Evaluating the “Darkness” of Melanin Materials.

Area Under The Curve ◽

Physical Property ◽

Reaction Conditions ◽

Exponential Equation ◽

Protective Properties ◽

Uv Protective Properties ◽

The Impact ◽

Mathematical Process

<p>We developed a mathematical process to quantify the apparent darkness of solutions containing melanin-like materials. The visible portion of their UV-Vis spectra is model using an exponential equation. Linear regression analysis provides the constants that define this exponential equation. Using these constants, the exponential equation is integrated between 400nm to 900nm to obtain the area-under-the-curve (AUC) of the visible portion of the UV-Vis spectra. This process was applied to data collected from various melanin-like materials discussed in earlier reports. By comparing the AUC values of different samples one can readily compare the “darkness” of melanins and evaluate the impact varying reaction conditions may have on this physical property. We revisited the results of earlier reports and discuss additional points related to the UV-protective properties attributed to melanins.</p>

Evaluating the “Darkness” of Melanin Materials.

10.26434/chemrxiv.12762179.v1 ◽

2020 ◽

Author(s):

Koen Vercruysse

Keyword(s):

Regression Analysis ◽

Area Under The Curve ◽

Physical Property ◽

Reaction Conditions ◽

Exponential Equation ◽

Protective Properties ◽

Uv Protective Properties ◽

The Impact ◽

Mathematical Process

Pengungkapan Corporate Social Responsibility (CSR) dan Kinerja Keuangan Perusahaan dengan Pengungkapan Anti Korupsi sebagai Variabel Moderasi

Akmenika: Jurnal Akuntansi dan Manajemen ◽

10.31316/akmenika.v16i2.393 ◽

2019 ◽

Vol 13 (2) ◽

Author(s):

Arief Hidayatullah Khamainy ◽

Dessy Novitasari Laras Asih

Keyword(s):

Regression Analysis ◽

Financial Performance ◽

Stock Exchange ◽

Sampling Technique ◽

Analysis Technique ◽

Study Population ◽

Csr Disclosure ◽

Corporate Social ◽

The research was carried out to find the influence of training material and methods of training toward workability. The study was conducted respectively from an employee of PD BPR Bantul Yogyakarta. The purpose of this research is expected to be useful for stakeholders in seeing CSR disclosure in the company in testing and analyzing its effect on the company's financial performance and with the presence of anti-corruption exposure, whether it will strengthen the impact of CSR disclosure on the company's financial performance. The study population in this study were all mining companies registered on the Indonesia Stock Exchange in 2016-2018 with a total of 63 companies. The research sample was taken using a random sampling technique that was calculated by the Slovin formula so that 54 samples were obtained for analysis. Linear Regression Analysis and Moderation Regression Analysis were chosen as the analysis technique used in this study. The results show that CSR disclosure does not affect the company's financial performance, and anti-corruption disclosure does not affect the relationship between the two.

THU0433 TREATMENT WITH PEGLOTICASE IMPROVES HEPATIC FIBROSIS ESTIMATED BY FIBROSIS-4 INDEX IN SUBJECTS WITH CHRONIC REFRACTORY GOUT

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2020-eular.2360 ◽

2020 ◽

Vol 79 (Suppl 1) ◽

pp. 454.1-454

Author(s):

N. Schlesinger ◽

A. Yeo ◽

P. Lipsky

Keyword(s):

