scholarly journals Validation of the Use of Region of Interest (ROI) Measurements for Objective Assessment of Post-Contrast Enhancement of Renal Lesions on Magnetic Resonance Imaging (MRI)

2019 ◽  
Author(s):  
Ishaq Sulaiman Al Salmi ◽  
Joshua Mark Halperin ◽  
Faten Al-Douri ◽  
Vincent Leung ◽  
Michael Patlas ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Enhancement ◽  
Objective Assessment ◽  
Region Of Interest ◽  
Resonance Imaging ◽  
Post Contrast ◽  
Renal Lesions ◽  
Magnetic Resonance Imaging Mri

scholarly journals NIMG-33. CHANGES IN MAGNETIC RESONANCE IMAGING AFTER PROTON BOOST THERAPY FOR GLIOBLASTOMA WITH AND WITHOUT TUMOR TREATING FIELDS THERAPY

2020 ◽  
Vol 22 (Supplement_2) ◽  
pp. ii155-ii155
Author(s):  
Hanna Goett ◽  
Alexandra Jensen ◽  
Tobias Struffert ◽  
Eberhard Uhl ◽  
Marco Stein
Keyword(s):  
Magnetic Resonance Imaging ◽  
Radiation Therapy ◽  
Magnetic Resonance ◽  
Contrast Enhancement ◽  
Median Overall Survival ◽  
Progressive Disease ◽  
Tumor Resection ◽  
Resonance Imaging ◽  
Tumor Treating Fields ◽  
Magnetic Resonance Imaging Mri

Abstract BACKGROUND Tumor treating fields (TTFields) are an approved glioblastoma (GBM) treatment modality that demonstrated a significant improved median overall survival in newly diagnosed GBM patients. Data about morphologic changes in serial magnetic resonance imaging (MRI) for patients with a combination therapy of TTFields and proton boost therapy does not exist. METHODS Twenty-two patients were included in this study. All patients were treated with initial tumor resection followed by combined chemo- and radiation therapy. Radiation therapy was performed with 50.0 Gy photons and a proton boost with 10 Gy equivalent (Gy(RBE)). 11 patients were additionally treated with TTFields. RESULTS A new increase in contrast enhancement and/or a progress in the T2 FLAIR hyperintensity was observed in 54.5% (N=12) at 3 months and in 31.8% (N=7) at 6 months. No differences were observed between patients with and without TTFields therapy at 3 months [63.6% (N=7) vs. 45.5% (N=5); P=0.392] and at 6 months [27.3 (N=3) vs. 36.3% (N=4); P=0.647). By the RANO criteria a progressive disease (PD) was observed in 6 patients (27.3%) at 3 months and in 7 patients (31.8%) at 6 months. Pseudoprogression (PP) was observed in in 36.4% (N=8) at months and in 27.3% (N=6) at 6 months. Neither for PD at 3 months [36.4% (N=4) vs. 18.2% (N=2); P=0.338] or at 6 months [36.4% (N=4) vs. 27.3% (N=3); P=0.647), nor for PP at 3 months [45.5% (N=5) vs. 27.2% (N=3); P=0.375] or at 6 months [18.2% (N=2) vs. 36.4% (N=4); P=0.338] differences for patients with and without TTFields therapy were found. CONCLUSION Increased contrast enhancement and/or increased T2 FLAIR MRI hyperintensity after proton boost therapy are common. Furthermore, the rates for new contrast enhancement, PD, and PP after photon therapy with and without additional TTFields therapy are comparable.

scholarly journals Correlative Magnetic Resonance Imaging and Histopathology in Small Ruminant Listeria Rhombencephalitis

2020 ◽  
Vol 11 ◽  
Author(s):  
Christina Precht ◽  
Peter Vermathen ◽  
Diana Henke ◽  
Anne Staudacher ◽  
Josiane Lauper ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Enhancement ◽  
Signal Intensity ◽  
Small Ruminants ◽  
Large Animal ◽  
Resonance Imaging ◽  
Post Contrast ◽  
Mri Features ◽  
Inflammatory Infiltrates

Background: Listeria rhombencephalitis, infection of the brainstem with Listeria monocytogenes, occurs mainly in humans and farmed ruminants and is associated with high fatality rates. Small ruminants (goats and sheep) are a large animal model due to neuropathological similarities. The purpose of this study was to define magnetic resonance imaging (MRI) features of listeria rhombencephalitis in naturally infected small ruminants and correlate them with histopathology. Secondly, the purpose of this study was to compare the results with MRI findings reported in humans.Methods: Twenty small ruminants (13 sheep and 7 goats) with listeria rhombencephalitis were prospectively enrolled and underwent in vivo MRI of the brain, including T2-weighted, fluid attenuation inversion recovery, and T1-weighted sequences pre- and post-contrast administration and postmortem histopathology. In MRI, lesions were characterized by location, extent, border definition, signal intensity, and contrast enhancement. In histopathology, the location, cell type, severity, and chronicity of inflammatory infiltrates and signs of vascular damage were recorded. In addition, histopathologic slides were matched to MRIs, and histopathologic and MRI features were compared.Results: Asymmetric T2-hyperintense lesions in the brainstem were observed in all animals and corresponded to the location and pattern of inflammatory infiltrates in histopathology. Contrast enhancement in the brainstem was observed in 10 animals and was associated with vessel wall damage and perivascular fibrin accumulation in 8 of 10 animals. MRI underestimated the extension into rostral brain parts and the involvement of trigeminal ganglia and meninges.Conclusion: Asymmetric T2-hyperintense lesions in the brainstem with or without contrast enhancement can be established as criteria for the diagnosis of listeria rhombencephalitis in small ruminants. Brainstem lesions were similar to human listeria rhombencephalitis in terms of signal intensity and location. Different from humans, contrast enhancement was a rare finding, and abscessation was not observed.

