Frequency of Stimulation during Early Life and Subsequent Emotionality in the Rat

1966 ◽  
Vol 18 (3) ◽  
pp. 695-701 ◽  
Author(s):  
Robert Ader
Keyword(s):  
Electric Shock ◽  
Early Life ◽  
Emotional Reactivity ◽  
Daily Frequency ◽  
The Relationship ◽  
Frequency Of Stimulation

Between 1 to 10 and 22 to 32 days of age rats were subjected to 3 min. of handling or electric shock at frequencies of 0, ½, 1, 2, or 4 times daily. Frequency of stimulation exerted significant effects either independently or in interaction with the age at which the manipulation occurred. For animals manipulated during the first 10 days of life, the relationship between magnitude of stimulation and emotional reactivity was curvilinear; stimulation at frequencies of up to 2 periods per day reduced emotionality, whereas emotionality in animals receiving 4 periods of stimulation per day tended to return to the level shown by control animals.

scholarly journals Gene regulation contributes to explain the impact of early life socioeconomic disadvantage on adult inflammatory levels in two cohort studies

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Cristian Carmeli ◽  
Zoltán Kutalik ◽  
Pashupati P. Mishra ◽  
Eleonora Porcu ◽  
Cyrille Delpierre ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Gene Regulation ◽  
Cohort Studies ◽  
Early Life ◽  
Life Experiences ◽  
Socioeconomic Disadvantage ◽  
Mediating Role ◽  
The Impact ◽  
The Relationship

AbstractIndividuals experiencing socioeconomic disadvantage in childhood have a higher rate of inflammation-related diseases decades later. Little is known about the mechanisms linking early life experiences to the functioning of the immune system in adulthood. To address this, we explore the relationship across social-to-biological layers of early life social exposures on levels of adulthood inflammation and the mediating role of gene regulatory mechanisms, epigenetic and transcriptomic profiling from blood, in 2,329 individuals from two European cohort studies. Consistently across both studies, we find transcriptional activity explains a substantive proportion (78% and 26%) of the estimated effect of early life disadvantaged social exposures on levels of adulthood inflammation. Furthermore, we show that mechanisms other than cis DNA methylation may regulate those transcriptional fingerprints. These results further our understanding of social-to-biological transitions by pinpointing the role of gene regulation that cannot fully be explained by differential cis DNA methylation.

scholarly journals 0262 An Exploratory Examination of the Relationship Between Negative Affect, Stress and Emotional Reactivity, Mindfulness, and Sleep Incompatible Behaviors

SLEEP ◽  
2020 ◽  
Vol 43 (Supplement_1) ◽  
pp. A100-A100
Author(s):  
S Nagy ◽  
S M Pickett ◽  
J Sosa ◽  
A Garcell
Keyword(s):  
Negative Affect ◽  
Stress Management ◽  
Emotional Reactivity ◽  
Rating Scale ◽  
Negative Emotion ◽  
Sleep Hygiene ◽  
Poor Sleep ◽  
Dispositional Mindfulness ◽  
Sleep Behaviors ◽  
The Relationship

Abstract Introduction Stress has been identified as a barrier to engaging in positive health behaviors. Sleep interventions, including sleep hygiene recommendations, highlight stress management as an important treatment component. However, the relationship between negative emotion, stress management or emotion regulation, and positive sleep behaviors has largely been unexamined. Therefore, the current study, through secondary analyses, examined the relationships between negative affect, stress and emotional reactivity and sleep incompatible behaviors. Lastly, the indirect effect that dispositional mindfulness, as a possible self-regulatory mechanism, may have on the relationship was also examined. It was hypothesized that greater levels of stress, emotional reactivity, and negative arousal along with lower levels of dispositional mindfulness would predict higher engagement in sleep incompatible behaviors. Methods Participants (n=308) identified mostly as female (55.8%) and White/Caucasian (83.2%) and with an average age of 36.76 (SD = 12.20). Participants completed the Perceived Stress and Reactivity Scale (PSRS), the Positive and Negative Affect Scale (PANAS), the Sleep Behaviors Self-Rating Scale, and the Five Facet Mindfulness Questionnaire (FFMQ). A multiple regression analysis was conducted using the relevant subscales from the PSRS, PANAS, and FFMQ to predict the occurrence of behaviors incompatible with healthy sleep. Results The hypothesis was partially supported. Results indicated that the model significantly predicted sleep incompatible behavior (R2= .108, F(9, 299) = 4.042, p < .001), with only negative affect (β= .163, t(299) = 2.555, p = .011) and nonreactivity (β= -.219, t(299) = -2.484, p = .014) remaining significant when all variables were entered in the model. Conclusion The findings demonstrate that negative affect and reactivity are significant predictors of engagement in poor sleep hygiene practices. They also suggest that certain facets of dispositional mindfulness has an indirect relationship with sleep incompatible behaviors. The results may contribute to the development of sleep health interventions and highlight the need for future research. Support N/A

Passing for Black

2018 ◽  
Author(s):  
Kendra Taira Field
Keyword(s):  
Early Life ◽  
Racial Violence ◽  
Racial Categories ◽  
Black Freedom ◽  
Reconstruction Era ◽  
Westward Migration ◽  
The Relationship

Chapter 2 situates Monroe Coleman’s decision to participate in black freedom movements in Oklahoma against the backdrop of his early life as a “mulatto” child in Reconstruction-era Mississippi, highlighting the relationship between migration and the construction of racial categories in this period. Reading Coleman’s life alongside the lives of his contemporaries, this chapter argues that the westward migration of “mulatto” freedpeople constituted a telling response to racial violence and white racial nationalism in the aftermath of Reconstruction. While the rise of black Oklahoma was promoted, narrated, memorialized, and ultimately historicized as “all-black” and self-consciously “domestic,” such an image stands in contrast to the racial and national realities of the period.