Liver Disease ◽

Linear Regression ◽

Rank Order ◽

Area Under The Curve ◽

Serum Urate ◽

Complete Analysis ◽

Alcoholic Fatty Liver ◽

Significant Difference ◽

Background:Hyperuricemia is associated with non-alcoholic fatty liver disease (NAFLD)1,2, but the relationship to fibrosis remains uncertain3. Moreover, it is not known whether lowering serum urate will affect the course of NAFLD. The availability of data from two randomized trials of pegloticase, a pegylated recombinant mammalian uricase, that profoundly decreases serum urate afforded the opportunity to test the hypothesis that lowering urate might improve NAFLD.Objectives:To determine whether treatment of chronic refractory gout patients with pegloticase was associated with improvement in NAFLD determined by Fibrosis 4 index (Fib4).Methods:Databases from patients with chronic refractory gout who participated in two randomized 6 month clinical trials (RCTs) of pegloticase were analyzed4. Sub-sets who had persistent urate lowering to levels <1 mg/dL in response to biweekly pegloticase (Responders, n=36) were compared to those who received placebo (n=43). Since liver biopsy information was not available on these subjects, we relied on Fib4, a validated non-invasive estimate of liver fibrosis in a variety of liver diseases5,6calculated from measurements of AST, ALT, platelet count and age (Age x AST/platelets x √ALT). A Fib4 value of 1.3 is an indication that further evaluation of liver disease is warranted.Results:At baseline, the mean Fib4 values were 1.40 ± 0.86 in pegloticase responders and 1.04 ± 0.53 in subjects receiving placebo. As shown in figure 1, subjects receiving placebo exhibited a change of 0.26 ± 0.41 in the Fib4 score over the six months of the RCTs compared with 0.13 ± 0.62 in the pegloticase responders (p=0.048; by linear regression). When only the subjects with a Fib4 value > 1.3 were considered, a significant difference in the change in the Fib4 values over the 6 months of the trial between pegloticase responders and those receiving placebo was also observed (-0.15 ± 0.67 vs 0.37 ± 0.42, p=0.004, by linear regression). The correlations between serum urate area under the curve (AUC) over the 6 months of the trial and the change in Fib4 value was rs=0.33, p=0.0.0004 (Spearman rank-order correlation coefficient). Finally, multiple linear regression analysis indicated serum urate AUC (as a surrogate measure for group) is the main contributor to the change in Fib4 (p=0.018 by linear regression).Conclusion:The data are consistent with the conclusion that persistent lowering of serum urate had a significant impact on Fib4 levels, implying a possible effect on the course of NAFLD. The results support a more complete analysis involving biopsy examination of the impact of urate on liver inflammation and fibrosis.References:[1]Yang C et al. PlosOne2017; 12:e0177249[2]Jaruvongvanich V et al. Eur J Gastroenterol Hepatol 2017; 29:1031[3]Jaruvongvanich V et al. Eur J Gastroenterol Hepatol 2017; 29:694[4]Sundy JS, et al. JAMA. 2011; 306 (7):711-20[5]Sterling RK et al. Hepatol 2006; 43:1317[6]Shah AG et al. Clin Gastroenterol Hepatol 2009;7:1104Disclosure of Interests: :Naomi Schlesinger Grant/research support from: Pfizer, Amgen, Consultant of: Novartis, Horizon Therapeutics, Selecta Biosciences, Olatec, IFM Therapeutics, Mallinckrodt Pharmaceuticals, Anthony Yeo Employee of: Horizon Therapeutics, Peter Lipsky Consultant of: Horizon Therapeutics

ANALISIS DAMPAK KEBERADAAN TOKO SWALAYAN TERHADAP OMZET PENJUALAN KIOS–KIOS KECIL DI KOTA MATARAM

JMM UNRAM - MASTER OF MANAGEMENT JOURNAL ◽

10.29303/jmm.v5i3.74 ◽

2016 ◽

Vol 5 (3) ◽

Author(s):

Basri Basri

Keyword(s):

Regression Analysis ◽

Linear Regression ◽

Product Diversification ◽

Sampling Techniques ◽

Study Guide ◽

Validity And Reliability ◽

The Impact ◽

Level 2

The objective of the study was to evaluate the impact of stores existence toward sales turnover of stalls in Mataram city. Associative research design was adopted as the study guide. Purposive sampling techniques were used in which 100 copies of the research instrument were administered to stalls owner in Mataram city, out of which 100 copies of questionnaire were filled and returned. Test of validity and reliability, classical assumption test, and multiple linear regression analysis was used to analyse the data generated from respondents. The findings revealed that stores existence variable consisted of services, product diversification, price, and comfortable of consumer have significant influence on sales turnover of stalls at 0,05 level (2-tailed). The result of the research shows the variables negatively affecting sales turnover of stalls. Furthermore, price ranks the first follow by comfortable, product diversification, and services. This research will help the owner of stalls to understand and recognize the ranking of variables affecting sales turnover of stalls in Mataram city. Keywords: Stores Existence, Stall, and Sales Turnover.

