KESAHIHAN DIAGNOSTIK HEMOGLOBIN RETIKULOSIT UNTUK DETEKSI DEFISIENSI ZAT BESI DI KEHAMILAN

Entering the second trimester of pregnancy, more iron is required due to the increase in erythrocyte mass, plasma volume and the development of fetus as well as chorion. Iron is needed the most in the third trimester. The existing hematological iron stage parameters can only detect iron deficiency in the latest stage. The aim of this study was to know the assessment validity of Ret-He examination as a new parameter to diagnose iron deficiency in pregnant women with anemia, as well as a screening tool for those interm pregnancy without anemia. The research design was cross sectional. The subjects were women in term pregnancy, gathered from PKU Muhammadiyah Hospital, Bantul Yogyakarta from May to November 2013. A seven (7) mL blood sample was taken from the cubital vein of the subjects. Two mL of the sample was tested for routine hematological examination using an EDTA tube, while the Ret-He was assessed using an automatic hematological instrument Sysmex XT-2000-i (Symex Corporation, Kobe, Japan). The serum of the remaining five (5) mL was used to check the serum iron and TIBC to obtain the saturation value (Tsat) using Cobas analyzer C501 (Roche Diagnostics, Germany), while the serum ferritin (SF) was examined using Minividas. The subjects were classified into two (2) groups based on the Hb levels, namely: anemia (Hb<11 g/dL) and those who did not (Hb≥11 g/dL). Furthermore, they were alsoclassified into two (2) groups based on transferrin saturation values: iron deficient (Tsat <9%) and normal (Tsat ≥9%). From 291 subjects, 59 (20.3%) were found to have anemia and 232 (79.7%) did not. The cut off value of Ret-He to diagnose iron deficiency in pregnant women with anemia was 29.8 pg (82% sensitivity and 72% specificity). Meanwhile, the cut-off value of Ret-He for iron deficiency screening in pregnant women without anemia was 29.8 pg, with a sensitivity and specificity of 92% and 87% respectively. The Ret-He holds a good diagnostic validity to detect iron deficiency in pregnancy, with or without anemia.

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KESAHIHAN DIAGNOSTIK HEMOGLOBIN RETIKULOSIT UNTUK DETEKSI DEFISIENSI ZAT BESI DI KEHAMILAN (Diagnostic Validity of Reticulocyte Hemoglobin for Iron Deficiency Detection in Pregnancy)

INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY ◽

10.24293/ijcpml.v21i3.1282 ◽

2018 ◽

Vol 21 (3) ◽

pp. 285

Author(s):

Tri Ratnaningsih ◽

Budi Mulyono ◽

Sutaryo Sutaryo ◽

Iwan Dwiprahasto

Keyword(s):

Iron Deficiency ◽

Pregnant Women ◽

Transferrin Saturation ◽

Diagnostic Validity ◽

Third Trimester ◽

Cross Sectional ◽

Iron Deficient ◽

Roche Diagnostics ◽

Edta Tube ◽

In Pregnancy

Entering the second trimester of pregnancy, more iron is required due to the increase in erythrocyte mass, plasma volume andthe development of fetus as well as chorion. Iron is needed the most in the third trimester. The existing hematological iron stageparameters can only detect iron deficiency in the latest stage. The aim of this study was to know the assessment validity of Ret-Heexamination as a new parameter to diagnose iron deficiency in pregnant women with anemia, as well as a screening tool for those interm pregnancy without anemia. The research design was cross sectional. The subjects were women in term pregnancy, gathered fromPKU Muhammadiyah Hospital, Bantul Yogyakarta from May to November 2013. A seven (7) mL blood sample was taken from thecubital vein of the subjects. Two mL of the sample was tested for routine hematological examination using an EDTA tube, while theRet-He was assessed using an automatic hematological instrument Sysmex XT-2000-i (Symex Corporation, Kobe, Japan). The serumof the remaining five (5) mL was used to check the serum iron and TIBC to obtain the saturation value (Tsat) using Cobas analyzerC501 (Roche Diagnostics, Germany), while the serum ferritin (SF) was examined using Minividas. The subjects were classified into two(2) groups based on the Hb levels, namely: anemia (Hb<11 g/dL) and those who did not (Hb≥11 g/dL). Furthermore, they were alsoclassified into two (2) groups based on transferrin saturation values: iron deficient (Tsat <9%) and normal (Tsat ≥9%). From 291subjects, 59 (20.3%) were found to have anemia and 232 (79.7%) did not. The cut off value of Ret-He to diagnose iron deficiency inpregnant women with anemia was 29.8 pg (82% sensitivity and 72% specificity). Meanwhile, the cut-off value of Ret-He for irondeficiency screening in pregnant women without anemia was 29.8 pg, with a sensitivity and specificity of 92% and 87% respectively.The Ret-He holds a good diagnostic validity to detect iron deficiency in pregnancy, with or without anemia.

