scholarly journals A systematic review of vitamin D status and dietary intake in various Slovenian populations

2021 ◽  
Vol 61 (1) ◽  
pp. 55-72
Author(s):  
Maša Hribar ◽  
Evgen Benedik ◽  
Matej Gregorič ◽  
Urška Blaznik ◽  
Andreja Kukec ◽  
...  
Keyword(s):  
Systematic Review ◽  
Vitamin D ◽  
Light Exposure ◽  
Meta Analysis ◽  
Daily Intake ◽  
Vitamin D Insufficiency ◽  
Ultraviolet B ◽  
Uvb Radiation ◽  
General Observation ◽  
Public Health Decision

Abstract Aim Vitamin D (VitD) is involved in calcium and phosphate homeostasis, bone health, and normal functioning of the immune system. VitD status is monitored using serum 25-hydroxy-vitamin D (25(OH)D) as a biomarker. Serum 25(OH)D concentrations below 30 nmol/L indicate VitD deficiency and below 50 nmol/L indicate insufficiency. VitD can be synthesised endogenously in human skin when exposed to ultraviolet B (UVB) radiation. In the absence of sufficient UVB-light exposure, VitD intake becomes the main source of VitD, with a recommended daily intake of 20 μg. The aim of this study was to conduct a review and meta-analysis on the abovementioned topics, focusing on scientific studies in various Slovenian populations. Methods We conducted a systematic review and meta-analysis of published scientific papers, academic theses, or conference contributions reporting serum 25(OH)D status and VitD intake across various Slovenian populations. A search was carried out using Web of Science, Scopus, Medline, and the Slovenian library database. Results We identified 43 pertinent studies that addressed 25(OH)D status and 16 that addressed VitD intake. Serum 25(OH)D status was generally low across all populations, and notable seasonal variability was observed. VitD intakes were below 5 μg in all studies. Conclusions A general observation is that various population groups across Slovenia are at high risk of vitamin D insufficiency and deficiency, particularly during wintertime. Regarding vitamin D intake, all included studies reported daily intakes below the recommended level. We also identified key research gaps that need to be addressed to support further public health decision-making.

scholarly journals Vitamin D Deficiency as a Risk Factor for Schizophrenia: A meta-analysis of Observational Studies

2019 ◽  
Author(s):  
Jia-Lian Zhu ◽  
Wen-Wen Luo ◽  
Xuan Cheng ◽  
Yun Li ◽  
Qi-Zhi Zhang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Vitamin D ◽  
Risk Factor ◽  
Vitamin D Deficiency ◽  
Meta Analysis ◽  
Vitamin D Insufficiency ◽  
Cochrane Library ◽  
Vitamin D Levels ◽  
Schizophrenic Patients

Abstract Background: Schizophrenia is a heterogeneous disorder in which there is interaction between genetic and environmental factors. Study have found that vitamin D deficiency is a risk factor for schizophrenia. We conducted a meta-analysis to investigate the relationship between schizophrenia and blood vitamin D level.Methods: A systematic review and meta-analysis have been conducted. All published observational articles have been searched from PubMed, Web of Science, Scopus, Cochrane library and Embase until September 2019. The Newcastle-Ottawa scale was used to examine the quality of the included studies.Results: A total of 38 articles have been included in this study. The lower level of vitamin D was found in people with schizophrenia compared with controls (WMD =-4.50, 95%CI [-6.69, -2.32]). Subgroup analyses based on study design, the patient’s hospitalization status, quality of the study, outcomes, and the country explained part of between-study heterogeneity. No significant differences in publication bias were observed. The overall prevalence of vitamin D deficiency and insufficiency in schizophrenic patients were 66%, 95%CI [57%–76%] and 76%, 95%CI [69%, 83%], respectively. Subjects with schizophrenia were more likely to have vitamin D deficiency or vitamin D insufficiency compared to controls (2.03, 95%CI [1.49, 2.77]; 2.43, 95%CI [1.40, 4.23]).Conclusion: The results of this systematic review show that low vitamin D levels might contribute to the development of schizophrenia. The prevalence of vitamin D deficient or insufficient in schizophrenia was higher than that in healthy controls or another psychotic disease .

High prevalence of vitamin D insufficiency among South Asian pregnant women: A systematic review and meta-analysis

2021 ◽  
pp. 1-32
Author(s):  
Mahbubul H Siddiqee ◽  
Badhan Bhattacharjee ◽  
Umme Ruman Siddiqee ◽  
Mohammad Meshbhaur Rahman
Keyword(s):  
Systematic Review ◽  
Vitamin D ◽  
Pregnant Women ◽  
South Asian ◽  
Meta Analysis ◽  
Vitamin D Insufficiency ◽  
Mitigation Strategies ◽  
Significant Heterogeneity ◽  
Asian Countries ◽  
Pooled Prevalence

Abstract Insufficiency of vitamin D, during pregnancy, is a common cause of various pregnancy-related complications. Despite such insufficiency being frequently reported among South Asian pregnant women, the absence of systematic review and meta-analysis renders the true extent of this problem poorly characterized. In this systematic review, three main databases (PubMed, Scopus, and Google Scholar) were searched for original studies. We included original studies published between 1st January 2001 to 31st December 2019, conducted on pregnant women who lived in South Asian countries and reported the prevalence of vitamin D insufficiency among the study participants. Twenty studies with a total of 7,804 participants from four South Asian countries finally met our selection criteria. Overall pooled prevalence of insufficiency was 65% [95 % CI: 51% to 78%] with a significant heterogeneity (I2 = 99.37 %; p = 0.00). The average level of vitamin D ranged from 9 ng/mL to 24.86 ng/mL with a weighted mean of 16.37 ng/mL (weighted standard deviation 7.13 ng/mL). The highest prevalence of insufficiency was found in Pakistan (76%) followed by India (67%), Bangladesh (64%), and Nepal (14%). Results obtained in this study suggest that vitamin D insufficiency is highly prevalent among South Asian pregnant women. Being the first systematic review in this region, findings from this study will help in future studies and strengthen the evidence for policymakers to develop effective mitigation strategies.

scholarly journals Pooled estimate of vitamin D deficiency among pregnant women in India: a systematic review and meta-analysis

2021 ◽  
Vol 40 (1) ◽  
Author(s):  
Angeline Jeyakumar ◽  
Vidhya Shinde ◽  
Reshma Ravindran
Keyword(s):  
Systematic Review ◽  
Vitamin D ◽  
Pregnant Women ◽  
Vitamin D Deficiency ◽  
Meta Analysis ◽  
Health Concern ◽  
Study Quality ◽  
Care Services ◽  
Pooled Prevalence ◽  
Women In India

Abstract Background Vitamin D deficiency among pregnant women is a public health concern globally. In India, individual studies report high prevalence. However, lack of national data masks the true burden. This work determined the pooled prevalence of vitamin D deficiency among pregnant women in India through a systematic review of literature and meta-analysis. Methods Three different search engines yielded 15 eligible articles. Study quality was assessed by 10 different criteria and summary of study quality was categorized as per Cochrane standards. Meta-analysis was performed to estimate pooled prevalence of vitamin D deficiency among healthy pregnant women and heterogeneity among selected studies. A sample of n = 4088 was used to study the pooled prevalence among pregnant women. Results The random effects combined estimate was 32.35% (95% CI, (12.58–117.48). High heterogeneity (tau2 = 0.39, I2 = 100%) and high risk of bias was observed among the selected studies. The test for overall effect was observed to be z = 2.54(P = 0.01). Conclusion Pooled estimate > 30% emphasizes the need for screening through antenatal care services and initiate preventive measures to address the deficiency.

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