STUDI EMPIRIS TENTANG PENGAWASAN KERJA, PENGALAMAN KERJA, DAN KEMAMPUAN KERJA SERTA PENGARUHNYA TERHADAP MOTIVASI BERPRESTASI KARYAWAN

RELASI JURNAL EKONOMI ◽

10.31967/relasi.v18i1.526 ◽

2022 ◽

Vol 18 (1) ◽

pp. 80-100

Author(s):

Rahayu Mardikaningsih ◽

Samsul Arifin

Keyword(s):

Regression Analysis ◽

Linear Regression ◽

Achievement Motivation ◽

Work Experience ◽

Sampling Method ◽

Main Function ◽

Quantitative Studies ◽

The Impact ◽

Analytical Device

Human assets as one of the elements of manufacturing are the riding pressure of each organisation. They have a main function in understanding the organisation's goals. Companies ought to constantly inspire them to offer the excellent paintings effects in order that organisation sports aren't hampered consistent with their workload and responsibilities. Good paintings effects are primarily based totally at the lifestyles of a cause for fulfillment and there are numerous variables that have effect on this. This studies targets to research and decide the impact of labor supervision, paintings revel in, and paintings cappotential on fulfillment motivation. This quantitative studies takes the populace targeted on personnel who paintings withinside the manufacturing phase of a multinational organisation in Sidoarjo. Respondents on this observe have been a hundred and twenty respondents. The analytical device used, particularly SPSS model 25 program. The sampling method on this observe the usage of purposive sampling method. The analytical device used is more than one linear regression analysis. The effects confirmed that each one hypotheses have been demonstrated correct. Work supervision has a massive effective impact on fulfillment motivation. Work revel in and paintings cappotential even have a massive have effect on fulfillment motivation. The 3 of them offer a massive impact concurrently on fulfillment motivation. Keywords: job supervision, work experience, work ability, achievement motivation.

The Impact of Leadership, Motivation and Discipline on Employee Performance (a Study on Employees of PT Surabaya Marine)

KnE Social Sciences ◽

10.18502/kss.v5i5.8825 ◽

2021 ◽

Author(s):

Eva Trisnawati Chumairoh ◽

Trianggoro Wiradinata

Keyword(s):

Regression Analysis ◽

Data Analysis ◽

Linear Regression ◽

Multiple Linear Regression ◽

Employee Performance ◽

Independent Variables ◽

Leadership Motivation ◽

This purpose of this study was to determine the effect of leadership, motivation and discipline on employee performance. The independent variables were leadership (X1), motivation (X1) and discipline (X3). The dependent variable was employee performance (Y). This was explanatory research with a quantitative approach. The study was conducted at PT Surabaya Marine with employees. Data analysis was carried out through multiple linear regression analysis with the F test and t test. Employee performance was strongly influenced by leadership, motivation and discipline. Keywords: leadership, motivation, discipline, employee performance

Advances in Business Information Systems and Analytics - Adapting and Mitigating Environmental, Social, and Governance Risk in Business ◽

The Impact of Adopting CSR on the Firm's Overall Performance

10.4018/978-1-7998-6788-3.ch012 ◽

2021 ◽

pp. 239-255

Author(s):

Abdelmajid Ibenrissoul ◽

Khawla Bouraqqadi ◽

Souhaila Kammoun

Keyword(s):

Developing Countries ◽

Regression Analysis ◽

Social Dimensions ◽

The Social ◽

Managerial Implications ◽

Overall Performance ◽

The Impact ◽

The Relationship

The purpose of the chapter is to study what effect CSR has on firms' overall performance in a developing country context. While most of the previous empirical researches focused on the relationship between CSR and financial performance, the present study suggests exploring the impact of CSR on overall performance which encompasses economic, environmental, and social dimensions as well as stakeholders. The empirical study aims to analyze and measure the social and environmental involvement of large Moroccan firms operating in the main sectors of activity and located in different geographical areas. Using multiple linear regression analysis, the authors empirically test the impact of CSR on overall performance on a sample of 44 companies. The main findings reveal that CSR is a driver for improving image and reputation, enabling the firm to achieve overall corporate performance. On the basis of the main results, they set out some managerial implications and further directions for CSR research in developing countries.

