Statins and hemoperfusion improve 28-day survival in septic shock patients

Open Medicine ◽  
2012 ◽  
Vol 7 (4) ◽  
pp. 475-480
Author(s):  
Tsukasa Nakamura ◽  
Eiichi Sato ◽  
Nobuharu Fujiwara ◽  
Yasuhiro Kawagoe ◽  
Sayaka Maeda ◽  
...  
Keyword(s):  
Septic Shock ◽  
Regression Analysis ◽  
Stepwise Regression ◽  
Hdl Cholesterol ◽  
Polymyxin B ◽  
Multiple Stepwise Regression Analysis ◽  
Time Of Admission ◽  
Complete History ◽  
Statin Use

AbstractUncontrolled inflammation and endotoxin play a central role in septic shock. Statins may possess anti-inflammatory properties, and removal of endotoxin by hemoperfusion with polymyxin B-immobilized fiber (PMX-F) could have favorable effects on sepsis. We examined retrospectively whether pre-existing statin and hemoperfusion with PMX-F at the time of admission were separately and independently associated with decreased overall 28-day mortality in septic shock patients. Consecutive 173 patients with septic shock (71.2±10.7 years old, 115 male and 58 female) were included in the present study. All patients underwent a complete history and physical examination, determination of blood chemistries. Multiple stepwise regression analysis revealed that albumin, creatinine (inversely), statin use, hemoperfusion with PMX-F and HDL-cholesterol were independently correlated to 28-day survival in septic shock patients (R2=0.464). Our present study suggests that pre-existing statin use and hemoperfusion with PMX-F may separately and independently contribute to blunt the process of septic shock.

scholarly journals Determination of individual teleroentgenographic characteristics of the face profile in ukrainian young men and girls with orthognathic bite

2018 ◽  
pp. 28-34
Author(s):  
М. О. Dmitriev
Keyword(s):  
Regression Analysis ◽  
Soft Tissue ◽  
Young Women ◽  
Stepwise Regression ◽  
Young Men ◽  
Stepwise Regression Analysis ◽  
Regression Equations ◽  
Determination Coefficient ◽  
Normal Occlusion

Modern dentistry requires the definition of individualized values of teleroentgenographic indicators. To solve such problems, methods of regression and correlation analysis are increasingly used, which help to establish not only the existence of various relationships between the anatomical structures of the head and the parameters of the dento-jaw system, but also allow more accurately predict the change in the contour of soft facial tissue in response to orthodontic treatment. The purpose of the study is to develop mathematical models for the determination of individual teleroentgenographic characteristics of the facial soft tissues by studying the cephalometric indices of young men and women of Ukraine with normal occlusion and balanced faces and conducting a direct stepwise regression analysis. With the use of Veraviewepocs 3D device, Morita (Japan) from 38 young men (17 to 21 years of age) and 55 young women (aged from 16 to 20 years) with occlusal close to the orthognathic bite and balanced faces received side teleroentgenograms. The cephalometric analysis was performed using OnyxCeph³™ licensed software. Cephalometric points and measurements were made according to the recommendations of Downs W. B., Holdway R. A., McNamara J., Schwarz A. M., Schmuth G. P. F., Steiner C. C. and Tweed C. H. With the help of direct stepwise regression analysis, in the licensed package “Statistica 6.0”, regression models of individual teleroentgenographic characteristics of the profile of soft facial tissues were constructed. In young men with normal occlusion close to the orthognathic bite of 19 possible models, 11 were constructed with a determination coefficient from 0.638 to 0.930, and in young women – 12 models with a determination coefficient from 0.541 to 0.927. The conducted analysis of models showed that in young men most often the regression equations included – angle N_POG, parameters of which indicate a linear interjaw relation in the anterior-posterior direction (14.0%); angle GL_SNPOG, or index of convexity of the soft tissue profile (8.8%); MAX maxillary length (7.0%), and GL_SN_S index, which defines vertical correlations in the facial profile (5.3%). The young women most often models included – the angle N_POG (12.5%); angle GL_SNPOG (7.5%); soft tissue front angle P_OR_N (6.25%); the reference angle ML_NL and the profile angle T (by 5.0%); the angle AB_NPOG, the angle NBA_PTGN, which defines the direction of development of the mandible and the distance PN_A (3.75%). Thus, in the work with the help of the method of stepwise regression with inclusion, among Ukrainians of adolescence age, based on the characteristics of teleroentgenographic indicators, reliable models of individual teleroentgenographic characteristics of the profile of soft facial tissues were developed and analyzed.

scholarly journals Residents’ Diachronic Perception of the Impacts of Ecological Resettlement in a World Heritage Site