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Iron deficiency among pregnant women attending an antenatal clinic in Northern Uganda: a cross-sectional study

10.21203/rs.2.14386/v1 ◽

2019 ◽

Author(s):

Samson Udho ◽

Joyce Nankumbi ◽

Mariam Namutebi ◽

Grace Ndeezi ◽

Joshua Epuitai ◽

...

Keyword(s):

Iron Deficiency ◽

Pregnant Women ◽

Serum Ferritin ◽

Antenatal Clinic ◽

Cross Sectional Study ◽

Sectional Study ◽

Third Trimester ◽

Cross Sectional ◽

Iron Supplements ◽

The Third

Abstract Background Iron deficiency is a leading cause of anemia among pregnant women in Uganda. However, due to the high cost of biochemical tests required to determine iron deficiency, the prevalence and factors associated with iron deficiency remain largely unstudied in our setting. Therefore, this study aimed at determining the prevalence of iron deficiency and its associated factors among pregnant women attending an antenatal clinic, Lira District-Uganda.Methods A cross-sectional study was conducted among 320 pregnant women attending an antenatal clinic at Lira Regional Referral Hospital. Maternal serum ferritin was used as a measure of iron deficiency and was determined using a Cobas 6000 Automated Analyzer. Iron deficiency was based on serum ferritin of <30 μg/L. A semi-structured questionnaire was used to obtain the characteristics of the study participants. Binary and multivariate logistic regression were performed to identify the associated factors.Results The prevalence of iron deficiency was 45%. Non-adherence to iron supplements (AOR: 2.05 95% CI: 1.02-4.12) & third trimester pregnancy (AOR: 1.88 95% CI: 1.20-2.94) were significantly associated with iron deficiency during pregnancy.Conclusion Nearly 5 in 10 of the participants had iron deficiency. Iron deficiency during pregnancy was associated with non-adherence to iron supplements and being in the third trimester of pregnancy. Midwives should encourage pregnant women to adhere to iron supplements during pregnancy especially pregnant women who are in the third trimester.

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Impact of Iron Status on Thyroid Function: A Community Based Cross-Sectional Study in Eastern Nepal

Journal of College of Medical Sciences-Nepal ◽

10.3126/jcmsn.v15i1.21022 ◽

2019 ◽

Vol 15 (1) ◽

pp. 18-21 ◽

Cited By ~ 1

Author(s):

Saroj Thapa ◽

Madhab Lamsal ◽

Sanjay Kumar Sah ◽

Rajendra Kumar Chaudhari ◽

Basanta Gelal ◽

...

Keyword(s):

Iron Deficiency ◽

Iron Status ◽

Transferrin Saturation ◽

Cross Sectional Study ◽

Sectional Study ◽

Community Based ◽

Cross Sectional ◽

Hormone Profile ◽

Iron Deficient ◽

The Mean

Background: Iron deficiency is the most common nutritional deficiency in the world. The relation between thyroid hormones and iron status is bidirectional. The aim of this study was to assess iron nutrition status and evaluate its relationship with thyroid hormone profile among children of Eastern Nepal. Methods: A community based cross-sectional study was conducted in eastern Nepal. A total of 200 school children aged 6-12 years were recruited after taking informed consent from their guardians. Blood samples were collected and assayed for free thyroid hormones (fT3 and fT4), thyroid stimulating hormone (TSH), serum iron, total iron binding capacity (TIBC) concentration and percentage transferrin saturation was calculated. Results: The mean serum iron and TIBC was 74.04 µg/dl and 389.38 µg/dl respectively. The median transferring saturation was 19.21%. The overall prevalence of iron deficiency (Transferrin saturation < 16%) was 34% (n=68). The mean concentration of fT3 and fT4 was 2.87 pg/ml and 1.21 ng/dl respectively, while the median TSH concentration was 3.03 mIU/L. Median TSH concentration in iron deficient group (3.11 µg/dl) and iron sufficient group (2.91 µg/dl) was not significantly different. Among iron deficient children 5.9% had subclinical hypothyroidism (n=4). Iron status indicators were not significantly correlated with thyroid profile parameters in the study population. Conclusions: The prevalence of iron deficiency is high and iron deficiency does not significantly alter the thyroid hormone profile in the study region.

