scholarly journals Pharmacological screening of anti-diabetic and antihyperlipidemic activity of aqueous extracts of leaves of Aloe barbadensis

2020 ◽  
Vol 11 (SPL4) ◽  
pp. 1197-1203
Author(s):  
Abdulaziz Khaled Hasan ◽  
Rakesh Kumar Jat ◽  
Abdul Mannan Khan
Keyword(s):  
Blood Glucose ◽  
Aqueous Extract ◽  
Serum Cholesterol ◽  
Diabetic Control ◽  
Significant Activity ◽  
Aqueous Extracts ◽  
Aloe Barbadensis ◽  
Standard Drug ◽  
Cholesterol Levels ◽  
Antihyperlipidemic Activity

The present study was to estimate the anti-diabetic and antihyperlipidemic activity of aqueous extract of leaves of plant Aloe barbadensis.In alloxan-induced diabetes in rats, the research examined six groups of six male wister rats every to value the hypoglycaemic effect of the barbadensis (ALEC) exposed to hostile to diabetic action in rodents where alloxan monohydrates were utilized as a portion of 120.00 mg/kg in intraperitoneal portion as a diabetogenic specialist to an acquainted diabetic with test rodents. In sub intense, treatment, bunch blood glucose levels are seen on 14.00th, 21.00th and 30.00th-day present treatment compare on typical control in diabetic control checked expanded blood glucose level was watched, with dosages of 100.00, 250.00 and 500.00 mg/kg b.w. A portion of 500.00 mg/kg b.w/day was seen as having the most significant activity. Glibenclamide was applied as a standard drug, and the outcome was compared about it. In the antihyperlipidemic activity, serum cholesterol levels were recorded at aqueous extracts of 100.00, 250.00 and 500.00 mg/kg, on 30.00th-day post-treatment. Serum cholesterol levels were ordinary benchmark groups was 107.70±01.21 mg/dl diabetic control 178.50±01.04 mg/dl and standard medications treatment bunches was 111.30±02.40 mg/dl and ALEC treatment bunches were 171.20±01.03 mg/dl, 145.80±02.92 mg/dl and 118.80±03.86 mg/dl for 100.00, 250.00 and 500.00 mg/kg separately. The results show that the aqueous extract of Aloe barbadensis has significant and continuous oral hypoglycaemic activity, equivalent to the hypoglycaemic result of glibenclamide, a sulfonylurea derivative and hyperlipidemic activity. Extracts also confirmed antihyperlipidaemic possible of the plant extract is establish to be comparable with that of the standard.

scholarly journals ARISTOLOCHIA BRACTEOLATA – ANTIHYPERGLYCEMIC AND ANTIHYPERLIPIDEMIC ACTIVITY IN DEXAMETHASONE-INDUCED DIABETIC RAT MODEL

2017 ◽  
Vol 10 (8) ◽  
pp. 75
Author(s):  
Ganga Rajum ◽  
Hema Sundar Reddy T ◽  
Hema Sundar Reddy T
Keyword(s):  
Blood Glucose ◽  
Methanolic Extract ◽  
Density Lipoprotein ◽  
Diabetic Rats ◽  
Diabetic Rat ◽  
Standard Drug ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Antihyperlipidemic Activity ◽  
Aristolochia Bracteolata

  Objective: The present study was aimed to evaluate antihyperglycemic and antihyperlipidemic activities of methanolic extract of Aristolochia bracteolata (MEAB) against dexamethasone-induced diabetic rat model.Methods: Methanolic extract was prepared by soxhlet extraction and was evaluated for antihyperglycemic and antihyperlipidemic activity using dexamethasone-induced model. The MEAB was administered orally at a dose of 200 and 400 mg/kg body weight glibenclamide was used as standard drug. On 0th and 11th day, blood was collected by retro-orbit plexus.Results: In this model blood glucose levels were determined on 0th and 11th days and MEAB significantly reduced the blood glucose levels in diabetic rats. The effect of MEAB on serum lipid profile such as total cholesterol (TC), triglycerides (TGs), low-density lipoprotein (LDL), very LDL (VLDL), and high-density lipoprotein (HDL) was also measured on the 11th day in the diabetic rats. Significant reduction in TC, TGs, LDL, and VLDL levels and improvement in HDL level were observed in diabetic rats.Conclusion: From the results, it was found that the MEAB possess antihyperglycemic and antihyperlipidemic activities.

scholarly journals Antinociceptive effect of Pleurotus ostreatus (Oyster Mushroom) Aqueous Extracts in Rattus norvegicus (Albino Rats)

