scholarly journals ANGKA KEJADIAN DIARE PADA ANAK DENGAN LEUKEMIA LIMFOBLASTIK AKUT DI RSUP PROF. DR. R. D. KANDOU MANADO PERIODE TAHUN 2011-2015

e-CliniC ◽  
2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Fatmawati Latamu ◽  
Jeanette I. Ch. Manoppo ◽  
Max F. J. Mantik
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Medical Records ◽  
Lymphoblastic Leukemia ◽  
Transmitted Disease ◽  
The Body ◽  
Induction Phase ◽  
Inclusion Criteria ◽  
Cross Sectional ◽  
Common Cause ◽  
Foreign Objects

ABSTRACTBackground : Leukemia is a type of non-transmitted disease that cause death with a large number of cases, especially in children. Leukemia is the most common childhood cancer. Acute Lymphoblastic Leukemia (ALL) is approximately 75% of all cases. One of the main consequences of leukemia is inability of the immune system defending the body from the invasion of foreign objects. As a result of infection or bleeding is the most common cause of death in patient with leukemia. Diarrhea is one of the infections that can be found in children with Acute Lymphoblastic Leukemia. Diarrhea in children with Acute Lymphoblastic Leukemia can occur either from the disease itself or due to chemotherapy. The purpose of this study is to describe the incidence of diarrhea in children with acute lymphoblastic leukemia in Prof. R. D. Kandou Hospital Manado year period 2011-2015.Methods : This study is a descriptive retrospective, with cross sectional approach by collecting data medical records of pediatric patient with ALL in RSUP Prof. Dr. R. D. Kandou Manado then describe the incidence of diarrhea. Samples were 60.Results : The result obtained 60 patients who met the inclusion criteria, and 17 patients had diarrhea. Diarrhea in children with ALL is more common in induction phase, and the duration of diarrhea more to less than 7 days (acute diarrhea).Conclusion : From this result, it can be concluded that the incidence of diarrhea in children with Acute Lymphoblastic Leukemia in Prof. DR. R. D. Kandou Hospital Manado year period 2011-2015 is low enough.Keywords : Acute Lymphoblastic Leukemia (ALL), Diarrhea, ChildABSTRAKLatar Belakang : Leukemia merupakan jenis penyakit tidak menular yang menyebabkan kematian dengan jumlah kasus yang tidak sedikit khususnya pada anak-anak. Leukemia adalah kanker anak yang paling sering. Leukemia Limfoblastik Akut (LLA) berjumlah kira-kira 75% dari semua kasus. Salah satu konsekuensi utama dari Leukemia adalah ketidakmampuan sistem imum mempertahankan tubuh dari invasi benda asing. Akibatnya infeksi atau perdarahan hebat adalah penyebab tersering kematian pada pasien leukemia. Diare merupakan salah satu infeksi yang dapat dijumpai pada anak dengan Leukemia Limfoblastik Akut. Diare pada anak dengan Leukemia Limfoblastik Akut dapat terjadi baik akibat dari Leukemia Limfoblastik Akut itu sendiri maupun akibat dari kemoterapi yang diberikan.Metode : Penelitian ini bersifat retrospektif deskriptif, dengan pendekatan potong lintang dengan cara mengumpulkan rekam medik pasien anak dengan LLA di RSUP Prof. Dr. R. D. Kandou Manado, kemudian mendeksripsikan kejadian diare.Hasil : Didapatkan 60 pasien yang memenuhi kriteria inklusi, dan 17 pasien mengalami diare. Diare pada anak dengan LLA lebih sering terjadi pada fase induksi, dan lamanya diare lebih banyak pada < 7 hari (diare akut).Kesimpulan : Angka kejadian diare pada anak dengan Leukemia Limfoblastik Akut di RSUP Prof. DR. R. D. Kandou periode tahun 2011-2015 cukup rendah.Kata Kunci : Leukemia Limfoblastik Akut (LLA), Diare, Anak

scholarly journals Gambaran Klinis Diare pada Pasien Anak Leukemia Limfoblastik Akut dengan Kemoterapi

e-CliniC ◽  
2017 ◽  
Vol 5 (1) ◽  
Author(s):  
Gregorius F. Anver ◽  
Max F.J. Mantik ◽  
Jeanette I. Ch. Manopo
Keyword(s):  
Retrospective Study ◽  
Acute Lymphoblastic Leukemia ◽  
Medical Records ◽  
Lymphoblastic Leukemia ◽  
The Body ◽  
Clinical Profile ◽  
Mucous Cells ◽  
Cross Sectional ◽  
Normal Cells ◽  
Cross Sectional Design

