
Acute Appendicitis ◽  
Serum Bilirubin ◽  
Diagnostic Marker ◽  
Clinical Signs ◽  
Perforated Appendicitis ◽  
Signs And Symptoms ◽  
Total Serum Bilirubin ◽  
Total Serum ◽  
Delay In Diagnosis ◽  
Clinical Signs And Symptoms

Background: Appendicitis is one of the commonest causes of abdominal pain requiring emergency surgery. Diagnosing acute appendicitis clinically still remains a common surgical problem as the clinical signs and symptoms of other abdominal pathologic conditions mimic the diagnosis of acute appendicitis. Delay in diagnosis and surgery for this condition may lead to various complications like perforation, abdominal abscess etc. By knowing perforation prior to the exploration, we can manage the condition very effectively in terms explaining the prognosis of disease, morbidity of surgery, wound infection, and requirement of emergent nature of surgery. Aim of the study is to determine of role of hyperbilirubinemia as a new diagnostic marker to predict gangrenous/perforated appendicitis.Methods: It’s a retrospective study was conducted in the department of surgery, MMCRI, Mysore during the period of January 2015 to December 2015 total of 100 patients with clinical as well as ultrasonographic diagnosis of acute appendicitis or appendiceal perforation were made. The serum bilirubin test was carried out in all the patients pre-operatively.Results: In the study, the total 100 patients enrolled for the study, hyperbilirubinemia (> 1.2 mg/dL) in present study was found in 47 patients with 19 acute and 28 patients perforated appendicitis of all the 100 patients while 53 patients had normal bilirubin levels (≤ 1.2 mg/dL) 51 patients acute and 2 patients perforated appendix.Conclusions: Total serum bilirubin appears to be a new promising laboratory marker for diagnosing appendicular perforation. The patients with clinical signs and symptoms of appendicitis and with hyperbilirubinemia without elevation of liver enzymes should be identified as having a higher probability of appendicular perforation, suggesting total serum bilirubin levels have a predictive potential for the diagnosis of appendicular perforation.

scholarly journals MICROBIOLOGICAL AND IMMUNOLOGICAL ASPECTS OFPATHOGENESISOFACUTE APPENDICITIS

2021 ◽  
Vol 29 (2) ◽  
pp. 221-233
Author(s):  
A.V. Sazhin ◽  
◽  
V.A. Petukhov ◽  
T.V. Nechay ◽  
G.B. Ivakhov ◽  
...  
Keyword(s):  
Acute Appendicitis ◽  
Acute Inflammation ◽  
Point Of View ◽  
Intraluminal Pressure ◽  
Medical Specialties ◽  
Fundamental Research ◽  
Current Point ◽  
Mucous Barrier ◽  
Almost All ◽  
Scientific Facts

Obstruction of the lumen of the appendix is still considered to be the main cause of acute appendicitis (including feces), followed by the increased intraluminal pressure, the development of ischemia and mucosal hypoxia of the appendix, ulceration, violation of the mucous barrier and the development of necrosis. A sufficient number of scientific facts have been accumulated completely refuting this postulate. Current fundamental achievements in molecular biology, biochemistry, etc. did not become the basis for a clinical revision of the ancient well-established theories and concepts of the etiopathogenesis of many diseases in almost all medical specialties. Surgery isn’t an exception in this context. The review considers the etiopathogenesis of acute inflammation of the appendix from the current point of view of the hypothesis of epithelial-endothelial dysfunction and epithelial-endothelial distress syndrome, since it most fully characterizes the integration of the etiopathogenesis of almost all common diseases of organs with mucous membranes and the recent fundamental research their structures and functions. It is based on general and local factors of violation of the lymphoid apparatus and the integumentary epithelium barrier functions. Thus, this work presents a new concept of the etiopathogenesis of acute appendicitis, which in turn will allow the surgery of acute appendicitis to reach new levels of understanding.

Schistosomal Appendicitis in Pregnancy

Swiss Surgery ◽  
2002 ◽  
Vol 8 (3) ◽  
pp. 121-122 ◽  
Author(s):  
Halkic ◽  
Abdelmoumene ◽  
Gintzburger ◽  
Mosimann
Keyword(s):  
Acute Appendicitis ◽  
Schistosoma Haematobium ◽  
Acute Inflammation ◽  
The Body ◽  
Parasitic Infections ◽  
Common Complication ◽  
Surgical Infection ◽  
High Prevalence ◽  
Potential Challenge ◽  
In Pregnancy

Acute appendicitis is the most common acute surgical infection during pregnancy. Although usually pyogenic in origin, parasitic infections account for a small percentage of cases. Despite the relatively high prevalence of acute appendicitis in our environment, it is not commonly associated with schistosomiasis. We report here the association of pregnancy and appendicitis caused by Schistosoma haematobium. Schistosomiasis is very common complication of pregnancy in hyperendemic areas. Schistosome egg masses can lodge throughout the body and cause acute inflammation of the appendix, liver and spleen. Congestion of pelvic vessels during pregnancy facilitates passage of eggs into the villi and intervillous spaces, causing an inflammatory reaction. Tourism and immigration make this disease a potential challenge for practitioners everywhere.

