Prosthodontic Perspectives in Mucormycosis: A Review

2021 ◽  
Vol 13 (4) ◽  
pp. 293-302
Author(s):  
P Roshan Kumar ◽  
N Kalavathy ◽  
Mitha M Shetty ◽  
Archana K Sanketh ◽  
Anuradha Venkataramani ◽  
...  
Keyword(s):  
Surgical Intervention ◽  
Virus Disease ◽  
Psychological Trauma ◽  
Tissue Loss ◽  
Treatment Modalities ◽  
Key Factors ◽  
Recent Trends ◽  
Soft Tissue Loss

Rhino-cerebral mucormycosis, a fateful fungal infection which was commonly known to affect the immunocompromised patients, is now thriving in conjunction with Corona virus disease 2019 (COVID-19). Early diagnosis and aggressive medical and surgical intervention are the key factors to extricate the patients. However, this leads to abundant hard and soft tissue loss, leaving behind a huge orofacial defect, along with certain morbidities and psychological trauma, necessitating surgical and prosthodontic rehabilitation. The present paper reviews on role of prosthodontist in various stages of treatment for mucormycosis patients. It also summarizes several treatment modalities including recent trends to rehabilitate the defect and restore the patients’ quality of life.

The Role of Cross-Finger Flaps in the Primary Management of Untidy Flexor Tendon Injuries

1993 ◽  
Vol 18 (3) ◽  
pp. 408-408
Author(s):  
D. T. Gault ◽  
A. A. Quaba
Keyword(s):  
Flexor Tendon ◽  
Favourable Outcome ◽  
Tendon Injuries ◽  
Tissue Loss ◽  
Traditional Teaching ◽  
Flexor Tendon Injuries ◽  
Soft Tissue Loss ◽  
Primary Management

This is a report of five patients who sustained untidy division of flexor tendons in zones 1 and 2, associated with overlying soft tissue loss. Contrary to traditional teaching, the tendon injuries were repaired primarily, and the tissue loss was made good with a cross-finger flap. At final evaluation, three cases were assigned excellent grades and two cases fair grades by Kleinert criteria. This unexpectedly favourable outcome may be due to a quality of the inner surface of the cross-finger flap and/or to staggering of the skin and tendon suture lines.

The Role of Cross-Finger Flaps in the Primary Management of Untidy Flexor Tendon Injuries

1988 ◽  
Vol 13 (1) ◽  
pp. 62-65
Author(s):  
D. T. GAULT ◽  
A. A. QUABA
Keyword(s):  
Flexor Tendon ◽  
Favourable Outcome ◽  
Tendon Injuries ◽  
Tissue Loss ◽  
Traditional Teaching ◽  
Flexor Tendon Injuries ◽  
Soft Tissue Loss ◽  
Primary Management

This is a report of five patients who sustained untidy division of flexor tendons in zones 1 and 2, associated with overlying soft tissue loss. Contrary to traditional teaching, the tendon injuries were repaired primarily, and the tissue loss was made good with a cross-finger flap. At final evaluation, three cases were assigned excellent grades and two cases fair grades by Kleinert criteria. This unexpectedly favourable outcome may be due to a quality of the inner surface of the cross-finger flap and/or to staggering of the skin and tendon suture lines.

Role of Erlotinib in Influencing the Quality of Life of Cancer Patients

2020 ◽  
Vol 07 ◽  
Author(s):  
Deepika Purohit ◽  
Parijat Pandey
Keyword(s):  
Quality Of Life ◽  
Lung Cancer ◽  
Cancer Patients ◽  
Kinase Inhibitors ◽  
Treatment Modalities ◽  
Pancreatic Cancers ◽  
Review Reports ◽  
Causes Of Deaths

Background:: Cancer is one of the significant causes of morbidity and mortality in patients globally. Lung cancer, among other cancers, remains to be one of the principal causes of deaths in both men and women. The most common type of lung cancer is the non-small-cell lung cancer (NSCLC). Apart from lung cancer, pancreatic cancer is also one of the common cancers currently. Objective:: The assessment of QoL in erlotinib-treated patients can also prove to be very useful in the establishment of this drug as the main treatment option for the patients with pancreatic and lung cancer. Methods:: Therapies that target EGFR-mediated signalling are the latest keystones for treating these two types of cancers. They comprise of two main treatment modalities: firstly, against the extracellular fields, that include monoclonal antibodies and secondly, mechanisms that create interferences in the signalling pathways, primarily the small molecule tyrosine kinase inhibitors. Results:: Quality of life (QoL) is one of the key advantages in erlotinib therapy over chemotherapy. Conclusion:: The present review reports the role of erlotinib in improving the quality of life of cancer patients especially in NSCLC and pancreatic cancers. The studies or trials establishing the relations between erlotinib and QoL are discussed in detail in this review.

scholarly journals Drought and Salinity in Citriculture: Optimal Practices to Alleviate Salinity and Water Stress

Agronomy ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 1283
Author(s):  
Vasileios Ziogas ◽  
Georgia Tanou ◽  
Giasemi Morianou ◽  
Nektarios Kourgialas
Keyword(s):  
Agricultural Sector ◽  
Review Paper ◽  
Cell Metabolism ◽  
High Water ◽  
Crop Productivity ◽  
Fruit Tree ◽  
Key Factors ◽  
Negative Effect

