Selected Trace Elements and Heavy Metals in the Serum of Postoperative Gastric Cancer Patients and Their Relationship to CEA

2021 ◽  
Vol 53 (03) ◽  
pp. 220-226
Author(s):  
Abbas Mohsin Abbas ◽  
Keyword(s):  
Gastric Cancer ◽  
Positive Association ◽  
Absorption Spectrometry ◽  
Serum Levels ◽  
The Body ◽  
Metal Exposure ◽  
Flame Atomic Absorption ◽  
Digestion Technique ◽  
Metal Levels ◽  
Gastric Cancer Patients

Introduction: Gastric cancer (GC) is the second and fourth most prevalent cancer in men and women, respectively, and is one of the leading causes of cancer death worldwide. Many studies have shown that heavy metal exposure and trace element levels in the body are the most critical etiologies for cancer development. As a result, the goal of our research was to assess the imbalances in the serum concentrations of selected elements (Cu, Co, Se, Ni, Cd, and Pb) in post-operative GC patients against healthy participants/ controls. Methods: The metal levels were determined using a nitric acid/perchloric acid-based wet digestion technique and flame atomic absorption spectrometry, Serum levels of CEA were measured using a two-site immunoenzymometric assay, which is performed entirely in the AIA-PACK SLa test cups. Results: Pb, Cd, and Ni concentrations were found to be significantly higher in the blood of GC patients than in the blood of controls, but Cu and Co levels were significantly lower in the blood of GC patients than in the blood of controls. In the blood of post-operative GC patients, correlation analysis revealed a positive association between CEA-Cd, CEA-Pb, and CEA-Ni, while the correlation was negative for CEA-Cu. These findings were statistically significant (p < 0.05). Conclusion: According to our findings, low Co and Se levels, as well as high Pb and Cd levels, may have a role in the development of stomach cancer.

scholarly journals Comparative Assessment of Trace Elements in the Blood of Gastric Cancer Patients and Healthy Subjects

2020 ◽  
Vol 11 (3) ◽  
pp. 10824-10843
Keyword(s):  
Gastric Cancer ◽  
Trace Elements ◽  
Healthy Subjects ◽  
Absorption Spectrometry ◽  
Correlation Study ◽  
Acid Mixture ◽  
Flame Atomic Absorption ◽  
Healthy Donors ◽  
Trace Elemental ◽  
Gastric Cancer Patients

Gastric cancer (GC) remains one of the most common malignancies globally, particularly in developing countries. Environmental contaminants such as trace elements are known to involve in a plethora of diseases, including cancer. The present study was carried out to find out the imbalances in trace elemental levels (Cd, Cr, Cu, Fe, Mn, Pb, and Zn) in the blood of GC patients in comparison with and healthy donors. The blood samples were digested in a nitric acid-perchloric acid mixture. The elemental levels were quantified by flame atomic absorption spectrometry. Significantly lower concentrations of zinc, iron, lead, cadmium, and chromium were found in the blood of GC patients than the controls. A correlation study revealed diverse relationships among the elements in the blood of cancerous patients and controls. Considerable variations in the elemental concentrations were observed with the gender, food habits, habitat, and smoking habits of the donors. Elemental contents revealed significant differences with the stages (I, II, III & IV) and types (adenocarcinoma & gastrointestinal stromal tumor) of GC patients. Multivariate analysis exhibited significantly divergent apportionment of the patients' elemental levels and healthy subjects, which may be linked with the altered metabolism of the elements in GC patients.

Levels of selected metals in coriander (Coriandrum sativum L.) leaves cultivated in four different areas of Ethiopia

2019 ◽  
Author(s):  
Chem Int
Keyword(s):  
Pearson Correlation ◽  
Absorption Spectrometry ◽  
Coriandrum Sativum ◽  
Good Source ◽  
Digestion Method ◽  
Flame Atomic Absorption ◽  
Significant Difference ◽  
Metal Levels ◽  
Good Percentage ◽  
Coriander Leaves

Coriander (Coriandrum sativum L.) is one of the herbs which is used for medicinal and food purposes. In the present study the levels of selected metals in coriander leaves were determined in the samples collected from four different farmlands (Sebeta, Mekanisa, Holeta and Gefersa) in Ethiopia where its cultivation is common. The levels of metals were determined after digestion of samples with the mixture of 4 mL of HNO3 and 4 mL of HClO4 at 300 oC for 3:00 hours by flame atomic absorption spectrometry. The optimized wet digestion method for coriander leaves analysis was validated through the recovery experiment and a good percentage recovery was obtained (93.2-101%). The levels of metals were found in the range Ca, 2319–3503 mg/kg; Zn, 33.4–54.8 mg/kg and Cr, 5.55-9.86 mg/kg while the trace metals Cu, Ni, Cd and Pb were too low to be detected. The results indicated that Ethiopian coriander is a good source of essential metals and free from the toxic metals Pb and Cd. A statistical analysis of variance (ANOVA) at 95% confidence level indicated that there is significant difference (p &lt; 0.05) in the levels of all detected metals between the four sample means. The Pearson correlation was used to predict the dependence of metal levels on one another. The levels of the metals determined in this study compared well with those reported for coriander leaves from some other parts of the world.

