Structure of concomitant somatic pathology in patients different age groups before ophthalmic surgery

Purpose. Analysis of structure somatic pathology in patients different age groups before planned ophthalmic surgery. Material and methods. Analyzed 1200 medical records patients previously operated in the Khabarovsk branch of the S. Fyodorov Eye Microsurgery Federal State Institution, 3 age groups were formed. The 1st group included 11 patients under age of 40 years (0.9%), the 2nd group – 234 patients from 41 to 60 years (19.5%), the 3rd group – 955 patients over 60 years (79.6%). In each of the groups, the frequency and structure of concomitant somatic pathology, the degree of its compensation were studied. Results. In the 1st group, 54.5% of patients were somatically healthy, 45.5% had a pathology, represented mainly by stage 1 hypertension and type 1 diabetes. All of them were compensated, there were no difficulties in preparing for the operation in this group. In the 2nd group, 90.2% of patients had somatic pathology. The leading positions were occupied by hypertension and type 2 diabetes, the respiratory system pathologies, rheumatic diseases and the carriage of chronic hepatitis B and C viruses were added. Treatment correction at the preoperative stage was required for 2 patients (0.9%), after which the patients were operated. In 3rd group, 100% of patients had somatic pathology. Its structure did not differ much from the 2nd group, but there were also complications such as heart attacks, acute cerebrovascular accidents, complicated diabetes. Correction of therapy was carried out in 61 people (6.4%), 60 of them were successfully operated, one did not appear for hospitalization. Conclusion. Somatic burden increased and degree of compensation for diseases decreased with increasing age of patients. Successful operations are facilitated by individual approach to patient, taking into account the existing pathology and preoperative preparation. Key words: patient's age, somatic burden, hypertension, diabetes mellitus, compensation.

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Frequency patients with hyperopia in refractive surgery department in ophthalmic surgery clinic

Modern technologies in ophtalmology ◽

10.25276/2312-4911-2021-1-44-46 ◽

2021 ◽

pp. 44-46

Author(s):

S.A. Shishkin ◽

◽

N.V. Samokhvalov ◽

I.V. Dutchin ◽

E.L. Sorokin ◽

...

Keyword(s):

Refractive Surgery ◽

Age Groups ◽

Anterior Segment ◽

State Institution ◽

Morphometric Parameters ◽

Federal State ◽

Moderate Degree ◽

Ophthalmic Surgery ◽

Number Of Patients ◽

Surgery Department

Purpose. Determination of proportion patients with hyperopia in refractive surgery department of ophthalmic surgery clinic, analysis of degree of their hyperopia, morphometric parameters of anterior segment of the eye. Material and methods. The proportion of patients with hyperopia who were operated in the refractive surgery department of the Khabarovsk branch of the S. Fyodorov Eye Microsurgery Federal State Institution in 2019 were assess. On limited sample of these patients, a quantitative assessment of degree of hyperopia was carried out, and morphometric parameters of the anterior segment of the eyes were studied. Results. In 2019, 141 patients with hyperopia were operated (282 operations), which amounted to 11.3% of the total number of patients in the department. The majority of patients had a moderate degree of hyperopia (55.3%). In 47.5% of eyes, hyperopia was combined with astigmatism up to 4 diopters. Conclusion. Femto LASIK technology made it possible to achieve maximum uncorrected visual acuity in 52% of patients with hyperopia in the study group. Modern capabilities of refractive surgery are capable of providing high functional results in patients with varying degrees of hyperopia. Key words:refractive errors, hyperopia, refractive surgery, Femto LASIK, age groups.

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Postoperative endophthalmitis

Modern technologies in ophtalmology ◽

10.25276/2312-4911-2021-3-185-187 ◽

2021 ◽

pp. 185-187

Author(s):

I.A. Frolychev ◽

◽

N.A. Pozdeyeva ◽

◽

...

