scholarly journals The Polyphenolics and Health Effects of Pomegranate

Sains Medika ◽  
2015 ◽  
Vol 6 (1) ◽  
pp. 30
Author(s):  
Sonya Titin Nge ◽  
Martanto Martosupono ◽  
Ferry Fredy Karwur
Keyword(s):  
Free Radicals ◽  
Vascular System ◽  
Bioactive Compound ◽  
Punica Granatum ◽  
In Vivo Test ◽  
Processed Products ◽  
Punica Granatum L ◽  
Health Function

Pomegranate (Punica granatum L.) is a useful fruit which mostly consumed as fresh fruit and can also be used as a various of processed products. Reports proved pomegranate were beneficial to health. Polyphenolic compounds in pomegranate especially ellagitannin (hydrolyzed), anthocyanins, gallotannin,and ellagic acid can maintain oral hygiene, healthy skin from the effects of free radicals caused by UV radiation, has the ability to synthesize cholesterol, destroying free radicals in the human vascular system and can prevent prostate cancer. In vitro and in vivo test has shown the fruit is acting as anti diabetic drug, and hypolipidemic, anticarcinogenic, antibacterial, anti inflamation, and antiviral. This review presenting an overview about the bioactive compound contents, physiological and health function of the fruit.

Punica granatum L. (Pomegranate): A Potential Anti-microbial Agent

2020 ◽  
Vol 18 (1) ◽  
pp. 2-14 ◽  
Author(s):  
Aida Doostkam ◽  
Kamyar Iravani ◽  
Shahindokht Bassiri-Jahromi
Keyword(s):  
Antimicrobial Properties ◽  
Punica Granatum ◽  
Future Application ◽  
Potential Health ◽  
Therapeutic Uses ◽  
Animal Trial ◽  
Microbial Infections ◽  
Punica Granatum L

: Polyphenols have received high attention due to their biological functions. Pomegranate (Punica granatum L.) is a rich source of polyphenols such as tannin, ellagitannin, flavonoids and other phenolic acids. The potential therapeutic uses of pomegranate appear to be wide diversity. Pomegranate contains strong antioxidant activity, and antimicrobial properties, with potential health interests. : This review has been performed on a method of systematic narrative review on the antimicrobial potency of different parts of pomegranate. A search was performed in PubMed, Web of Science, Science Direct, Scopus and Google Scholar from 1986 to 2018 to obtain related studies. The aim of this review present an overview of the aspect and advantages of Punica granatum L. and summarize the present data on the pomegranate anti-microbial activity in in-vitro and in-vivo tests, animal trial systems and human clinical trials. Also, this review discussed the pomegranate extracts activities and their future application. : The findings of this review support that the pomegranate might be possible to use in the control and potential therapeutics of some microbial infections. This review highlights the new researches on the anti-microbial activities of pomegranate.

scholarly journals Antioxidant, Biochemical, and In-Life Effects of Punica granatum L. Natural Juice vs. Clarified Juice by Polyvinylidene Fluoride Membrane

Foods ◽  
2020 ◽  
Vol 9 (2) ◽  
pp. 242 ◽  
Author(s):  
Valeria Maria Morittu ◽  
Vincenzo Mastellone ◽  
Rosa Tundis ◽  
Monica Rosa Loizzo ◽  
Raffaella Tudisco ◽  
...  
Keyword(s):  
Polyvinylidene Fluoride ◽  
Creatine Phosphokinase ◽  
Hollow Fiber Membrane ◽  
Punica Granatum ◽  
Pomegranate Juice ◽  
Reactive Oxygen Metabolites ◽  
Water Control ◽  
Punica Granatum L

A clarification method was proposed to ameliorate the technological quality of fruit juices by preserving bioactive compounds. This study evaluated the in vitro antioxidant and hypoglycemic activities and the in vivo effects of Punica granatum L. natural (NJ) and clarified (CJ) juice by polyvinylidene fluoride (PVDF) hollow fiber membrane. CJ was more active as an antioxidant and as a α-glucosidase inhibitor than NJ. Mice were orally gavaged with water (Control), NJ, and CJ for 28 days. NJ group showed significant decrease of alanine aminotransferase, aspartate amino transferase, and creatine-phosphokinase. CJ administration was associated with urea, creatine-phosphokinase, and triglycerides values significantly lower with respect to the control. Oxidative status was ameliorated with CJ administration, showing a reactive oxygen metabolites (d-ROMs) reduction of 32% and a biological antioxidant potential (BAP) boosting of 23% compared to the control, whereas NJ did not show a similar effect. Results confirmed the beneficial properties of pomegranate juice, showing that membrane clarification may enhance such effects in terms of antioxidant activity.

scholarly journals Avaliação da atividade antibacteriana de Punica granatum Linn. (Romã) frente a bactérias orais: Uma revisão integrativa

2021 ◽  
Vol 10 (7) ◽  
pp. e16010716238
Author(s):  
Jullierme de Oliveira Morais ◽  
Jamile Marinho Bezerra de Oliveira Moura ◽  
Pablo de Castro Santos ◽  
Gilmara Celli Maia de Almeida
Keyword(s):  
Streptococcus Mutans ◽  
Punica Granatum ◽  
Punica Granatum L