2019 ◽  
Vol 16 (19) ◽  
pp. 3556
Author(s):  
Kai Wang ◽  
Menghan Wang ◽  
Chang Gan ◽  
Mihai Voda
Keyword(s):  
Regression Analysis ◽  
Stepwise Regression ◽  
World Heritage ◽  
Stepwise Regression Analysis ◽  
World Heritage Site ◽  
The Sustainable Development ◽  
Multiple Stepwise Regression Analysis ◽  
Heritage Site ◽  
Negative Perceptions ◽  
Main Factors

As one of the main factors in any tourist destination, residents’ perception of the impacts of ecological resettlement has a substantial influence on the sustainable development of any world heritage site. Our research takes the residents of three different resettlement locations in the Wulingyuan scenic area, a world heritage site, as the object of our survey. Based on questionnaire investigations in 2010 and 2016, this article analyzes the residents’ diachronic perception of the impacts of ecological resettlement. Independent sample t-tests and Analysis of Variance (ANOVA) are used to compare the differences in residents’ perception toward ecological relocation and analyse how demographic characteristics affect residents’ perception. Multiple stepwise regression analysis is applied to explore the main factors that contribute to the differences in the perception of impacts of ecological resettlement. The results show that during the study period, respondents have the strongest perceptions of the economic, socio-cultural, resource-environment and psychological impacts. However, they have negative perceptions of relocation policy impacts. Compared with 2010, residents with different gender, age, education level, income level and engagement in tourism have significant differences in perception of impacts of resettlement in 2016. Multiple stepwise regression analysis demonstrates that the perceptions of impacts of the ecological resettlement and economic policy are the primary factors to affect residents’ overall perceptions.

scholarly journals Association of serum fetuin-B with insulin resistance and pre-diabetes in young Chinese women: evidence from a cross-sectional study and effect of liraglutide

PeerJ ◽  
2021 ◽  
Vol 9 ◽  
pp. e11869
Author(s):  
Xuyun Xia ◽  
Shiyao Xue ◽  
Gangyi Yang ◽  
Yu Li ◽  
Hua Liu ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Young Women ◽  
Stepwise Regression ◽  
Chinese Women ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Multiple Stepwise Regression Analysis ◽  
Glucose And Lipid Metabolism ◽  
The Relationship ◽  
Group Serum

Background and Aims Fetuin-B has been reported to be involved in glucose and lipid metabolism and associated with the occurrence of diabetes. The main purpose of this study is to explore the changes of circulating fetuin-B in young women with pre-diabetes and to analyze the relationship between fetuin-B and the occurrence and development of IR. Methods A total of 304 women were enrolled in this study and subjected to both OGTT and EHC. A subgroup of 26 overweight/obese womenwas treated with Lira for 24 weeks. serum fetuin-B concentrations were measured by ELISA. Results In IGT and IR-NG groups, serum fetuin-B levels were higher than those in the NGT group. The serum fetuin-B levels in the IGT group were higher than those in the IR-NG group. serum fetuin-B was positively correlated with BMI, WHR, 2h-BG, FIns, HbA1c, and HOMA2-IR, but negatively correlated with the M-value in all study populations. Multiple stepwise regression analysis showed that the M-value was independently and inversely associated with serum fetuin-B. Logistic regression analysis showed that serum fetuin-B was independently associated with IGT and significantly increased the risk of IGT. During the OGTT, serum fetuin-B increased significantly in the NGT group, but there were no significant changes in other groups. During the EHC, serum fetuin-B increased in the IGT group, but there was no change in other groups. After Lira intervention, serum fetuin-B decreased significantly in IGT women. Conclusions serum fetuin-B levels are elevated in young women with IR or IGT and may be associated with IR.

scholarly journals Determination of Infiltration Model Parameters Using Basic Soil Physical Properties

2021 ◽  
Author(s):  
Tabasum Rasool ◽  
Abdul Qayoom Dar ◽  
Mushtaq Ahmad Wani
Keyword(s):  
Regression Analysis ◽  
Performance Evaluation ◽  
Soil Properties ◽  
Stepwise Regression ◽  
Accurate Estimation ◽  
Model Parameters ◽  
Predictive Equations ◽  
Infiltration Model ◽  
Infiltration Models

Abstract Quantification of infiltration rate is a time-consuming process because of its variability and challenges in the accurate estimation of infiltration model parameters. In this study predictive equations for parameters of Horton, Kostiakov, Modified Kostiakov and Philip infiltration models were developed using basic soil-properties. The model-parameters were initially determined applying non-linear Levenberg Marquardt algorithm (LMA) on field-observed infiltration data and were subsequently determined by predictive equations developed after applying regression analysis to investigated soil-properties. Regression analysis was carried-out using stepwise-regression (SR) where all the measured soil-properties were used, and by applying principal component analysis (PCA) prior to multiple linear-regression for reducing number of predictors. The results revealed that developed equations using stepwise regression and the ones developed after applying PCA were able to explain 40- 78% and 10- 50% of variation respectively. The performance evaluation of developed regression equations at two information levels along with LMA for prediction of infiltration model-parameters was carried out by computing an overall performance index (OPI), which combines relative weight of different statistical indicators, namely, Coefficient of Determination (R2), Nash–Sutcliffe Efficiency (ENS), Willmott’s Index of Agreement (W), Mean Absolute Error (MAE) and Root Mean Square Error (RMSE). Performance evaluation revealed, LMA with highest OPI-value is most suitable to ascertain parameters of studied infiltration models. However, for selected models using parameters determined at two information levels, it was observed that there exists no significant difference in OPI-value of computed infiltration rates suggesting that equations developed after PCA can be used successfully for determination of infiltration model-parameters.

