scholarly journals Endothelial damage and circadian blood pressure profile in rheumatoid arthritis

2019 ◽  
Vol 91 (5) ◽  
pp. 89-95 ◽  
Author(s):  
N P Shilkina ◽  
I E Yunonin ◽  
S V Butusova ◽  
E V Mikhailova ◽  
A A Vinogradov
Keyword(s):  
Rheumatoid Arthritis ◽  
Endothelial Dysfunction ◽  
Arterial Pressure ◽  
Pressure Profile ◽  
Endothelial Damage ◽  
Control Group ◽  
Endothelial Adhesion Molecule ◽  
Daily Monitoring ◽  
Immunoenzyme Analysis ◽  
Positive Correlations

Aim. To study the influence of the state of endothelium on the daily profile of arterial pressure (AP) in patients with rheumatoid arthritis (RA). Materials and methods. In 70 RA pts carried out C-reactive protein (CRP), vascular endothelial adhesion molecule type 1 (sVCAM-1), antigen von Willebrand Factor (AG WF), interleukin-8 (Il-8), rheumatoid factor (RF), IgG, endotheline-1 (ET-1), number of desquamated endotheliocytes cells (DE), VS, activity of renin by immunoenzyme analysis. The dysfunction of endothelium was evaluated by calculation of DE. The functional methods included the daily monitoring of arterial pressure (AP). Results. Arterial hypertension (AH) occurred in 40 (57.1%) pts. RA pts are revealed the signs of endothelial dysfunction, about which significant differences among the indices of activation of endothelium in comparison with control group testify. ET-1, sVCAM-1, vWF AG, Il-8, CRP content was higher in RA pts. Reliably above there was a number of DE. Reliable differences according to these indices depending of RA activity were discovered. With conducting of correlation analysis it is revealed, that markers of the activation of endothelium: sVCAM-1, vWF AG positively correlated with increasing RF IgG and indices of the immune inflammation: CRP, and DE number. In patients suffering from RA, showed signs of endothelial dysfunction. The positive correlation between endothelial damage and daily profile of AP show the relationship of these processes. Conclusion. Positive correlations between the damage of endothelium and disturbance of AP daily profile testify about the interrelation of these processes.

Inflammation and Microvascular and Macrovascular Endothelial Dysfunction in Rheumatoid Arthritis: Effect of Treatment

2010 ◽  
Vol 37 (4) ◽  
pp. 711-716 ◽  
Author(s):  
WILL FOSTER ◽  
DAVID CARRUTHERS ◽  
GREGORY Y.H. LIP ◽  
ANDREW D. BLANN
Keyword(s):  
Rheumatoid Arthritis ◽  
Endothelial Dysfunction ◽  
Vascular Function ◽  
Venous Blood ◽  
Microvascular Function ◽  
Control Group ◽  
Antirheumatic Therapy ◽  
Antiinflammatory Therapy ◽  
Patients With Diabetes ◽  
Plasma Markers

Objective.To determine whether abnormalities in microvascular and macrovascular function in rheumatoid arthritis (RA) are associated with plasma markers [von Willebrand factor (VWF)] of endothelial dysfunction and inflammation [C-reactive protein (CRP)] and whether the abnormalities would be altered by treatment. Endothelial dysfunction and inflammation in RA may contribute to adverse cardiovascular events. Although endothelial dysfunction in RA has been demonstrated by altered plasma markers, the relationships with macrovascular and microvascular function are relatively unexplored.Methods.We recruited 66 patients with chronic RA, 48 community controls (CC), and 25 patients with diabetes and hypertension as a disease control group (DC). Subjects had venous blood sampled for plasma markers, and underwent laser Doppler perfusion imaging of forearm skin (to assess microvascular circulation) following acetylcholine and sodium nitroprusside iontophoresis, to assess endothelium-dependent and endothelium-independent responses, respectively. Brachial artery flow-mediated dilatation assessed endothelial dysfunction in a macrovascular bed. A subgroup of 29 patients with RA were assessed pretherapy and after 2–4 weeks of antirheumatic therapy.Results.As expected, patients with RA had higher CRP, erythrocyte sedimentation rate (ESR), and VWF. Endothelium-independent vasoreactivity was abnormal in RA, and this correlated negatively with CRP. All aspects of microvascular function were abnormal in the DC compared to the CC. Macrovascular function was preserved in RA but was abnormal in the DC group. Four weeks of antiinflammatory therapy reduced CRP and ESR but had no effect on any vascular function index in the patients with RA.Conclusion.Patients with RA have abnormal endothelium-independent microvascular function that correlates with inflammation but is not altered by short-term antiinflammatory therapy.

