scholarly journals Collateral Damage: A Mixed Methods Study to Investigate the Use and  Withdrawal of Antidepressants Within a Naturalistic Population

2021 ◽  
Author(s):  
◽  
Susan Thrasher
Keyword(s):  
Side Effects ◽  
Online Survey ◽  
Antidepressant Drug ◽  
Well Being ◽  
Antidepressant Therapy ◽  
Control Group ◽  
Emotional Symptoms ◽  
Study Results ◽  
Significant Difference ◽  
Antidepressant Use

<p>The use of modern antidepressants has flourished over the past few decades with the modern attribution of affective disorders such as depression to biomedical causation. However, recent re-examination of clinical trials has raised questions regarding antidepressant drug efficacy, and issues around side effects and dependency are prevalent. In spite of this, as many as 10% of us may be taking these medications (Szabo, 2009). This study examines responses to an anonymous online survey about antidepressant use and withdrawal. Participants included 176 current users, 181 currently withdrawing, 108 ex-users, and a control group of 44 participants who had never used antidepressants. Participant groups were compared quantitatively regarding attitude towards antidepressants use and perceived value, effect on well-being and mood, symptoms and side effects, and their perceived changes in themselves on and off the drugs. Participants were also given the opportunity to include spontaneous comments at the end of the survey which were analysed thematically. Key findings include: 1) Antidepressant users have a more positive estimation of the value of the drugs than those who have discontinued the drugs or who have never used them; 2) Scores on the WHO-5 well-being survey for all three groups with antidepressant experience (users, those withdrawing, and ex-users) showed poor levels of wellbeing, suggesting that neither antidepressant therapy nor cessation of antidepressant therapy were adequate interventions to create positive well-being; 3) Multivariate analysis of participant responses revealed a significant difference between the four groups on 35 of 37 physical and emotional symptoms associated with antidepressant use or withdrawal, with the never-used group scored the lowest in all cases except one, and the withdrawing group scoring the highest for 27 of the symptoms; 4) Concern over antidepressant dependency and withdrawal was the most prevalent topic reported by all user groups in spontaneous comments; other key themes included frustration with side effects and lack of information and support from the medical profession; 5) study results suggest that antidepressant withdrawal may take longer and be more challenging than the assumed "mild", "self-limiting" and "resolving spontaneously…three weeks after onset" (Haddad & Anderson, 2007); and 6) 30% of ex-users spontaneously reported what they believed were adverse drug reactions, or withdrawal reactions, months or years after antidepressant use had ceased, a long-term iatrogenic disablement that has yet to be addressed in the literature. Overall, the study reveals that antidepressants are not an adequate intervention to create positive well-being in patients and their use comes with a substantial risk of unpleasant side effects, dependency, and the potential for residual post-drug health complications.</p>

scholarly journals Collateral Damage: A Mixed Methods Study to Investigate the Use and  Withdrawal of Antidepressants Within a Naturalistic Population

2021 ◽  
Author(s):  
◽  
Susan Thrasher
Keyword(s):  
Side Effects ◽  
Online Survey ◽  
Antidepressant Drug ◽  
Well Being ◽  
Antidepressant Therapy ◽  
Control Group ◽  
Emotional Symptoms ◽  
Study Results ◽  
Significant Difference ◽  
Antidepressant Use