Keyword(s):

Visual Acuity ◽

Surgical Treatment ◽

Silicone Oil ◽

Angiogenesis Inhibitor ◽

Cataract Extraction ◽

State Institution ◽

Federal State ◽

Postoperative Endophthalmitis ◽

Ophthalmic Surgery ◽

Corrected Visual Acuity

Surgical treatment of postoperative endophthalmitis is an urgent problem of ophthalmic surgery. Purpose.The aim of the study was to analyze the results of treatment of patients with postoperative endophthalmitis using perfluorodecalin and antibiotic solutions for vitreal cavity tamponade. Materials and methods. For the period 2016-2020, 35 patients (35 eyes) were operated in the Cheboksary branch of the S. Fyodorov Eye Microsurgery Federal State Institution. In 26 patients, this complication occurred after cataract extraction, in 7 after vitreoretinal operations, in 2 after intravitreal administration of an angiogenesis inhibitor. Visual acuity before treatment of endophthalmitis in 3 patients was to 0.02– 0.08, in 16 – counting of fingers in the face, in 13 – pr.l.certa, in 3-pr. l. incerta. All patients underwent vitrectomy with perfluorodecalin tamponade of the vitreal cavity for up to 14 days and intravitreal administration of vancomycin 1 mg and ceftazidime 2.25 mg at the end of the operation. On day 2-3, all patients underwent additional intravitreal administration of antibiotics, depending on the detected pathogen. Further, in 22 patients, the removal of perfluorodecalin and the remaining preretinal and peripherally located exudate was performed, in 13 patients - tamponade of the vitreal cavity with silicone oil. Results. As a result of the treatment according to the developed method, it was possible to preserve visual functions in 32 patients (91%) out of 35. At discharge, the corrected visual acuity was from 0.1 to 0.7 (0.28±0.2). After 6 months, the corrected visual acuity in 32 patients was from 0.1 to 0.9 (0.36±0.2). Visual acuity (above 0.3) was achieved in 26 cases (74.3%). Conclusion. Clinical results demonstrate the effectiveness of the developed method of surgical treatment of endophthalmitis. Key words: postoperative endophthalmitis, perfluorodecalin, intravitreal administration of vancomycin and ceftazidime.

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The world pandemic of diabetes

Oxford Textbook of Endocrinology and Diabetes ◽

10.1093/med/9780199235292.003.1395 ◽

2011 ◽

pp. 1795-1799

Author(s):

Nigel Unwin

Keyword(s):

Risk Factors ◽

Type 2 Diabetes ◽

Type 1 Diabetes ◽

Geographical Area ◽

Age Groups ◽

The World ◽

Level Of Economic Development ◽

Increasing Trends

A pandemic refers to a disease that is rapidly increasing in frequency across many populations, over a wide geographical area (1). Put another way, it refers to the situation in which epidemics of the disease are occurring simultaneously in many countries. This is the case for diabetes, which has the dubious distinction of being one of the few chronic non-communicable diseases known to be increasing in all countries from which data are available, irrespective of the level of economic development (2). This is mirrored by a pandemic of people who are overweight or obese (3), the major risk factors for type 2 diabetes. This chapter focuses on diabetes in adults (aged 20 years old and above), of which 85% to more than 95%, depending on the population, have type 2 diabetes (2, 4), which is thus the main contributor to the growing burden of diabetes. However, it is worth noting that, in children (<15 years old), the incidence of type 1 diabetes is also increasing, particularly in the youngest age groups, across the vast majority of countries from which good data are available (5). The reasons for this increase are unclear, although various environmental risk factors have been implicated (5). This chapter aims to do the following: ◆ provide an overview of the prevalence and trends in diabetes in adults across the world and its contribution to mortality ◆ describe the broad determinants that underlie the increasing trends in diabetes in adults ◆ provide an introduction to variations by ethnicity in the prevalence of type 2 diabetes

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Prevalence, morbidity and mortality of hypertriglyceridemic acute pancreatitis in the General Hospital of Playa del Carmen, México. Analysis of five years