ENDOTHELIAL DYSFUNCTION AND NEUROHUMORAL REGULATION OF BLOOD PRESSURE IN PATIENTS WITH SYSTEMIC SCLEROSIS

2019 ◽  
Vol 57 (4) ◽  
pp. 445-451
Author(s):  
N. P. Shilkina ◽  
I. E. Yunonin ◽  
S. A. Stolyarova ◽  
A. A. Vinogradov
Keyword(s):  
Blood Pressure ◽  
Systemic Sclerosis ◽  
Endothelial Dysfunction ◽  
Clinical Symptoms ◽  
Negative Impact ◽  
Endothelial Activation ◽  
Control Group ◽  
Neurohumoral Regulation ◽  
Positive Correlations

Objective: to investigate the effect of endothelial dysfunction, catecholamines, and renin on the diurnal blood pressure (BP) profile in patients with systemic sclerosis (SS).Subjects and methods. Twenty-five patients with SS underwent determination of the blood count of desquamated endotheliocytes by the method described by J. Hladovec (1978), the plasma levels of endothelin-1 (ET-1), adrenaline, norepinephrine, and renin by enzyme immunoassay. All the patients underwent 24-hour BP monitoring with calculating the time index, daily index, the magnitude and rate of a morning rise in BP, as well as its daily variability.Results and discussion. Hypertension was detected in 8 (32%) patients with SS. All the patients with SS showed signs of endothelial dysfunction, as evidenced by considerable differences in endothelial activation measures compared with the control group: the mean level of ET-1 was 5.8±2.3 and 0.48±0.21 fmol/ml (p<0.05); the number of desquamated endotheliocytes was 4.50 [3.00; 7.00] and 2.10 [1.00; 3.20] • 104/l, respectively (p<0.05). The levels of adrenaline and norepinephrine in SS were significantly higher than those in the control. There were positive correlations between endothelial dysfunction and the degree of an increase in BP. Endothelial dysfunction was found to have a negative impact on the diurnal BP profile in the presence of pathological types of night-peaker and non-dipper. Conclusion. Two mechanisms, such as endothelial dysfunction and sympathoadrenal activation, are responsible for the pathogenesis of clinical symptoms of SS, including hypertension.

Neurovegetative status and 24 hours´ arterial pressure profile of hypertensive patients

10.12737/5483 ◽  
2014 ◽  
Vol 8 (1) ◽  
pp. 1-6
Author(s):  
Чеснокова ◽  
V. Chesnokova
Keyword(s):  
Arterial Pressure ◽  
Arterial Hypertension ◽  
Antihypertensive Therapy ◽  
Cardiac Rhythm ◽  
Pressure Profile ◽  
Control Group ◽  
Autonomic Balance ◽  
Efficient Treatment ◽  
National Joint Committee ◽  
Vegetative Status

The aim of research is study peculiar properties of vegetative status and 24 hours&#180; arterial pressure profile in inefficient antihypertensive therapy patients. It was examined 180 patients in age from 42 to 65 with diagnosis I-III degree of arterial hypertension on classification RSOC; volunteers without arterial hypertension and sporadic rise of pressure has been integrated into research (n=36). Clinical and biochemical monitoring realized to the whole of examines in accordance with standards on diagnostic of arterial hypertension. 24 hours&#180; profile arterial pressure will be done in conformity with guideline national joint committee on cure of arterial hypertension JNK VI, WHO/ISH. Determination predominant autonomic balance carried out from system for integrated vegetative status, by its results patients were divided into subgroups. Then the patients were separated into subgroups by predominant autonomic balance with a glance degree and phase of arterial hypertension; modification key indicator of 24 hours&#180; arterial pressure profile in subgroups was investigated. It has been found experimentally that type of predominant autonomic balance varies with the phase, by not with degree of arterial hypertension. Inefficient antihypertensive therapy patients have more high frequency and variability of cardiac rhythm, which combine with insufficient degree decrease of cardiac rhythm at night; more high value of systolic, diastolic, sphygmic and medium pressure comparison with control group. Complex hemodynamic rates (DP, maxIMP) and also bodymass index in inefficient antihypertensive therapy patients exceed the same in efficient treatment cluster.

scholarly journals Could there be an association between chronic brucellosis and endothelial damage?

