scholarly journals The current state and prospects of the development of soft dosage forms with Boraginaceae species

2021 ◽  
pp. 59-65
Author(s):  
S. Svirska
Keyword(s):  
Dosage Forms ◽  
Pharmaceutical Market ◽  
Biologically Active ◽  
Borago Officinalis ◽  
Arnebia Euchroma ◽  
Current State ◽  
Alkanna Tinctoria ◽  
Myosotis Arvensis ◽  
Anchusa Officinalis ◽  
Active Substances

Soft dosage forms make up a significant segment in the structure of medicines both pharmaceutical and industrial production. Herbal ointments are an integral part of this group. Species of the Boraginaceae family are the source of biologically active substances used to treat inflammatory processes of all layers of the skin, muscle tissue, tendons and joints.Aim. To determine data on the current state of the development of soft dosage forms based on species of the Boraginaceae family and identify further prospects for studies in this area.Materials and methods. The scientific databases, in particular Abdata Pharma-Daten-Service, BioMed Central, Scopus, scientific periodicals of Ukraine – Vernadsky National Library of Ukraine, etc., were analyzed.Results and discussion. As a result of the data analysis of the Information Fund “State Register of Medicines of Ukraine” it has been found that only medicines with comfrey (Symphytum officinale L.) are registered in Ukraine. In the EU countries, only soft dosage forms with comfrey are registered, with the exception of Greece where there are ointments with Alkanna tinctoria (L.) Taush, and France where there are substances for the production of ointments withPulmonaria obscura Dumort. and Anchusa officinalis L. There are many soft homeopathic dosage forms with comfrey at the US pharmaceutical market; however, there are ointments and suppositories with Borago officinalis L. and a gel with Myosotis arvensis (L.) Hill. At the Brazilian pharmaceutical market there is the cream “Acheflan” based on Cordia verbenacea DC. The European and Asian scientists study ointments with Cordia myxa L., Cordia obliqua Willd., Heliotropium indicum L., Arnebia euchroma Rolye. (Johnst.), Onosma dichroanthum Boiss, Arnebia densiflora (Nordm.) Ledeb, Ehretia microphylla Lam., Anchusa officinalis L.Conclusions. Homeopathic products predominate among the soft dosage forms based on Boraginaceae species. At the pharmaceutical market, along with comfrey drugs, there are medicines and active substances with Borago officinalis, Myosotis arvensis (L.) Hill, Alkanna tinctoria (L.) Taush, Pulmonaria obscura Dumort., Anchusa officinalis L. and Cordia verbenacea DC. There is an active research of the existing products with comfrey, as well as the development and study of new soft dosage forms with species of Arnebia, Heliotropium, Cordia, Onosma, Ehretia and Anchusa genus. Taking the above into account the further research for creating effective and safe drugs based on the Boraginaceae species is promising. 

scholarly journals Characteristics of the world and Russian production of fruits products (apples and pears)

2018 ◽  
Vol 7 (2) ◽  
pp. 20-26
Author(s):  
Lyubov Georgievna Demenina ◽  
Anna Borisovna Petrova ◽  
Kristina Andreevna Savitskaya ◽  
Lyudmila Mikhailovna Kavelenova
Keyword(s):  
Statistical Data ◽  
Fruit Production ◽  
Biologically Active ◽  
Human Diet ◽  
Current State ◽  
The World ◽  
The Status ◽  
Fruit Growing ◽  
Rosaceae Family ◽  
Active Substances

The paper deals with the peculiarities of the biological characteristics of the most important fruit crops of temperate climates - apple and pear (Rosaceae family, subfamily Maloideae), taking into account the world, national and regional cultivation. Both cultures are characterized by significant food and commodity value, have some differences in the chemical composition of the fruit, including the leading components of the mass and biologically active substances, which determine the peculiarities of their use in the human diet. In both global and national fruit-growing, pears play a secondary role compared to apple, giving way to the number of varieties, the volume of production and the areas occupied. Based on the analysis of available statistical data of the FAO database, the dynamics of changes from 1990 to 2016 of the world production of apple and pear fruits with visualization on the continents, identifying world leaders and major trends are considered. For the USSR (from 1962 to 1990) and in Russian Federation (from 1992 to 2016) the paper presents a picture of changes in the volume of fruit production, discusses the status of fruit production in the country. The features of the historical development and current state of fruit growing in the Samara Region and prospects are discussed.