10.36811/ijcgh.2019.110001 ◽

2019 ◽

pp. 01-06

Author(s):

Argel de Jesús Concha May ◽

Guillermo Padrón Arredondo

Keyword(s):

Diabetes Mellitus ◽

Acute Pancreatitis ◽

Age Groups ◽

Morbidity And Mortality ◽

Cross Sectional ◽

History Of ◽

Hospital Stays ◽

Clinical Conditions

Introduction: Hypertriglyceridemia (HTG) is the underlying cause of pancreatitis in 7% of the general population and is the third cause after gallstones and alcohol. HTG may be associated with acute pancreatitis as an epiphenomenon or as a precipitant thereof. Generally, more than 75% of pancreatitis induced by hypertriglyceridemia is due to secondary causes and although these are not sufficient to elevate triglycerides to cause pancreatitis, a preexisting defect is required to obtain a TG>1000 mg/dL to induce acute pancreatitis. Material and Method: To identify the prevalence morbidity and mortality of acute pancreatitis due to hypertriglyceridemia, a retrospective and cross-sectional observational clinical study was performed for a period of five years. Results: During the study period, 100 cases of acute pancreatitis of various etiologies were collected, 29 (29%) of which corresponded to acute pancreatitis of hypertriglyceridemic origin; history of risk: type 1 Diabetes mellitus one case (3.4%); Type 2 Diabetes mellitus 27 cases (24%); history of alcoholism nine cases (31%); positive smoking 4 cases (13.8%); hypertriglyceridemia 27 cases (94%); obesity 17 cases (59%); lipemic serum 19 cases (65.5%), and In-hospital stays average six days. Mortality in one case. Discussion: In the Mexican national survey of ENASUT 2012, it was found by age group that hypercholesterolemia is highest in the age groups of 50-69 years of age. (Table 1) The frequency of hyperlipidemia in patients with pancreatitis ranges from 12 to 38%, and of hypertriglyceridemia, between 4 and 53%; what is important is to define whether its presence is primary or causal, or secondary or consequence of other clinical conditions such as Diabetes mellitus, alcohol abuse, pregnancy or use of medications. The triglycerides were obtained on routine laboratory tests in our hospital and their values were steadily elevated and the hipertrigliceridemic acute pancreatitis is the principal cause instead the alcoholic acute pancreatitis. Keywords: Pancreatitis acute;Hypertriglyceridemic; Prevalence; Morbidity; Mortality

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Trends in Glycemic among Youth with Diabetes: The SEARCH for Diabetes in Youth Study

10.2337/figshare.17052590.v1 ◽

2022 ◽

Author(s):

Faisal S. Malik ◽

Katherine A. Sauder ◽

Scott Isom ◽

Beth A. Reboussin ◽

Dana Dabelea ◽

...

Keyword(s):

Type 2 Diabetes ◽

Type 1 Diabetes ◽

Glycemic Control ◽

Household Income ◽

Age Groups ◽

Race Ethnicity ◽

Youth Study ◽

Diabetes In Youth

OBJECTIVES: To describe temporal trends and correlates of glycemic control in youth and young adults (YYA) with youth-onset diabetes. RESEARCH DESIGN AND METHODS: The study included 6,492 participants with type 1 or type 2 diabetes from the SEARCH for Diabetes in Youth study. Participant visit data were categorized into time periods 2002-2007, 2008-2013 and 2014-2019, diabetes durations of 1-4, 5-9, and 10+ years, and age groups 1-9, 10-14, 15-19, 20-24, 25+ years. Participants contributed one randomly selected data point to each duration and age group per time period. Multivariable regression models were used to test differences in hemoglobin A1c (HbA1c) over time by diabetes type. Models were adjusted for site, age, sex, race/ethnicity, household income, health insurance status, insulin regimen and diabetes duration, overall and stratified for each duration and age group. RESULTS: Adjusted mean HbA1c for the 2014-2019 cohort of YYA with type 1 diabetes was 8.8%±0.04%. YYA with type 1 diabetes in the 10-14, 15-19, and 20-24 age groups from the 2014-2019 cohort had worse glycemic control than the 2002-2007 cohort. Race/ethnicity, household income and treatment regimen predicted differences in glycemic control in 2014-2019 type 1 diabetes participants. Adjusted mean HbA1c was 8.6%±0.12% for 2014-2019 YYA with type 2 diabetes. Participants age 25+ with type 2 diabetes had worse glycemic control relative to the 2008-2013 cohort. Only treatment regimen was associated with differences in glycemic control in type 2 diabetes participants. CONCLUSIONS: Despite advances in diabetes technologies, medications, and dissemination of more aggressive glycemic targets, many current YYA are less likely to achieve desired glycemic control relative to earlier cohorts.