Sabe-se que há um grande potencial de plantas medicinais com atividade antibacteriana, tornando-se alternativa para o combate às infecções. Dentre as plantas medicinais destaca-se a Punica granatum Linn.  (Romã), que possui compostos bioativos utilizados para o tratamento de doenças e é utilizada como antisséptico oral para tratar a dor de garganta. Assim, o estudo apresentou como objetivo avaliar a atividade antibacteriana de Punica granatum L. frente a bactérias orais. Para isso, foi realizada uma revisão integrativa, com busca de artigos nas bases de dados PubMed, LILACS e SciELO, utilizando os termos “punica granatum”, “pomegranate”’, “dentistry”, “mouth” e “oral”. Foram selecionados artigos de acordo com os seguintes critérios para inclusão: artigos originais disponíveis na íntegra, publicados nos idiomas inglês, espanhol ou português e publicados nos últimos 10 anos (2010 a 2020). A busca resultou em 126 artigos e após leitura de título e resumo, 16 artigos atenderam aos objetivos da pesquisa e foram incluídos na revisão. Os resultados demonstram que há efeitos antibacterianos principalmente a partir de estudos in vitro (n=13; 81,25%), com ação, na maioria dos estudos da revisão, sobre Streptococcus mutans e outras espécies de Streptococcus orais. Através das análises, constata-se que diferentes formas de utilização do material da planta possuem atividade antibacteriana in vivo e in vitro, em especial o extrato da casca. Portanto, a utilização da romã tem potencial antibacteriano podendo ser uma alternativa para prevenção e terapêutica de infecções orais.

scholarly journals Efecto Quimiopreventivo de un extracto de cáscara de granada (Punica granatum)

2015 ◽  
Vol 4 (7) ◽  
Author(s):  
MI Sánchez Crisóstomo ◽  
G. Betanzos Cabrera ◽  
JJ Manríquez Torres ◽  
R. Cariño Cortés
Keyword(s):  
Punica Granatum ◽  
Punica Granatum L

Los componentes de la granada (Punica granatum L.) han sido estudiados experimentalmente por sus efectos antiinflamatorios y anticarcinogénicos. Sin embargo, no existen estudios concluyentes sobre la eficacia del extracto del jugo y la cáscara del fruto para proteger la integridad del material genético de células de mamíferos; así como de su capacidad protectora frente al daño inducido por la doxorrubicina (DOXO), un agente antineoplásico utilizado clínicamente para el tratamiento de leucemia linfocítica aguda principalmente en niños. Por lo tanto los objetivos del presente trabajo fueron: Obtener los extractos de granada, determinar su contenido de polifenoles y capacidad antioxidante in vitro y evaluar el potencial genotóxico y antigenotóxico mediante el ensayo de micronúcleos in vivo. Los resultados revelaron ausencia de toxicidad letal hasta con 5 g/kg en ratón macho CD1+, genotoxicidad y citotoxidad en eritrocitos de sangre periférica durante 15 días de tratamiento, en cambio 70 y 700 mg/kg del extracto de cáscara protegieron 40-56% contra el daño clastogénico ocasionado por la administración sistémica única de 10 mg/kg de doxorubicina. Los resultados se analizaron por ANOVA de dos vías, consideraron los datos estadísticamente significativos si p<0.05.

scholarly journals Food Applications and Potential Health Benefits of Pomegranate and its Derivatives

Foods ◽  
2020 ◽  
Vol 9 (2) ◽  
pp. 122 ◽  
Author(s):  
Panagiotis Kandylis ◽  
Evangelos Kokkinomagoulos
Keyword(s):  
Health Benefits ◽  
Punica Granatum ◽  
Physicochemical Characteristics ◽  
In Vivo Studies ◽  
Protective Agent ◽  
Potential Health ◽  
Food Applications ◽  
Punica Granatum L

Pomegranate (Punica granatum L.) is an ancient fruit that is particularly cultivated in west Asia, though it is also cultivated in the Mediterranean region and other parts of the world. Since ancient years, its consumption has been associated with numerous health benefits. In recent years, several in vitro and in vivo studies have revealed its beneficial physiological activities, especially its antioxidative, antimicrobial and anti-inflammatory properties. Furthermore, human-based studies have shown promising results and have indicated pomegranate potential as a protective agent of several diseases. Following that trend and the food industry’s demand for antioxidants and antimicrobials from natural sources, the application of pomegranate and its extracts (mainly as antioxidants and antimicrobials), has been studied extensively in different types of food products with satisfactory results. This review aims to present all the recent studies and trends in the applications of pomegranate in the food industry and how these trends have affected product’s physicochemical characteristics and shelf-life. In addition, recent in vitro and in vivo studies are presented in order to reveal pomegranate’s potential in the treatment of several diseases.