2015 ◽  
Vol 9 (01) ◽  
pp. 048-054 ◽  
Author(s):  
Turhan Togan ◽  
Ozgur Ciftci ◽  
Hale Turan ◽  
Huseyin Narci ◽  
Hakan Gullu ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
Patient Group ◽  
Intima Media Thickness ◽  
Endothelial Damage ◽  
Control Group ◽  
Percentage Increase ◽  
Reactive Protein ◽  
Highly Sensitive ◽  
Flow Mediated Dilatation ◽  
Hs Crp

Introduction: In this study, we examined the effects of Brucella infection on endothelial dysfunction. Flow-mediated dilatation (FMD) measurement is indicator of the endothelial function, and abnormal values indicating endothelial dysfunction are accepted as the first stage of atherosclerosis. Methodology: Twenty-four patients who had been treated for acute brucellosis two years before, and who had had no relapses in the follow-up, were prospectively included in the study, along with 30 healthy individuals in the control group. Results: While the highly sensitive C-reactive protein (hs-CRP) value was 2.42 ± 1.45 in the patient group, it was 1.72 ± 0.61 in the control group (p = 0.025). While the FMD value was 3.50 ± 1.58 in the patient group, it was 5.88 ± 1.88 in the control group (p < 0.001). While the percentage increase in FMD was 9.88 ± 4.92 in the patient group, it was 17.49 ± 6.3 in the control group (p < 0.001). It was observed that FMD value, the percentage increase in FMD, and basal radius were correlated with hs-CRP (r = -0.644, p < 0.001; r = - 0.558, p = 0.002; r = 0.444, p = 0.018, respectively). The carotid artery intima media thickness (IMT) value was found to be 0.61 ± 0.17 in the patient group and 0.49 ± 0.12 in the control group (p = 0.004). Conclusions: The abnormal FMD and IMT values observed in brucellosis patients might be an indicator of more frequent arterial dysfunction, increased cardiovascular risk, and atherosclerosis.

Utilization of longitudinal ultrasound measurements to quantify changes in knee joint synovial vascularity in a rabbit model of rheumatoid arthritis

2020 ◽  
Author(s):  
Hui Liu ◽  
Chao Huang ◽  
Shuqiang Chen ◽  
Qing Zheng ◽  
Yuhong Ye ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Time Course ◽  
Early Stage ◽  
Power Doppler ◽  
Rabbit Model ◽  
Knee Joints ◽  
Control Group ◽  
Vascular Morphology ◽  
Contrast Enhanced ◽  
Positive Correlations

Abstract Objective: This study of rabbits with ovalbumin-induced arthritis (OIA), a model of rheumatoid arthritis (RA), examined the time course of changes in synovial neovascularization based on imaging from power Doppler ultrasound (PDUS) and contrast-enhanced ultrasound (CEUS).Methods: 25 male New Zealand rabbits were in the OIA group and 5 were in the control group. Both rear knee joints of all rabbits were examined using conventional US and CEUS over 16 weeks. The knee synovia of OIA rabbits were sampled by US-guided biopsy, and the expression of CD31 and VEGF were determined by immunohistochemistry. The correlation of microvessel density (CD31 positivity) and VEGF at different times was analyzed using multimodal US.Results: OIA rabbits had increased synovial expression of CD31 and VEGF from week 6 to 12 (P<0.01). During the early stage of CEUS enhancement, dot enhancement was more common on weeks 6 and 8, and strip enhancement was more common on weeks 12 and 16 (P<0.05). There were significant positive correlations of synovial CD31 and VEGF expression with PDI grade, CEUS grade, and peak intensity (PI) (P<0.05 for all).Conclusions: OIA rabbits mimicked early-stage RA at 4 to 8 weeks, middle-stage RA at 8 to 12 weeks, and late-stage RA at 12 to 16 weeks. PDI, CEUS, and PI, especially when combined with CD31 expression, accurately characterized the extent of synovial vascularization. Increased vascular morphology based on CEUS may have value for the early diagnosis of RA.

scholarly journals Study of Lipid per Oxidation and Enzymatic Antioxidant Activity in Rheumatoid Arthritis: Relation with Disease Activity

2021 ◽  
pp. 51-56
Author(s):  
Dipali Khopade ◽  
Anita Kadam ◽  
Subodhini Abhang ◽  
Adinath Suryakar
Keyword(s):  
Rheumatoid Arthritis ◽  
Oxidative Stress ◽  
Disease Activity ◽  
Disease Activity Score ◽  
Activity Score ◽  
Control Group ◽  
Antioxidant Enzyme Activities ◽  
Positive Correlations ◽  
Control Study