Abstract: Chemotherapy is usually used in acute lymphoblastic leukemia (ALL) patients to kill the neoplasmic cells. Albeit, this chemotherapy also destroys normal cells in the body. One of the complications of chemotherapy is destruction of digestive mucous cells that results in diarrhea. Diarrhea can cause dehydration, hypokalemia, acidosis that could lead to shock as well as death. This study was aimed to obtain the clinical profile of diarrhea in children with ALL treated with chemotherapy. This was a descriptive retrospective study with a cross sectional design using 60 medical records of children with ALL treated with chemotherapy and suffered from diarrhea in Estella room at Pediatrics Department Prof. Dr. R. D. Kandou Hospital in 2011-2015. Conclusion: In this study, there were only a fiew ALL patients treated with chemotherapy that got diarrhea. Diarrhea associated with blood and vomiting was very minimal meanwhile diarrhea associated with fever occured in some cases.Keywords: acute lynphoblastic leukemia, chemotherapy diarrhea Abstrak: Kemoterapi merupakan salah satu metode pengobatan yang sering digunakan pada penderita leukemia limfoblastik akut (LLA) untuk membunuh sel neoplasma. Dilain pihak kemoterapi tidak hanya membuhuh sel-sel leukemia tetapi juga menyerang sel-sel normal. Salah satu contoh efek samping kemoterapi yaitu kerusakan sel mukosa saluran cerna yang menyebabkan diare. Hal ini dapat mengakibatkan terjadinya dehidrasi, hipokalemia dan asidosis yang tidak jarang berakhir dengan syok dan kematian. Penelitian ini bertujuan untuk mengetahui gambaran klinis diare pada pasien anak dengan LLA yang menjalani kemoterapi. Jenis penelitian ialah deskriptif retrospektif dengan desain potong lintang yang dilakukan pada 60 data rekam medik pasien anak yang mengidap LLA dengan kemoterapi dan disertai diare di Pusat Pengobatan Kanker Ruang Estella Bagian Ilmu Kesehatan Anak RSUP Prof. Dr. R. D. Kandou pada tahun 2011-2015. Simpulan: Pada penelitian ini hanya sebagian kecil pasien LLA dengan kemoterapi yang mengalami diare. Kejadian diare yang disertai darah dan muntah sangat rendah, sedangkan kejadian diare yang disertai demam hanya terjadi pada sebagian anak.Kata kunci: leukemia limfoblastik akut, kemoterapi, diare

scholarly journals HUBUNGAN KARAKTERISTIK PASIEN DENGAN TOKSISITAS HEPATOLOGI AKIBAT PENGGUNAAN 6-MERKAPTOPURIN DALAM FASE PEMELIHARAAN PADA PASIEN PEDIATRI KANKER LEUKIMIA LIMFOBLASTIK AKUT DI RS KANKER DHARMAIS JAKARTA

2020 ◽  
Vol 3 (2) ◽  
pp. 361-368
Author(s):  
Nazhipah Isnani ◽  
◽  
Dyah Aryani Perwitasari ◽  
Rizka Andalusia ◽  
Haridini Intan Mahdi ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Medical Records ◽  
Pediatric Patients ◽  
Lymphoblastic Leukemia ◽  
Maintenance Phase ◽  
Inclusion Criteria ◽  
Cross Sectional ◽  
Cancer Hospital ◽  
Phase Data ◽  
Observational Design

