Adolescents perceive an image of themselves, a feeling of acceptance or rejection, represented by appreciation and self-confidence. The objective was to determine self-esteem and gender in the professional choice of adolescents entering a University of Trujillo 2017. The method was a descriptive quantitative study, cross section, The population made up of adolescents (60%) of males and (40%) of females of entrants, The self-esteem inventory of Stanley Cooper Smith was applied; submitted to tests of validity and reliability; using the Likert scale considering the respective ethical aspects. The results were: The high levels of self-esteem were reached by men in 34% and 22% in women, in relation average level 16% were men and women 10% and finally 10% of women and 8% of men obtained low levels of self-esteem. In relation to adolescents with high levels of self-esteem, they chose professions such as Accounting (11%), Primary Education (9%), Nursing (8%), Computer and Systems Engineering (8%) and Law (8%), while the low level of self-esteem was found in Careers: Nursing (4%) Early Education and Accounting (2%), and Psychology with (1%).