scholarly journals An evolutionary process without variation and selection

2021 ◽  
Vol 18 (180) ◽  
pp. 20210334
Author(s):  
Liane Gabora ◽  
Mike Steel
Keyword(s):  
Germ Cells ◽  
Cultural Evolution ◽  
Self Assembly ◽  
Early Life ◽  
Evolutionary Process ◽  
Adaptive Change ◽  
Assembly Code ◽  
The Relationship ◽  
Special Case ◽  
Variation And Selection

Natural selection successfully explains how organisms accumulate adaptive change despite that traits acquired over a lifetime are eliminated at the end of each generation. However, in some domains that exhibit cumulative, adaptive change—e.g. cultural evolution, and earliest life—acquired traits are retained; these domains do not face the problem that Darwin’s theory was designed to solve. Lack of transmission of acquired traits occurs when germ cells are protected from environmental change, due to a self-assembly code used in two distinct ways: (i) actively interpreted during development to generate a soma, and (ii) passively copied without interpretation during reproduction to generate germ cells. Early life and cultural evolution appear not to involve a self-assembly code used in these two ways. We suggest that cumulative, adaptive change in these domains is due to a lower-fidelity evolutionary process, and model it using reflexively autocatalytic and foodset-generated networks. We refer to this more primitive evolutionary process as self–other reorganization (SOR) because it involves internal self-organizing and self-maintaining processes within entities, as well as interaction between entities. SOR encompasses learning but in general operates across groups. We discuss the relationship between SOR and Lamarckism, and illustrate a special case of SOR without variation.

scholarly journals The differential calibration of the HPA axis as a function of trauma versus adversity: A systematic review and p-curve meta-analyses

2021 ◽  
Author(s):  
Niki H. Kamkar ◽  
Cassandra J Lowe ◽  
J. Bruce Morton
Keyword(s):  
Hpa Axis ◽  
Early Life ◽  
Life Experiences ◽  
Curve Analysis ◽  
Early Life Adversity ◽  
Cortisol Reactivity ◽  
Evidential Value ◽  
Dsm 5 ◽  
Meta Analyses ◽  
The Relationship

Although there is an abundance of evidence linking the function of the hypothalamic-pituitary-adrenal (HPA) axis to adverse early-life experiences, the precise nature of the association remains unclear. Some evidence suggests early-life adversity leads to cortisol hyper-reactivity, while other evidence suggests adversity leads to cortisol hypo-reactivity. Here, we distinguish between trauma and adversity, and use p-curves to interrogate the conflicting literature. In Study 1, trauma was operationalized according to DSM-5 criteria; the p-curve analysis included 68 articles and revealed that the literature reporting associations between trauma and blunted cortisol reactivity contains evidential value. Study 2 examined the relationship between adversity and cortisol reactivity. Thirty articles were included in the analysis, and p-curve demonstrated that adversity is related to heightened cortisol reactivity. These results support an inverted U-shaped function relating severity of adversity and cortisol reactivity, and underscore the importance of distinguishing between “trauma” and “adversity”.

THE RELATIONSHIP OF INTELLIGENCE AND CEREBRAL MANTLE IN TREATED INFANTILE HYDROCEPHALUS (IQ Potential in Hydrocephalic Children)

PEDIATRICS ◽  
1973 ◽  
Vol 52 (1) ◽  
pp. 38-44 ◽  
Author(s):  
Harold F. Young ◽  
Frank E. Nulsen ◽  
Martin H. Weiss ◽  
Paula Thomas
Keyword(s):  
Early Life ◽  
Infantile Hydrocephalus ◽  
Normal Intelligence ◽  
Relationship Of ◽  
The Relationship

Hydrocephalus in early life can often be so successfully treated as to allow children to live and grow with normal intelligence. Whereas untreated hydrocephalus allows only unpredictable intelligence when arrested, a far better prognosis holds for treated hydrocephalus. In an analysis of 147 patients with hydrocephalus treated by valveregulated ventriculovenous shunt, IQ can be related to ultimate frontal cerebral mantle. We have sought to correlate late IQ with the nature of the presenting abnormality, the age at which treatment was instituted, and the adequacy of control of the hydrocephalus as reflected in growth of cerebral mantle. This analysis indicates that in certain specific situations, prognosis for good IQ is predictable. At the same time, the study suggests guidelines for adequacy of shunting and the urgency for early shunting to allow for maximum benefits.

Muhammad Mustafa Badawi in Conversation

2015 ◽  
Author(s):  
Abdul-Nabi Isstaif
Keyword(s):  
Early Life ◽  
World Literature ◽  
English Language ◽  
English Literature ◽  
Arabic Literature ◽  
Literature And Politics ◽  
The Family ◽  
Essential Questions ◽  
The Relationship ◽  
The City

This chapter presents a 1997 interview with Mustafa Badawi and includes sections relating to his early life and education until 1947 when he was sent to England to pursue further studies in English. Badawi first talks about the years of his early formation in the family, the neighbourhood and his various schools in Alexandria before discussing his cultural formation in the city. He reveals that he decided to specialise in English language in order to deepen his study of English literature so that he could see Arabic literature in the wider context of world literature. Badawi also describes his attitudes towards literature and criticism, which he says involved three essential questions: the relationship between literature and politics; the relationship between literature and morality; and the nature of language and its function in poetry, and consequently the relationship between poetry and science, or between poetry and thought or knowledge in general.

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