Appendicitis: a rare adverse event in colonoscopy

2021 ◽  
Vol 14 (7) ◽  
pp. e242523
Author(s):  
Samer Al-Dury ◽  
Mohammad Khalil ◽  
Riadh Sadik ◽  
Per Hedenström
Keyword(s):  
Emergency Department ◽  
Adverse Event ◽  
Abdominal Pain ◽  
Acute Appendicitis ◽  
Physical Examination ◽  
De Novo ◽  
Perforated Appendicitis ◽  
Lower Quadrant ◽  
The Right ◽  
Right Lower Quadrant

We present a case of a 41-year-old woman who visited the emergency department (ED) with acute abdomen. She was diagnosed with perforated appendicitis and abscess formation on CT. She was treated conservatively with antibiotics and discharged. On control CT 3 months later, the appendix had healed, but signs of thickening of the terminal ileum were noticed and colonoscopy was performed, which was uneventful and showed no signs of inflammation. Twelve hours later, she developed pain in the right lower quadrant, followed by fever, and visited the ED. Physical examination and blood work showed signs consistent with acute appendicitis, and appendectomy was performed laparoscopically 6 hours later. The patient recovered remarkably shortly afterwards. Whether colonoscopy resulted in de novo appendicitis or exacerbated an already existing inflammation remains unknown. However, endoscopists should be aware of this rare, yet serious complication and consider it in the workup of post-colonoscopy abdominal pain.

scholarly journals The diagnostic value of white cell count, C-reactive protein and bilirubin in acute appendicitis and its complications

2013 ◽  
Vol 95 (3) ◽  
pp. 215-221 ◽  
Author(s):  
I G Panagiotopoulou ◽  
D Parashar ◽  
R Lin ◽  
S Antonowicz ◽  
AD Wells ◽  
...  
Keyword(s):  
Acute Appendicitis ◽  
Diagnostic Accuracy ◽  
Cell Count ◽  
Inflammatory Markers ◽  
White Cell Count ◽  
Perforated Appendicitis ◽  
Diagnostic Value ◽  
White Cell ◽  
C Reactive Protein ◽  
Reactive Protein

Introduction Inflammatory markers such as white cell count (WCC) and C-reactive protein (CRP) and, more recently, bilirubin have been used as adjuncts in the diagnosis of appendicitis. The aim of this study was to determine the diagnostic accuracy of the above markers in acute and perforated appendicitis as well as their value in excluding the condition. Methods A retrospective analysis of 1,169 appendicectomies was performed. Patients were grouped according to histological examination of appendicectomy specimens (normal appendix = NA, acute appendicitis = AA, perforated appendicitis = PA) and preoperative laboratory test results were correlated. Receiver operating characteristic (ROC) curve area analysis (area under the curve [AUC]) was performed to examine diagnostic accuracy. Results ROC analysis of all laboratory variables showed that no independent variable was diagnostic for AA. Good diagnostic accuracy was seen for AA when all variables were combined (WCC/CRP/bilirubin combined AUC: 0.8173). In PA, the median CRP level was significantly higher than that of AA (158mg/l vs 30mg, p<0.0001). CRP also showed the highest sensitivity (100%) and negative predictive value (100%) for PA. CRP had the highest diagnostic accuracy in PA (AUC: 0.9322) and this was increased when it was combined with WCC (AUC: 0.9388). Bilirubin added no diagnostic value in PA. Normal levels of WCC, CRP and bilirubin could not rule out appendicitis. Conclusions CRP provides the highest diagnostic accuracy for PA. Bilirubin did not provide any discriminatory value for AA and its complications. Normal inflammatory markers cannot exclude appendicitis, which remains a clinical diagnosis.

scholarly journals DIFFERENCES IN LEUKOCYTE RATE BETWEEN ACUTE NONPERFORATED AND PERFORATED APPENDICITIS IN HOSPITALISED PATIENTS BANDAR LAMPUNG-INDONESIA