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Mechanisms of Diabetic Complications

Physiological Reviews ◽

10.1152/physrev.00045.2011 ◽

2013 ◽

Vol 93 (1) ◽

pp. 137-188 ◽

Cited By ~ 949

Author(s):

Josephine M. Forbes ◽

Mark E. Cooper

Keyword(s):

Diabetic Complications ◽

Filtration Rate ◽

Microvascular Complications ◽

Disease Process ◽

Underlying Disease ◽

Heart Attacks ◽

Current Therapies ◽

Per Se

It is increasingly apparent that not only is a cure for the current worldwide diabetes epidemic required, but also for its major complications, affecting both small and large blood vessels. These complications occur in the majority of individuals with both type 1 and type 2 diabetes. Among the most prevalent microvascular complications are kidney disease, blindness, and amputations, with current therapies only slowing disease progression. Impaired kidney function, exhibited as a reduced glomerular filtration rate, is also a major risk factor for macrovascular complications, such as heart attacks and strokes. There have been a large number of new therapies tested in clinical trials for diabetic complications, with, in general, rather disappointing results. Indeed, it remains to be fully defined as to which pathways in diabetic complications are essentially protective rather than pathological, in terms of their effects on the underlying disease process. Furthermore, seemingly independent pathways are also showing significant interactions with each other to exacerbate pathology. Interestingly, some of these pathways may not only play key roles in complications but also in the development of diabetes per se. This review aims to comprehensively discuss the well validated, as well as putative mechanisms involved in the development of diabetic complications. In addition, new fields of research, which warrant further investigation as potential therapeutic targets of the future, will be highlighted.

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Releasing factors of diabetes mellitus

Journal of Medical Research and Health Sciences ◽

10.15520/jmrhs.v6i7.209 ◽

2020 ◽

Vol 6 (7) ◽

Author(s):

Collinlaw Joseph NDOUYANG ◽

Wague RIDINE ◽

Kebzabo Ruth YADANG ◽

Manta RITOÏNGUE

Keyword(s):

Clinical Laboratory ◽

Age Groups ◽

Economic Reason ◽

Long Period ◽

Social Reason ◽

Staple Foods ◽

Releasing Factors ◽

Ranking Order

In order to establish a link between staple foods and prevalence of diabetes in populations, a preliminary survey aiming at diabetes frequencies has been executed with 16 diabetics. Glycaemia was evaluated in clinical laboratory and survey slip was used to collect information from patients. Results were analyzed at a threshold a = 0.05 with XLSTAT. Frequencies of higher glycaemia in diabetics for staple food were found in this ranking order: rice > sorghum > wheat > maize > millet > others. Such foods were eaten during a long period before diabetes symptoms. Patients of 36-40 years old were numerous in proportion (31.25%). Others cases of age groups go from 0.0% to 6.25% frequencies. Type 1 diabetes is found in sedentary persons and sellers with positive and significant correlation with glycaemia over 1.25 g/L (r =0.785-0.850) because of consummation of sorghum (r = 0.755) and wheat (r = 0.674) for social reason (r = 0.738). Type 2 diabetes is linked to economic reason (r = 0.688). Only cultivators have glycaemia between 1 g/L and 1.25 g/L. Contrary, sedentary, salaried and seller people showed glycaemia over 1.25 g/L. Consequently, significant correlations indicate wheat (r =0.851), rice (r = 0.815), sorghum (r = 0.753), maize (r = 0.655) and tea (r = 0.646); all are correlated social reasons (r = 0.825). Thus, many factors especially foods and life system contribute in releasing diabetes.

