Antiepileptic effects of short-wave radiation in hypogeomagnetic conditions

Open Medicine ◽  
2013 ◽  
Vol 8 (4) ◽  
pp. 517-522
Author(s):  
Leonid Godlevsky ◽  
Semen Tsevelev ◽  
Vyacheslav Polyasny ◽  
Igor Samchenko ◽  
Tatyana Muratova
Keyword(s):  
Thermal Effects ◽  
Electromagnetic Waves ◽  
Brain Cortex ◽  
Short Wave ◽  
Epileptic Activity ◽  
Wave Radiation ◽  
Exposure Effect ◽  
Extremely High Frequency ◽  
Generalized Seizures ◽  
The Brain

AbstractThe work was dedicated to investigation of dynamics of epileptic activity in conditions of extremely high frequency electromagnetic waves (EHF) radiation (7,1 mm, 0,1 mW/cm2) upon focal epileptic activity. Epileptic activity was penicillin-induced (10,000 IU/ml) in the frontal region of the brain cortex in myorelaxed and artificially ventilated rats under acute experimental condition. Thermal effects were absent as far as absorbed dosage of energy did not exceed 0,1 J/ animal. It was established that preliminarily performed hypogeomagnetic period (3,0 h) with the inductivity of geomagnetic field at 5×10−8 Tesla caused the intensification of antiepileptic effects of EHF (15,0 min of exposure). It was pronounced in the form of decrease of foci intensity and significant reduction of lifespan of foci — up to 115,3±13,4 minutes, which was both significant when compared with separate effects of hypogeomagnetic influence (187,3±12,5 min) and EHF (15,0 minutes of exposure) effect (164,2±12,5 minutes) (P<0,05). Besides, EHF (15,0 min) which was made after 3,0 h exposure to hypogeomagnetic influence suppressed generalized seizures in amygdalarly kindled rats.

scholarly journals Intermittent Hypoxic Conditioning Rescues Cognition and Mitochondrial Bioenergetic Profile in the Triple Transgenic Mouse Model of Alzheimer’s Disease

2021 ◽  
Vol 22 (1) ◽  
pp. 461
Author(s):  
Sónia C. Correia ◽  
Nuno J. Machado ◽  
Marco G. Alves ◽  
Pedro F. Oliveira ◽  
Paula I. Moreira
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Brain Cortex ◽  
Neurodegenerative Disorder ◽  
Special Focus ◽  
Mitochondrial Bioenergetics ◽  
Related Phenotype ◽  
Brain Resilience ◽  
The Brain

The lack of effective disease-modifying therapeutics to tackle Alzheimer’s disease (AD) is unsettling considering the actual prevalence of this devastating neurodegenerative disorder worldwide. Intermittent hypoxic conditioning (IHC) is a powerful non-pharmacological procedure known to enhance brain resilience. In this context, the aim of the present study was to investigate the potential long-term protective impact of IHC against AD-related phenotype, putting a special focus on cognition and mitochondrial bioenergetics and dynamics. For this purpose, six-month-old male triple transgenic AD mice (3×Tg-AD) were submitted to an IHC protocol for two weeks and the behavioral assessment was performed at 8.5 months of age, while the sacrifice of mice occurred at nine months of age and their brains were removed for the remaining analyses. Interestingly, IHC was able to prevent anxiety-like behavior and memory and learning deficits and significantly reduced brain cortical levels of amyloid-β (Aβ) in 3×Tg-AD mice. Concerning brain energy metabolism, IHC caused a significant increase in brain cortical levels of glucose and a robust improvement of the mitochondrial bioenergetic profile in 3×Tg-AD mice, as mirrored by the significant increase in mitochondrial membrane potential (ΔΨm) and respiratory control ratio (RCR). Notably, the improvement of mitochondrial bioenergetics seems to result from an adaptative coordination of the distinct but intertwined aspects of the mitochondrial quality control axis. Particularly, our results indicate that IHC favors mitochondrial fusion and promotes mitochondrial biogenesis and transport and mitophagy in the brain cortex of 3×Tg-AD mice. Lastly, IHC also induced a marked reduction in synaptosomal-associated protein 25 kDa (SNAP-25) levels and a significant increase in both glutamate and GABA levels in the brain cortex of 3×Tg-AD mice, suggesting a remodeling of the synaptic microenvironment. Overall, these results demonstrate the effectiveness of the IHC paradigm in forestalling the AD-related phenotype in the 3×Tg-AD mouse model, offering new insights to AD therapy and forcing a rethink concerning the potential value of non-pharmacological interventions in clinical practice.

scholarly journals Preparation and electromagnetic properties characterization of reduced graphene oxide/strontium hexaferrite nanocomposites

2020 ◽  
Vol 9 (1) ◽  
pp. 105-114 ◽  
Author(s):  
Shumin Du ◽  
Huaiyin Chen ◽  
Ruoyu Hong
Keyword(s):  
Electromagnetic Wave ◽  
Environmental Pollution ◽  
Electromagnetic Interference ◽  
Electromagnetic Waves ◽  
Rapid Development ◽  
Living Environment ◽  
World Health ◽  
Electromagnetic Properties ◽  
Strontium Hexaferrite ◽  
Wave Radiation

AbstractWith the rapid development of electronics and information technology, electronics and electrical equipment have been widely used in our daily lives. The living environment is full of electromagnetic waves of various frequencies and energy. Electromagnetic wave radiation has evolved into a new type of environmental pollution that has been listed by the WHO (World Health Organization) as the fourth largest source of environmental pollution after water, atmosphere, and noise. Studies have shown that when electromagnetic wave radiation is too much, it can cause neurological disorders. And electromagnetic interference will cause the abnormal operation of medical equipment, precision instruments and other equipment, and therefore cause incalculable consequences. Therefore, electromagnetic protection has become a hot issue of concern to the social and scientific circles.