1,2,3-Triazole- and Quinoline-Based Hybrids with Potent Antiplasmodial Activity

2021 ◽  
Vol 18 ◽  
Author(s):  
Isabela A. Graciano ◽  
Alcione S. de Carvalho ◽  
Fernando de Carvalho da Silva ◽  
Vitor F. Ferreira
Keyword(s):  
Antimalarial Activity ◽  
Biological Activities ◽  
Review Article ◽  
Pharmaceutical Market ◽  
Biologically Active ◽  
New Drugs ◽  
Synthetic Methods ◽  
Antiplasmodial Activity ◽  
New Chemical Entities ◽  
Active Substances

Background: Malaria is a disease causing millions of victims every year and requires new drugs, often due to parasitic strain mutations. Thus, the search for new molecules that possess antimalarial activity is constant and extremely important. However, the potential that an antimalarial drug possesses cannot be ignored, and molecular hybridization is a good strategy to design new chemical entities. Objective: This review article aims to emphasize recent advances in the biological activities of new 1,2,3-triazole- and quinoline-based hybrids and their place in the development of new biologically active substances. More specifically, it intends to present the synthetic methods that have been utilized for the syntheses of hybrid 1,2,3-triazoles with quinoline nuclei. Method: We have comprehensively and critically discussed all the information available in the literature regarding 1,2,3-triazole- and quinoline-based hybrids with potent antiplasmodial activity. Results: The quinoline nucleus has already been proven to lead to new chemical entities in the pharmaceutical market, such as drugs for the treatment of malaria and other diseases. The same can be said about the 1,2,3-triazole heterocycle, which has been shown to be a beneficial scaffold for the construction of new drugs with several activities. However, only a few triazoles have entered the pharmaceutical market as drugs. Conclusion: Many studies have been conducted to develop new substances that may circumvent the resistance developed by the parasite that causes malaria, thereby improving the therapy currently used.

CURRENT STATE OF TECHNOLOGY FOR OBTAINING EXTRACT FROM CORN GERM (ZEA MAYS GERMINIS)

2021 ◽  
pp. 79-83
Author(s):  
А.Б. ЯРМАГАМЕТОВА ◽  
М.Ж. КИЗАТОВА
Keyword(s):  
Zea Mays ◽  
Chemical Composition ◽  
Human Body ◽  
Corn Germ ◽  
Biologically Active ◽  
Cosmetic Products ◽  
Current State ◽  
Therapeutic Value ◽  
Definition Of ◽  
Active Substances

В данной статье расматривается получение экстракта из зародыша кукурузы. Дается определение зародыша кукурузы (Zea mays germinis) и его значимость, как компонента, богатого биологически активными веществами, которые имеют терапевтическое значение для организма человека. Устанавлено, что получение экстракта из кукурузного зародыша для приготовления лекарственных и кометических средств является более выгодным процессом и имеет ценность благодаря своему богатому химическому составу и численности БАВ. This article discusses the preparation of an extract from the corn germ. The definition of the corn germ and its significance as a component rich in biologically active substances that have therapeutic value for the human body is given. It has been established that obtaining an extract from the corn germ for the preparation of medicinal and cosmetic products is a more profitable process and has value due to its rich chemical composition and the number of BAS.

scholarly journals REVIEW OF THE CURRENT STATUS OF STUDY OXYTROPIS

2018 ◽  
Vol 11 (4) ◽  
pp. 50
Author(s):  
Amirkhanova A Sh ◽  
Ustenova G O
Keyword(s):  
Pharmacological Action ◽  
Modern Medicine ◽  
Biologically Active ◽  
Herbal Remedies ◽  
Current Status ◽  
Internet Resources ◽  
Current State ◽  
The Family ◽  
Ancient Times ◽  
Active Substances