Mercaptopurine is a chemotherapy drug that used in the consolidation and maintenance phase in pediatric patients with acute lymphoblastic leukemia ( ALL). Mercaptopurine is supposed to have relationship with the occurrence of toxicity in hepatology. This study was aimed to determine the patient incidence , severity and management of toxicity and risk factors that affect the occurrence of hepatologic toxicity using of 6 - MP in the maintenance phase in pediatric patients with acute lymphoblastic leukemia in Dharmais Cancer Hospital Jakarta. This research was carried out by cross-sectional observational design with data was taken retrospectively and prospectively during the period from March to April 2014. The study subjects were patient who have been getting treatment of maintenace phase in Dharmais Cancer Hospital Jakarta from 2013 until March-April 2014. The Subjects who met the inclusion criteria were 23 patients of ALL received 6 - MP in the maintenance phase. Data was collected by looking at the medical records for getting of the patient's identity and data hepatology. The result showed that there was a correlation between patient characterision on hepatology toxicity, on SGOT age and weight with SGPT both of them has significant value, it was 0,036 (P<0,05)

scholarly journals Correlative Study Between Nutritional Status and Remission Outcome in Childhood Acute Lymphoblastic Leukemia in Dr. Soetomo General Hospital Surabaya

2019 ◽  
Vol 2 (1) ◽  
pp. 27
Author(s):  
Asma' Athifah ◽  
Siti Nurul Hidayati ◽  
Sulistiawati Sulistiawati
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Nutritional Status ◽  
General Hospital ◽  
Risk Group ◽  
Lymphoblastic Leukemia ◽  
High Risk Group ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
Induction Phase ◽  
Cross Sectional ◽  
Term Survival

Introduction: The most common malignancy that is diagnosed in children is acute lymphoblastic leukemia. Undernourished children tend to have poorer long term survival. This descriptive analytic study is aimed towards analyzing the correlation between nutritional status at diagnosis and outcomes of induction phase therapy in childhood acute lymphoblastic leukemia at the Department of Pediatrics Dr. Soetomo General Hospital Surabaya in 2014.Methods: A cross-sectional method using the medical records of patients is used in this study. The nutritional statuses of patients are calculated using weight for length/height trough curves of WHO 2006 or CDC 2000.Results: The results show that from 45 children diagnosed with ALL, 53% are of the age ≤ 5 years old, with 58% males and 42% females. 13% of the patients are in the high risk group and 87% are in the standard risk group. Nutritional statuses of patients are 2% of them obese experienced remission after induction phase therapy, 56% normal with 80% of them experienced remission. 40% underweight with 89% of them experienced remission and 11% not experienced remission, 2% malnutrition and experienced remission. There is no correlation between the nutritional status of children with acute lymphoblastic leukemia with the outcome of induction phase (p = 0.798).Conclusion: In conclusion, there is no correlation between nutritional status and remission outcome of patients with ALL in the induction phase of therapy. However, high percentage of underweight patients shows nutrition needs special attention to improve therapy outcomes.

scholarly journals Karakteristik dan Jumlah Leukosit pada Anak Penderita Leukemia Limfoblastik Akut yang Menjalani Kemoterapi Fase Induksi di Rumah Sakit Al Islam Bandung

2021 ◽  
Vol 3 (2) ◽  
Author(s):  
Fairuz Fakhri Luthfiyan ◽  
Lia Marlia Kurniawati ◽  
Ieva Baniasih Akbar
Keyword(s):  
Bone Marrow ◽  
Acute Lymphoblastic Leukemia ◽  
Nutritional Status ◽  
Lymphoblastic Leukemia ◽  
Genetic Disorders ◽  
Current Therapy ◽  
Induction Phase ◽  
Cross Sectional ◽  
Leukocyte Counts ◽  
Cross Sectional Design