The correlation among tissue, serum adiponectin levels and histopathological variables in gastric cancer patients

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e22199-e22199
Author(s):  
A. Bilici ◽  
D. O. Guler ◽  
M. Seker ◽  
B. O. Ustaalioglu ◽  
B. Sonmez ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Perineural Invasion ◽  
Tumor Tissue ◽  
Inverse Correlation ◽  
Serum Levels ◽  
Serum Adiponectin ◽  
Tissue Levels ◽  
Gastric Cancer Patients ◽  
Demographic Features

e22199 Background: Adiponectin is a new peptide hormone secreted from the adipose tissue, affecting the proliferation and insulin sensitivity in different cell types.The previous studies showed that the serum levels of adiponectin are decreased in patients with endometrial and breast cancer.In our study, demographic features and histopathological variables and the relationship among adiponectin levels of serum and gastric tissue were analyzed in gastric cancer patients. Methods: Thirty-five consecutive patients with gastric cancer included in this study.The serum levels of glucose, insulin, c-peptide, HbA1c, lipids and adiponectin were measured in patients.In addition, normal and tumor tissue levels of adiponectin were also detected.We analyzed the correlation among these parameters and patients demographic features, such as age, gender, body mass index (BMI) and histopathological variables. Results: Patients characteristics included 24 males (68.5%), 11 females (31.5%); median age was 64 (range:41–85). The mean serum, normal and tumor tissue levels of adiponectin were 49.4±0.8, 48.2±4.2, 48.6±2.9 ng/ml, respectively. There was no relationship among serum, normal and tumor tissue adiponectin levels (p>0.05).There was inverse correlation between the normal tissue levels of adiponectin and insulin (p=0.002).The serum adiponectin levels were significantly associated with tumor localization (p=0.03).However, there was inverse correlation between serum adiponectin levels and perineural invasion (p=0.02).In subgroup analysis, the serum, normal and tumor tissue levels of adiponectin in woman were not different compared with those in male patients (p>0.05).No relations were detected among tumor stage, grade, nodal status, lymphatic and vascular invasion, the other insulin-resistant status parameters and the levels of serum, normal and tumor tissue adiponectin (p>0.05). Conclusions: Our results suggest that no correlations among the levels of serum adiponectin,normal tissue and tumor tissue adiponectin levels,patients demographic features and histopathological variables except for the association of serum adiponectin with tumor localization and perineural invasion detected in gastric cancer patients. No significant financial relationships to disclose.

scholarly journals The association between dietary inflammatory index and gastric cancer: A case control study

2020 ◽  
Author(s):  
Ahmad Mujtaba Barekzai ◽  
Azadeh Aminianfar ◽  
Seyed Mohammad Mousavi ◽  
Ahmad Esmaillzadeh
Keyword(s):  
Gastric Cancer ◽  
Case Control Study ◽  
Dietary Assessment ◽  
Positive Association ◽  
Case Control ◽  
Dietary Inflammatory Index ◽  
Significant Positive Association ◽  
Inflammatory Index ◽  
Gastric Cancer Patients ◽  
Control Study

Abstract Background No report is available about diet-disease associations in the understudied region of Afghanistan. Although inflammatory potential of diet has been linked with several cancers, information about gastric cancer is scarce. This study aimed to investigate the relationship between dietary inflammatory index (DII) and odds of gastric cancer in Afghanistan. Methods In this hospital-based case-control study, we enrolled 90 newly-diagnosed cases of gastric cancer and 180 age (± 5) and sex-matched controls. All cases were pathologically confirmed gastric cancer patients, with no history of any type of other pathologically confirmed cancers. Controls were healthy individuals and relatives of patients in the hospital. Dietary assessment was done by a pre-tested food frequency questionnaire. DII was calculated based on energy-adjusted amounts of several foods and nutrients with inflammatory or anti-inflammatory potential, as introduced by earlier studies. Results Mean age of study participants was 54 years, of them 73% were males. After adjustment for age and sex, individuals in the highest tertile of DII were 2.47 times (95% CI: 1.31–4.66) more likely to have gastric cancer compared with those in the lowest tertile. Further adjustment for other potential confounders did not substantially affect the association; such that participants with the greatest DII had approximately 3.59 times (95% CI: 1.16, 11.02) increased odds of gastric cancer than those with the lowest adherence. Additional adjustment for BMI strengthened the association (OR: 3.75; 95% CI: 1.14–12.30). Conclusion We found a significant positive association between inflammatory potential of diet and risk of gastric cancer. Further studies with prospective nature are required to confirm this association.

