Vitamin E and omega-3 fatty acids independently attenuate plasma concentrations of proinflammatory cytokines and prostaglandin E2 in Escherichia coli lipopolysaccharide-challenged growing–finishing pigs1

Abstract. Background: Elevated homocysteine levels and malnutrition are frequently detected in hemodialysis patients and are believed to exacerbate cardiovascular comorbidities. Omega-3 fatty acids have been postulated to lower homocysteine levels by up-regulating metabolic enzymes and improving substrate availability for homocysteine degradation. Additionally, it has been suggested that prevention of folate depletion by vitamin E consumption decreases homocysteine levels. However, data on the effect of omega-3 fatty acids and/or vitamin E on homocysteine levels and nutritional status have been inconclusive. Therefore, this study was planned to examine the effect of combined supplementation of fish oil, as a source of omega-3 fatty acids, with wheat germ oil, as a source of vitamin E, on homocysteine and nutritional indices in hemodialysis patients. Methods: This study was a randomized, double-blind, placebo-controlled trial. Forty-six hemodialysis patients were randomly assigned to two equally-sized groups; a supplemented group who received 3000 mg/day of fish oil [1053 mg omega-3 fatty acids] plus 300 mg/day of wheat germ oil [0.765 mg vitamin E], and a matched placebo group who received placebo capsules for 4 months. Serum homocysteine and different nutritional indices were measured before and after the intervention. Results: Twenty patients in each group completed the study. At the end of the study, there were no significant changes in homocysteine levels and in the nutritional indices neither in the supplemented nor in the placebo-control groups (p > 0.05). Conclusions: Fish oil and wheat germ oil combination did not produce significant effects on serum homocysteine levels and nutritional indices of hemodialysis patients.

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Effect of mode of addition of flaxseed oil on the quality characteristics of chicken sausage containing vitamin E and omega 3 fatty acids at levels to support a health claim

Food & Function ◽

10.1039/c7fo00929a ◽

2017 ◽

Vol 8 (10) ◽

pp. 3563-3575 ◽

Cited By ~ 6

Author(s):

Zara Bolger ◽

Nigel P. Brunton ◽

Frank J. Monahan

Keyword(s):

Fatty Acids ◽

Vitamin E ◽

Quality Characteristics ◽

Flaxseed Oil ◽

Sensory Properties ◽

Omega 3 Fatty Acids ◽

Omega 3 ◽

Health Claim

Direct or pre-emulsified flaxseed oil addition did not affect sensory properties of high omega-3/vitamin E sausages but encapsulation did, negatively.

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Fructose, Omega 3 Fatty Acids, and Vitamin E: Involvement in Pediatric Non-Alcoholic Fatty Liver Disease

Nutrients ◽

10.3390/nu12113531 ◽

2020 ◽

Vol 12 (11) ◽

pp. 3531

Author(s):

Gigliola Alberti ◽

Juan Cristóbal Gana ◽

José L. Santos

Keyword(s):

Oxidative Stress ◽

Fatty Acids ◽

Liver Disease ◽

Vitamin E ◽

Fatty Liver ◽

Fatty Liver Disease ◽

Omega 3 Fatty Acids ◽

Omega 3 ◽

Alcoholic Fatty Liver ◽

Alcoholic Fatty Liver Disease

Non-alcoholic fatty liver disease (NAFLD) is currently the most common form of liver disease in both adults and children, becoming the leading cause for liver transplant in many countries. Its prevalence has increased considerably in recent years, mainly due to the explosive increase in pediatric obesity rates. NAFLD is strongly associated with central obesity, diabetes, dyslipidemia and insulin resistance, and it has been considered as the hepatic manifestation of the metabolic syndrome. Its complex pathophysiology involves a series of metabolic, inflammatory and oxidative stress processes, among others. Given the sharp increase in the prevalence of NAFLD and the lack of an appropriate pharmacological approach, it is crucial to consider the prevention/management of the disease based on lifestyle modifications such as the adoption of a healthy nutrition pattern. Herein, we review the literature and discuss the role of three key nutrients involved in pediatric NAFLD: fructose and its participation in metabolism, Omega-3 fatty acids and its anti-inflammatory effects and vitamin E and its action on oxidative stress.