 The use of plants for medical purposes has been known since ancient times, and despite progress in the synthesis of medicinal products, herbal remedies continue to occupy a significant place in modern medicine. As promising sources of biologically active substances of natural origin, attention is attracted by representatives of the domestic flora from the family Fabaceae. The article gives an analysis of the current state of the study of the genus of Oxytropis and shows the prospects for their comprehensive study. Work in the herbarium fund of the Institute with a collection of species of Oxytropis glabra Lam. DC. allowed to identify the presence of at least 10 herbarium sheets. While analyzing the internet sources, we collected materials on the genus and species of Oxytropis which have been investigated for many years. When analyzing internet resources, it was established that the widely used traditional Tibetan, Chinese, Mongolian, and Buryat medicine should include representatives of the genus Oxytropis (DC.) of the family Fabaceae (L.).We have studied the species of the Oxytropis and compiled a table on their chemical composition and pharmacological action.

Wound dressings and soft dosage forms based on collagen for the treatment of wounds of various etiologies

2020 ◽  
pp. 10-16
Author(s):  
S.I. Melnik ◽  
V.D. Torikashvili ◽  
K.D. Yakuta ◽  
S.A. Lebedeva
Keyword(s):  
Healing Process ◽  
Dosage Forms ◽  
The Body ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Wound Dressings ◽  
Auxiliary Substance ◽  
Treatment Of Wounds ◽  
Active Substances

Collagen is a promising auxiliary substance in the manufacture of soft dosage forms (DF). Wound dressings and gels based on collagen are of great interest, as they allow speeding up the healing process, are completely utilized by the body, and can serve as a carrier for various medicinal and biologically active substances. An important advantage of using collagen is a large number of sources of its acquisition, which minimizes the risks of missing the necessary basis for the production of new medicines.

MEDICINAL PLANT PRODUCTION IN RUSSIA IN THE 21ST CENTURY (CHALLENGES AND DEVELOPMENT PROSPECTS)

2021 ◽  
pp. 42-54
Author(s):  
A.N. TSITSILIN ◽  
◽  
N.I. KOVALEV
Keyword(s):  
Medicinal Plants ◽  
Medicinal Plant ◽  
Raw Materials ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Plant Production ◽  
Growth Trend ◽  
Current State ◽  
Basic Production ◽  
Active Substances

The cultivation of medicinal plants is currently the main way of providing the pharmaceutical industry with raw materials for obtaining biologically active substances for the production of drugs. The use of natural resources of wild species is decreasing every year for a number of reasons, the biotechnological method has not been properly expanded yet, and in some cases it is possible to reproduce only a part of the complex of target biologically active substances contained in an intact plant. In recent years, a positive growth trend has been outlined in the domestic production of medicinal starting materials of herbal origin. However, there are a number of problematic issues that inhibit the development of medicinal plant growing and lead to a certain stagnation. These are general legislative and organizational problems, as well as deterioration or deficiency of material resources – basic production assets, lack of comprehensive mechanization, shortage of qualified specialists and a number of other obstacles. Nevertheless, the actively growing demand for high-quality raw materials from medicinal plant both in our country and abroad opens up great prospects for the development of medicinal plant production. It should be noted that the analysis of the current state of collection and cultivation of medicinal plants in Russia is poorly developed or is practically absent. The paper examines the current state of medicinal plant production; attempts are made to identify the main problems and possible growth points. Finding solutions to the problems and using the growth points show promise for the transformation of medicinal plant production into an industry with a large import substituting and export potential.

Neutral Lipids of Oats Fruit (Avena Sativa L.)