1970 ◽  
Vol 20 (2) ◽  
pp. 483-487
Author(s):  
LF Zitte ◽  
RS Konya
Keyword(s):  
Aqueous Extract ◽  
Rattus Norvegicus ◽  
Pleurotus Ostreatus ◽  
Hot Water ◽  
Oyster Mushroom ◽  
Albino Rats ◽  
Thermal Stimulus ◽  
Aqueous Extracts ◽  
Standard Drug ◽  
Nociceptive Responses

Antinociceptive is reducing sensitivity to painful stimuli for the individual. The objective of this study was to evaluate the antinociceptive potentials of graded doses of Pleurotus ostreatus (Oyster Mushroom) aqueous extract in Rattus norvegicus (Albino Rats) and its chemical pattern by comparing it with a standard drug and a control using the hot water based flick tail test. Thirty five adult rats of both sexes were used for the experiment which, were divided into five groups of seven rats per group. Group one was used as the control (with 1ml normal saline), while groups two, three and four were treated with 100, 200 and 400 mg/kg of Pleurotus ostreatus aqueous extracts and group five treated with 15 mg/kg Aspirin (a standard drug) as positive control. Hot water at 550C was used to determine the nociceptive responses of the animals to detect anti-nociceptive effects of Pleurotus ostreatus extracts as compared to the control in hot water inflicted pain. The results suggested that Pleurotus ostreatus aqueous extract exhibits antinociceptive properties against thermal stimulus at 550C. The diversity of individual animals’ pain tolerance threshold when immersed in hot water was also observed during the experiment. However, the extract indicated a high degree of anti-nociceptive effect at 30, 60, 90 and 120 minutes post treatment period, with a progressively longer threshold time for pain sensitivity. It was also found that at 90 minute period, the control portrayed a relatively short response time.KEY WORDS: Anti-nociceptive, threshold pain, Pleurotus ostreatus, hot water test flick tail.

scholarly journals Modulations of Some Carbohydrate Metabolic Enzymes by Aqueous and Ethanol Buchholzia coriacea Seed Extract in Alloxan Induced Diabetic Rats

2018 ◽  
pp. 1-9
Author(s):  
K. O. Gbagbeke ◽  
A. O. Naiho ◽  
P. R. C. Esegbue ◽  
M. O. Odigie ◽  
M. A. Omoirri
Keyword(s):  
Blood Glucose ◽  
Aqueous Extract ◽  
Fasting Blood Glucose ◽  
Ethanol Extract ◽  
Metabolic Enzymes ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Total Carbohydrate ◽  
Adult Rats ◽  
Ethanol Extracts

Characterised by abnormal increase in blood glucose level, Diabetes is a metabolic disorder that is associated with complications in carbohydrate, protein and fat metabolism. In recent times, medicinal herbs have been implicated in traditional medical practice for the treatment of this ailment. Studies have shown that Buchholzia coriacea seed possesses some anti-hyperglycemic properties that may be useful in the management of diabetes. To this point, present study investigated the effect(s) of oral administration of aqueous and ethanol extracts of Buchholzia coriacea on some carbohydrate metabolism parameters in normal and alloxan-induced diabetic rats. Forty (40) adult rats of both sexes were randomly assigned into two groups (normoglycemic and hyperglycemic). While group 1 (normoglycemic) had normal control, metformin, aqueous extract (250mg/kg) and ethanol extract (250 mg/kg) treated sub-groups respectively, Group 2 (hyperglycemic) contained the diabetic control, metformin, aqueous extract (250 mg/kg), and ethanol extracted (250mg/kg) treated sub-groups dosed daily by oral gavage for 14 days. At the end of the treatment, rats were euthanized via cervical dislocation; blood samples were collected by cardiac puncture for statistical analysis. One-way analysis of variance (ANOVA) revealed that dosing with extracts had insignificant effect(s) on body weight of rats. Fasting Blood Glucose (FBG) levels were elevated before and after extracts administration. Metformin, aqueous and ethanol extracts significantly reduced (p<0.05) FBG levels. Also, compared with control, total carbohydrate, liver glucose, glycosylated haemoglobin, Lactate Dehydrogenase, Isocitrate dehydrogenase, MDH, SDH, 6-phosphogluconate dehydrogenase, G6PD and CcO activities were significantly reduced (p<0.05) in diabetic treated rats. Buccholzia Coriacea was therefore seen to pose hypoglycemic and glycolytic effects, regulating activities of carbohydrate metabolic enzymes. Apparently, there is a scientific merit in the use of the extract in the management of diabetes.

scholarly journals Antidiabetic activity of curry leaves Murraya koenigii on glucose level, kidney and islets of langerhans in streptozotocin induced diabetes in rats