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Analysis of the iron profile and the incidence of iron deficiency anemia in the third-trimester pregnant women in the coendemic areas of Bengkulu City, Indonesia

Journal of Public Health in Africa ◽

10.4081/jphia.2019.1197 ◽

2019 ◽

Author(s):

Mohammad Zulkarnain ◽

Rizka Muliani ◽

Rico Januar Sitorus ◽

Nurlaili Nurlaili

Keyword(s):

Iron Deficiency ◽

Pregnant Women ◽

Iron Deficiency Anemia ◽

Total Sample ◽

Deficiency Anemia ◽

P Value ◽

Binary Logistic Regression Analysis ◽

Third Trimester ◽

Cross Sectional ◽

The Third

Pregnant women are at risk for iron deficiency anemia especially pregnant women in malaria-endemic areas. This study aimed to analyze the profile of iron in the third trimester pregnant women with iron deficiency anemia in co-endemic area of Bengkulu city. This study was cross-sectional study with a total sample of 66 pregnant women who met the inclusion criteria. Examination profile of iron in pregnant women is done by taking blood specimen through the vena cubity. Profile iron includes examination sTfR levels, hepcidin, transferrin were examined by ELISA. Determination of iron deficiency anemia is based on the results of Hb, serum iron and TIBC. The results showed 39.4% of pregnant women experience iron deficiency anemia. There is an average difference between hepcidin levels with the incidence of iron deficiency anemia (p-value 0.031). Based on binary logistic regression analysis profile iron with irondeficiency anemia in pregnant women, hepcidin levels are predictors factors on the incidence of iron deficiency anemia (p-value 0.000, 95% CI .296-.709).

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Prevalence of Iron, Vitamin B12 deficiency and inflammatory anaemia in treatment naive individual consecutive cancer patients: A cross sectional study.

10.1101/2020.07.29.20164426 ◽

2020 ◽

Author(s):

Avinash Pandey ◽

Shivkant Singh ◽

Raj Aryan ◽

Krishna Murari

Keyword(s):

Iron Deficiency ◽

Vitamin B12 ◽

Cancer Patients ◽

Serum Ferritin ◽

Transferrin Saturation ◽

Vitamin B12 Deficiency ◽

Cross Sectional ◽

Iron Deficient ◽

Treatment Naïve ◽

B12 Deficiency

Background: In treatment naive Indian cancer patients, prevalence of iron, B12 deficiency and inflammatory anaemia in poorly known. Aims and Objectives : To evaluate prevalence of anaemia and iron, B12 deficiency along with inflammation in treatment naive individual consecutive cancer patients. Material and Methods: All patients registered from 1st July 2019 till 31st December 2019 in Medical Oncology Outpatient Department were offered to undergo Iron profile, Serum B12 levels and Serum ferritin along with routine haematological investigations. Anaemia was defined as Haemoglobin < 11gm/dL. Transferrin saturation <20%, Serum Ferritin >300 microgram/litre and Vitamin B12 level <200 picogram/millilitre were 'cut-offs' used to define iron deficiency, inflammation and Vitamin B12 deficiency respectively. Data was analysed using descriptive statistics, frequency distribution, crosstabs and Bar Diagram in SPSS version 17.0. Pearsons Chi square test and Odds ratio was used to measure the strength of association with variables. Results: 311/441 (70.5%) were found eligible. Median age was 52 + 15.9 (Range 18-84 ) years with 144/331(46%) females. The prevalence of anaemia was 61% + 2.7 (95% CI 55-66%). Mean Haemoglobin was 9.86 + 2.08 (range 3-16) gram/decilitre. 21/311(7%) had severe anaemia (Haemoglobin < 6.9 gm/dl). 135/311 (71%), 61/189 (32%) and 89/189 (47%) anaemic patients had iron deficiency, inflammation and B12 deficiency respectively. More than 70% of Gastrointestinal (50/69), Gynaecological(17/24) and Lung Cancer(18/22) patients had underling Iron deficiency. Conclusion: Two-third of cancer patients are iron deficient. B12 deficiency and inflammation are present in half and one-third patients respectively.