Endocrine ophthalmopathy

2019 ◽  
Vol 44 (2) ◽  
pp. 22-27
Author(s):  
T. L. Pavlova ◽  
G. A. Kotova ◽  
G. A. Gerasimov
Keyword(s):  
Magnetic Resonance Imaging ◽  
Computed Tomography ◽  
Magnetic Resonance ◽  
Objective Assessment ◽  
The State ◽  
Resonance Imaging ◽  
Treatment Methods ◽  
Ultrasound Computed Tomography ◽  
Endocrine Ophthalmopathy ◽  
Magnetic Resonance Imaging Mri

The urgency of the problem of endocrine ophthalmopathy (EOP) is currently in no doubt. This is due to the fact that relatively recently methods of objective assessment of the state of the eyeball and orbital tissues using ultrasound (ultrasound), computed tomography (CT) and magnetic resonance imaging (MRI) have appeared. At the same time, the etiology and pathogenesis of EOP are not well understood, which undoubtedly affects the validity and effectiveness of various treatment methods.

scholarly journals Magnetic Nanoparticles Supporting Bio-responsive T1/T2 Magnetic Resonance Imaging

Materials ◽  
2019 ◽  
Vol 12 (24) ◽  
pp. 4096 ◽  
Author(s):  
Connor M. Ellis ◽  
Juan Pellico ◽  
Jason J. Davis
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Nanoparticles ◽  
Magnetic Resonance ◽  
Region Of Interest ◽  
Response To Treatment ◽  
Resonance Imaging ◽  
Non Invasive ◽  
Magnetic Resonance Imaging Mri ◽  
Diagnostic Capabilities ◽  
Nanoparticulate Systems

The use of nanoparticulate systems as contrast agents for magnetic resonance imaging (MRI) is well-established and known to facilitate an enhanced image sensitivity within scans of a particular pathological region of interest. Such a capability can enable both a non-invasive diagnosis and the monitoring of disease progression/response to treatment. In this review, magnetic nanoparticles that exhibit a bio-responsive MR relaxivity are discussed, with pH-, enzyme-, biomolecular-, and protein-responsive systems considered. The ability of a contrast agent to respond to a biological stimulus provides not only enriched diagnostic capabilities over corresponding non-responsive analogues, but also an improved longitudinal monitoring of specific physiological conditions.

Uterine fibroid embolization can still be improved: observations on post-procedure magnetic resonance imaging

2005 ◽  
Vol 46 (5) ◽  
pp. 547-553 ◽  
Author(s):  
E. J. Dorenberg ◽  
Z. Novakovic ◽  
H.-J. Smith ◽  
G. Hafsahl ◽  
J. Å. Jakobsen
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Enhancement ◽  
Uterine Fibroid ◽  
Uterine Fibroids ◽  
Resonance Imaging ◽  
Post Contrast ◽  
Uterine Fibroid Embolization ◽  
Uterine Arteries ◽  
Uterine Volume

Purpose: To evaluate the efficacy and completeness of uterine fibroid embolization (UFE) measured by changes in volume and signal intensity at magnetic resonance imaging (MRI), and to compare with clinical outcome. Material and Methods: 40 women with symptomatic uterine fibroids underwent bilateral uterine artery embolization. At MRI studies, including post-contrast sequences before and repeatedly after treatment, the uterus and dominant fibroids were evaluated for volume, location, and contrast enhancement. Prior to treatment, all myomas showed significant contrast enhancement. The mean uterine volume was 929 ml. Clinical examinations with emphasis on menorrhagia, pelvic pain, and urinary dysfunction were performed before and 6 and 12 months after treatment. Results: UFE was bilaterally successful in 38 patients. After UFE, MRI showed no enhancement of myomas in 30 patients. In 8 patients, post-procedural MRI revealed partially remaining vascularization of fibroids despite angiographically complete embolization of the uterine arteries. On average, uterine volume decreased by 46.2% at 12 months. There was significant improvement of symptoms in the majority of patients, but slightly less improvement in patients with partially remaining vascularization of myomas. Conclusion: UFE causes significant volume reduction of myomas and clinical improvement. MRI can reveal remaining vascularization in myomas despite angiographically complete embolization of uterine arteries.

scholarly journals Adrenal radiology diagnostics – modern review

2021 ◽  
Vol 25 (2) ◽  
pp. 21-41
Author(s):  
A. V. Arablinskiy ◽  
V. D. Rumer
Keyword(s):  
Magnetic Resonance Imaging ◽  
Computed Tomography ◽  
Magnetic Resonance ◽  
Contrast Enhancement ◽  
Diagnostic Methods ◽  
Resonance Imaging ◽  
Fundamental Knowledge ◽  
Different Types ◽  
Magnetic Resonance Imaging Mri ◽  
Clinical Cases

In this article we would like to discuss the issues of adrenal pathology and its diagnostics. This is a complex review according to modern sources, fundamental knowledge and author’s experience. All clinical cases are original and morphologically verified. There are different types of classifications with different features, showed in this article. The most useful diagnostic methods are computed tomography (CT) and magnetic resonance imaging (MRI) with special contrast enhancement protocols, described in article.

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