<p>The use of modern antidepressants has flourished over the past few decades with the modern attribution of affective disorders such as depression to biomedical causation. However, recent re-examination of clinical trials has raised questions regarding antidepressant drug efficacy, and issues around side effects and dependency are prevalent. In spite of this, as many as 10% of us may be taking these medications (Szabo, 2009). This study examines responses to an anonymous online survey about antidepressant use and withdrawal. Participants included 176 current users, 181 currently withdrawing, 108 ex-users, and a control group of 44 participants who had never used antidepressants. Participant groups were compared quantitatively regarding attitude towards antidepressants use and perceived value, effect on well-being and mood, symptoms and side effects, and their perceived changes in themselves on and off the drugs. Participants were also given the opportunity to include spontaneous comments at the end of the survey which were analysed thematically. Key findings include: 1) Antidepressant users have a more positive estimation of the value of the drugs than those who have discontinued the drugs or who have never used them; 2) Scores on the WHO-5 well-being survey for all three groups with antidepressant experience (users, those withdrawing, and ex-users) showed poor levels of wellbeing, suggesting that neither antidepressant therapy nor cessation of antidepressant therapy were adequate interventions to create positive well-being; 3) Multivariate analysis of participant responses revealed a significant difference between the four groups on 35 of 37 physical and emotional symptoms associated with antidepressant use or withdrawal, with the never-used group scored the lowest in all cases except one, and the withdrawing group scoring the highest for 27 of the symptoms; 4) Concern over antidepressant dependency and withdrawal was the most prevalent topic reported by all user groups in spontaneous comments; other key themes included frustration with side effects and lack of information and support from the medical profession; 5) study results suggest that antidepressant withdrawal may take longer and be more challenging than the assumed "mild", "self-limiting" and "resolving spontaneously…three weeks after onset" (Haddad & Anderson, 2007); and 6) 30% of ex-users spontaneously reported what they believed were adverse drug reactions, or withdrawal reactions, months or years after antidepressant use had ceased, a long-term iatrogenic disablement that has yet to be addressed in the literature. Overall, the study reveals that antidepressants are not an adequate intervention to create positive well-being in patients and their use comes with a substantial risk of unpleasant side effects, dependency, and the potential for residual post-drug health complications.</p>

Effects of Virgin Coconut Oil as Adjunct Therapy in the Treatment of Allergic Rhinitis

2016 ◽  
Vol 1 (1) ◽  
pp. 22
Author(s):  
Nazli Zainuddin ◽  
Nurul Azira Mohd Shah ◽  
Rosdan Salim
Keyword(s):  
Allergic Rhinitis ◽  
Side Effects ◽  
Coconut Oil ◽  
Test Group ◽  
Nasal Symptom ◽  
Control Group ◽  
Virgin Coconut Oil ◽  
Control Groups ◽  
Significant Difference ◽  
And Control

Introduction: The role of virgin coconut oil in the treatment of allergic rhinitis is controversial. Thus, the aim of the present study is to determine the effects of virgin coconut oil ingestion, in addition to standard medications, on allergic rhinitis. We also studied the side effects of consumption of virgin coconut oil. Methods: Fifty two subjects were equally divided into test and control groups. All subjects received a daily dose of 10mg of loratadine for 28 days. The test group was given 10ml of virgin coconut oil three times a day in addition to loratadine. The symptoms of allergic rhinitis were scored at the beginning and end of the study. Results:, the symptom score were divided into nasal and non-nasal symptom scores. Sneezing score showed a significant difference, however the score was more in control group than test group, indicating that improvement in symptom was more in control group. The rest of the nasal symptom and non-nasal symptom score showed no significant difference between test and control groups. Approximately 58% of the test subjects developed side effects from consumption of virgin coconut oil, mainly gastrointestinal side effects. Conclusion: In the present study, ingestion of virgin coconut oil does not improve the overall and individual symptoms of allergic rhinitis, furthermore it has side effects.

scholarly journals The Relationship between Well-Being and Knowledge Sharing

2021 ◽  
Vol 13 (9) ◽  
pp. 4978
Author(s):  
Kei Aoki
Keyword(s):  
Knowledge Sharing ◽  
Paradigm Shift ◽  
Online Survey ◽  
Positive Impact ◽  
Well Being ◽  
Control Group ◽  
User Innovation ◽  
Work Style ◽  
Financial Benefits ◽  
The Relationship

This research studies the relationship between well-being and knowledge sharing. While user innovation has garnered greater attention in recent years, the market has failed to properly incentivize the diffusion of user innovations. This study proposes that this shortcoming could be resolved through a consumer-to-consumer (C-to-C) marketplace and sheds light on non-financial benefits for the contributors, specifically, how knowledge sharing impacts contributor well-being. This research consists of two online survey studies. In both studies, the level of well-being was compared between knowledge sharing contributors and a control group using a scale developed in positive psychology. This study empirically shows that participation in knowledge sharing has a significant positive impact on contributor well-being. In a C-to-C marketplace, contributors diffuse and monetize their creations themselves, resulting in increased well-being. Contributing to knowledge sharing may be a sufficient incentive for user innovators to diffuse their innovations. The findings of this study will gain significance as the utilization of personal knowledge increases due to the expansion of the C-to-C business and the paradigm shift in work style.