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FREQUENCY, DISTRIBUTION AND DETERMINANTS OF IRON DEFICIENCY ANEMIA AMONG THIRD TRIMESTER INDOOR PREGNANT WOMEN

Gomal Journal of Medical Sciences ◽

10.46903/gjms/16.03.1868 ◽

2018 ◽

Vol 16 (3) ◽

pp. 79-82

Author(s):

Asif Rehman ◽

Farhat Rehana Malik ◽

Mir Abid Jan ◽

Mahvash Zeb ◽

Zia Ul Ain Sabiha ◽

...

Keyword(s):

Social Class ◽

Iron Deficiency ◽

Pregnant Women ◽

Frequency Distribution ◽

Iron Deficiency Anemia ◽

Deficiency Anemia ◽

Third Trimester ◽

Cross Sectional ◽

Gynecology And Obstetrics ◽

The Mean

Background: Iron deficiency anemia is a common health problem during pregnancy in developing countries. The objectives of this study were to determine the frequency, distribution & determinants of iron deficiency anemia among third trimester pregnant women in our population. Materials & Methods: This cross-sectional study was conducted in Department of Gynecology and Obstetrics, Hayatabad Medical Complex, Peshawar, Pakistan from October 2015 to March 2016. Sample size was 360 calculated through an online calculator. The inclusion criteria was third trimester pregnant women. Demographic variables were age in years, age groups and social class. Research variables were Hb in mg/dL, presence of iron deficiency anemia, grades of iron deficiency anemia (mild/ moderate/ severe) and iron intake (yes/no). Numeric variables such as age in years and Hb were analyzed as mean and SD, whereas rest of the variables being categorical as count and percentages. Chi-square tests of association was computed. Result: The mean age of the sample was 29.31 ±6.99 and CI of 27.92-30.70. The mean hemoglobin level was 10.33 ±1.7 and 95% CI of 9.99-10.67. The overall frequency of iron deficiency anemia was found out to be 52%, in which 25% were mild, 22% moderate and 5% were severely anemic. Women with middle class had higher frequency of 145 cases. Association of iron deficiency anemia with social class (χ2=7.95, p

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The Paediatric Iron Deficiency Assessment with Reticulocyte Haemoglobin Equivalent (Ret-He) in Comparison with Biochemical Markers of Serum Ferritin and Transferrin Saturation

Medicine & Health ◽

10.17576/mh.2021.1602.10 ◽

2021 ◽

Vol 16 (2) ◽

pp. 138-147

Author(s):

Nurasyikin Yusof ◽

Keyword(s):

Iron Deficiency ◽

Sensitivity And Specificity ◽

Serum Ferritin ◽

Serum Iron ◽

Screening Tool ◽

Transferrin Saturation ◽

Good Sensitivity ◽

Operating Characteristics ◽

Iron Deficient ◽

Conventional Methods

Diagnosis of iron deficiency anaemia (IDA) is a challenge as the conventional methods often diagnose the disease at the later stage. Haemoglobin content of reticulocytes is useful to identify IDA at earlier stage. The objective of this study was to evaluate reticulocyte-haemoglobin equivalent (Ret-He) in diagnosing IDA in children and to compare it with other conventional methods. This prospective study was conducted on 120 paediatric patients aged 12 years and below, who attended Hospital Sultanah Aminah Johor Bahru, Malaysia with haemoglobin <12 g/dL. Ret-He and serum iron, ferritin and transferrin saturation were measured. Using a cut-off point of 20% for transferrin saturation, 81 out of 120 subjects (67.5%) were found as iron deficient. Based on the diagnosis of IDA, cut-off value for Ret-He using the Receiver Operating Characteristics (ROC) curve analysis was found as 22.65 pg. Ret-He showed a good sensitivity and specificity of 77.8% and 66.7%, respectively. As compared with Ret-He, serum ferritin showed a sensitivity of only 18.9%. However, a good specificity of 100% suggest it is useful for ruling in the disease but not suitable for screening. Transferrin saturation showed a good sensitivity and specificity, but it is biologically variable and not cost effective as a screening tool. Correlation study showed serum iron and transferrin saturation have significant positive correlation with Ret-He (r=0.415 to 0.518). However, there was no correlation between Ret-He and serum ferritin (r=0.051, p=0.578). This study shows that Ret-He at a cut-off point of 22.65 pg has a better sensitivity and potentially be useful as a screening tool in the paediatric population.

