scholarly journals Implantation and Retrieval of Magnetic Nanobots for Treatment of Endodontic Re-Infection in Human Dentine

2021 ◽  
Author(s):  
Debayan Dasgupta ◽  
Shanmukh Srinivas Peddi ◽  
Deepak K. Saini ◽  
Ambarish Ghosh
Keyword(s):  
Root Canal ◽  
Treatment Method ◽  
Therapeutic Modality ◽  
Clinical Practices ◽  
Human Teeth ◽  
Dentinal Tubules ◽  
Current State ◽  
Human Dentine ◽  
New Treatment ◽  
Magnetic Drive

<div> <div> <div> <p>More than 10% of root canal treatments undergo failure worldwide due to remnant bacteria deep in the dentinal tubules located within the dentine tissue of human teeth. Owing to the complex and narrow geometry of the tubules, current techniques relying on passive diffusion of anti-bacterial agents are inadequate. Here, we present a new treatment method using actively maneuvered nanobots, which can be incorporated during standard root canal procedure. Our technique will enable dentists to execute procedures inside the dentine not yet possible by current state of the art. We demonstrate that magnetically driven nanobots can reach the depths of the tubules up to hundred times faster than current clinical practices. Subtle modifications of the magnetic drive allowed deep implantation of the nanobots isotopically distributed throughout the dentine, along with spatially controlled retrieval from selected areas. Finally, we demonstrate the integration of bactericidal therapeutic modality with the nanobots, thereby validating the tremendous potential of nanobots in dentistry, and nanomedicine in general. </p> </div> </div> </div>

scholarly journals Implantation and Retrieval of Magnetic Nanobots for Treatment of Endodontic Re-Infection in Human Dentine

2021 ◽  
Author(s):  
Debayan Dasgupta ◽  
Shanmukh Srinivas Peddi ◽  
Deepak K. Saini ◽  
Ambarish Ghosh
Keyword(s):  
Root Canal ◽  
Treatment Method ◽  
Therapeutic Modality ◽  
Clinical Practices ◽  
Human Teeth ◽  
Dentinal Tubules ◽  
Current State ◽  
Human Dentine ◽  
New Treatment ◽  
Magnetic Drive

<div> <div> <div> <p>More than 10% of root canal treatments undergo failure worldwide due to remnant bacteria deep in the dentinal tubules located within the dentine tissue of human teeth. Owing to the complex and narrow geometry of the tubules, current techniques relying on passive diffusion of anti-bacterial agents are inadequate. Here, we present a new treatment method using actively maneuvered nanobots, which can be incorporated during standard root canal procedure. Our technique will enable dentists to execute procedures inside the dentine not yet possible by current state of the art. We demonstrate that magnetically driven nanobots can reach the depths of the tubules up to hundred times faster than current clinical practices. Subtle modifications of the magnetic drive allowed deep implantation of the nanobots isotopically distributed throughout the dentine, along with spatially controlled retrieval from selected areas. Finally, we demonstrate the integration of bactericidal therapeutic modality with the nanobots, thereby validating the tremendous potential of nanobots in dentistry, and nanomedicine in general. </p> </div> </div> </div>

Cardioneuroablation as a method of therapy in vasovagal syncope

2020 ◽  
Vol 2 (55) ◽  
pp. 20-28
Author(s):  
Roman Piotrowski ◽  
Jakub Baran ◽  
Piotr Kułakowski
Keyword(s):  
Lifestyle Modification ◽  
Vasovagal Syncope ◽  
Treatment Method ◽  
Current Treatment ◽  
Loss Of Consciousness ◽  
Common Cause ◽  
Current State ◽  
Transient Loss ◽  
New Treatment

Vasovagal syncope is the most common cause of transient loss of consciousness, may significantly impair quality of life and lead to injury. Current treatment of vasovagal syncope is based on patient education, lifestyle modification, pharmacotherapy and, in extreme cases, implantation of a pacemaker. In recent years, more and more data on cardioneuroablation have been published – a new treatment method for neurally mediated asystolic syncope. This article summarizes the current state of knowledge about this method, presents indications for this procedure and shows perspectives for its development.