scholarly journals Characterization of calcium-dependent membrane binding proteins of brain cortex

1985 ◽  
Vol 229 (3) ◽  
pp. 587-593 ◽  
Author(s):  
A R Rhoads ◽  
M Lulla ◽  
P B Moore ◽  
C E Jackson
Keyword(s):  
Brain Cortex ◽  
Peptide Mapping ◽  
Bovine Brain ◽  
Particulate Fraction ◽  
Structural Homology ◽  
One Dimensional ◽  
Calcium Dependent ◽  
Stokes Radius ◽  
The Brain

Proteins of Mr 68 000, 34 000 and 32 000 were selectively extracted by EGTA from brain cortex. The three proteins that were extracted along with calmodulin were acidic, monomeric, and did not exhibit structural homology, as demonstrated by one-dimensional peptide mapping. The Mr-68 000 protein was purified to homogeneity and had a Stokes radius of 3.54 nm and S20,W value of 5.1S. Purified calmodulin, Mr-68 000 protein and two proteins of Mr 34 000 and Mr 32 000, interacted with the brain particulate fraction, with half-maximal binding occurring at 3.5 microM, 8.3 microM and 150 microM-Ca2+ respectively. Proteins were bound independently of each other and calmodulin. Pretreatment of the particulate fraction with trypsin prevented the Ca2+-dependent binding of calmodulin; however, the binding of the Mr-68 000 protein or the Mr−32 000 and −34 000 proteins was unaffected. The Mr-68 000 protein of bovine brain did not cross-react immunologically with Mr-67 000 calcimedin from chicken gizzard.

scholarly journals Evaluating the Effects of Façade Greening on Human Bioclimate in a Complex Urban Environment

2015 ◽  
Vol 2015 ◽  
pp. 1-15 ◽  
Author(s):  
Britta Jänicke ◽  
Fred Meier ◽  
Marie-Therese Hoelscher ◽  
Dieter Scherer
Keyword(s):  
Heat Stress ◽  
Short Wave ◽  
Wave Radiation ◽  
Short Wave Radiation ◽  
Long Wave ◽  
Building Facades ◽  
Urban Heat ◽  
The Mean ◽  
Human Bioclimate ◽  
Radiant Temperature

The evaluation of the effectiveness of countermeasures for a reduction of urban heat stress, such as façade greening, is challenging due to lacking transferability of results from one location to another. Furthermore, complex variables such as the mean radiant temperature(Tmrt)are necessary to assess outdoor human bioclimate. We observedTmrtin front of a building façade in Berlin, Germany, which is half-greened while the other part is bare.Tmrtwas reduced (mean 2 K) in front of the greened compared to the bare façade. To overcome observational shortcomings, we applied the microscale models ENVI-met, RayMan, and SOLWEIG. We evaluated these models based on observations. Our results show thatTmrt(MD = −1.93 K) and downward short-wave radiation (MD = 14.39 W/m2) were sufficiently simulated in contrast to upward short-wave and long-wave radiation. Finally, we compare the simulated reduction ofTmrtwith the observed one in front of the façade greening, showing that the models were not able to simulate the effects of façade greening with the applied settings. Our results reveal that façade greening contributes only slightly to a reduction of heat stress in front of building façades.

Well-Preserved Cholinergic Neuronal Activity in the Brain Cortex of the Severely Uremic Rats

Renal Failure ◽  
1999 ◽  
Vol 21 (5) ◽  
pp. 551-554
Author(s):  
Hiroshi Tanaka ◽  
Hideki Hirakata ◽  
Hidetoshi Kanai ◽  
Itsuko Ishida ◽  
Masatoshi Fujishima
Keyword(s):  
Neuronal Activity ◽  
Brain Cortex ◽  
The Brain

scholarly journals Albedo of Melting Sea Ice in the Southern Beaufort Sea

1971 ◽  
Vol 10 (58) ◽  
pp. 101-104 ◽  
Author(s):  
M.P. Langleben
Keyword(s):  
Sea Ice ◽  
Northwest Territories ◽  
Beaufort Sea ◽  
Ice Cover ◽  
Short Wave ◽  
Wave Radiation ◽  
Short Wave Radiation ◽  
Melting Period ◽  
Fast Ice ◽  
Made In

AbstractTwo Kipp hemispherical radiometers mounted back to back and suspended by an 18 m cable from a helicopter flying at an altitude of about 90 m were used to make measurements of incident and reflected short-wave radiation. The helicopter was brought to a hovering position at the instant of measurement to ensure that the radiometers were in the proper attitude and a photograph of the ice cover was taken at the same time. The observations were made in 1969 during 16 flights out of Tuktoyaktuk, Northwest Territories (lat. 69° 26’N., long. 133° 02’W.) over the fast ice extending 80 km north of Tuktoyaktuk. Values of albedo of the ice cover were found to decrease during the melting period according to the equation A = 0.59 —0.32P where P is the degree of puddling of the surface.

An accurate 3-D model for magnetic stimulation of the brain cortex

1995 ◽  
Vol 19 (1) ◽  
pp. 7-16 ◽  
Author(s):  
G. Cerri ◽  
R. De Leo ◽  
F. Moglie ◽  
A. Schiavoni
Keyword(s):  
Magnetic Stimulation ◽  
Brain Cortex ◽  
D Model ◽  
The Brain ◽  
Stimulation Of
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