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296 Evaluation of interactive effects of vitamin E and linseed oil as a source of omega-3 fatty acids on growth performance, blood characteristics and meat quality of finishing pigs

Journal of Animal Science ◽

10.2527/msasas2016-296 ◽

2016 ◽

Vol 94 (suppl_2) ◽

pp. 139-139

Author(s):

S. D. Upadhaya ◽

T. S. Li ◽

Y. M. Kim ◽

I. H. Kim

Keyword(s):

Fatty Acids ◽

Vitamin E ◽

Meat Quality ◽

Linseed Oil ◽

Interactive Effects ◽

Finishing Pigs ◽

Omega 3 Fatty Acids ◽

Omega 3 ◽

Blood Characteristics

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Omega-3 fatty acids inhibit an increase of proinflammatory cytokines in patients with active Crohn's disease compared with omega-6 fatty acids

Alimentary Pharmacology & Therapeutics ◽

10.1111/j.1365-2036.2005.02698.x ◽

2005 ◽

Vol 22 (11-12) ◽

pp. 1121-1128 ◽

Cited By ~ 33

Author(s):

A. A. NIELSEN ◽

L. G. M. JORGENSEN ◽

J. N. NIELSEN ◽

M. EIVINDSON ◽

H. GRONBAEK ◽

...

Keyword(s):

Fatty Acids ◽

Crohn’S Disease ◽

Crohn's Disease ◽

Proinflammatory Cytokines ◽

Omega 3 Fatty Acids ◽

Omega 3 ◽

Omega 6

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The Evaluation Of Concurrent Supplementation With Vitamin E And Omega- 3 Fatty Acids On Plasma Lipid Per Oxidation And Antioxidant Levels In Patients With Rheumatoid Arthritis

The Internet Journal of Rheumatology ◽

10.5580/1cf7 ◽

2011 ◽

Vol 7 (1) ◽

Cited By ~ 1

Keyword(s):

Rheumatoid Arthritis ◽

Fatty Acids ◽

Vitamin E ◽

Plasma Lipid ◽

Omega 3 Fatty Acids ◽

Omega 3

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Are the Adaptogenic Effects of Omega 3 Fatty Acids Mediated via Inhibition of Proinflammatory Cytokines?

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2012/209197 ◽

2012 ◽

Vol 2012 ◽

pp. 1-14 ◽

Cited By ~ 4

Author(s):

Joanne Bradbury ◽

Lyndon Brooks ◽

Stephen P. Myers

Keyword(s):

Fatty Acids ◽

Proinflammatory Cytokines ◽

Structural Equation ◽

Ex Vivo ◽

Equation Modeling ◽

Omega 3 Fatty Acids ◽

Omega 3 ◽

The Impact ◽

Necrosis Factor ◽

Analyze Data

The study was undertaken to estimate the size of the impact of n-3 fatty acids in psychological stress and the extent to which it is mediated via proinflammatory cytokines. Structural equation modeling (SEM) was used to analyze data from 194 healthy Australians. Biomarkers used were erythrocyte polyunsaturated fatty acids (docosahexaenoic acid (DHA) and arachidonic acid (AA)),ex-vivostimulated secretion of proinflammatory cytokines (interleukins (IL-1 and IL-6), and tumor necrosis factor (TNF)). Stress was measured with the perceived stress scale (PSS-10), found to comprise three factors: Coping (items 4, 7, 5), Overwhelm (2, 10, 6 and 8), and Emotional (1, 9 and 3). This modeling demonstrated that the effects of DHA on coping are largely direct effects (0.26,t=2.05) and were not significantly mediated via the suppression of proinflammatory cytokines. Future modeling should explore whether adding EPA to the model would increase the significance of the mediation pathways.

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The Effect of Administration of Omega-3 and Vitamin E on the Levels of Reactive Oxygen Species (ROS) and Nitric Oxide (NO) in Preeclampsia White Rats (Rattus Norvegicus)

International Journal of Research and Review ◽

10.52403/ijrr.20211202 ◽

2021 ◽

Vol 8 (12) ◽

pp. 7-15

Author(s):

Dina Taufia ◽

Syamel Muhammad ◽

Arni Amir

Keyword(s):