An Investigation into the Spatial and Temporal Variability of the Meteorological Drought in Jordan

Climate ◽

10.3390/cli7060082 ◽

2019 ◽

Vol 7 (6) ◽

pp. 82 ◽

Cited By ~ 5

Author(s):

Haitham Aladaileh ◽

Mohammed Al Qinna ◽

Barta Karoly ◽

Emad Al-Karablieh ◽

János Rakonczai

Keyword(s):

Regression Analysis ◽

Hierarchical Clustering ◽

Meteorological Drought ◽

Kendall Test ◽

Spatial And Temporal Variability ◽

Drought Event ◽

Mann Kendall Test ◽

Following the impact of droughts witnessed during the last decade there is an urgent need to develop a drought management strategy, policy framework, and action plan for Jordan. This study aims to provide a historical baseline using the standardized precipitation index (SPI) and meteorological drought maps, and to investigate the spatial and temporal trends using long-term historical precipitation records. Specifically, this study is based on the statistical analysis of 38 years of monthly rainfall data, gathered from all 29 meteorological stations that cover Jordan. The Mann–Kendall test and linear regression analysis were used to uncover evidence of long-term trends in precipitation. Drought indices were used for calculating the meteorological SPI on an annual (SPI12), 6-months (SPI6), and 3-months basis (SPI3). At each level, every drought event was characterized according to its duration, interval, and intensity. Then, drought maps were generated using interpolation kriging to investigate the spatial extent of drought events, while drought patterns were temporally characterized using multilinear regression and spatial grouped using the hierarchical clustering technique. Both annual and monthly trend analyses and the Mann–Kendall test indicated significant reduction of precipitation in time for all weather stations except for Madaba. The rate of decrease is estimated at approximately 1.8 mm/year for the whole country. The spatial SPI krig maps that were generated suggest the presence of two drought types in the spatial dimension: Local and national. Local droughts reveal no actual observed trends or repeatable patterns of occurrence. However, looking at meteorological droughts across all time scales indicated that Jordan is facing an increasing number of local droughts. With a probability of occurrence of once every two years to three years. On the other hand, extreme national droughts occur once every 15 to 20 years and last for two or more consecutive years. Linear trends indicated significant increase in drought magnitude by time with a rate of 0.02 (p < 0.0001). Regression analysis indicated that draught in Jordan is time dependent (p < 0.001) rather than being spatially dependent (p > 0.99). Hierarchical clustering was able to group national draughts into three zones, namely the northern zone, the eastern zone, and the southern zone. This study highlights the urgent need for a monitoring program to investigate local and national drought impacts on all sectors, as well as the development of a set of proactive risk management measures and preparedness plans for various physiographic regions.

Serum Bilirubin Concentrations in Patients With Takayasu Arteritis

Archives of Pathology & Laboratory Medicine ◽

10.5858/arpa.2016-0362-oa ◽

2017 ◽

Vol 141 (6) ◽

pp. 846-850 ◽

Cited By ~ 3

Author(s):

You-Fan Peng ◽

Yi-Bin Deng

Keyword(s):