Background: Rheumatoid Arthritis (RA) is one of the known Autoimmune diseases in patients with age group of 25 to 60. A significant aspect of disease development should be Reactive Oxygen Species (ROS). Few studies have shown an association between oxidative stress and RA disease activity. This study was therefore intended to examine whether there is a link between oxidative stress and disease activity. Methods and Materials: This case-control study on 120 individuals was conducted. In accordance with the Disease Activity Score (30) were healthy controls with 90 RA patients in mild (30), moderate (30) and severe (30). Malondialdehyde Measured Lipid Per Oxidation (MDA). Antioxidant enzyme activities such as Superoxide Dismutase (SOD), Catalase (CAT) and glutathione peroxidase (GPX) have been also measured. A correlation coefficient was also used to evaluate the strength of the link between oxidative stress and activity of the illness. Results: the MDA levels in all the RA subgroups were substantially higher than those in the control group, but the activity of antioxidant enzymes was significantly lower. Between Malondialdehyde Measured Lipid Per Oxidation (MDA) and Disease Activity score of 28 RA patients (DAS28) there were positive correlations. Conclusion: Significant increase in RA patients' lipid per oxidization supports the role of oxidative stress in RA aetiology and the usage of MDA for disease control.

scholarly journals Relation of smoking and endothelial dysfunction markers in systemic hypertension

2018 ◽  
Vol 17 (5) ◽  
pp. 11-16
Author(s):  
V. I. Podzolkov ◽  
A. E. Bragina ◽  
N. A. Druzhinina
Keyword(s):  
Endothelial Dysfunction ◽  
Smoking Status ◽  
Systemic Hypertension ◽  
Control Group ◽  
Smoking Duration ◽  
The Mean ◽  
Positive Correlations ◽  
Von Willebrand ◽  
And Control ◽  
Willebrand Factor

Aim. Assessment of the markers levels of endothelial dysfunction (ED): stable metabolites of nitric oxide (NOx), endothelin-1 (E1), homocysteine (HC), von Willebrand factor (vWF) and tissue plasminogen activator (tPA) in blood plasma of smoker and nonsmoker patients with arterial hypertension (AH) of low and moderate risk, not taking antihypertension therapy regularly.Material and methods. Totally, 124 AH patients included, 45 males and 79 females, mean age 51,4±6,5 y.o., mean AH duration 7,9±7,3 y. Controls included 35 healthy volunteers (20 males, 15 females). Concentration of NOx in plasma was measured with spectrophotometry, and of vWF, HC, E1 and tPA — with immune enzyme assay.Results. To evaluate the relation of smoking and ED markers levels, AH patients and controls were selected to subgroups according to smoking status: smoker (35,5%) and non-smoker (64,5%) AH patients; smoker (38%) and non-smoker (62%) controls. In smoker AH patients comparing to non-smoking there were significantly higher concentrations of NOx — 48,2±18,8 mcM/L and 40,3±21,2 mcM/L, respectively (р<0,05), E1 — 1,2±0,16 and 0,6±0,2 fM/L, resp. (р<0,05), HC — 25,7±6,04 and 16,2±6,5 mcM/L, resp. (р<0,05), vWF — 1,39±0,7 and 1,1±0,6 mg/dL, resp (р<0,05) and tPA — 13,05±6,2 and 8,5±6,2 mcM/L, resp. (р<0,05). There was correlation in the AH group, of NOx concentration and smoking (r=0,46, р<0,05), and tobacco smoking duration (r=0,83, р<0,05). Also, there were positive correlations of HC and smoking (r=0,4, p<0,05). In control group smokers had higher HC — 20,7±5,3 and 17,2±4,7 mcM/L, resp. (р<0,05), vWF — 1,3±0,8 and 0,8±0,6 mg/dL, resp. (р<0,05) and tPA — 11,1±6,5 and 6,6±5,2 mcM/L, resp. (р<0,05). There were no significant changes in NOx and E1.Conclusion. In smokers of both AH and control groups the levels of HC, vWF and tPA were significantly higher in comparison with nonsmokers. In smoker AH patients the mean concentrations of NOx and E1 are higher than in non-smoker patients. Levels of ED are related with not only the fact of smoking itself (р<0,05), but smoking duration (р<0,05).

scholarly journals Interrelation of the maintenance endotehelin 1-21 in serum of blood and indicators of daily monitoring of arterial pressure with diabetic nephropathy in children and the teenagers of diabetes mellitus type 1

2010 ◽  
Vol 9 (1) ◽  
pp. 63-69
Author(s):  
A. V. Enert ◽  
S. N. Ivanov ◽  
Yu. G. Samoilova
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Nephropathy ◽  
Arterial Pressure ◽  
Diabetes Mellitus Type 1 ◽  
Control Group ◽  
Daily Monitoring ◽  
Low Degree ◽  
Duration Of Disease ◽  
Stable Forms