Oxidative Stress ◽

Fatty Acids ◽

Vitamin E ◽

Control Group ◽

Omega 3 Fatty Acids ◽

Omega 3 ◽

Pregnant Rats ◽

White Rats ◽

Significant Difference ◽

One Way Anova

Background: Preeclampsia is a disease with a variety of theories that describe the uncertainty of the pathophysiology. According to the oxidative stress theory, preeclampsia originates from the failure of trophoblast invasion during the implantation process, causing ischemia and placental hypoxia, which in turn causes cell damage, including placental endothelial cell dysfunction. Omega-3 fatty acids and vitamin E have an important role in preventing preeclampsia. Omega-3 fatty acids play an important role in maintaining cell membranes and anti-inflammatory processes. At the same time, vitamin E acts as a fat-soluble antioxidant that can prevent oxidative stress, inhibit proinflammatory cytokines, and protect fatty acids from oxidation. Aim: The purpose of this study was to determine the effect of omega-3 and vitamin E on the level of ROS and NO in pregnant rats with preeclampsia models. Method & Material: This type of research is experimental with Post-Test Only Control Group Design. The sample consisted of 35 pregnant rats, which were divided into five groups. On the 19th day, blood serum was taken to check the levels of ROS and NO. The measuring instrument used is a spectrophotometer with the ELISA method. Data were analyzed using the Shapiro Wilks normality test. After the parametric test was completed, the hypothesis was tested using one-way ANOVA. Results: The average levels of ROS in each group were K- : 121,684 ng/L, K+ : 143,885 ng/L, P1 : 136,250 ng/L, P2 : 132.433 ng/L, and P3 : 122,993 ng/L. The average levels of NO obtained were K-: 29,502 ng/L, K+: 26,053 ng/L, P1: 27,250 ng/L, P2: 27,555 ng/L, and P3: 32,278 ng/L. The results of one-way ANOVA analysis showed that the administration of omega-3 and vitamin E had a significant difference between the control and treatment groups, both at levels of ROS (p=0.001) and levels of NO (p=0.001). Conclusion: The administration of omega-3, vitamin E, and omega-3 plus vitamin E can reduce ROS levels in pregnant rats with preeclampsia models. There is an increase of NO levels only in the administration of omega-3 plus vitamin E. Keywords: [Omega-3, Vitamin E, Oxidative stress, ROS, NO, Preeclampsia].

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Changes in Oxidative Stress Parameters as Response to Supplementation With Vitamin E and Omega-3 Fatty Acids in Male Workers Exposed to High Level Noise

10.21203/rs.3.rs-850400/v1 ◽

2021 ◽

Author(s):

Hamzeh Mohammadi ◽

Farideh Golbabaei ◽

Somayeh Farhang Dehghan ◽

Nariman Moradi ◽

Maryam Chamari ◽

...

Keyword(s):

Oxidative Stress ◽

Fatty Acids ◽

Vitamin E ◽

Assay Method ◽

Omega 3 Fatty Acids ◽

Omega 3 ◽

Decremental Effect ◽

Oxidative Stress Parameters ◽

Incremental Effect ◽

Stress Parameters

Abstract Background: The present study aimed to assess the effects of the supplementation consumption of vitamin E and Omega 3 fatty acid on the oxidative stress parameters among workers exposed to high levels of noise in an automobile parts manufacturing plant. Moreover, the effects of the exposure to noise on SOD, total oxidative stress (TAC) and MDA will be investigated. Methods: The participants were deployed into 4 groups (vitamin E (100 mg), Omega 3 fatty acids (180 mg EPA and 120 mg DHA), vitamin E+ Omega 3 and Placebo), as per the double-blind block randomization method. The oxidative stress parameters of the participants were analyzed before and after three month consumption of supplements via enzyme-linked immunosorbent assay method. The level of workers' exposure to noise, was measured according to ISO 9612. Results: Before intervention, mean MDA, SOD and TAC were 27.52 (7.46) nmol/ml, 58.84 (10.44) U/ml and 2.57 (0.67) mM respectively. After intervention, mean MDA, SOD and TAC were 24.57 (7.58) nmol/ml, 63.46 (11.02) U/ml and 2.70 (0.84) mM respectively. The use of supplement Omega 3 fatty acids had a significant decremental effect on MDA levels. The use of vitamin E alongside Omega 3 fatty acids had a significant incremental effect on SOD activity.Conclusion: Noise exposure had a decremental effect on TAC and SOD as well as an incremental effect on MDA, but this was only statistically significant for TAC. It appears that the simultaneous use of vitamin E and Omega 3 fatty acids for three months had a positive effect on the anti-oxidant performance of workers exposed to noise.

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