Efficacy of Punica granatum extract on in vitro and in vivo control of Trichomonas vaginalis

Planta Medica ◽  
2011 ◽  
Vol 77 (12) ◽  
Author(s):  
GT El Sherbini ◽  
KM Ibrahim ◽  
ET El Sherbini ◽  
NM Abdel Hady ◽  
TA Morsy
Keyword(s):  
Trichomonas Vaginalis ◽  
Punica Granatum

Defibrotide Inhibits Platelet Activation by Cathepsin G Released From Stimulated Polymorphonuclear Leukocytes

1992 ◽  
Vol 67 (06) ◽  
pp. 660-664 ◽  
Author(s):  
Virgilio Evangelista ◽  
Paola Piccardoni ◽  
Giovanni de Gaetano ◽  
Chiara Cerletti
Keyword(s):  
Platelet Activation ◽  
Polymorphonuclear Leukocytes ◽  
Direct Interaction ◽  
Cathepsin G ◽  
In Vivo Test ◽  
Cell Functions ◽  
Test Models ◽  
Antithrombotic Effects

SummaryDefibrotide is a polydeoxyribonucleotide with antithrombotic effects in experimental animal models. Most of the actions of this drug have been observed in in vivo test models but no effects have been reported in in vitro systems. In this paper we demonstrate that defibrotide interferes with polymorphonuclear leukocyte-induced human platelet activation in vitro. This effect was not related to any direct interaction with polymorphonuclear leukocytes or platelets, but was due to the inhibition of cathepsin G, the main biochemical mediator of this cell-cell cooperation. Since cathepsin G not only induces platelet activation but also affects some endothelial cell functions, the anticathepsin G activity of defibrotide could help to explain the antithrombotic effect of this drug.

Identification of punicalagin as the bioactive compound behind the antimicrobial activity of pomegranate (Punica granatum L.) peels

2021 ◽  
Vol 352 ◽  
pp. 129396
Author(s):  
Clarisse Gosset-Erard ◽  
Minjie Zhao ◽  
Sonia Lordel-Madeleine ◽  
Saïd Ennahar
Keyword(s):  
Antimicrobial Activity ◽  
Bioactive Compound ◽  
Punica Granatum ◽  
Punica Granatum L

Comparative Evaluation of In Vitro and In Vivo Assays for the Detection of Avian Infectious Bronchitis Virus as a Contaminant of Live Poultry Vaccines

1998 ◽  
Vol 26 (5) ◽  
pp. 629-634
Author(s):  
Emiliana Falcone ◽  
Edoardo Vignolo ◽  
Livia Di Trani ◽  
Simona Puzelli ◽  
Maria Tollis
Keyword(s):  
Infectious Bronchitis Virus ◽  
Serological Response ◽  
Avian Infectious Bronchitis Virus ◽  
Animal Testing ◽  
Rt Pcr ◽  
Pcr Assay ◽  
In Vivo Test ◽  
Infectious Bronchitis

A reverse transcriptase polymerase chain reaction (RT-PCR) assay specific for identifying avian infectious bronchitis virus (IBV) in poultry vaccines, and the serological response to IBV induced by the inoculation of chicks with a Newcastle disease vaccine spiked with the Massachusetts strain of IBV, were compared for their ability to detect IBV as a contaminant of avian vaccines. The sensitivity of the IBV-RT-PCR assay provided results which were at least equivalent to the biological effect produced by the inoculation of chicks, allowing this assay to be considered a valid alternative to animal testing in the quality control of avian immunologicals. This procedure can easily be adapted to detect a number of contaminants for which the in vivo test still represents the only available method of detection.

scholarly journals Oxidized LDLs as Signaling Molecules

Antioxidants ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 1184
Author(s):  
Jean-Marc Zingg ◽  
Adelina Vlad ◽  
Roberta Ricciarelli
Keyword(s):  
Free Radicals ◽  
Cellular Response ◽  
Vascular System ◽  
Signaling Molecules ◽  
Scavenger Receptors ◽  
Physiological Relevance ◽  
Reactive Radicals ◽  
Accumulation Of Lipids

Levels of oxidized low-density lipoproteins (oxLDLs) are usually low in vivo but can increase whenever the balance between formation and scavenging of free radicals is impaired. Under normal conditions, uptake and degradation represent the physiological cellular response to oxLDL exposure. The uptake of oxLDLs is mediated by cell surface scavenger receptors that may also act as signaling molecules. Under conditions of atherosclerosis, monocytes/macrophages and vascular smooth muscle cells highly exposed to oxLDLs tend to convert to foam cells due to the intracellular accumulation of lipids. Moreover, the atherogenic process is accelerated by the increased expression of the scavenger receptors CD36, SR-BI, LOX-1, and SRA in response to high levels of oxLDL and oxidized lipids. In some respects, the effects of oxLDLs, involving cell proliferation, inflammation, apoptosis, adhesion, migration, senescence, and gene expression, can be seen as an adaptive response to the rise of free radicals in the vascular system. Unlike highly reactive radicals, circulating oxLDLs may signal to cells at more distant sites and possibly trigger a systemic antioxidant defense, thus elevating the role of oxLDLs to that of signaling molecules with physiological relevance.

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