Prevalence of HER2/neu overexpression/amplification in a Hispanic population with gastric adenocarcinoma.

2011 ◽  
Vol 29 (4_suppl) ◽  
pp. 25-25
Author(s):  
M. Rodarte Shade ◽  
J. Flores Gutierrez ◽  
L. Garcia Labastida ◽  
L. Villela ◽  
A. Barbosa Quintana ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Gastric Adenocarcinoma ◽  
The Body ◽  
Hispanic Population ◽  
Hispanic Patients ◽  
Cancer Tumor ◽  
Study Population ◽  
Gastric Cancer Patients ◽  
Degree Of Differentiation

25 Background: In Europe, Asia, and North America, studies have identified that approximately 20% of patients with gastric adenocarcinoma exhibit overexpression of HER2/neu. This group of patients has been shown to benefit from combination therapy with the anti-HER2/neu monoclonal antibody trastuzumab. These findings have not been studied in Hispanics who may possess a distinct gastric cancer genotype. The aim of this study is to determine the rate of HER2/neu positivity in a completely Hispanic population with gastric adenocarcinoma and to analyze the clinical factors associated with HER2/neu. Methods: We conducted a retrospective study in three different hospitals in Monterrey, Mexico. The study population consisted of Hispanic patients with gastric adenocarcinoma who have had a gastric resection and for whom there were adequate amounts of tissue available in paraffin blocks. Tissue was tested for HER2/neu using both Immunohistochemistry (IHC) and the fluorescent in situ hybridization (FISH) techniques. Results: From 2000 to 2010, we initially evaluated 27 gastric cancer tumor samples. Sex distribution was 15 males and 12 females with a mean age of 57±15 (SD) years. Anatomic distribution of tumor was 4% in the cardias, 40% in the body and 56% in the antrum. Lauren's histological type distribution was 52% diffuse and 48% intestinal. Fifty-three percent of the tumors were high grade and nodal positivity was present in 69%. Overexpression of Her-2/neu (IHC ++ and +++) was found in five (17.4%) of the samples, being moderate (++) in two (7.4%) and strong (+++) in three (11%) tumor samples. FISH amplification for the HER2/neu gene was found in two (7.4%) tumors and was only seen in samples with a strong (+++) IHC result. There was no association identified between HER2/neu status with age, gender, degree of differentiation, T stage, or nodal status. Conclusions: In a homogeneous Hispanic population, 17.4% of gastric cancer patients were found to overexpress HER2/neu by IHC. FISH did not identify any additional HER2/neu positive tumors. It is important to consider IHC testing for HER2/neu in Hispanic gastric cancer patients as they could benefit from a chemotherapy regimen containing trastuzumab. No significant financial relationships to disclose.

Influence of age on soluble E-cadherin serum levels prevents its utility as a disease marker in gastric cancer patients

2008 ◽  
Vol 43 (6) ◽  
pp. 765-766 ◽  
Author(s):  
Corrado Pedrazzani ◽  
Stefano Caruso ◽  
Giovanni Corso ◽  
Daniele Marrelli ◽  
Alessandro Neri ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Serum Levels ◽  
Disease Marker ◽  
Gastric Cancer Patients ◽  
E Cadherin

scholarly journals Prognostic significance of the preoperative serum levels of soluble form of endoglin in gastric cancer patients

2013 ◽  
Vol 114 (10) ◽  
pp. 566-568
Author(s):  
I. Gomceli ◽  
M. Tez ◽  
E. B. Bostanci ◽  
A. S. Kemik ◽  
B. Demiriz ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Prognostic Significance ◽  
Serum Levels ◽  
Soluble Form ◽  
Preoperative Serum ◽  
Gastric Cancer Patients

scholarly journals Levels of CEA and Ca 19 - 9 in the sera and peritoneal cavity in patients with gastric and pancreatic cancers