scholarly journals Die voorspelling van kredietrisiko met behulp van biografiese veranderlikes: Is dit die antwoord?

1983 ◽  
Vol 14 (4) ◽  
pp. 166-171
Author(s):  
P. L.S. Ackermann ◽  
W. P. Jansen van Rensburg
Keyword(s):  
Regression Analysis ◽  
Discriminant Analysis ◽  
Credit Risk ◽  
Representative Sample ◽  
Stepwise Regression ◽  
Stepwise Regression Analysis ◽  
Stepwise Discriminant Analysis ◽  
Relative Importance ◽  
Multiple Stepwise Regression Analysis

The prediction of credit risk by means of biographic variables: Is this the answer? The objective of this study is to identify specific biographical variables, to quantity them and to investigate their relative importance in the prediction of credit risk. A representative sample of 250 bad credit risk clients and 250 good credit risk clients is used in the study. A multiple stepwise regression analysis and multiple stepwise discriminant analysis were carried out. Nine biographical variables were identified which explain approximately 16% of the variance of credit risk.

scholarly journals Implications of Statin Use on Vasopressor Therapy in the Setting of Septic Shock

2018 ◽  
Vol 53 (3) ◽  
pp. 152-156
Author(s):  
Chelsey M. McPheeters ◽  
Jennifer A. Wiedmar ◽  
Christina M. Pinkston ◽  
Kyle A. Weant
Keyword(s):  
Septic Shock ◽  
Inflammatory Responses ◽  
Control Group ◽  
Vasopressor Therapy ◽  
Statin Group ◽  
Improved Outcomes ◽  
Anti Inflammatory ◽  
Time Of Admission ◽  
Statin Use

Background: Pleiotropic anti-inflammatory and immunomodulatory effects of statins have been associated with improved outcomes in the critically ill population. Objective: To evaluate the implications of prior statin use on the duration of vasopressor therapy in the setting of septic shock. Methods: This was a retrospective, multicenter study of adult patients who were diagnosed with septic shock. Patients were included if they were treated with any vasopressor for greater than 6 hours from the time of admission. The primary outcome was to compare the duration of vasopressor therapy in patients with septic shock with and without previous statin exposure. Results: A total of 88 statin-exposed cases and 205 unexposed controls were included in the analysis. Despite 92% of statin-exposed patients being reinitiated on therapy within 24 hours, the duration of vasopressors did not differ between groups (44 hours, statin group vs 53 hours, control group, P = .51). There were also no mortality differences between the statin group and the controls (40% vs 47%, P = .27). Conclusions: Long-term statin exposure does not impact the duration of vasopressor therapy in septic shock. The lack of differences in clinical outcomes supports the concept that sepsis involves pro- and anti-inflammatory pathways as well as other nonimmunologic pathways. Results lend further credence to the recent conceptualization of sepsis, with complications leading to organ dysfunction caused not primarily due to inflammatory responses but by a dysregulated response to infection.

scholarly journals A Preliminary Luminosity Calibration of the Uvby, β Systems for Supergiant F-Type Stars

1985 ◽  
Vol 111 ◽  
pp. 491-494
Author(s):  
E. Antonello
Keyword(s):  
Regression Analysis ◽  
Statistical Method ◽  
Stepwise Regression ◽  
Class Ii ◽  
Stepwise Regression Analysis ◽  
Class V ◽  
Luminosity Class ◽  
Multiple Stepwise Regression Analysis ◽  
Comparison Of The Results ◽  
Hr Diagram

Calibrations of the uvby, β photometric systems have been made by Crawford (1975, 1978, 1979) for F, B and late A-type stars of luminosity class V-III; the calibration for early A-type stars has been made by Hilditch et al. (1983). One of the remaining areas of the HR diagram to be calibrated is that of the bright giant to supergiant region (luminosity class II-I). We have attempted to obtain a calibration in terms of luminosity for supergiant F-type stars. To this end we have used the statistical method of multiple stepwise regression analysis. Before doing the calibration for supergiants, we show the usefulness of this method by a comparison of the results obtained for dwarf F-type stars with the previous calibration given by Crawford (1975).

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