Regression Analysis ◽

Erythrocyte Sedimentation Rate ◽

Takayasu Arteritis ◽

Sedimentation Rate ◽

Serum Bilirubin ◽

Multiple Logistic Regression Analysis ◽

Area Under The Curve ◽

Prednisone Therapy ◽

Erythrocyte Sedimentation

Context.— Bilirubin has strong anti-inflammatory and antioxidative stress action. Progression of inflammation involving arteries is a crucial activator in pathogenesis of Takayasu arteritis (TA). Objective.— To investigate the relationship between serum bilirubin and TA. Design.— Our study involved 115 consecutive TA patients. Patients with active-phase disease were followed and received prednisone therapy. Results.— Lower concentrations of serum bilirubin were detected in TA patients compared with healthy subjects (0.6 ± 0.31 versus 0.7 ± 0.22 mg/dL, P = .02). Serum bilirubin concentrations in active TA patients were lower than those in inactive patients (0.5 ± 0.20 versus 0.8 ± 0.32 mg/dL, P < .001). In all patients with TA, serum bilirubin correlated positively with total protein (r = 0.193, P = .04) and negatively with C-reactive protein and erythrocyte sedimentation rate (r = −0.213, P = .03, and r = −0.532, P < .001, respectively). Multiple logistic regression analysis showed that each decrease of 1 mg/dL in serum bilirubin was associated with a 1.10 times increase in the odds for TA compared with the controls (odds ratio = 0.913, 95% CI, 0.856–0.974; P = .006). Serum bilirubin was correlated with erythrocyte sedimentation rate (β = −0.170, P < .001) in multiple linear regression analysis. The area under the curve for serum bilirubin in predicting active TA patients was 0.802. Serum bilirubin levels were found to be significantly increased after prednisone treatment (0.5 ± 0.20 versus 0.7 ± 0.15 mg/dL, P = .002). Conclusions.— Lower serum bilirubin levels are associated with TA, and serum bilirubin may be influenced by prednisone therapy in active TA patients. Serum bilirubin levels in TA patients correlate negatively with erythrocyte sedimentation rate.

Impact of Obesity on Voriconazole Pharmacokinetics among Pediatric Hematopoietic Cell Transplant Recipients

Antimicrobial Agents and Chemotherapy ◽

10.1128/aac.00653-20 ◽

2020 ◽

Vol 64 (12) ◽

Author(s):

Takuto Takahashi ◽

Angela R. Smith ◽

Pamala A. Jacobson ◽

James Fisher ◽

Nathan T. Rubin ◽

...

Keyword(s):

Area Under The Curve ◽

Therapeutic Index ◽

Future Research ◽

Cell Transplant ◽

Hematopoietic Cell Transplant ◽

Hematopoietic Stem ◽

Minimum Concentration ◽

ABSTRACT Voriconazole (VCZ) is an antifungal agent with wide inter- and intrapatient pharmacokinetic (PK) variability and narrow therapeutic index. Although obesity was associated with higher VCZ trough concentrations in adults, the impact of obesity had yet to be studied in children. We characterized the PK of VCZ in obese patients by accounting for age and CYP2C19 phenotype. We conducted intensive PK studies of VCZ and VCZ N-oxide metabolite in 44 hematopoietic stem cell transplantation (HSCT) recipients aged 2 to 21 years who received prophylactic intravenous VCZ every 12 hours (q12h). Blood samples were collected at 5 and 30 minutes; at 1, 3, 6, and 9 hours after infusion completion; and immediately before the next infusion start. We estimated PK parameters with noncompartmental analysis and evaluated for an association with obesity by multiple linear regression analysis. The 44 participants included 9 (20%) with obesity. CYP2C19 metabolism phenotypes were identified as normal in 22 (50%), poor/intermediate in 13 (30%), and rapid/ultrarapid in 9 patients (21%). Obesity status significantly affects the VCZ minimum concentration of drug in serum (Cmin) (higher by 1.4 mg/liter; 95% confidence interval [CI], 0.0 to 2.8; P = 0.047) and VCZ metabolism ratio (VCZRATIO) (higher by 0.4; 95% CI, 0.0 to 0.7; P = 0.03), while no association was observed with VCZ area under the curve (AUC) (P = 0.09) after adjusting for clinical factors. A younger age and a CYP2C19 phenotype were associated with lower VCZ AUC. Obesity was associated with decreased metabolism of VCZ to its inactive N-oxide metabolite and, concurrently, increased VCZ Cmin, which is deemed clinically meaningful. Future research should aim to further characterize its effects and determine a proper dosing regimen for the obese.