scholarly journals Optimization And Evaluation Of Polyherbal Topical Cream

2021 ◽  
Vol 12 (1) ◽  
pp. 940-946
Author(s):  
Sameer Shafi ◽  
Shendarkar G R
Keyword(s):  
Plant Extracts ◽  
Skin Diseases ◽  
Ocimum Sanctum ◽  
Antimicrobial Spectrum ◽  
Topical Cream ◽  
Cream Formulation ◽  
Herbal Plants ◽  
Improve Patient ◽  
Evaluation Parameters ◽  
Potential Antimicrobial Activity

Herbal plants and their combination report therapeutic as a well synergistic effect that has been recognized in medicine. So, taking into account this factor, the polyherbal topical cream formulation was prepared by using plant extracts to improve patient compliance, enhance antimicrobial spectrum and enhance aesthetic properties. The study focused on the topical polyherbal cream formulation for delivery of the active constituents present in plants to improve skin diseases. The plant extracts of Ocimum sanctum (OS), Rubia cordifolia (RC), Glycyrrhiza glabra (GG) were utilized for the preparation of cream. The formulated cream was subjected to different evaluation parameters and the results depicted that the spreadability of the formulation was low (17.80 ± 1.10g. cm/sec) and that indicates trouble-free spreading, free from grittiness. In rheological properties all the cream formulations also exhibited the same non-Newtonian behaviour. Polyherbal topical cream showed potential antimicrobial activity against all selected microorganisms. Polyherbal topical cream (PHC-5) was ideal in terms of viscosity than other formulations and showed good drug release. Thus, the formulated polyherbal cream was found to be stable in terms of all physicochemical properties.

scholarly journals Antiviral Natural Products for Arbovirus Infections

Molecules ◽  
2020 ◽  
Vol 25 (12) ◽  
pp. 2796 ◽  
Author(s):  
Vanessa Shi Li Goh ◽  
Chee-Keng Mok ◽  
Justin Jang Hann Chu
Keyword(s):  
Natural Products ◽  
Side Effects ◽  
Plant Extracts ◽  
Antiviral Drug ◽  
Good Tolerability ◽  
Antiviral Compounds ◽  
Potential Source ◽  
Herbal Plants ◽  
Antiviral Activities ◽  
Arboviral Diseases

Over the course of the last 50 years, the emergence of several arboviruses have resulted in countless outbreaks globally. With a high proportion of infections occurring in tropical and subtropical regions where arthropods tend to be abundant, Asia in particular is a region that is heavily affected by arboviral diseases caused by dengue, Japanese encephalitis, West Nile, Zika, and chikungunya viruses. Major gaps in protection against the most significant emerging arboviruses remains as there are currently no antivirals available, and vaccines are only available for some. A potential source of antiviral compounds could be discovered in natural products—such as vegetables, fruits, flowers, herbal plants, marine organisms and microorganisms—from which various compounds have been documented to exhibit antiviral activities and are expected to have good tolerability and minimal side effects. Polyphenols and plant extracts have been extensively studied for their antiviral properties against arboviruses and have demonstrated promising results. With an abundance of natural products to screen for new antiviral compounds, it is highly optimistic that natural products will continue to play an important role in contributing to antiviral drug development and in reducing the global infection burden of arboviruses.

scholarly journals Activity of Medicinal Plant Extracts on Multiplication ofMycobacterium tuberculosisunder Reduced Oxygen Conditions Using Intracellular and Axenic Assays

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Purva D. Bhatter ◽  
Pooja D. Gupta ◽  
Tannaz J. Birdi
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Medicinal Plant ◽  
Plant Extracts ◽  
Bactericidal Activity ◽  
Piper Nigrum ◽  
Ocimum Sanctum ◽  
Acorus Calamus ◽  
Anaerobic Conditions ◽  
Bacterial Killing ◽  
Medicinal Plant Extracts

Aim.Test the activity of selected medicinal plant extracts on multiplication ofMycobacterium tuberculosisunder reduced oxygen concentration which represents nonreplicating conditions.Material and Methods.Acetone, ethanol and aqueous extracts of the plantsAcorus calamusL. (rhizome),Ocimum sanctumL. (leaf),Piper nigrumL. (seed), andPueraria tuberosaDC. (tuber) were tested onMycobacterium tuberculosisH37Rv intracellularly using an epithelial cell (A549) infection model. The extracts found to be active intracellularly were further studied axenically under reducing oxygen concentrations.Results and Conclusions.Intracellular multiplication was inhibited ≥60% by five of the twelve extracts. Amongst these 5 extracts, in axenic culture,P. nigrum(acetone) was active under aerobic, microaerophilic, and anaerobic conditions indicating presence of multiple components acting at different levels andP. tuberosa(aqueous) showed bactericidal activity under microaerophilic and anaerobic conditions implying the influence of anaerobiosis on its efficacy.P. nigrum(aqueous) andA. calamus(aqueous and ethanol) extracts were not active under axenic conditions but only inhibited intracellular growth ofMycobacterium tuberculosis, suggesting activation of host defense mechanisms to mediate bacterial killing rather than direct bactericidal activity.