Leukemia limfoblastik akut (LLA) adalah kelompok keganasan heterogen dengan sejumlah kelainan genetik khas yang menghasilkan berbagai perilaku klinis dan respons terhadap terapi. Pasien LLA pada umumnya identik dengan jumlah leukosit yang tinggi,  terapi saat ini adalah dengan cara kemoterapi yang terdiri atas 3 fase, yaitu induksi, konsolidasi, dan pemeliharaan. Keberhasilan kemoterapi ditentukan banyak faktor antara lain adalah terjadi remisi setelah kemoterapi fase induksi. Penelitian ini bertujuan mengetahui karakteristik dan jumlah leukosit pada anak penderita LLA setelah fase induksi kemoterapi. Metode yang digunakan adalah deskriptif dengan rancangan potong lintang  yang menggunakan data rekam medik pasien LLA  periode tahun 2019 usia 0 - 15 tahun. Penelitian ini dilaksanakan selama bulan Oktober 2020, teknik pengambilan data menggunakan total sampling. Pada penelitian ini didapatkan 137 data rekam medik, data yang memenuhi kriteria inklusi sebanyak 74 data. Kasus LLA paling banyak terjadi pada usia 0 - 5 tahun pada 41 pasien (55%), jenis kelamin laki-laki 43 pasien (58%), status gizi baik 46 pasien (62%), morfologi sumsum tulang remisi 63 pasien (85%), dan jumlah leukosit 4500-13500/mm3 pada 52 pasien (70%), remisi sumsum tulang terbanyak pada jumlah leukosit 4 pada 45 pasien (61%). Simpulan,  karakteristik pasien LLA terba500-13500/mm3nyak laki-laki, usia 0 - 5 tahun status gizi baik dan morfologi sumsum tulang remisi.  Characteristics and Number of Leukocytes in Children with Acute Lymphoblastic Leukemia who Underwent Induction Phase Chemotherapy at Al Islam Hospital BandungAcute lymphoblastic leukemia (ALL) is a heterogeneous group of malignancies with a number of characteristic genetic disorders that produce a variety of clinical behaviors and responses to therapy. LLA patients are generally synonymous with high leukocyte counts. Current therapy is chemotherapy which consists of 3 phases, namely induction, consolidation, and maintenance. The success of chemotherapy is determined by many factors, including remission after induction phase chemotherapy. This study aims to determine the characteristics and number of leukocytes in children with LLA after the chemotherapy induction phase. The method used was descriptive with a cross-sectional design using medical records of LLA patients periode 2019 aged 0-15 years. study was held in October 2020. In this study, there were 137 medical record data, data that met the inclusion criteria were 74 data. LLA cases in this study mostly occurred at the age of 0 - 5 years, amounting to 41 patients (55%), male gender totaled 43 patients (58%), good nutritional status totaled 46 patients (62%). ), the morphology of bone marrow remission totaled 63 patients (85%), and for the number of leukocytes 4500 - 13500/mm3 as many as 52 patients (70%), the greatest occurrence of bone marrow remission was in the number of leukocytes 4500/mm3-13500/mm3 as many as 45 patients (61%). In conclusion, characteristics of most ALL patients are male, age of 0 - 5 years with good nutritional status and bone marrow morphology showing remission. Characteristics and Number of Leukocytes in Children with Acute Lymphoblastic Leukemia who Underwent Induction Phase Chemotherapy at Al Islam Hospital Bandung

scholarly journals Effect of methotrexate and doxorubicin cumulative doses on superoxide dismutase levels in childhood acute lymphoblastic leukemia

2015 ◽  
Vol 55 (5) ◽  
pp. 239
Author(s):  
Khalida Fetriyani Ningsih ◽  
Sri Mulatsih ◽  
Sasmito Nugroho
Keyword(s):  
Superoxide Dismutase ◽  
Cohort Study ◽  
Acute Lymphoblastic Leukemia ◽  
Retrospective Cohort ◽  
Lymphoblastic Leukemia ◽  
The Body ◽  
Protein Damage ◽  
Induction Phase ◽  
Oxygen Species ◽  
Chemotherapeutic Drugs