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HUBUNGAN PENDIDIKAN DAN STATUS EKONOMI DENGAN STATUS GIZI IBU HAMIL TRIMESTER III DI PUSKESMAS SOSIAL PALEMBANG TAHUN 2012

Jurnal Kebidanan : Jurnal Medical Science Ilmu Kesehatan Akademi Kebidanan Budi Mulia Palembang ◽

10.35325/kebidanan.v3i1.38 ◽

2019 ◽

Vol 3 (1) ◽

Author(s):

Tirta Anggraini Tirta Anggraini

Keyword(s):

Nutritional Status ◽

Pregnant Women ◽

Health Center ◽

Economic Status ◽

Social Health ◽

World Health ◽

Third Trimester ◽

Chi Square ◽

Cross Sectional ◽

Health Organization

ABSTRACT According to the World Health Organization (WHO), maternal nutritional status at the time of growth and during pregnancy can affect fetal growth and development. Based on (IDHS) survey of 2007 AKI Indonesia at 228 per 100,000 live births, although this figure is still the highest in Asia. Social health center in Palembang in 2011 the number of pregnant women with good nutritional status of 67 men (97.1%). factors that influence the nutritional status of pregnant women is the temperature of the environment, economic status, habits and views of women to food, age, education, and health status. The purpose of this study is a known relationship education and economic status with nutritional status of pregnant women in the third trimester of Social Health Center Palembang in 2012. This study uses analytic survey with cross sectional approach. The population in this study were all third trimester pregnant women who visit the health center Social Palembang in May 2012, with a sample of 30 respondents. Sampling in this study with non-random methods with techniques Accidental Sampling. Data analysis carried out univariate and bivariate statistics with Chi-Square test with significance level α = 0.05. The results showed than 30 respondents there (73.3%) of respondents that good nutritional status, higher education (76.7%), and high economic status (70.0%). The results of this study showed no significant association education and economic status with nutritional status of pregnant women in the third trimester of Social Health Center Palembang in 2012. From the results of this study, researchers hope to improve the health care workers, especially health services in Antenatal Care services pay more attention to maternal risk of poor nutritional status. ABSTRAK Menurut World Health Organization (WHO), status gizi ibu hamil pada waktu pertumbuhan dan selama hamil dapat mempengaruhi pertumbuhan dan perkembangan janin. Berdasarkan (SDKI) survei terakhir tahun 2007 AKI Indonesia sebesar 228 per 100.000 Kelahiran Hidup, meskipun demikian angka tersebut masih tertinggi di Asia. Di Puskesmas Sosial Palembang tahun 2011 jumlah ibu hamil yang berstatus gizi baik sebesar 67 orang (97,1%). faktor-faktor yang mempengaruhi status gizi ibu hamil adalah suhu lingkungan, status ekonomi, kebiasaan dan pandangan wanita terhadap makanan, usia, pendidikan, dan status kesehatan. Tujuan penelitian ini adalah diketahuinya hubungan pendidikan dan status ekonomi dengan status gizi ibu hamil trimester III di Puskesmas Sosial Palembang tahun 2012. Penelitian ini menggunakan metode survey analitik dengan pendekatan cross sectional. Populasi pada penelitian ini adalah semua ibu hamil trimester III yang berkunjung di Puskesmas Sosial Palembang pada bulan Mei tahun 2012, dengan jumlah sampel 30 responden. Pengambilan sampel pada penelitian ini dengan metode non random dengan teknik Accidental Sampling. Analisa data dilakukan secara univariat dan bivariat dengan uji statistik Chi-Square dengan tingkat kemaknaan α = 0,05. Hasil penelitian menunjukkan dari 30 responden terdapat (73,3%) responden yang berstatus gizi baik, pendidikan tinggi (76,7%), dan status ekonomi tinggi (70,0%). Hasil penelitian ini menunjukkan ada hubungan yang bermakna pendidikan dan status ekonomi dengan status gizi ibu hamil trimester III di Puskesmas Sosial Palembang tahun 2012. Dari hasil penelitian ini, peneliti berharap petugas pelayanan kesehatan dapat meningkatkan pelayanan kesehatan terutama dalam pelayanan Antenatal Care lebih memperhatikan kehamilan ibu yang berisiko status gizi buruk.