2012 ◽  
Vol 27 (6) ◽  
pp. 410-416 ◽  
Author(s):  
David Hoskovec ◽  
Jozef Varga ◽  
Ellen Konečná ◽  
František Antoš
Keyword(s):  
Gastric Cancer ◽  
Pancreatic Cancer ◽  
Pancreatic Carcinoma ◽  
Cancer Patients ◽  
Tumor Markers ◽  
Peritoneal Cavity ◽  
Residual Disease ◽  
Biological Fluids ◽  
The Body ◽  
Gastric Cancer Patients

PURPOSE: Tumor markers are substances found in blood and other biological fluids if tumor is present in the body. They can be produced by tumor itself or can be results of cancer - body relation. They may be used in the follow-up of cancer patients to identify tumor recurrence. Pre-treatment levels have prognostic tool and could signalize persistence of minimal residual disease despite radical surgery. METHODS: We operated on 52 patients with upper GI malignancy (32 with gastric cancer and 20 with pancreatic cancer). Blood samples were taken before surgery and peritoneal samples immediately after laparotomy before any manipulation with tumor. All samples were examined by standard biochemical technique and the level was compared with a stage of the disease. RESULTS: Patients suffering from gastric carcinoma of stage I and II had higher level of both markers in sera then in the peritoneal cavity, however most of them were within physiological range. Patients in stage III and IV had average marker levels in the peritoneal cavity higher than in sera. Number of positive findings was increasing according to the stage of the disease. The peritoneal levels of both markers varied extremely in higher stages. In patients suffering from pancreatic carcinoma the CEA levels both in sera and peritoneal cavity were parallel but peritoneal levels were slightly higher in stages III and IV. Ca 19 - 9 was more sensitive for pancreatic cancer. The percentage of positive findings was higher in sera but the level of Ca 19 - 9 was higher in the peritoneal cavity. The number of positive findings again correlated with the stage of the disease. CONCLUSIONS: Levels of tumor markers in sera could signalize inoperability of tumor (Ca 19 - 9 in cases of pancreatic carcinoma); peritoneal levels could predict R1 resection especially in gastric cancer patients and risk of early peritoneal recurrence of the disease. Difference between the levels in the peritoneum and sera may signalize the route of dissemination (hematogenous and intraperitoneal).

Comparison of CA 72-4, CA 19-9 and CEA in the diagnosis and monitoring of gastric cancer

1995 ◽  
Vol 10 (2) ◽  
pp. 100-106 ◽  
Author(s):  
F. Safi ◽  
V. Kuhns ◽  
H.G. Beger
Keyword(s):  
Gastric Cancer ◽  
Malignant Disease ◽  
Normal Limit ◽  
Serum Levels ◽  
Tumor Stage ◽  
Benign Diseases ◽  
Tumor Associated Antigen ◽  
Gastric Cancer Patients ◽  
Screening And Diagnosis ◽  
Care Period

In order to assess the utility of the tumor-associated antigen CA 72-4 in the diagnosis and monitoring of gastric cancer, this tumor marker was measured preoperatively in 718 patients. This group comprised 282 patients with malignant disease (115 with gastric cancer and 167 with other malig-nancies not involving the stomach) and 476 patients with benign surgical diseases. The results were compared with those for carcinoembryonic antigen (CEA) and the tumor-associated antigen CA 19-9. CA 72-4 was above the normal limit of 2.5 U/ml in 61% of the patients with gastric cancer, in 35% of the patients with other malignancies, and in 7% of the patients with benign diseases. CEA and CA 19-9 were elevated in 37% of the patients with gastric cancer (>3 ng/mlfor CEA and >37 U/ml for CA 19-9). CA 72-4 levels were above 10 U/ml in 26% of the gastric cancer patients, in 15% of patients with other malignancies, and in 0.4% of the patients with benign diseases. There was a good correlation between CA 72-4 level and tumor stage in gastric cancer. CA 72-4 serum levels were over 2.5 U/ml in 31%, 48%, 68% and 88% of patients with stage I, II, III and IV disease, respectively. CA 72-4 was found to be more sensitive than CEA and CA 19-9 in detecting recurrences of gastric cancer. In the postoperative-care period, carcinoma recurred in 29 patients. Of these 93% had CA 72-4 concentrations above 2.5 U/ml, whereas only 59% and 35% had pathological CEA and CA 19-9 serum levels (p<0.002, p<0.0001). Although neither CA 72-4 nor CEA and CA 19-9 are sensitive enough for screening and diagnosis of early gastric cancer, CA 72-4 is superior to CEA and CA 19-9 in the detection of gastric cancer recurrences.

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