scholarly journals Pancreatic Duodenal Homeobox Factor-1 and Neurogenin-3 Serum Expression in Gestational Diabetes

2020 ◽  
Vol 15 ◽  
pp. 6
Author(s):  
Arturo González Santana ◽  
Jessica María Rodríguez Cortés ◽  
Leicy Jazmin Ruíz Barrera ◽  
Bacteriologist ◽  
Araceli Consuelo Hinojosa Juárez ◽  
...  
Keyword(s):  
Gestational Diabetes ◽  
Multiple Regression ◽  
Statistical Significance ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Normal Weight ◽  
Cross Sectional ◽  
Neurogenin 3 ◽  
Glucose Levels ◽  
Normal Gestation

Objectives: Pancreatic duodenal homeobox factor-1 (PDX-1) and neurogenin-3 (NGN-3) are progenitor cell markers in the pancreas. The aim was to compare their serum levels in women with and without gestational diabetes mellitus (GDM). Material and Methods: This prospective, cross-sectional study included two groups: (a) Women with normal gestation and (b) with GDM. PDX-1 and NGN-3 serum expression was determined by qRT-PCR. Student’s t-test or the Mann–Whitney U-test was used to contrast both groups and the Pearson or Spearman correlation was used. A multiple regression was done introducing body mass index and the relative expression of both genes as independent variables and glucose as dependent variable. Statistical significance was tested at P ≤ 0.05 level. Results: Thirty-eight patients (mean age was of 29.00 ± 7.74 years) were included, 22 belonged to the normal pregnancies, and 16 to GDM. Using the ΔΔCt method, the expression fold change for PDX-1 was 0.458 and for NGN-3 it was 0.361. There was a significant positive correlation between the expressions of both genes. The multiple regression was significant for both genes expression and glucose levels in case of having normal weight. Conclusion: PDX-1 and NGN-3 low serum expression could be predictors of higher glucose levels in normal pregnancies.

scholarly journals Association between maternal glucose levels during pregnancy and gestational diabetes mellitus: an analytical cross-sectional study

2015 ◽  
Vol 7 (1) ◽  
Author(s):  
Gisele Seabra ◽  
Cláudia Saunders ◽  
Patrícia de Carvalho Padilha ◽  
Lenita Zajdenverg ◽  
Letícia Barbosa Gabriel da Silva ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Glucose Levels ◽  
Maternal Glucose Levels ◽  
Maternal Glucose

Influence of Metabolic Syndrome on Factors Associated with Chronic Kidney Disease: A Cross-Sectional Study

2021 ◽  
Vol 17 ◽  
Author(s):  
Camila Santos Marreiros ◽  
Thaís Rodrigues Nogueira ◽  
Paulo Pedro do Nascimento ◽  
Diana Stefany Cardoso de Araújo ◽  
Nayara Vieira do Nascimento Monteiro ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Serum Glucose ◽  
Cross Sectional ◽  
Significance Level ◽  
Glucose Levels ◽  
Progression Of Kidney Disease

Background: Metabolic Syndrome (MetS) is defined by the presence of three or more of the following components: inadequate fasting serum glucose levels and elevated waist circumference, hypertension and dyslipidemia, which represent a potential risk for the development and/or worsening of Chronic Kidney Disease. Objective: This research aimed to investigate the presence of MetS and its influence on associated factors in patients with Chronic Kidney Disease undergoing hemodialysis. Methods: This is an evaluation of a cross-sectional multicenter research project, carried out with 95 patients with Chronic Kidney Disease, seen at outpatient clinics in the state capital Piaui. Anthropometric, biochemical and hemodynamic parameters were determined. The data were analyzed using the Stata® v.12 software (Statacorp, College Station, Texas, USA), adopting a significance level of p < 0,05. The survey received ethical approval (nº 2.527.329). Results: It was observed that individuals with elevated BMI, WC, NC, SBP, DBP were more likely to develop MetS, with significant differences (p <0.001). In addition, it was found that serum levels of glucose, insulin, HOMA-IR, TC, LDL, TG and blood pressure were higher in the group with MetS. Conclusion: It was concluded that changes in the parameters analyzed in patients with CKD reinforce MetS as a predictive condition for worsening nutritional status and a factor for the progression of kidney disease.

scholarly journals Serum electrolytes levels in patients with type 2 diabetes mellitus: a cross-sectional study

2020 ◽  
Vol 23 (3) ◽  
pp. 223-228
Author(s):  
Shridhar Reshma ◽  
Sushith Sushith ◽  
Mangalore Balakrishna Prathima ◽  
D'Sa Janice ◽  
Gopal R Madan ◽  
...  
Keyword(s):  
Serum Levels ◽  
Cross Sectional Study ◽  
The Body ◽  
Serum Electrolytes ◽  
Cross Sectional ◽  
Glucose Levels ◽  
Electrolyte Disturbances ◽  
Group 2 ◽  
Group 1