scholarly journals Immunity Boosting Medicinal Plants to Beat Covid -19 in Seraj Block of Mandi District, Himachal Pradesh

2021 ◽  
Vol 2 (4) ◽  
pp. 44-56
Author(s):  
Manju Lata ◽  
Mohammad Jamali
Keyword(s):  
Clinical Trials ◽  
Drug Therapy ◽  
Medicinal Plants ◽  
Curcuma Longa ◽  
Taraxacum Officinale ◽  
Urtica Dioica ◽  
Ocimum Sanctum ◽  
Wide Range ◽  
Herbal Plants ◽  
Near Future

Purpose: This study aimed to document the present status of medicinal plants used to boost the immunity to combat Coronavirus. Materials and Methods: For the assessment and use of herbs during the Covid 19 pandemic, surveys were conducted in different villages of  Seraj block. The surveys were conducted during the spread of the pandemic from 2020 to 2021. Local people were interviewed and information on the utilization of local herbs during this pandemic was recorded. Information on parts used, the procedure of use, habit, habitat, etc. was also collected. Results: A total of 58 species of medicinal plants from 27 families and 42 genera were documented. Among them, the most dominant family was Rosaceae.  Most of the plants such as Morchella sp, Naustratium officinale,Taraxacum officinale ,Urtica dioica ,Allium sp,Withania foraminifera, Curcuma longa, Cannabis, Mentha, Ocimum sanctum are rich in antioxidants and have a wide range of medicinal values used to treat cough, cold, fever, and bronchitis. All these plants were used traditionally to boost immunity. Due to the covid -19 pandemic, the utilization of these herbal plants has increased many folds in the area. These medicinal plants should be made available to scientists to design clinical trials. Integration of this concept would certainly develop drug therapy in the near future. Conclusion: The study found that the use of medicinal plants has increased during COVID-19 and most of the respondents recommended medicinal plants to prevent COVID-19 and to boost immunity. More studies should be conducted to develop certain formulations.

scholarly journals ANTIBACTERIAL EFFICACY OF PLANT EXTRACTS OF OCIMUM SANCTUM L.

2017 ◽  
Vol 5 (9) ◽  
pp. 260-263
Author(s):  
Babaloo Kumar ◽  
◽  
Nishu a ◽  
Swetnisha b ◽  
◽  
...  
Keyword(s):  
Plant Extracts ◽  
Ocimum Sanctum ◽  
Antibacterial Efficacy

scholarly journals The Effectiveness of Three Different Plant Extracts Used as Irrigant in Removal of Smear Layer: A Scanning Electron Microscope Study

2015 ◽  
Vol 9 (1) ◽  
pp. 16-22 ◽  
Author(s):  
A Gupta ◽  
V Goyal ◽  
J Duhan ◽  
S Hans ◽  
P Sangwan
Keyword(s):  
Plant Extracts ◽  
Root Canal ◽  
Smear Layer ◽  
Ocimum Sanctum ◽  
Control Group ◽  
Syzygium Aromaticum ◽  
Distilled Water ◽  
Scanning Electron Microscope Study ◽  
Layer Removal ◽  
Scanning Electron

ABSTRACT Aim In the present study, the role of three plant extracts as irrigant in root canal cleaning after instrumentation was evaluated. The effect of Syzygium aromaticum (S. Aromaticum), Ocimum sanctum (O. Sanctum) and Cinnamomum zeylanicum (C. zeylanicum) plant extracts was evaluated in smear layer removal. Methods The study was divided into different groups having 5 teeth each using various irrigating agents to evaluate smear layer removal. Group A: O. Sanctum extract; group A1: O. Sanctum extract with EDTA, group B: S. Aromaticum extract; group B1 S. Aromaticum extract with EDTA, group C: C. zeylanicum extract; group C1 C. zeylanicum extract with EDTA and two control group of 5 teeth each in group D: 3% NaOCl; group D1 3% NaOCl with EDTA (as positive control) and group E: Distilled water (as negative control); group E1 3% Distilled water with EDTA. Each tooth was split longitudinally and prepared for examination by scanning electron microscopy. Results The herbal extracts were effective in cleaning root canal walls when combine with EDTA with maximum activity of S. Aromaticum extract with EDTA group. Conclusion Under the condition of present study the three herbal plant extracts were ineffective in removal of smear layer when used alone.

scholarly journals Chemical constituents and pharmacological action of Ocimum sanctum (Indian holy basil-Tulsi)

2016 ◽  
Vol 5 (5) ◽  
pp. 205-207
Author(s):  
Sunita Verma ◽  
Keyword(s):  
Skin Diseases ◽  
Chemical Constituents ◽  
Pharmacological Action ◽  
Ocimum Sanctum ◽  
Hepatic Diseases ◽  
Botanical Description ◽  
Digestive Disorders ◽  
Prevention And Cure ◽  
Different Parts ◽  
Holy Basil