Background Acute lymphoblastic leukemia (ALL) is the mostcommon malignancy in children. Chemotherapeutic drugs forALL such as methotrexate (Mtx) and doxorubicin producereactive oxygen species (ROS), a type of free radical. The ROScan reduce levels of antioxidants in the body, including superoxidedismutase (SOD). Decreased SOD levels can cause DNA, lipid,and protein damage, which in turn may lead to adverse effectsand treatment failure.Objective To determine the effect of Mtx and doxorubicincumulative doses on SOD levels in children with ALL.Methods We conducted a retrospective cohort study in childrenwith ALL who underwent chemotherapy in Dr. Sardjito Hospitalin October 2011 who had completed the induction phase. Riskfactors for decreased SOD levels were analyzed by Cox regressionand hazard ratio, with a significant level of P <0.05.Results Of 40 patients enrolled, Mtx ≥ 3000 mg/m2 significantlydecreased SOD levels (HR 9.959; 95%CI 2.819 to 35.183; P=0.001). However, doxorubicin ≥90 mg/m2 did not significantlydecrease SOD levels (HR 0.59 95%CI 0.194 to 1.765; P=0.34).Conclusion Methotrexate is associated with decreased SOD levelsin children with ALL. However, doxorubicin is not associated withdecreased SOD levels in the same patient population.

scholarly journals Hypertension, high-dose corticosteroids, and renal infiltration in children with acute lymphoblastic leukemia

2014 ◽  
Vol 54 (6) ◽  
pp. 372 ◽  
Author(s):  
Andry Juliansen ◽  
Murti Andriastuti ◽  
Sudung Pardede ◽  
Rini Sekartini
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Cross Sectional Study ◽  
High Dose ◽  
Induction Phase ◽  
Newly Diagnosed ◽  
Sectional Study ◽  
Cross Sectional ◽  
Common Risk Factors ◽  
The Difference

Background Hypertension is a rarely recognized complicationof acute lymphoblastic leukemia (ALL). The incidence ofhypertension in ALL patients in Indonesia remains unknown,but the most common risk factors are corticosteroid use duringinduction-phase chemotherapy and renal leukemic infiltration.Objective To determine the incidence of hypertension in childrenwith ALL, and to assess for associations of high-dose corticosteroids,renal infiltration, and hyperleukocytosis to hypertension.Methods This was a cross-sectional study involving 100 childrenaged 2-18 years. Subjects were newly diagnosed ALL patients andthose underwent induction-phase chemotherapy in the PediatricWard or Outpatient Clinic at Cipto Mangunkusumo or DharmaisHospitals.Results Hypertension occurred in 6 (10%) of 60 newly diagnosedALL patients and 8 (20%) of 40 patients who had receivedhigh-dose corticosteroids, but the difference was not statisticallysignificant (OR=2.25; 95%CI 0.72 to 7.07; P=0.239). Hypertensionwas reported in 8 of 29 subjects who received dexamethasone,but in none of the subjects who received prednisone. However, thedifference in these subgroups was also not statistically significant.Renal enlargement was found in 1 of 14 hypertensive patients, butit was not associated with hypertension (OR=0.80; 95%CI 0.52to 1.24; P=0.417). Hyperleukocytosis was also not associated withhypertension (OR= 0.79; 95% CI 0.20 to 3.11; P=1.000).Conclusion The incidence of hypertension in ALL patients was14%. Hypertension is not associated with renal infiltration orhyperleukocytosis. Furthermore, hypertension is not associatedwith corticosteroid dose, though is found only in subjects whoreceive dexamethasone. [Paediatr Indones. 2014;54:372-6.].

scholarly journals Hubungan Indeks Massa Tubuh dan Tercapainya Remisi pada Anak Penderita Leukemia Limfoblastik Akut

e-CliniC ◽  
2019 ◽  
Vol 8 (1) ◽  
Author(s):  
Venita S. Pojoh ◽  
Max F. J. Mantik ◽  
Jeanette I. Ch. Manoppo
Keyword(s):  
Body Mass Index ◽  
Acute Lymphoblastic Leukemia ◽  
Body Mass ◽  
Immune Cell ◽  
Lymphoblastic Leukemia ◽  
Cancer Center ◽  
Induction Phase ◽  
Cross Sectional ◽  
Cross Sectional Design ◽  
The Relationship