2019 ◽  
Vol 2 (1) ◽  
pp. 25-31
Author(s):  
Festy Ladyani ◽  
Nur Fitria Dewi
Keyword(s):  
Acute Appendicitis ◽  
Public Hospital ◽  
Leucocyte Count ◽  
Univariate Analysis ◽  
Perforated Appendicitis ◽  
Sampling Technique ◽  
Bivariate Analysis ◽  
P Value ◽  
Cross Sectional ◽  
Hospitalised Patients

Background: Acute appendicitis is one of the most common acute abdominal pain. A late check up and diagnosis could bring harms which is turning into perforated appendicitis. Leukocyte count is a laboratory collation that is generous and quick to diagnose the acute apendicitis and perforated appendicitis, however there’s no certain limit of the leukocytes count to recognize whether it is acute apendicitis or perforated appendicitis.Purpose: This research was to find out the comparison of leucocyte count average between acute appendicitis and perforation appendicitis in Dr. H. Abdul Moeleok public hospital of Lampung province in 2014-2016.Methods: An analytic research with cross sectional approach. Population was 382 patients with appendicitis in Dr. Hi. Abdul Moeloek public hospital. Samples were taken using total sampling technique with 196 respondent samples for acute appendicitis and 196 respondent samples for perforation appendicitis. Data were analyzed by using univariate analysis with percentage and bivariate analysis with t-test.Results: the average of leucocyte count of acute appendicitis patients was 10,907 with minimum and maximum leucocyte count of 5,000 and 18,500 respectively. The average of leucocyte count of perforation appendicitis patients was 22,789 with minimum and maximum leucocyte count of 16,500 and 31,000 respectively. There were differences of leucocyte counts between acute appendicitis patients and perforation appendicitis patients with p-value < 0.05.Conclusion: there were significant differences of leucocyte count averages between acute appendicitis and perforation appendicitis.

scholarly journals Simple versus complicated appendicitis

2021 ◽  
Author(s):  
Mahendra Pal Singh
Keyword(s):  
Acute Appendicitis ◽  
Clinical Experience ◽  
Surgical Techniques ◽  
Perforated Appendicitis ◽  
Complicated Appendicitis ◽  
Natural Course ◽  
Intraluminal Pressure ◽  
Research Papers

Aim of this study is to understand appendicitis in its various presentations. We encounter patients in different stages of the disease. One end of the spectrum is presenting with simple acute appendicitis while other extreme is represented by serious cases of perforated appendicitis. In between cases with various stages of complications could be seen. Simple appendicitis progresses towards complicated one in its natural course. Rise in intraluminal pressure leads to gangrenous perforation. Expertise of the treating surgeon lies in timely detection and intervention. Desired and favorable results are possible to achieve with judicious use of gastrointestinal surgical techniques by the expert. Present study reviews the literature, different research papers and studies available. My own clinical experience in the understanding of appendicitis and its management has enabled me to shape up the article.

scholarly journals Antibiotics in acute appendicitis. When and how? A general review

2019 ◽  
Vol 6 (1) ◽  
pp. 30-33
Author(s):  
L. Alecu ◽  
C. Niţipir ◽  
Iulian Slavu ◽  
V. Braga ◽  
D. Mihăilă ◽  
...  
Keyword(s):  
Acute Appendicitis ◽  
Antibiotic Treatment ◽  
Complication Rate ◽  
Acquired Resistance ◽  
Perforated Appendicitis ◽  
Interval Appendectomy ◽  
Bacterial Proliferation ◽  
Long Period ◽  
Clinical Surveillance ◽  
Relapse Rates

Introduction: An increasing interest exits towards the use of antibiotics in the treatment of uncomplicated acute appendicitis.Discussion: For a long period of time, surgery was the only treatment for acute appendicitis. Due to recent research in the etiology of acute appendicitis which seems to be driven by intraluminal bacterial proliferation, new data suggests that for non-perforated appendicitis confirmed with the help of CT, antibiotics may play a central role in the treatment. As relapse rates amount in some cases to only 5% after antibiotic treament, a discussion is required regarding the risks of interval appendectomy and its use. The debate regarding the optimal antibiotic course is on-going as some surgeons advocate for amoxicillin/clavulanic while others, due to acquired resistance recommend Ertapenem.Conclusion:  Selective antibiotic treatment for selected forms of acute appendicitis, uncomplicated without perforation is safe and has a relatively low complication rate. However, certain mentions must be made:  surgery must not be delayed if failure of antibiotics exists as it can lead to higher rates of peritonitis. Close clinical surveillance is of utmost importance

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