scholarly journals The Combined Effects of Sports Smart Bracelet and Multi-Component Exercise Program on Exercise Motivation among the Elderly in Macau

Medicina ◽  
2021 ◽  
Vol 57 (1) ◽  
pp. 34
Author(s):  
Cheuk Kei Lao ◽  
Bing Long Wang ◽  
Richard S. Wang ◽  
Hsiao Yun Chang
Keyword(s):  
Artificial Intelligence ◽  
Exercise Training ◽  
Training Programs ◽  
Exercise Program ◽  
The Elderly ◽  
Control Group ◽  
Exercise Motivation ◽  
Sport Training ◽  
Study Results ◽  
Significant Difference

Background and objectives: Faced with the serious problem of an aging population, exercise is one of the most effective ways to maintain the health of the elderly. In recent years, with the popularization of smartphones, the elderly have increasingly accepted technological products that incorporate artificial intelligence (AI). However, there is not much research on using artificial intelligence bracelets to enhance elders’ motivation and participation in exercise. Therefore, the purpose of this study is to evaluate the effectiveness of the combination of sports smart bracelets and multi-sport training programs on the motivation of the elderly in Macau. Materials and Methods: The study was conducted with a randomized trial design in a 12 week multi-sport exercise training intervention. According to the evaluation, a total of sixty elders’ pre- and post-test data were included in this study. Results: After 12 weeks of multi-sport exercise training, the evaluation scores on the exercise motivation scale (EMS) increased significantly in the group wearing exercise bracelets and those taking part in the multi-component exercise program, and the degree of progress reached a statistically significant level, but the control group did not show any statistically significant difference. The influence of the combination of sports smart bracelets and multi-sport training programs on elders’ motivation is clearer. Conclusions: The use of sports smart bracelets by elderly people in conjunction with diverse exercise training can effectively enhance elders’ motivation and increase their participation in regular exercise. The combination of sports smart bracelets and multi-sport training programs is worth promoting in the elderly population.

scholarly journals Comorbidity and COVID-19: Investigating the Relationship between Medical and Psychological Well-being

2021 ◽  
pp. 1-22
Author(s):  
Owen Stafford ◽  
Anna Berry ◽  
Laura K. Taylor ◽  
Sinead Wearen ◽  
Cian Prendergast ◽  
...  
Keyword(s):  
Public Health ◽  
Psychological Distress ◽  
Vulnerable Populations ◽  
Illness Perceptions ◽  
Medical Condition ◽  
Well Being ◽  
Control Group ◽  
Medical Conditions ◽  
Significant Difference ◽  
The Relationship

Abstract Objective: The unprecedented occurrence of a global pandemic is accompanied by both physical and psychological burdens that may impair quality of life. Research relating to COVID-19 aims to determine the effects of the pandemic on vulnerable populations who are at high risk of developing negative health or psychosocial outcomes. Having an ongoing medical condition during a pandemic may lead to greater psychological distress. Increased psychological distress may be due to preventative public health measures (e.g. lockdown), having an ongoing medical condition, or a combination of these factors. Methods: This study analyses data from an online cross-sectional national survey of adults in Ireland and investigates the relationship between comorbidity and psychological distress. Those with a medical condition (n128) were compared to a control group without a medical condition (n128) and matched according to age, gender, annual income, education, and work status during COVID-19. Participants and data were obtained during the first public lockdown in Ireland (27.03.202008.06.2020). Results: Individuals with existing medical conditions reported significantly higher levels of anxiety (p<.01) and felt less gratitude (p.001). Exploratory analysis indicates that anxiety levels were significantly associated with illness perceptions specific to COVID-19. Post-hoc analysis reveal no significant difference between the number of comorbidities and condition type (e.g. respiratory disorders). Conclusion: This research supports individualised supports for people with ongoing medical conditions through the COVID-19 pandemic, and has implications for the consideration of follow-up care specifically for mental health. Findings may also inform future public health policies and post-vaccine support strategies for vulnerable populations.