Abstract: Acute lymphoblastic leukemia (LLA) is the most common type of leukemia in children. Until now chemotherapy is still used as the main treatment. One aspect that affects the success of chemotherapy is body mass index (BMI). BMI values in children with LLA tend to be unstable, low, or high. This is triggered by natural immune cell disorders which have an impact on increasing cytokines and side effects of treatment. This study was aimed to determine the relationship between BMI and the achievement of remission in children with ALL. This was a retrospective and analytical study with a cross-sectional design. Samples were ALL patients who had been given induction phase of chemotherapy during 2015-2018 based on medical records at Estella Children's Cancer Center, Prof. Dr. R. D. Kandou Hospital Manado. The results obtained 52 samples which were evaluated and analyzed to determine the relationship of BMI and the achievement of remission. The Spearman correlation test showed a significant value of p=0.799 (p>0.05). In conclusion, there was no relationship between BMI and the achievement of remission in children with ALLKeywords: body mass index, remission, acute lymphoblastic leukemia Abstrak: Leukemia limfoblastik akut (LLA) merupakan jenis leukemia yang paling sering terjadi pada anak-anak. Sampai saat ini kemoterapi masih dipakai sebagai pengobatan utama. Salah satu aspek yang memengaruhi keberhasilan kemoterapi yaitu indeks massa tubuh (IMT). Nilai IMT pada anak penderita LLA cenderung tidak stabil, bisa kurang tetapi juga lebih. Hal ini dipicu oleh gangguan sel imun alami yang dialami penderita kemudian berdampak terhadap peningkatan sitokin serta efek samping pengobatan. Penelitian ini bertujuan untuk mengetahui hubungan antara IMT dan tercapainya remisi pada anak penderita LLA. Jenis penelitian ialah analitik retrospektif dengan desain potong lintang. Sampel penelitian ialah pasien LLA yang telah diberikan kemoterapi fase induksi periode 2015-2018, didapatkan dari rekam medik di Pusat Kanker Anak Estella RSUP Prof Dr. R. D. Kandou Manado. Hasil penelitin mendapatkan 52 sampel, kemudian dievaluasi dan dianalisis untuk melihat hubungan IMT dan tercapainya remisi pada sampel. Hasil uji korelasi Spearman menunjukkan nilai p=0,799 (p>0,05). Simpulan penelitian ini ialah tidak terdapat hubungan antara IMT dan tercapainya remisi pada anak penderita LLA.Kata kunci: Indeks massa tubuh, remisi, leukemia limfoblastik akut

scholarly journals Hubungan Indeks Massa Tubuh dan Tercapainya Remisi pada Anak Penderita Leukemia Limfoblastik Akut

e-CliniC ◽  
2019 ◽  
Vol 8 (1) ◽  
Author(s):  
Venita S. Pojoh ◽  
Max F. J. Mantik ◽  
Jeanette I. Ch. Manoppo
Keyword(s):  
Body Mass Index ◽  
Acute Lymphoblastic Leukemia ◽  
Body Mass ◽  
Immune Cell ◽  
Lymphoblastic Leukemia ◽  
Cancer Center ◽  
Induction Phase ◽  
Cross Sectional ◽  
Cross Sectional Design ◽  
The Relationship