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Trends in Glycemic Control Among Youth and Young Adults With Diabetes: The SEARCH for Diabetes in Youth Study

Diabetes Care ◽

10.2337/dc21-0507 ◽

2022 ◽

Author(s):

Faisal S. Malik ◽

Katherine A. Sauder ◽

Scott Isom ◽

Beth A. Reboussin ◽

Dana Dabelea ◽

...

Keyword(s):

Type 2 Diabetes ◽

Type 1 Diabetes ◽

Glycemic Control ◽

Age Groups ◽

Youth And Young Adults ◽

Race Ethnicity ◽

Youth Study ◽

Diabetes In Youth

OBJECTIVES To describe temporal trends and correlates of glycemic control in youth and young adults (YYA) with youth-onset diabetes. RESEARCH DESIGN AND METHODS The study included 6,369 participants with type 1 or type 2 diabetes from the SEARCH for Diabetes in Youth study. Participant visit data were categorized into time periods of 2002–2007, 2008–2013, and 2014–2019, diabetes durations of 1–4, 5–9, and ≥10 years, and age groups of 1–9, 10–14, 15–19, 20–24, and ≥25 years. Participants contributed one randomly selected data point to each duration and age group per time period. Multivariable regression models were used to test differences in hemoglobin A1c (HbA1c) over time by diabetes type. Models were adjusted for site, age, sex, race/ethnicity, household income, health insurance status, insulin regimen, and diabetes duration, overall and stratified for each diabetes duration and age group. RESULTS Adjusted mean HbA1c for the 2014–2019 cohort of YYA with type 1 diabetes was 8.8 ± 0.04%. YYA with type 1 diabetes in the 10–14-, 15–19-, and 20–24-year-old age groups from the 2014–2019 cohort had worse glycemic control than the 2002–2007 cohort. Race/ethnicity, household income, and treatment regimen predicted differences in glycemic control in participants with type 1 diabetes from the 2014–2019 cohort. Adjusted mean HbA1c was 8.6 ± 0.12% for 2014–2019 YYA with type 2 diabetes. Participants aged ≥25 years with type 2 diabetes had worse glycemic control relative to the 2008–2013 cohort. Only treatment regimen was associated with differences in glycemic control in participants with type 2 diabetes. CONCLUSIONS Despite advances in diabetes technologies, medications, and dissemination of more aggressive glycemic targets, many current YYA are less likely to achieve desired glycemic control relative to earlier cohorts.

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DEVELOPMENT, PERSISTENCE, AND SIGNIFICANCE OF TYPE 2, POLIOMYELITIS COMPLEMENT-FIXING ANTIBODY IN MAN

Journal of Experimental Medicine ◽

10.1084/jem.96.1.35 ◽

1952 ◽

Vol 96 (1) ◽

pp. 35-53 ◽

Cited By ~ 12

Author(s):

Jordi Casals ◽

Peter K. Olitsky ◽

Albert B. Sabin

Keyword(s):