The Efficacy and Mechanism of Positive Psychological Intervention on Well-Being for Colostomy Patients: A Randomized Controlled Trial

2021 ◽  
Author(s):  
Yanfei Jin ◽  
Yuqing Wang ◽  
Hongwen Ma ◽  
Xu Tian ◽  
Wang Honghong
Keyword(s):  
Life Satisfaction ◽  
Psychological Distress ◽  
Standard Care ◽  
Psychological Capital ◽  
Psychological Intervention ◽  
Well Being ◽  
Control Group ◽  
Significant Difference ◽  
Experimental Group ◽  
Positive Psychological Intervention

Abstract Aims To evaluate the efficacy and mechanism of positive psychological intervention (PPI) on the psychological capital, psychological distress, and life satisfaction among colostomy patients. Methods Patients (n=120) with permanent stomas were recruited and randomly assigned into two groups. Patients in the experimental group (n=60) received standard care and PPI, whereas patients in the control group (n=60) only received standard care. The psychological capital, psychological distress, and life satisfaction were measured and compared between two groups before the intervention, the immediate post-intervention, and follow-up. Results All 120 patients completed the study. The hope, optimism, resilience, psychological distress, and life satisfaction score of the experimental group were significantly higher than those of the control group at T1 and T2 (P<0.05). Self-efficacy score of the experimental group had no significant difference at the two-time points after the intervention than the control group (P>0.05). Changes in hope and resilience which belong to psychological capital mediated the intervention’s efficacy on changes in PPI on life satisfaction (β = 0.265, P=0.005; β = 0.686, P=0.002). Conclusions PPI could effectively improve psychological capital, psychological distress, and life satisfaction among patients with stomas. Besides, our findings add novel support that increased hope and resilience are the active ingredients that promote intervention change.

Effects of a physical self-care support program for patients with fibromyalgia: A randomized controlled trial

2021 ◽  
pp. 1-10
Author(s):  
Suélem B. de Lorena ◽  
Angela L.B.P. Duarte ◽  
Markus Bredemeier ◽  
Vanessa M. Fernandes ◽  
Eduardo A.S. Pimentel ◽  
...  
Keyword(s):  
Controlled Trial ◽  
Fibromyalgia Impact Questionnaire ◽  
Self Care ◽  
Support Program ◽  
Control Group ◽  
Study Objective ◽  
Study Results ◽  
Significant Difference ◽  
Stretching Exercises ◽  
Care Support

BACKGROUND: The effects of stretching exercises in fibromyalgia (FM) deserves further study. OBJECTIVE: To evaluate the effectiveness of a Physical Self-Care Support Program (PSCSP), with emphasis on stretching exercises, in the treatment of FM. METHODS: Forty-five women with FM were randomized to the PSCSP (n= 23) or to a control group (n= 22). The PSCSP consisted of weekly 90-minute learning sessions over 10 weeks, providing instructions on wellness, postural techniques, and active stretching exercises to be done at home. The control group was monitored through 3 medical appointments over 10 weeks and included in a waiting list. The primary outcomes were the Fibromyalgia Impact Questionnaire (FIQ), the Visual Analogue Scale (VAS) for pain, and the Sit and Reach Test (SRT) at the end of the study. RESULTS: Nineteen and 21 patients completed the trial in PSCSP and control groups, respectively. After 10 weeks, the PSCSP group showed significantly better FIQ (difference between adjusted means, -13.64, 95% CI, -21.78 to -5.49, P= 0.002) and SRT scores (7.24 cm, 3.12 to 11.37, P= 0.001) than the CONTROL group, but no significant difference in pain VAS (-1.41, -3.04 to 0.22, P= 0.088). Analysis using multiple imputation (MI) and delta-adjusted MI for missing outcomes rendered similar results. CONCLUSIONS: A PSCSP emphasizing stretching exercises significantly improved FIQ and SRT scores, and may be a helpful therapy for FM.

Studying Subjective Well-Being during a Quarantine

2021 ◽  
Author(s):  
Samuel Browning ◽  
E. Scott Geller
Keyword(s):  
Positive Psychology ◽  
Mood State ◽  
Well Being ◽  
Potential Effect ◽  
Mood States ◽  
Control Group ◽  
Subjective Well Being ◽  
Psychology Class ◽  
Significant Difference ◽  
The Impact