2016 ◽  
Vol 15 (1) ◽  
Author(s):  
Imad M. Al-Ani ◽  
Rahajoe I. Santosa ◽  
Muhammad H. Yankuzo
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Aqueous Extract ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Murraya Koenigii ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Curry Leaves ◽  
Aqueous Leaf Extract

Introduction: This study examined the antihyperglycemic effect of curry leaves, Murraya koenigii “MK” aqueous extract, and to examine its possible protective effects on the Islets of Langerhans and kidneys in streptozotocin (STZ) induced diabetic rats.  Methods: Thirty healthy adult male Sprague Dawley rats were randomized into five groups (n=6); normal control, normal treated with “MK” control, diabetic control (non-treated with “MK”), diabetic treated with 200mg/kg MK aqueous leaf extract and diabetic treated with 400mg/kg MK aqueous leaf extract. Blood glucose levels and body weight were monitored. The animals were sacrificed on the 30th day; the kidney and pancreatic tissues were processed for histological studies. Results: The diabetic control group significantly (p<0.001) showed considerable loss of body weight and increase in blood glucose levels and degeneration of the glomeruli and renal convoluted tubules and atrophied islets with disintegration of β-cells. Treatment of diabetic rats with aqueous extract showed significant (p<0.001) improvement in blood glucose levels and body weight gain.  The MK extract also caused an improvement in tissue injury induced by STZ injection in the kidney and endocrine pancreas.  Conclusions: These findings highlighted the beneficial effects of MK aqueous extract against cellular oxidative damage in STZ-induced diabetic rats.

scholarly journals TEKNIK KROMATOGRAFI KOLOM VAKUM UNTUK PEMURNIAN SENYAWA ANTI-HIPERGLIKEMIK PADA TANAMAN JUWET (EUGENIA CUMINI): TANAMAN OBAT TRADISIONAL SUKU SASAK LOMBOK

2011 ◽  
Vol 6 (2) ◽  
Author(s):  
Sukib Sukib ◽  
Kusmiyati Kusmiyati
Keyword(s):  
Blood Glucose ◽  
Column Chromatography ◽  
Methanol Extract ◽  
Solvent System ◽  
Diabetic Control ◽  
Elution Time ◽  
Standard Drug ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Vacuum Column

ABSTRAKTelah dilakukan penelitian tentang penerapan teknik kromatografi kolom vakum untuk pemisahan senyawa anti-hiperglikemik dalam ekstrak metanol kulit kayu juwet Eugenia cumini. Kondisi pemisahan optimum: fasa pendukung/adsorben silikagel G60 (63 – 200 mm), F = 3,5 cm, l = 30 cm, laju alir 1 ml per menit, dan komposisi eluen Et-OAc:Me-OH (5 : 5). Penentuan aktivitas anti-hipeglikemik dilakukan dengan menggunakan mencit normal dan diabetes induksi aloksan 50 mg/kg bb, yang terbagi menjadi 3 kelompok, kontrol, pelakuan ekstrak/fraksi, dan obat standar metformin. Sampel darah diambil pada hari ke - 0, 1, 2, 4, 6, 8, dan 10 sesaat setelah 1 jam perlakuan. Kadar glukosa darah ditentukan dengan metode orto-toluidin. Hasil yang diperoleh menunjukkan bahwa persentase penurunan kadar glukosa darah mencit setelah 8 hari perlakuan adalah: untuk kontrol normal 0%, kontrol diabetes 4%. Untuk perlakuan ekstrak dengan dosis 300 mg/kg terhadap mencit diabetes terjadi penurunan kadar glukosa darah masing-masing: heksana 9%, DCM 18%, Me-OH 38%. Untuk perlakuan fraksi Et-OAc:Me-OH (5 : 5) dengan dosis 50 mg/kg bb terjadi penurunan  sebesar 34%, dan untuk obat pembanding metformin (5mg/kg) sebesar 42%. Kesimpulan yang diperoleh dari penelitian ini adalah bahwa ekstrak metanol dari kulit kayu juwet dan fraksi Et-OAc – Me-OH yang diisolasi dengan teknik kromatografi kolom vakum memiliki aktivitas anti-hiperglikemik. Penurunan kadar glukosa darah mencit diabetes memerlukan waktu sampai 8 hari  Kata kunci: Kromatogtafi kolom vakum, Juwet,  Anti-hiperglikemik,  Glukosa DarahABSTRACT: Vacuum column chromatography technique has been developed for separation anti-hyper-glycemic compound on methanol extract from juwet Eugenia cumini barks. Optimum condition this method are: the adsorbent is silica Gel G60 (63 – 200 mm), F = 3,5 cm, l = 30 cm, elution time 1 ml menit-1, and solvent system Et-OAc:Me-OH (5 : 5). Normal and alloxan induced diabetic rats were undertaken to evaluated anti-hyperglycemic activity and divided in to three groups, control, extract/fraction, and standar drug metformin. Blood samples were collected one hour after administration on the day 0, 1, 2, 4, 6, 8, and 10. Blood glucose level was determined by the ortho-toluidine method. Treatment with the extract and fraction was isolated from methanol extract resulted in reduction in blood glucose levels after 8 days: for normal control is 0%, diabetic control is 4%. For treatment with the extract at dose 300 mg/kg to diabetic groups decrease in blood glucose is 9% (extract hexane), 18% (extract dichloro-methane), 38% (extract methanol). For treatment with Et-OAc:Me-OH (5 : 5) fraction at dose 50 mg/kg  decrease in blood glucose is 34%, and standard drug metformin at dose 5 mg/kg is 42%.The finding of this study indicated that the methanol extract juwet bark and Et-OAc – Me-OH (5:5) fraction was isolated from methanol extract with Vacuum column chromatography technique have anti-hyperglygemic effect. Reduction in blood glucose levels of diabetics rats happened after treatment 8 days Key words: Vacuum column chromatography, Juwet, Anti-hyperglycemic, Blood                         Glucose