BACKGROUND:Diabetes Mellitus (DM) is a common metabolic disease worldwide. Electrolyte played significant roles in thenormal functioning of the body, and deregulation is indicative of different types of disease and electrolyte disturbances are often reported in type 2 DM (T2DM). AIM:The aim of the study was to estimate the levels of serum electrolytes in outpatients with T2DM and correlate serum electrolytes with random blood sugar (RBS). MATERIALS AND METHODS:Patients with T2DM visiting the outpatient Departments of Medicine, between April 2016 and March 2017 were included. Of 148 diagnosed T2DM cases, 74 were had RBS level 300mg/dL (group-1) and 74 had RBSlevel 300mg/dL (group-2). Serum sodium (Na+), potassium (K+), chloride (Cl-) levels were measured by using the Roche 9180electrolyte analyzer. RESULTS:In this study, there was a significant decrease in serum Na+levels in group 1 (131.834.36 mmol/L) compared to group 2(134.154.90mmol/L).The serum levels of K+was found to be increased in group 1 (4.510.61 mmol/L) in comparison with group 2 (4.260.52 mmol/L). In group-1, an inverse relationship was present between serum Na+(r=-0.342) and Cl-(r=-0.538) with RBS which was statistically significant. In group-2, a significant correlation was present between serum K+and RBS (r=0.356, p0.05). CONCLUSIONS:The study showed lower levels of Na+and higher K+levels in group-1 compared to group-2 subjects. This study showed that the distribution of serum Na+and K+levels is dependent on plasma glucose levels in patients with DM and also suggests that monitoring the electrolyte levels in hyperglycemia is pertinent in the management of diabetes.

scholarly journals Levels of Physical Activity in Spanish Asthmatics: A Cross-Sectional Study

Medicina ◽  
2020 ◽  
Vol 56 (12) ◽  
pp. 643
Author(s):  
Sheila Sánchez Castillo ◽  
Lee Smith ◽  
Arturo Díaz Suárez ◽  
Guillermo Felipe López Sánchez
Keyword(s):  
Physical Activity ◽  
Sex Education ◽  
Statistical Significance ◽  
Cross Sectional Study ◽  
Study Data ◽  
Normal Weight ◽  
Short Version ◽  
Cross Sectional ◽  
Living Together ◽  
Metabolic Equivalent Of Task

Background and objectives: 339 million people in the world suffer from asthma. Regular physical activity (PA) could help in its control. Therefore, the aim of this research was to determine the level of PA in Spanish people with asthma considering variation by, age, sex, education, marital status, living together, smoking habits, alcohol intake and body mass index (BMI). Materials and Methods: 1014 Spanish people from 15 to 69 years were included in the study. Data of the Spanish Health Survey (year 2017) were analysed. PA levels were measure with the international physical activity questionnaire short version (IPAQ-SF). PA was categorized as low, moderate and high, and analyzed by sample characteristics. Mann-Whitney U test, Kruskall Wallis H and crosstabs were used to calculate statistical significance (p < 0.05). Results: On average, Spanish asthmatics engaged in a weekly volume of 2228.9 metabolic equivalent of task (MET)·min/week. Males revealed significantly higher PA than females (2516.8 vs. 2019.5 MET·min/week; p = 0.005), younger participants (<30 years) compared to people aged 30–60 years and older than 60 years (2699.0; 2243.2; 1619.3 MET·min/week; p < 0.001) and those with tertiary level of education than those without secondary (2368.3 vs. 2168.3 MET·min/week; p = 0.001). Level of PA was lower in those married (p = 0.001) and/or living together (p = 0.010). Alcohol consumers showed a higher level than the participants who did not drink (2378.3 vs. 1907.9 MET·min/week; p = 0.001), but no significant differences were found within current, past and never smokers (p = 0.890). Obese asthmatics engaged in less PA than their normal weight and overweight peers (p < 0.001). Overall, moderate level was significantly the most frequent (47.7%), but 31.6% showed a low level. Conclusions: Three out of ten Spanish people with asthma do not achieve PA recommendations, so PA programs should be executed to make people aware of its benefits in asthma control, focusing on those groups with lower PA levels.

scholarly journals Identifying Metabolomic Profiles of Insulinemic Dietary Patterns (OR31-03-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Fred Tabung ◽  
Raji Balasubramanian ◽  
Steven Clinton ◽  
Liming Liang ◽  
Clary Clish ◽  
...  
Keyword(s):  
Dietary Patterns ◽  
Statistical Significance ◽  
Cross Sectional Study ◽  
Normal Weight ◽  
Validation Dataset ◽  
Plasma Metabolites ◽  
Obese Women ◽  
Cross Sectional ◽  
Funding Sources ◽  
Secondary Analyses