To investigate the impact of writing a gratitude letter on particular mood states, we asked students in two university classes (a research class and a positive psychology class) to complete a 15-item mood assessment survey (MAS) twice a day (once in the morning and once at night). The research students who signed up for one or two pass/fail field-study credits in a research class also completed the MAS twice a day, but they did not write the weekly gratitude letter that was expected from the students in the positive psychology class. Each mood state was averaged per each day for the participants in each group and compared between the Gratitude Group and the Control Group. No group difference occurred for some mood states like “incompetent,” but for the “unmotivated” mood state, a significant difference was found. To investigate the potential effect of weekday, we compared the average mood rating between groups for each day of the week. For the mood state of “unmotivated”, a remarkable dip occurred on Wednesday for the Gratitude group, but not for the Control group. These results indicated that writing a gratitude letter increased the benefactor’s motivation, especially on the day when it was accomplished.

scholarly journals Subjective Well-being, Mental Health and Concerns During the COVID-19 Pandemic: Evidence From the Global South

2021 ◽  
Vol 13 (2) ◽  
pp. 72
Author(s):  
Lina Martínez ◽  
Valeria Trofimoff ◽  
Isabella Valencia
Keyword(s):  
Mental Health ◽  
Life Satisfaction ◽  
Positive Emotions ◽  
Online Survey ◽  
Well Being ◽  
Global South ◽  
Subjective Well Being ◽  
Depression And Anxiety ◽  
Current Crisis ◽  
Study Results

COVID-19 pandemic is harming many social and economic spheres beyond physical health. The subjective well-being of the population (positive emotions and life satisfaction) and the prevalence of stressors affecting good mental health like worry, depression, and anxiety are increasing worldwide. This analysis presents evidence of subjective well-being and mental health in Colombia, South America, during the current crisis. The data for this analysis comes from an online survey released after one month of quarantine. In total, 941 adults participated in the study. Results show that women are more affected by their well-being and experience more often worry, depression, and anxiety than males. In particular, younger women and from the lower socioeconomic strata. Respondents identify three primary concerns because of the pandemic: i) financial consequences, ii) health (personal and loved one&#39;s health), and iii) productivity. Respondents are, on average, more concerned for the health of loved ones than their health. 49% of study participants report having an income reduction as a consequence of the pandemic, but women in all subgroups analyzed are more affected than males. In terms of productivity &ndash;working remotely-, educated people, and from 50+ age range, feels more productive working from home. Evidence from this analysis contributes to the broader research of the consequences of COVID-19 on the well-being of the population. Evidence comes from a country in the global South with high population ratings of subjective well-being, happiness, and life satisfaction before the pandemic.&nbsp;

scholarly journals Evaluation of balance, fall risk, and related factors in patients with fibromyalgia syndrome

2021 ◽  
Vol 67 (4) ◽  
pp. 409-415
Author(s):  
Köksal Sarıhan ◽  
Hülya Uzkeser ◽  
Akın Erdal
Keyword(s):  
Social Isolation ◽  
Fall Risk ◽  
Nottingham Health Profile ◽  
Risk Index ◽  
Control Group ◽  
Healthy Individuals ◽  
Increased Risk ◽  
Study Results ◽  
Significant Difference ◽  
Risk Of Falls

Objectives: In this study, we aimed to evaluate whether fibromyalgia patients had a higher fall risk compared to healthy individuals and to identify its relationship, if there was an increase, with clinical features. Patients and methods: Between March 2018 and September 2018, a total of 50 consecutive female patients with fibromyalgia (median age: 35 years; interquantile range [IQR], 27 to 40 years) and 50 healthy female volunteers (median age: 30 years; IQR, 23 to 40 years) were included in the study. Pain was evaluated with the Visual Analog Scale (VAS), life quality with the Nottingham Health Profile (NHP), balance functions with the Berg Balance Test (BBT), and the risk of falls with a posturography device. Disease activity of fibromyalgia patients was evaluated with the Fibromyalgia Impact Questionnaire (FIQ). Results: The mean fall risk index of the fibromyalgia patients was 45%. The fall risk index was significantly higher (p=0.010) and the BBT scores were significantly lower in the patient group (p<0.001). There was a significant difference in terms of fall risk between the control group and drug-free fibromyalgia patients; however, no significant difference was found between the balance scores of the two groups. In the fibromyalgia group, a weak positive relationship was determined between the fall risk index and the social isolation subscale of the NHP. Conclusion: Our study results showed an increased risk of loss of balance and falls in fibromyalgia patients, compared to healthy individuals. This fall risk increase was also detected in fibromyalgia patients who did not use drugs. These findings suggest a possible relationship between social isolation and an increased risk of falls.

Sign in / Sign up

Export Citation Format

Share Document