scholarly journals Physiotherapeutic methods of processing root channels with application of light exposure in dentistry

2020 ◽  
Vol 18 (3) ◽  
pp. 10-14
Author(s):  
A. V. Larinskaya ◽  
A. V. Yurkevich ◽  
I. D. Ushnitsky ◽  
V. F. Mikhalchenko ◽  
A. V. Mikhalchenko ◽  
...  
Keyword(s):  
Root Canal ◽  
Beam Energy ◽  
Laser Light ◽  
Light Exposure ◽  
Canal System ◽  
Human Teeth ◽  
Dentinal Tubules ◽  
Main Research ◽  
Root Canal System ◽  
And Diffusion

Aim. Substantiate the use of light exposure as physiotherapeutic methods of root canal treatment.Materials and methods. For the study, 93 human teeth were taken, all teeth were divided into 3 groups of 31 samples. Optical microscopy was used as the main research method.Results. The effect of laser radiation on biological structures depends on the wavelength of the energy emitted by the laser, the energy density of the beam, and the temporal characteristics of the beam energy. The processes that can occur in this case are reflection, absorption, scattering and transmission. The interaction of laser light and tissues occurs with optical proximity between them. This interaction is specific and selective, based on absorption and diffusion. The smaller the approach, the more light will be reflected or transmitted.Conclusions. Currently, in endodontics, diode lasers are the best systems for disinfecting the root canal system due to their ability to penetrate the dentinal tubules. The optical proximity of their wavelengths to bacteria leads to the destruction of the latter due to the photo-thermal effect.

Etching Treatment Effect on Surface Morphology of Dental Structures

2017 ◽  
Vol 68 (11) ◽  
pp. 2700-2703 ◽  
Author(s):  
Kamel Earar ◽  
Vasile Iulian Antoniac ◽  
Sorana Baciu ◽  
Simion Bran ◽  
Florin Onisor ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Surface Morphology ◽  
Phosphoric Acid ◽  
Human Teeth ◽  
Strong Bond ◽  
Force Microscopy ◽  
Atomic Force ◽  
Human Dentine ◽  
Dental Surface ◽  
Scanning Electron

This study examined and compared surface of human dentine after acidic etching with hydrogen peroxide, phosphoric acid liquid and gel. Surface demineralization of dentin is necessary for a strong bond of adhesive at dental surface. Split human teeth were used. After application of mentioned substances at dentin level measures of the contact angle and surface morphology were employed. Surface morphology was analyzed with the help of scanning electron microscopy and atomic force microscopy. Liquid phosphoric acid yielded highest demineralization showing better hydrophobicity than the rest, thus having more contact surface. Surface roughness are less evident and formed surface micropores of 4 �m remained open after wash and air dry providing better adhesive canalicular penetration and subsequent bond.

scholarly journals A narrative overview of utilizing biomaterials to recapitulate the salient regenerative features of dental-derived mesenchymal stem cells

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Sevda Pouraghaei Sevari ◽  
Sahar Ansari ◽  
Alireza Moshaverinia
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Tissue Regeneration ◽  
3D Structure ◽  
Three Dimensional ◽  
Scientific Data ◽  
Clinical Practices ◽  
Human Teeth ◽  
Innovative Strategies ◽  
Local Recruitment

AbstractTissue engineering approaches have emerged recently to circumvent many limitations associated with current clinical practices. This elegant approach utilizes a natural/synthetic biomaterial with optimized physiomechanical properties to serve as a vehicle for delivery of exogenous stem cells and bioactive factors or induce local recruitment of endogenous cells for in situ tissue regeneration. Inspired by the natural microenvironment, biomaterials could act as a biomimetic three-dimensional (3D) structure to help the cells establish their natural interactions. Such a strategy should not only employ a biocompatible biomaterial to induce new tissue formation but also benefit from an easily accessible and abundant source of stem cells with potent tissue regenerative potential. The human teeth and oral cavity harbor various populations of mesenchymal stem cells (MSCs) with self-renewing and multilineage differentiation capabilities. In the current review article, we seek to highlight recent progress and future opportunities in dental MSC-mediated therapeutic strategies for tissue regeneration using two possible approaches, cell transplantation and cell homing. Altogether, this paper develops a general picture of current innovative strategies to employ dental-derived MSCs combined with biomaterials and bioactive factors for regenerating the lost or defective tissues and offers information regarding the available scientific data and possible applications.