Abstract Objectives The empirical dietary index for hyperinsulinemia (EDIH) is a food-based score derived from correlations with plasma c-peptide. Our aim is to use the EDIH to discover metabolites associated with insulinemic dietary patterns. Methods This baseline cross-sectional study evaluated associations between continuous EDIH scores from food frequency questionnaires and 448 log-transformed plasma metabolites as outcomes in multivariable linear regression analyses. Metabolites were measured with liquid chromatography tandem mass spectroscopy. Metabolite discovery was conducted among 1109 Women's Health Initiative (WHI) Hormone Therapy trial participants and results replicated in an independent dataset of 810 WHI Observational Study participants. In both discovery and replication datasets statistical significance was based on false-discovery rate adjusted P < 0.05. Secondary analyses were conducted in body mass index (BMI: <25, >=25 kg/m2) categories. Results After adjustment for energy intake, BMI, physical activity, and other confounding variables, 26 metabolites were significantly associated with EDIH in the discovery dataset, and included: trigonelline, C14:0 CE, C16:1 CE, C18:1 CE, C18:3 CE, C20:3 CE. C20:5 CE, C36:1 PS plasmalogen and eicosapentaenoate were associated with lower dietary insulinemic potential, whereas C36:3 DAG, C51:3 TAG, C52:3 TAG, C52:4 TAG, C54:2 TAG, C54:3 TAG, C54:4 TAG, C54:6 TAG, C36:4 DAG-A, cystathionine, isoleucine, N4-acetylcytidine, C10:2 carnitine, cAMP, C18:2 SM, C4-OH carnitine, and myristoleic acid were associated with higher dietary insulinemic potential. 25 out of the 26 metabolites replicated in the validation dataset except myristoleic acid. In secondary analyses within BMI strata, Associations differed by BMI category: 12 metabolites were significant among normal weight women whereas 64 metabolites were associated with EDIH among overweight/obese women. Conclusions Cholesterol esters, triglycerides, carnitines and amino acids may constitute metabolites that are associated with insulinemic dietary patterns. Funding Sources R00CA207736, NHLBI HHSN268201300008C.

scholarly journals Ultrasound as a method to evaluate the distribution of abdominal fat in obese prepubertal children and the relationship between abdominal fat and metabolic alterations

2018 ◽  
Vol 51 (5) ◽  
pp. 293-296 ◽  
Author(s):  
Arine Santos Peçanha ◽  
Alexandra Maria Monteiro ◽  
Fernanda Mussi Gazolla ◽  
Isabel Rey Madeira ◽  
Maria Alice Neves Bordallo ◽  
...  
Keyword(s):  
Hdl Cholesterol ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Abdominal Fat ◽  
Normal Weight ◽  
Model Assessment ◽  
Obese Children ◽  
Cross Sectional ◽  
Prepubertal Children ◽  
Metabolic Alterations

Abstract Objective: To evaluate, using ultrasound, the distribution of abdominal fat in obese prepubertal children, as well as its possible correlation with metabolic changes due to obesity. Materials and Methods: This was a cross-sectional study of prepubescent children: 77 obese children (33 girls and 44 boys), with a mean age of 7.31 years; and 31 normal-weight children (17 girls and 14 boys), with a mean age of 7.32 years. In all of the children, abdominal wall thickness (AWT) and abdominal fat thickness (AFT) were measured by ultrasound. For the evaluation of the associated metabolic alterations, serum levels of glycemia, HDL cholesterol, triglycerides, and insulin were determined. Results: The obese children presented with greater abdominal fat, predominantly greater AWT, without a significant gender-related difference in AWT or AFT. The homeostasis model assessment of insulin resistance (HOMA-IR) showed a significant direct correlation with AWT and AFT. Conclusion: In obese prepubertal children, the AWT, as measured by ultrasound, was shown to be more closely related to the HOMA-IR than to the lipid metabolism or glycemia.

scholarly journals Bone status and aortic calcifications in chondrocalcinosis patients

2020 ◽  
Vol 28 (2) ◽  
pp. 195-204
Author(s):  
Paulina Vele ◽  
Ciprian Nicolae Silaghi ◽  
Laura Otilia Damian ◽  
Siao-Pin Simon ◽  
Alexandra Craciun ◽  
...  
Keyword(s):  
Bone Turnover ◽  
Bone Turnover Markers ◽  
Statistical Significance ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Mineral Density ◽  
Cross Sectional ◽  
Turnover Markers