scholarly journals ANTIDIABETIC EFFECT OF MIKANIA SCANDENS ON ALLOXAN-INDUCED RAT MODEL

2018 ◽  
Vol 11 (3) ◽  
pp. 109
Author(s):  
Rimashree Baishya ◽  
Anjan Adhikari ◽  
Sharmistha Biswas ◽  
Soma Banerjee
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Ethanolic Extract ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Standard Drug ◽  
Glucose Levels ◽  
Male Wistar Rats ◽  
Histopathological Studies ◽  
Alloxan Monohydrate

 Objective: The objective was to study the evaluation of antidiabetic and antioxidant activity of different doses ethanolic extract of Mikania scandens leaves.Methods: The rats were divided into five groups of six animals each (non-diabetic control, diabetic control, standard drug-treated, and plant treated groups (250 and 500 mg/kg body weight)). Diabetes was induced in the healthy male Wistar rats (150–200 g body weight, 4–6 weeks old) by the administration of alloxan monohydrate (150 mg/kg, i.p.). On the 0th, 3th, 7th, 11th, and 15th days, the blood samples were analyzed for blood glucose. The antioxidant and antidiabetic parameters were evaluated by standard protocol. The liver tissue was used for histopathological assessment of liver damage.Results: The ethanolic extract of leaves of M. scandens showed a significant reduction (p<0.001) in the blood glucose levels and the antioxidant levels, with 500 mg/kg of body weight in the alloxan-induced diabetic rats as compared to the controls. Histopathological studies provided evidence that the leaf extract possesses antidiabetic activity.Conclusions: The ethanolic extract of leaves of M. scandens showed potent antidiabetic and antioxidant abilities against alloxan-induced rats, which indicate the presence of hypoglycemic constituents in the plant.

scholarly journals ANALGESIC EFFECT AND ANTI-INFLAMMATORY ACTIVITY OF AQUEOUS EXTRACT OF BOSWELLIA DALZIELII (BURSERACEAE) STEM BARK

2018 ◽  
Vol 10 (4) ◽  
pp. 139
Author(s):  
Iyabo M. ◽  
Adebisi . ◽  
Abba Abubakar ◽  
Kabiru Abubakar ◽  
Tijjani R. ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Aqueous Extract ◽  
Analgesic Effect ◽  
Late Phase ◽  
Significant Activity ◽  
Oral Toxicity ◽  
Standard Drug ◽  
Writhing Test ◽  
Paw Oedema ◽  
Anti Inflammatory