scholarly journals Debunking the Concept of Dentinal Tubule Penetration of Endodontic Sealers: Sealer Staining with Rhodamine B Fluorescent Dye Is an Inadequate Method

Materials ◽  
2021 ◽  
Vol 14 (12) ◽  
pp. 3211
Author(s):  
David Donnermeyer ◽  
Sina Schmidt ◽  
Arno Rohrbach ◽  
Johannes Berlandi ◽  
Sebastian Bürklein ◽  
...  
Keyword(s):  
Penetration Depth ◽  
Rhodamine B ◽  
Root Canal ◽  
Laser Scanning Microscopy ◽  
Confocal Laser ◽  
Dentinal Tubule ◽  
Dentinal Tubules ◽  
Ah Plus ◽  
Root Dentin ◽  
Rhodamine B Dye

The aim of this study was to investigate the suitability of rhodamine B dye staining of an epoxy resin sealer (AH Plus) and calcium-silicate-based sealers (Total Fill BC Sealer, BioRoot RCS) to represent the penetration depth of the sealers into dentinal tubules after root canal obturation. In a three-step process, (1) leaching of rhodamine B from sealers into a buffer solution, (2) passive penetration of leached rhodamine B into dentinal tubules, and (3) conformity of rhodamine B penetration assessed by confocal laser scanning microscopy (CLSM), and sealer penetration assessed by scanning electron microscopy (SEM), in root-canal-filled teeth, were evaluated. Rhodamine B dye massively leached out of Total Fill BC Sealer and BioRoot RCS into the phosphate-buffered saline (PBS). A pinkish coloration of AH Plus was found after contact with PBS. Leached rhodamine B dye passively penetrated dentinal tubules from all three sealers when placed on root dentin. No correlation was observed between sealer penetration in SEM and rhodamine B penetration in CLSM. Staining of sealers using rhodamine B is an inadequate method with which to evaluate sealer penetration depth into dentinal tubules, as it overestimates the penetration of sealers into root dentin tubules.

scholarly journals Development of A Nano-Apatite Based Composite Sealer for Endodontic Root Canal Filling

2021 ◽  
Vol 5 (1) ◽  
pp. 30
Author(s):  
Angelica Bertacci ◽  
Daniele Moro ◽  
Gianfranco Ulian ◽  
Giovanni Valdrè
Keyword(s):  
Citric Acid ◽  
Liquid Phase ◽  
Calcium Phosphate ◽  
Root Canal ◽  
Acid Attack ◽  
Root Canal Filling ◽  
Bioactive Materials ◽  
Dentinal Tubules ◽  
Sealing Capacity ◽  
Endodontic Sealers

Recently, endodontic sealers based on injectable bioactive materials were proposed to improve the filling of anatomical irregularities during root canal obturation. In this context, this preliminary work investigated the possibility of realizing a new calcium phosphate-based composite sealer for root canal filling with an optimized composition on setting kinetics and dentin tubules occlusion. Several calcium phosphate/liquid phase mixtures were initially evaluated for their workability, finding two suitable formulations. Both of them contained 66 wt.% of a nano-apatite-based cement (solid powdered phase). The liquid phase (34 wt.%) comprised 13.6% propanediol and 20.4% PEG 1000 (formulation 1), and formulation 2 comprised 27.2% glycerin and 6.8% PEG 200 (formulation 2). Then, these formulations were tested by means of permeability measurements and observation by scanning electron microscopy of treated model dentin samples. Both formulations succeeded in occluding dentinal tubules: the first one was able to create a full-bodied layer on dentin surface and, moreover, to resist, at least to a large extent, against citric acid attack. The second one showed a lower effectiveness after citric acid exposure. The composite compound that better satisfied the overall required characteristics of use, workability and sealing capacity was formulation 1.