The plant of Oscimum sanctum commonly known as “Tulsi”, belong to Lamiaceae family. It is an erect, much branched, fragrant and erected plant attaining a height of about 20-50 cm. Different parts of the plant are used in Ayurveda and Siddha systems of medicine for prevention and cure of many illnesses like cough, influenza, common cold, headache, fever, colic pain, bronchitis, asthma, hepatic diseases, fatigue, skin diseases, arthritis, digestive disorders. The present paper is an attempt to provide a detailed botanical description, taxonomy, traditionally used and various pharmacological activity study of the plant.

scholarly journals FORMULATION AND EVALUATION OF POLYHERBAL CREAM

2020 ◽  
pp. 75-77
Author(s):  
PRASHANT CHAVAN ◽  
MALLINATH KALSHETTI ◽  
NIKHIL NAVINDGIKAR
Keyword(s):  
Rheumatoid Arthritis ◽  
Phase Separation ◽  
Medicinal Plants ◽  
Physical Parameter ◽  
Zingiber Officinale ◽  
Slab Method ◽  
Cream Formulation ◽  
Herbal Medicinal ◽  
Time Required ◽  
Evaluation Parameters

Objective: Eugenia caryophyllus, Zingiber officinale and Nyctanthes arbor-tristis are medicinal plants; these plants are used traditionally from ancient year in the various herbal medicinal system such as Ayurvedic, Homeopathic and Siddha. The clove buds of Eugenia caryophyllus, rhizomes of Zingiber officinale and dried leaves of Nyctanthes arbor-tristis have anti-inflammatory analgesic activity. The present research was focus on the formulation of polyherbal cream and their evaluation by using various evaluation parameters of the present research are to formulate polyherbal cream and to evaluate the polyherbal cream. Methods: the slab method was used for the preparation of cream. Results: The evaluation parameters are coming under this heading physical parameter like color was slightly white green, the odor was characteristics, consistency was smooth and the state was semisolid. PH of the cream was 6.5; Spreadability was 7.4g. cm/sec time required for this test was 15 sec, Washability was easily washable, the cream was nonirritant, viscosity of the formulated cream was 39010 cps and no phase separation was observed during storage of polyherbal cream. Conclusion: This cream formulation was used in rheumatoid arthritis to reduce joint pains. This cream formulation was o/w type of emulsion; hence this formulation was easily washed with plane water after application.

A Tutorial for Developing a Topical Cream Formulation Based on the Quality by Design Approach

2018 ◽  
Vol 107 (10) ◽  
pp. 2653-2662 ◽  
Author(s):  
Ana Simões ◽  
Francisco Veiga ◽  
Carla Vitorino ◽  
Ana Figueiras
Keyword(s):  
Quality By Design ◽  
Design Approach ◽  
Topical Cream ◽  
Cream Formulation ◽  
Quality By Design Approach

scholarly journals Efficacy of a New Cream Formulation of Mupirocin: Comparison with Oral and Topical Agents in Experimental Skin Infections

2000 ◽  
Vol 44 (2) ◽  
pp. 255-260 ◽  
Author(s):  
John Gisby ◽  
Joanna Bryant
Keyword(s):  
Fusidic Acid ◽  
Oral Treatment ◽  
Similar Efficacy ◽  
Skin Infections ◽  
Surgical Wound ◽  
Cream Formulation ◽  
Wound Model ◽  
Relevant Dose ◽  
Mupirocin Ointment ◽  
Improve Patient

ABSTRACT A new cream formulation of mupirocin developed to improve patient compliance was compared with systemic and topical antibiotics commonly used to treat primary and secondary skin infections. A mouse surgical wound model infected with Staphylococcus aureus orStreptococcus pyogenes was used. Topical treatment was applied at 4 and 10 h postinfection or oral treatment at a clinically relevant dose was administered 4, 8, and 12 h postinfection; treatments were continued three times daily for a further 3 days. Mupirocin cream was significantly more effective than (P < 0.01; two of eight studies) or not significantly different from (six of eight studies) mupirocin ointment in reducing bacterial numbers. Mupirocin cream was similar in efficacy to oral flucloxacillin but significantly more effective (P < 0.001) than oral erythromycin. It was also similar in efficacy to cephalexin against S. pyogenes but superior againstS. aureus (P < 0.01). Mupirocin cream had a similar efficacy to fusidic acid cream against S. aureusbut was significantly superior against S. pyogenes(P < 0.01). A hamster impetigo model infected withS. aureus was also used. Topical or oral treatment was administered at 24 and 30 h postinfection (also 36 h postinfection for oral therapy) and then three times daily for a further 2 days. On day 5, mupirocin cream was significantly more effective than mupirocin ointment in one study (P < 0.01) and of similar efficacy in the other two studies. Mupirocin cream was not significantly different from fusidic acid cream or neomycin-bacitracin cream, but it was significantly superior (P < 0.01) to oral erythromycin and cephalexin. Mupirocin cream was as effective as, or superior to, oral and other topical agents commonly used for skin infections.

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