2020 ◽  
Vol 9 (4) ◽  
pp. 40-43
Author(s):  
N. K. Yuldasheva ◽  
S. D. Gusakova ◽  
D. Kh. Nurullaeva ◽  
N. T. Farmanova ◽  
R. P. Zakirova ◽  
...  
Keyword(s):  
Avena Sativa ◽  
Neutral Lipids ◽  
The Body ◽  
Biologically Active ◽  
Absorption Bands ◽  
Vital Functions ◽  
The Republic ◽  
Living Organisms ◽  
Main Components ◽  
Active Substances

Introduction. Lipids are a widespread group of biologically active substances in nature, making up the bulk of the organic substances of all living organisms. They accumulate in plants in seeds, as well as in fruits and perform a number of vital functions: they are the main components of cell membranes and the energy reserve for the body.Aim. Study of neutral lipids of sown oats (Avena sativa L.).Materials and methods. The objects of the study were fruits (grains) of oats of the sown variety "Tashkent 1," harvested in the Republic of Uzbekistan. Results and discussions. Neutral lipids of oat grains have been found to contain 13 fatty acids with a predominance of the sum of oleic, linolenic and linoleic acids. The total degree of unsaturation was almost 78%. Absorption bands characteristic of these substances were observed in the IR spectrum of MEGC.Conclusion. According to the results of the NL analysis, oat grains consisted of triacylglycerides and free LCDs, which were accompanied by hydrocarbons, phytosterols, triterpenoids and tocopherols.

Microscopic fungi of lithobiont communities of Argentine Islands Region: Data from the 22nd Ukrainian Antarctic Expedition

2020 ◽  
Vol 62 (1-2) ◽  
pp. 49-68
Author(s):  
T. O. Kondratiuk ◽  
T. V. Beregova ◽  
I. Yu. Parnikoza ◽  
S. Y. Kondratyuk ◽  
A. Thell
Keyword(s):  
Filamentous Fungi ◽  
Mucor Circinelloides ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Microscopic Fungi ◽  
Rhodotorula Rubra ◽  
Yeast Fungi ◽  
Antarctic Expedition ◽  
Geomyces Pannorum ◽  
Active Substances

The identification of the diversity of microscopic fungi of lithobiont communities of the Argentine Islands in specimens collected during the 22nd Ukrainian Antarctic Expedition was the purpose of this work. Samples of rock, soil, mosses and lichens of rock micro-habitats of “Crustose lichen sub-formation and fruticose lichen and moss cushion sub-formation” were used in the work. These samples were used for extracting and cultivation of filamentous fungi on dense nutrient media. Determination of physiological and biochemical characteristics and identification of yeast-like fungi were performed using a microbiological analyser ‘Vitek-2’ (‘Bio Merieux’, France). Cultivation of microorganisms was carried out at temperatures from +2 to +37 °C. In results cultures of microscopic fungi of Zygomycota (Mucor circinelloides), Ascomycota (species of the genera cf. Tlielebolus, Talaromyces), representatives of the Anamorphic fungi group (Geomyces pannorum, species of the genera Alternaria, Acremonium, Aspergillus, Penicillium, and Cladosporium) were isolated from Antarctic samples. Microscopic fungi Penicillium spp. were dominated after the frequency in the studied samples (54.5%). Rhodotorula rubra and Candida sp. among isolated yeast fungi, and dark pigmented fungi represented by Aureobasidium pulhdans and Exophiala spp. were identified. The biological properties of a number of isolated fungi (the potential ability to synthesise important biologically active substances: melanins, carotenoids, lipids) are characterised. Mycobiota of rock communities of Argentine Islands is rich on filamentous and yeast fungi similarly to other regions of Antarctica. A number of fungi investigated are potentially able to synthesise biologically active substances. The dark pigmented species of the genera Cladosporium, Exophiala, Aureobasidium pulhdans, capable of melanin synthesis; ‘red’ yeast Rhodotorula rubra (carotenoid producers and resistant to toxic metals); Mucor circinelloides and Geomyces pannorum, lipid producers, are among these fungi. Yeast-like fungi assimilated a wide range of carbohydrates, which will allow them to be further used for cultivation in laboratory and process conditions. The collection of technologically promising strains of microorganisms, part of the Culture Collection of Fungi at Taras Shevchenko National University of Kyiv (Ukraine), is updated with isolated species (strains) of filamentous fungi and yeast – potential producers of biologically active substances, obtained within this study.

Sign in / Sign up

Export Citation Format

Share Document