AbstractAim: We aimed to examine the association between several circulating bone turnover markers [ osteocalcin (OC), osteoprotegerin (OPG), beta-CrossLaps (β-CTx)], hip and spine bone mineral density (BMD) and abdominal aortic calcification (AAC) in patients with chondrocalcinosis (CC).Methods: Thirty-six patients with CC and thirty-seven controls were consecutively enrolled in this pilot case-control, cross-sectional study. The following parameters were assessed: serum levels of OC, OPG and β-CTx by enzyme-linked immunosorbent assay (ELISA); hip and spine BMD by dual-energy X-ray absorptiometry and AAC score by lateral radiography.Results: Patients with CC had higher levels of serum bone turnover markers and AAC score than the control group: OC [6.5 (3.5-9.9) vs 4.5 (2.6-7.2) ng/ml; p=0.05], OPG [(7.7 (6.2-9.4) vs 6.5 (5.5-8.12) pmol/ml; p=0.02], β-CTx [6078 (5870-6171) vs 5851 (5465-6109) pg/ml; p=0.02] and AAC score (3.6±6.2 vs 0.5±2; p=0.006). Conversely, even if statistical significance was not reached, hip and spine BMD was lower in patients with CC. Additionally, we found a positive correlation between OPG and AAC, but also between OPG and osteoporosis in patients with CC.Conclusion: Patients with CC are characterized by higher circulating OC, OPG and β-CTx. The presence of AAC was more common in patients with CC, being only associated with serum OPG.

Clinical Utility of the Ankle-Brachial Index and Toe Brachial Index in Patients with Diabetic Foot Ulcers

2020 ◽  
Vol 16 (3) ◽  
pp. 270-277 ◽  
Author(s):  
Mutasem Ababneh ◽  
Mousab Y. Al Ayed ◽  
Asirvatham A. Robert ◽  
Mohamed A. Al Dawish
Keyword(s):  
Diabetic Foot ◽  
Statistical Significance ◽  
Ankle Brachial Index ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Arterial Disease ◽  
Cross Sectional Study ◽  
Screening Tests ◽  
Cross Sectional ◽  
Toe Brachial Index

Background: This cross sectional study investigated the clinical use of the ankle-brachial index (ABI) and toe brachial index (TBI) in 91 type 2 diabetic foot ulcer patients who visited the diabetic foot clinic, Prince Sultan Military Medical City, Saudi Arabia during July 2017 and January 2018. Materials and Methods: The ABI and TBI facilitated the detection of peripheral arterial disease (PAD) and the patients’ medical records were used to collect the clinical and demographic variables. The variables of duration (p = 0.047) and treatment (p = 0.046) of the ABI showed significant differences. Age (p = 0.034) and duration (p = 0.001) were the factors related to the diagnosis of TBI by the “χ2” test. Results: From the TBI, 26.4% of the patients were found to have PAD, while the ABI showed that 21.8% of patients had the condition. However, no statistical significance was noted. From the regression analysis, the variable duration of diabetes (≥ 20 years of age) was recognized as an independent risk factor for TBI. Conclusion: In conclusion, it is recommended both the ABI and TBI to be used as screening tests for PAD in diabetic foot ulcer patients.

Is there a relationship between gestational diabetes and postpartum depression?

2020 ◽  
Vol 16 ◽  
Author(s):  
Salman Khazaei ◽  
Erfan Ayubi ◽  
Saeid Bashirian ◽  
Ronak Hamzehei ◽  
Ensiyeh Jenabi
Keyword(s):  
Gestational Diabetes ◽  
Postpartum Depression ◽  
Odds Ratio ◽  
Depression Scale ◽  
Binary Logistic Regression ◽  
Cross Sectional Study ◽  
University Education ◽  
P Value ◽  
Cross Sectional ◽  
The Relationship

Background: The relationship between gestational diabetes and postpartum depression (PPD) is poorly understood and seldom studied. Objective: In an effort to explore this issue, the present study investigated the relationship between gestational diabetes and PPD. Methods: The present cross-sectional study was performed with 342 women who were referred to four urban health centers of Hamadan city, west of Iran. We used convenience sampling as a method to recruit women in each health center. We used a researcher-made checklist for gathering data on socio-demographic characteristics and potential risk factors of PPD. The Persian validated version of the Edinburgh Postnatal Depression Scale (EPDS) was used to assess PPD. Univariate and multivariable binary logistic regression was applied to estimate the odds ratio (OR) (95% confidence interval [CI]). Results: Gestational diabetes was identified as the most important risk factor for PPD with OR (95% CI) of 2.19 (1.11, 4.31); P-value=0.02 after adjusting for other variables. Moreover, the adjusted odds ratio showed that PPD among lesseducated women (primary school) was 3.5 times higher compared to women with a university education (OR=3.54, 95% CI: 1.27, 9.84; P-value=0.01). Conclusion: Our findings suggested that PPD is more likely among women with gestational diabetes and those who were less educated. Interventional and educational activities for reducing the risk of PPD can be targeted for use with this population.

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