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Pengaruh Umur Ibu Hamil Dan Dukungan Keluarga Terhadap Kepatuhan Mengkonsumsi Tablet Besi (Fe) Dan Anemia Pada Ibu Hamil Di Puskesmas Kota Wilayah Selatan Kota Kediri

Jurnal Ilmu Kesehatan MAKIA ◽

10.37413/jmakia.v4i1.28 ◽

2017 ◽

Vol 4 (1) ◽

Author(s):

Dina Dewi Anggraini

Keyword(s):

Pregnant Women ◽

Health Center ◽

Family Support ◽

Random Sampling ◽

Maternal Age ◽

Sampling Technique ◽

Deficiency Anemia ◽

Third Trimester ◽

Regional Health ◽

Cross Sectional

ABSTRAKPerdarahan merupakan prosentase tertinggi penyebab terjadinya kematian ibu. Dan anemia zat besi merupakan penyebab utama terjadinya perdarahan. Pencegahan anemia gizi besi dilakukan melalui pemberian tablet besi dengan dosis pemberian sebanyak 1 tablet berturut-turut minimal selama 90 hari selama kehamilan. Pada kecamatan dan Puskesmas Kota Kediri 2014, cakupan Fe1 dan Fe3 yang terendah adalah pada Kecamatan Kota, yaitu Puskesmas Kota Wilayah Selatan, dengan Fe1 sebesar 69,81% dan Fe3 sebesar 66,29%. Penelitian dilakukan untuk menganalisis pengaruh umur ibu hamil dan dukungan keluarga terhadap kepatuhan mengkonsumsi tablet besi dan anemia pada ibu hamil di Puskesmas Kota Wilayah Selatan Kota Kediri 2016. Metode pada penelitian ini dengan observasi analitik dan rancang bangun cross sectional. Populasi pada penelitian ini 63 orang ibu hamil trimester III dan sampelnya 34 orang ibu hamil trimester III yang telah mendapatkan 90 tablet besi (Fe), dengan teknik simpel random sampling. Data diperoleh dari kuesioner, buku Kesehatan Ibu dan Anak, dan wawancara yang mendalam. Analisis data yang dilakukan dengan menggunakan regresi ordinal dan regresi logistik. Hasil uji didapatkan nilai p = 0,000 0,05 untuk variabel umur ibu hamil 20 tahun terhadap kepatuhan mengkonsumsi tablet besi (Fe), nilai p = 0,238 0,05 untuk variabel dukungan keluarga terhadap kepatuhan mengkonsumsi tablet besi (Fe), dan nilai p = 0,012 0,05 untuk variabel kepatuhan yang cukup dalam mengkonsumsi tablet besi (Fe) terhadap anemia pada ibu hamil. Semakin tinggi faktor risiko umur pada ibu hamil, maka semakin cenderung ibu hamil untuk patuh mengkonsumsi tablet besi (Fe) pada masa kehamilan. Semakin tinggi tingkat kepatuhan ibu hamil dalam mengkonsumsi tablet besi (Fe), maka semakin tinggi pula kecenderungan ibu hamil untuk tidak terkena anemia pada masa kehamilan. Kata kunci: Umur, Dukungan Keluarga, Kepatuhan, Anemia. ABSTRACTBleeding is the highest percentage of the causes of maternal mortality. And iron anemia is a major cause of bleeding. Prevention of iron deficiency anemia is done through the provision of iron tablets with doses as much as 1 tablet in a row for a minimum of 90 days during pregnancy. In the town of Kediri district and health center in 2014, Fe1 and Fe3 coverage is lowest in the City District, the Southern Regional Health Center, with Fe1 amounted to 69,81% and amounted to 66,29% Fe3. The study was conducted to analyze the effect of maternal age and family support for adherence to consume iron tablets and anemia in pregnant women in the South Regional Health Center of Kediri, 2016. The method in this study with analytic observation and cross sectional design. The population in this study 63 third trimester pregnant women and the sample 34 third trimester pregnant women who have received 90 tablets of iron (Fe), with a simple random sampling technique. Data obtained from questionnaires, books Maternal and Child Health, and in-depth interviews. Data analysis was performed using ordinal regression and logistic regression. The test results obtained value of p = 0,000 0,05 for the variable maternal age 20 years of adherence to consume tablets of iron (Fe), p = 0,238 0,05 for the variable of family support for adherence to consume tablets of iron (Fe), and p = 0,012 0,05 for the variable adherence sufficient to consume iron tablet (Fe) against anemia in pregnant women. The higher the risk factors of age in pregnant women, pregnant women, the more it tends to stick to consume tablets of iron (Fe) during pregnancy. The higher the level of adherence of pregnant women consume iron tablet (Fe), the higher the tendency of pregnant women not exposed to anemia during pregnancy. Keywords: Age, Family Support, Adherence, Anemia.