Complement Fixation ◽

Age Groups ◽

Neutralizing Antibody ◽

Paralytic Poliomyelitis ◽

Newborn Mice ◽

History Of ◽

Almost All ◽

Type 3

Sera from 81 patients with a diagnosis of paralytic or non-paralytic poliomyelitis, and from 159 individuals of similar age groups giving no history of the disease, were tested with a high titered, complement-fixing poliomyelitis antigen of Type 2 (Lansing-like). The antigen consisted of brain tissue from newborn mice injected with the MEF1 strain of virus as previously adapted to these animals. The presence or absence of Type 2 neutralizing antibody in the sera under test was found not to affect the complement fixation. Positive reactions were obtained with 57 per cent of the sera deriving from non-paralytic patients and in 70 per cent from paralytics, when the specimens were tested at a dilution of 1:16. The complement-fixing antibody was often present in highest titer as early as 24 hours after the onset of poliomyelitis, and in almost all instances within 7 days. In about half of the patients a 4-fold or greater drop in titer occurred within 3 months, with little or no change in the others. The incidence of titers of 1:16 or higher with the control sera varied with the season of the year at which they were procured, 3 per cent of the winter samples proving positive and 13 per cent of the summer. The tests of sera from the group of patients from whom poliomyelitis virus was recovered, disclosed no significant differences between those having the paralytic and those having the non-paralytic disease. Type 1 (Brunhilde-like) strains of virus were recovered from many of the patients yielding positive tests, although they presented no evidence of previous or concurrent infection with Type 2 virus. This finding shows that Type 1 virus can give rise in patients to Type 2 complement-fixing antibody. The application of these data to the serologic diagnosis of poliomyelitis infection in man will of necessity be limited until information is obtained on the development, persistence, and significance of complement-fixation reactions with antigens deriving from Type 1 and Type 3 poliomyelitis strains.

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Palaeozoic stromatoporoid diagenesis: a synthesis

Facies ◽

10.1007/s10347-021-00628-x ◽

2021 ◽

Vol 67 (3) ◽

Cited By ~ 1

Author(s):

Stephen Kershaw ◽

Axel Munnecke ◽

Emilia Jarochowska ◽

Graham Young

Keyword(s):

Sediment Surface ◽

Pore Waters ◽

Middle Ordovician ◽

Low Magnesium ◽

Magnesium Calcite ◽

Stage 1 ◽

Diagenetic History ◽

Pressure Dissolution

AbstractPalaeozoic stromatoporoids, throughout their 100-million + year history (Middle Ordovician to Late Devonian and rare Carboniferous), are better preserved than originally aragonite molluscs, but less well-preserved than low magnesium-calcite brachiopods, bryozoans, trilobites and corals. However, the original mineralogy of stromatoporoids remains unresolved, and details of their diagenesis are patchy. This study of approximately 2000 stromatoporoids and the literature recognises three diagenetic stages, applicable throughout their geological history. Timing of processes may vary in and between stages; some components are not always present. Stage 1, on or just below sediment surface, comprises the following: micrite filling of upper gallery space after death, then filling of any remaining space by non-ferroan then ferroan calcite in decreasing oxygen of pore-waters; partial lithification of associated sediment from which stromatoporoids may be exhumed and redeposited, evidence of general early lithification of middle Palaeozoic shallow-marine carbonates; microdolomite formation, with the Mg interpreted to have been derived from original high-Mg calcite (HMC) mineralogy (likely overlaps Stage 2). Stage 2, short distance below sediment surface, comprising the following: fabric-retentive recrystallisation (FRR) of stromatoporoid skeletons forming fabric-retentive irregular calcite (FRIC), mostly orientated normal to growth layers, best seen in cross-polarised light. FRIC stops at stromatoporoid margins in contact with sediment and bioclasts. FRIC geometry varies, indicating some taxonomic control. Evidence that FRIC formed early in diagenetic history includes syntaxial continuation of FRIC into some sub-stromatoporoid cavities (Type 1 cement), although others were pre-occupied by early cement fills (Type 2 cement) formed before FRR, preventing syntaxial continuation of FRIC into cavities. Likely contemporaneous with FRIC formation, stromatoporoids in argillaceous micrites drew carbonate from adjacent sediment during reorganisation of argillaceous micrite into limestone–marl rhythms that are also early diagenetic. Stage 3, largely shallow burial, comprises the following: dissolution and silicification, but these may have occurred earlier in stromatoporoid diagenetic histories (more data required); burial pressure dissolution forming stylolites.

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