Abstract: Acute lymphoblastic leukemia (LLA) is the most common type of leukemia in children. Until now chemotherapy is still used as the main treatment. One aspect that affects the success of chemotherapy is body mass index (BMI). BMI values in children with LLA tend to be unstable, low, or high. This is triggered by natural immune cell disorders which have an impact on increasing cytokines and side effects of treatment. This study was aimed to determine the relationship between BMI and the achievement of remission in children with ALL. This was a retrospective and analytical study with a cross-sectional design. Samples were ALL patients who had been given induction phase of chemotherapy during 2015-2018 based on medical records at Estella Children's Cancer Center, Prof. Dr. R. D. Kandou Hospital Manado. The results obtained 52 samples which were evaluated and analyzed to determine the relationship of BMI and the achievement of remission. The Spearman correlation test showed a significant value of p=0.799 (p>0.05). In conclusion, there was no relationship between BMI and the achievement of remission in children with ALLKeywords: body mass index, remission, acute lymphoblastic leukemia Abstrak: Leukemia limfoblastik akut (LLA) merupakan jenis leukemia yang paling sering terjadi pada anak-anak. Sampai saat ini kemoterapi masih dipakai sebagai pengobatan utama. Salah satu aspek yang memengaruhi keberhasilan kemoterapi yaitu indeks massa tubuh (IMT). Nilai IMT pada anak penderita LLA cenderung tidak stabil, bisa kurang tetapi juga lebih. Hal ini dipicu oleh gangguan sel imun alami yang dialami penderita kemudian berdampak terhadap peningkatan sitokin serta efek samping pengobatan. Penelitian ini bertujuan untuk mengetahui hubungan antara IMT dan tercapainya remisi pada anak penderita LLA. Jenis penelitian ialah analitik retrospektif dengan desain potong lintang. Sampel penelitian ialah pasien LLA yang telah diberikan kemoterapi fase induksi periode 2015-2018, didapatkan dari rekam medik di Pusat Kanker Anak Estella RSUP Prof Dr. R. D. Kandou Manado. Hasil penelitin mendapatkan 52 sampel, kemudian dievaluasi dan dianalisis untuk melihat hubungan IMT dan tercapainya remisi pada sampel. Hasil uji korelasi Spearman menunjukkan nilai p=0,799 (p>0,05). Simpulan penelitian ini ialah tidak terdapat hubungan antara IMT dan tercapainya remisi pada anak penderita LLA.Kata kunci: Indeks massa tubuh, remisi, leukemia limfoblastik akut

scholarly journals Hubungan Pemberian Kortikosteroid terhadap Kenaikan Berat Badan pada Anak Penderita Leukemia Limfoblastik Akut Fase Induksi di RSUP Haji Adam Malik Medan

2021 ◽  
Vol 2 (2) ◽  
pp. 76-83
Author(s):  
Isni Dhiyah Almira ◽  
Selvi Nafianti
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Induction Phase ◽  
Spearman Correlation ◽  
Event Free Survival ◽  
Cross Sectional ◽  
Corticosteroid Administration ◽  
Free Survival

Background: Glucocorticoid corticosteroids have vasoconstrictive, anti-proliferation, anti-inflammatory, and immunosuppressant effects through interactions with glucocorticoid receptors which have also been found in one type of leukemia, acute lymphoblastic leukemia (ALL). The most common side effect long-term use of high dose corticosteroids is increase in body weight resulting in obesity. It is one of the main problems in ALL patients, because it leads to persistent leukemia, increase of the risk of recurrence, and poor event-free survival. This has been associated with the use of glucocorticoids namely dexamethasone and prednisone in the induction phase chemotherapy process. Objectives: This study was intended to determine the association of corticosteroid administration to weight gain in children with ALL induction phase. Methods: The study was analytic-cross sectional. A total of 62 medical records of pediatric patients with ALL in Haji Adam Malik General Hospital Medan in 2015-2018. The data obtained were processed using the Wilcoxon statistical test, the Mann-Whitney test, and the Spearman-Correlation Rank test. Results: Wilcoxon test showed the effect of corticosteroid administration on body weight in the sample (p = 0.001). The Mann-Whitney test showed a difference in the influence of the use of prednisone and dexamethasone on sample body weight (p = 0.001), but it was not found regarding the nutritional status of the sample (p = 0.149). The Spearman-correlation test showed that there was no association of weight gain with the total corticosteroid dose given (p = 0.251). Conclusion: There is an association of corticosteroid administration to body weight in children with ALL induction phase. There are differences in the influence of the use of prednisone and dexamethasone on body weight, while there is no such difference on nutritional status in children with ALL induction phase. There is no association of weight gain based on the total corticosteroid dose given during the induction phase in children with ALL. Keywords: acute lymphoblastic leukemia, corticosteroid, induction phase chemotherapy, weight gain   Latar Belakang: Kortikosteroid golongan glukokortikoid memiliki efek vasokontriksi, anti-proliferasi, anti-inflamasi, dan imunosupresan melalui interaksinya dengan glucocorticoid receptor yang juga telah ditemukan pada salah satu jenis leukemia yaitu leukemia limfoblastik akut (LLA). Efek samping paling sering dari penggunaan kortikosteroid jangka panjang dengan dosis tinggi adalah peningkatan berat badan berlebih yang berakibat pada obesitas. Hal ini menjadi salah satu masalah utama pada pasien LLA, karena dapat menyebabkan leukemia persisten, meningkatkan risiko kekambuhan, dan event-free survival yang buruk. Hal tersebut telah dikaitkan dengan penggunaan glukokortikoid deksametason dan prednisone dalam proses kemoterapi LLA fase induksi. Tujuan: Penelitian ini dimaksudkan untuk mengetahui hubungan pemberian kortikosteroid terhadap kenaikan berat badan pada anak penderita leukemia limfoblastik akut fase induksi. Metode: Penelitian yang dilakukan bersifat analitik-cross sectional. Dikumpulkan sebanyak 62 rekam medis pasien anak penderita LLA di RSUP Haji Adam Malik Medan tahun 2015-2018. Data yang diperoleh diolah menggunakan uji statistik Wilcoxon, uji Mann-Whitney, dan uji Rank Spearman-Correlation. Hasil: Uji Wilcoxon menunjukkan adanya pengaruh pemberian kortikosteroid terhadap berat badan pada sampel (p = 0,001). Uji Mann-Whitney menunjukkan adanya perbedaan pengaruh penggunaan prednison dan deksametason terhadap berat badan sampel (p = 0,001), tetapi tidak terhadap status gizi sampel (p = 0,149). Uji Rank Spearman-Correlation menunjukkan tidak terdapat hubungan kenaikan berat badan terhadap total dosis kortikosteroid yang diberikan (p = 0,251). Kesimpulan: Terdapat hubungan pemberian kortikosteroid terhadap berat badan anak penderita LLA fase induksi. Terdapat perbedaan pengaruh penggunaan prednison dan deksametason terhadap berat badan anak penderita LLA fase induksi, tetapi tidak terhadap status gizi. Tidak terdapat hubungan kenaikan berat badan berdasarkan total dosis kortikosteroid yang diberikan selama fase induksi pada anak penderita LLA. Kata kunci: kemoterapi fase induksi, kenaikan berat badan, kortikosteroid, leukemia limfoblastik akut