Objective: To evaluate the analgesic effect and anti-inflammatory properties of Boswellia dalzielii (Burseraceae), a medicinal plant commonly used in northern Nigeria as an anti-diarrhoeal, antipyretic, analgesic and anti-inflammatory agent.Methods: Three doses (25 mg/kg, 50 mg/kg and 100 mg/kg) of the crude aqueous extract of Boswellia dalzielii were evaluated for analgesic and anti-inflammatory activities using the acetic acid-induced writhing test, formalin-induced nociception and formalin-induced hind paw oedema in rats. The acute oral toxicity was carried out using the up and down procedure as described by the OECD guidelines.Results: All doses (25, 50 and 100 mg/kg) of the extract tested were effective against acetic acid induced abdominal constrictions producing a percentage inhibition of (55.43, 69.56 and 71.73%) respectively. A percentage inhibition of the formalin-induced nociception of (7.31, 31.70 and 48.78%-early phase) and (12.82, 21.79 and 48.71%-late phase) respectively was also produced. For the acetic acid writhing test, the percentage inhibition obtained at the dose of 50 and 100 mg/kg (69.56 and 71.73%) were higher than that of the standard drug (Piroxicam, 10 mg/kg) (59.78%). For formalin-induced nociception, the test extract at 100 mg/kg showed a higher percentage inhibition compared to Piroxicam, in early (48.78 and 43.90%) and late phase (48.71 and 39.74 %) respectively. The extract, however, did not show a significant activity against formalin-induced paw oedema at all the doses used.Conclusion: The present study demonstrated that Boswellia dalzielii has significant analgesic properties comparable to that of the standard drug (10% Piroxicam), thus validating the traditional claim of its antinociceptive property.

scholarly journals Evaluation of antihyperlipidemic activity of polyherbal capsules

2018 ◽  
Vol 8 (1) ◽  
pp. 1-4
Author(s):  
Soujanya H ◽  
Purushothaman M ◽  
Jagadeeshwari S ◽  
Shiva Kumar K
Keyword(s):  
Chemical Constituents ◽  
The Body ◽  
Human Beings ◽  
Standard Drug ◽  
Cholesterol Levels ◽  
The People ◽  
Fat Deposits ◽  
Antihyperlipidemic Activity ◽  
Elevated Cholesterol ◽  
Almost All

Hypercholesterolemia is one of the dreadful conditions that coexist in almost all the heart and endocrine-related dysfunctions. Simply elevated cholesterol levels in the blood is termed as hypercholesterolemia. Hyperlipidemia is also a synonym term and used to define elevated lipid levels. It affects almost all human beings in the world currently because of the changes in the food and living habits of the people. Most works proved those chemical constituents are antioxidants that demonstrate that the assertion that the oxidation is the main problem in causing the hyperlipidemia. So, in this research, antioxidant herbs like Psidium guava, Tephrosia and Moringa are used to prepare a gel that targets the fat deposits it the body and investigate for the antihyperlipidemic property. Herbal microspheres were prepared using the extracts of Tephrosia, Moringa and Psidium, which are incorporated into the sodium alginate and calcium carbonate. These microspheres were tested for their hyperlipidemic activity along with the extracts as such, and the results showed the microspheres showing better activity compared to the extracts compared to the standard drug atorvastatin.

scholarly journals In-vitro anthelmintic activity of Boswellia serrata and Aloe barbadensis extracts on Pheretima posthuma: Indian earthworm

2020 ◽  
Vol 8 (5) ◽  
pp. 1843
Author(s):  
Pallavi Sitaram Shelke ◽  
Pradnya Nilesh Jagtap ◽  
Prajakta Rohidas Tanpure
Keyword(s):  
Anthelmintic Resistance ◽  
Anthelmintic Activity ◽  
Significant Activity ◽  
Alcoholic Extract ◽  
Dependent Manner ◽  
Aloe Barbadensis ◽  
Boswellia Serrata ◽  
Standard Drug ◽  
Anthelmintic Drugs

Background: The development of anthelmintic resistance and the high cost of conventional anthelmintic drugs led to the evaluation of medicinal plants as an alternative source of anthelmintics. In the current study, in- vitro experiments were conducted to determine the possible anthelmintic effects of crude aqueous and alcoholic extracts of the resins of Boswellia serrata and leaves of Aloe barbadensis on adult Indian earthworm (Pheretima posthuma).Methods: Various concentrations (50, 100, 150 mg/ml) of each extracts were tested and results were expressed in terms of time for paralysis and time for death of worms. The activities are well compared with the standard drug Albendazole as a positive control and saline water as negative control.Results: Anthelmintic activity was observed as dose dependent manner. It was found that alcoholic  extract exhibited maximum anthelmintic activity at concentration 100 and 150 mg/ml compared to standard drug Albendazole (10mg/ml) while aqueous extract show modest significant activity at concentration 150 mg/ml against worm Pheretima posthuma. All results was statistically analysed by using ‘Dunnett’s test’ one- way ANOVA; the p<0.001 were significant when compared with control and standard group.Conclusions: The present study proves the potential of combination of B. serrata and A. barbadensis as an anthelmintic drugs. Further studies are necessary to isolate and reveal the active compounds and to establish the mechanism of action.

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