Daily monitoring arterial pressure (DMAP) and definition endotehelin 1-21 immunofermentat a method was perfermed in 79 children and teenagers with type 1 diabetes mellitus (DM1) in the age 10—18 years, with duration of disease 2—16 years auskultative a method on the apparate “Shiller BR-102 plus” (Switzerland). Depending on a degree of expressiveness diabetic nephropathy (DN) patients have been distributed on three groups: 1st — normalalbuminuria (n = 31), 2nd — microalbumiuria (n = 32), 3rd — proteinuria (n = 16) and 16 person the control group comparable on a floor and age. At children and teenagers with DM1 according to DMAP, attributes of a labile arterial hypertension (AH), met at 34,1%, stable at 25,5%. Frequency of revealing of stable forms АГ depend on expressiveness DN. The daily rhythm the AP at patients DM1 was characterized by a low degree of night decrease the AP. 47,1% patients 1st groups, 72,7% patients 2nd and 75% patients 3rd had no adequate decrease the AP at night. Communication between the raised level endotehelin 1-21 with development and progressing diabetic nephropathy, and also with indicators diastolic AP is revealed.

scholarly journals Vitamin D Status, Disease Activity, and Endothelial Dysfunction in Early Rheumatoid Arthritis Patients

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Alexandru Caraba ◽  
Viorica Crişan ◽  
Ioan Romoşan ◽  
Ioana Mozoş ◽  
Marius Murariu
Keyword(s):  
Rheumatoid Arthritis ◽  
Insulin Resistance ◽  
Vitamin D ◽  
Endothelial Dysfunction ◽  
Disease Activity ◽  
Serum Levels ◽  
Control Group ◽  
Early Ra ◽  
Vitamin D Levels ◽  
25 Oh Vitamin D

Cardiovascular diseases represent important complications in rheumatoid arthritis (RA) patients, generated by an accelerated atherosclerosis. The aim of this study is represented by the assessment of the correlations between serum levels of vitamin D, disease activity, and endothelial dysfunction in patients with early RA. Material and Methods. The study was performed on a group of 35 patients with early RA and 35 healthy subjects matched for age and gender, as controls. In all studied subjects, the following were determined: inflammatory markers, insulin resistance, vitamin D levels, and endothelial dysfunction. Statistical analysis were performed using the Student’s t-test and the Pearson’s test. p values of less than 0.05 were considered statistically significant. Results. The group of patients with RA patients presented inflammation, low levels of vitamin D, elevated insulin resistance, and reduced flow-mediated vasodilation, statistically significant compared to the control group (p<0.00001). Significant inverse correlations between the levels of 25(OH) vitamin D and DAS28, respective insulin resistance, and significant positive correlation between 25(OH) vitamin D and endothelial function were demonstrated. Conclusion. In early RA patients with moderate and high disease activity, low serum levels of vitamin D were associated with disease activity, increased insulin resistance, and endothelial dysfunction.

scholarly journals Endothelial function in patients with asthma according to circadian blood pressure profile

2010 ◽  
Vol 16 (4) ◽  
pp. 390-394
Author(s):  
N. A. Karoli ◽  
A. A. Roschina ◽  
A. P. Rebrov
Keyword(s):  
Blood Pressure ◽  
Endothelial Dysfunction ◽  
Endothelial Function ◽  
Arterial Hypertension ◽  
Bronchial Asthma ◽  
Blood Pressure Monitoring ◽  
Pressure Profile ◽  
Control Group ◽  
Essential Arterial Hypertension ◽  
Functional Features

Objective. The aim of study is asses of the endothelial functional features in patient with bronchial asthma with different types of blood pressure (BP) circadial rhythm. Design and methods. 62 patients with bronchial asthma (from 25 to 60 years old) were included in our study. Control group was represented by 30 healthy people for examination of endothelial function and 77 patients with essential arterial hypertension for 24-h blood pressure rhythm analysis. We described 2 groups of patients («dippers» and «non-dippers») by ambulatory 24-h blood pressure monitoring. Results. «Non-dipper» type was significantly prevalent in patient with asthma in comparative with patients with essential arterial hypertension (51,6% opposite 33,7%). The flow-depended endothelial dysfunction is most common in patient with asthma (dippers and non-dippers) than in control group. Negative correlation between nitroglycerin-depended vasodilatation and night-depressing systolic and diastolic blood pressure degree was presented in the study. Conclusion. We founded associations between endothelial dysfunction and BP circadial rhythm in patients with bronchial asthma, especially in «non-dippers».

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