The incidence of hyperglycemia during the induction phase of chemotherapy in patients with acute lymphoblastic leukemia

2019 ◽  
Author(s):  
Ahmad Tamaddoni ◽  
Morteza Alijanpour ◽  
Hassan Mahmoodi ◽  
Beniamin Miladi ◽  
Ali Bijani ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Acute Lymphoblastic Leukemia ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Lymphoblastic Leukemia ◽  
Fasting Blood Glucose ◽  
Induction Phase ◽  
Fasting Blood Glucose Level ◽  
Chi Square ◽  
Cross Sectional

Background: Hyperglycemia is one of the most complications of corticosteroid and asparaginase during induction phase of chemotherapy in children suffering from acute lymphoblastic leukemia (ALL). This study was carried out to evaluate the incidence of hyperglycemia and associated risk factors during chemotherapy induction phase at Amirkola Children's Hospital. Materials and Methods: In this cross-sectional (retrospective) study, 150 children (mean age: 79.16±42.68 months) with ALL were evaluated (2000- 2011). Hyperglycemia was described as random blood glucose level more than 200mg/dl in patients less than 2 years old. In patients older than 2 years, fasting blood glucose level more than 110-125 mg/dl was considered as impaired glucose level and fasting blood glucose level more than 126 mg/dl was defined as diabetes mellitus. The data were analyzed using SPSS (version 18) and running chi square test, pearson Ccorrelation, and logistic regression. P-values less than0.05 was considered statistically significant. Results: Out of 150 children with ALL, 21 (14%) of them had hyperglycemia, but none of them had diabetic ketoacidosis. Hyperglycemia was significantly associated with gender (P=0.014) and age. (P=0.000) which was more likely in patients older than 10 years. The incidence of hyperglycemia was also related to BMI (P=0.000). Relapse rate for ALL was 14.7%, which was not significantly associated with hyperglycemia. Conclusion: Hyperglycemia was common and transient during induction phase of chemotherapy and it was correlated with age, sex, and weight.

Sign in / Sign up

Export Citation Format

Share Document