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Perbedaan Kadar Brain Derived Neurotropic Factor Neonatus Dari Ibu Hamil Normal Dan Anemia Defisiensi Besi

Jurnal Endurance ◽

10.22216/jen.v3i3.3706 ◽

2018 ◽

Vol 3 (3) ◽

pp. 568

Author(s):

Ainal Mardiah ◽

Arni Amir ◽

Andi Friadi ◽

Ellyza Nasrul

Keyword(s):

Iron Deficiency ◽

Pregnant Women ◽

Community Health ◽

Health Center ◽

Iron Deficiency Anemia ◽

Community Health Center ◽

Deficiency Anemia ◽

Cross Sectional ◽

Consecutive Sampling ◽

Neurotropic Factor

Iron deficiency anemia is anemia caused by iron deficiency in the blood. Maternal iron deficiency affects the low iron reserves in neonates and it also influences on Brain Derived Neurotropic Factor (BDNF) which affects cognitive function. The purpose of this study was to determine the difference mean of BDNF in neonates from normal pregnant women and pregnant women with iron deficiency. The design of this research was Cross Sectional design. This research was conducted in Community Health Center of Lubuk Buaya, Ambacang Community Health Center, Community Health Center of Ikur Koto Health Center and Biomedical Laboratory of Andalas University on February 2017 to April 2018. There were 42 pregnant women was selected as sample e of this research. The samples were chosen by Consecutive Sampling. Then, the sample is divided into two groups: normal pregnant women and pregnant women with iron deficiency anemia. BDNF are examined by the ELISA. Next, the data were analyzed by using T test. The levels of BDNF neonates in normal pregnant group was 3.65(ng/ml) and the anemia pregnant group was 1.74(ng/ml) (p <0.05). There was significant difference of BDNF levels in neonates from normal pregnant women and pregnant women with iron deficiency anemia. The conclusion of this study is there is a difference of average BDNF in neonates from normal pregnant women and pregnant women with iron deficiency. Anemia defisiensi besi adalah anemia yang disebabkan karena kekurangan zat besi dalam darah. Defisiensi besi maternal berdampak pada rendahnya cadangan besi pada neonatus dan berdampak terhadap ekspresi Brain Derived Neurotropic Factor (BDNF) yang berpengaruh pada fungsi kognitif. Tujuan penelitian ini adalah untuk mengetahui perbedaan rerata kadar BDNF pada neonatus dari ibu hamil normal dan ibu hamil defisiensi besi. Desain penelitian ini adalah Cross Sectional. Penelitian dilakukan di Puskesmas Lubuk Buaya, Puskesmas Ambacang, Puskesmas Ikur Koto dan Laboratorium Biomedik Universitas Andalas pada bulan Februari 2017 – Juli 2018. Sampel Penelitian adalah ibu hamil sebanyak 42 orang yang dipilih secara Consecutive Sampling, sampel dibagi menjadi dua kelompok yaitu ibu hamil normal dan ibu hamil anemia defisiensi besi. BDNF diperiksa dengan metode ELISA. Data dianalisa menggunakan uji T test. Kadar BDNF neonatus pada ibu kelompok normal adalah 3,65(ng/ml) dan kelompok ibu anemia adalah 1,74(ng/ml) (p<0,05). Terdapat perbedaan bermakna kadar BDNF pada neonatus dari ibu hamil normal dan ibu anemia defisiensi besi.

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