scholarly journals Characteristics, Treatment, and Prognosis of Cracked Teeth: A Comparison with Data from 10 Years Ago

2021 ◽  
Author(s):  
Tae Yeon Lee ◽  
Sung Eun Yang ◽  
Hye Min Kim ◽  
Min Joo Kye
Keyword(s):  
Root Canal ◽  
Statistical Significance ◽  
Treatment Method ◽  
Root Canal Treatment ◽  
Periodontal Pocket ◽  
P Value ◽  
Chi Square ◽  
Pocket Depth ◽  
Persistent Symptoms ◽  
Probing Depth

Abstract Objectives The purpose of this study was to analyze and to compare retrospectively the characteristics, the treatment process, and the prognosis of cracked teeth by comparing recent data with data from 10 years ago. Materials and Methods Sixty-eight cracked teeth from March 2009 to June 2010 (2009 data) and 185 cracked teeth from March 2019 to June 2020 (2019 data) were analyzed. The characteristics of cracked teeth and the treatment method depending on probing depth, caries, and symptoms, and prognosis depending on pocket depth and apical lesions were analyzed using R version 3.3.3 (R Foundation for Statistical Computing, Vienna, Austria) and T&F version 3.0 (YooJin BioSoft, Korea). To compare proportions, the two-sample proportion test was performed. The distribution of proportions within the samples from 2009 and 2019 data was analyzed using the Chi-square test or binomial test. A p-value <0.05 was considered to indicate statistical significance. Results Significantly fewer cracked teeth received root canal treatment before crown in 2019 than in 2009 (p = 0.032). In both 2009 and 2019, symptomatic cracked teeth and those with deep periodontal pockets (>6 mm) were significantly more likely to receive root canal treatment. In both years, cracked teeth with a probing depth less than 6 mm or without an apical lesion were significantly more likely to be asymptomatic at 3-month and 6-month follow-ups (p < 0.001). Conclusion Cracked teeth with a deep periodontal pocket or symptoms had a higher likelihood of endodontic treatment, and the presence of a deep periodontal pocket or apical lesion was associated with a higher risk of persistent symptoms. Therefore, clinicians should consider these factors when planning treatment and predicting patients’ prognosis.

scholarly journals Pulp Revascularization of Immature Permanent Teeth: A Review of the Literature and a Proposal of a New Clinical Protocol

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Mélanie Namour ◽  
Stephanie Theys
Keyword(s):  
Treatment Method ◽  
Permanent Teeth ◽  
Clinical Protocol ◽  
Therapeutic Success ◽  
Immature Teeth ◽  
Triple Antibiotic Paste ◽  
New Treatment ◽  
Near Future ◽  
Pulp Revascularization ◽  
Stimulation Of

Tissue engineering is a growing field. In the near future, it will probably be possible to generate a complete vital tooth from a single stem cell. Pulp revascularization is dependent on the ability of residual pulp and apical and periodontal stem cells to differentiate. These cells have the ability to generate a highly vascularized and a conjunctive rich living tissue. This one is able to colonize the available pulp space. Revascularization is a new treatment method for immature necrotic permanent teeth. Up to now, apexification procedures were applied for these teeth, using calcium dihydroxide or MTA to produce an artificial apical barrier. However, the pulp revascularization allows the stimulation of the apical development and the root maturation of immature teeth. Two pulp revascularization techniques are used in the literature, one using calcium dihydroxide and the second using a triple antibiotic paste. Based on these two different pulp revascularization protocols, which obtain the desired therapeutic success, the literature will be reviewed and analyzed according to the relevance of their choice of materials. Based on the literature, we propose a new relevant protocol and a new mixture of antibiotics.

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