Among the various abiotic stresses, drought is the major factor limiting crop productivity worldwide. Citrus has been recognized as a fruit tree crop group of great importance to the global agricultural sector since there are 140 citrus-producing countries worldwide. The majority of citrus-producing areas are subjected to dry and hot summer weather, limited availability of water resources with parallel low-quality irrigation water due to increased salinity regimes. Citrus trees are generally classified as “salt-intolerant” with high water needs, especially during summer. Water scarcity negatively affects plant growth and impairs cell metabolism, affecting the overall tree growth and the quality of produced fruit. Key factors that overall attempt to sustain and withstand the negative effect of salinity and drought stress are the extensive use of rootstocks in citriculture as well as the appropriate agronomical and irrigation practices applied. This review paper emphasizes and summarizes the crucial role of the above factors in the sustainability of citriculture.

scholarly journals Cell Therapy in Patients with Critical Limb Ischemia

2015 ◽  
Vol 2015 ◽  
pp. 1-13 ◽  
Author(s):  
Rita Compagna ◽  
Bruno Amato ◽  
Salvatore Massa ◽  
Maurizio Amato ◽  
Raffaele Grande ◽  
...  
Keyword(s):  
Cell Therapy ◽  
Critical Limb Ischemia ◽  
Limb Ischemia ◽  
Tissue Loss ◽  
Systematic Analysis ◽  
Peripheral Arterial Obstructive Disease ◽  
Peripheral Arterial ◽  
Cellular Components

Critical limb ischemia (CLI) represents the most advanced stage of peripheral arterial obstructive disease (PAOD) with a severe obstruction of the arteries which markedly reduces blood flow to the extremities and has progressed to the point of severe rest pain and/or even tissue loss. Recent therapeutic strategies have focused on restoring this balance in favor of tissue survival using exogenous molecular and cellular agents to promote regeneration of the vasculature. These are based on stimulation of angiogenesis by extracellular and cellular components. This review article carries out a systematic analysis of the most recent scientific literature on the application of stem cells in patients with CLI. The results obtained from the detailed analysis of the recent literature data have confirmed the beneficial role of cell therapy in reducing the rate of major amputations in patients with CLI and improving their quality of life.

Pharmacotherapy review: Emerging treatment modalities in transthyretin cardiac amyloidosis

2021 ◽  
Author(s):  
Emily Plumadore ◽  
Lindsay Lombardo ◽  
Katherine P Cabral
Keyword(s):  
Treatment Options ◽  
Disease State ◽  
Treatment Modalities ◽  
Limited Data ◽  
Limited Evidence ◽  
Agent Selection ◽  
Selection For ◽  
Tea Extract

Abstract Disclaimer In an effort to expedite the publication of articles , AJHP is posting manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time. Purpose This review aims to summarize the evidence and pharmacological characteristics of treatment options for transthyretin amyloid cardiomyopathy (ATTR-CM). Additionally, this review highlights the role of clinical pharmacists in helping to secure newly introduced therapies. Summary ATTR-CM, a disease characterized by misfolded protein that is deposited in the myocardium and disrupts cardiac functioning, has historically been underdiagnosed due to the need for invasive biopsy and an illusion of rarity. Once diagnosed, limited treatment modalities for ATTR-CM have led providers to rely on nonpharmacological remedies or off-label use of medications with limited evidence of benefit. However, recent noninvasive diagnostic advancements and heightened disease state awareness have revealed increased prevalence of ATTR-CM. This has led to the introduction of several first-in-class pharmaceuticals with actions targeted at inhibiting the various phases of amyloidosis: TTR stabilizers include diflunisal and first-in-class, Food and Drug Administration (FDA)-approved tafamidis; TTR silencers include patisiran and inotersen; fibril disrupters include doxycycline with tauroursodeoxycholic acid; and alternative agents include green tea extract and curcumin. Conclusion ATTR-CM treatments have emerged and, despite current limited data, are continuing to evolve. Tafamidis, the only agent approved by FDA for ATTR-CM, shows promise to improve survival and quality of life in patients with ATTR-CM. Pharmacists can play a key role in assisting with agent selection for this disease state, as well as providing knowledge about current and future clinical trials evaluating the safety and efficacy of the available treatment modalities.

The Role of Nursing in Caring for Patients Receiving Palliative Surgery or Chemotherapy

2019 ◽  
pp. 660-669
Author(s):  
Virginia Sun ◽  
Tami Tittelfitz ◽  
Marjorie J. Hein
Keyword(s):  
Palliative Treatment ◽  
Symptom Control ◽  
Palliative Surgery ◽  
Treatment Modalities ◽  
Indications For Surgery ◽  
Role Of Nursing ◽  
Definition Of ◽  
Treatment Intent

Surgery and chemotherapy are common treatment modalities used to manage disease and symptoms in palliative settings where the disease is incurable. These treatment modalities can lead to deteriorations in a patient’s quality of life (QOL). The benefits of palliative surgery and chemotherapy should always focus on QOL, symptom control, and symptom prevention. The purpose of this chapter is to provide an overview of the definition of palliative surgery and chemotherapy, describe common indications for surgery and chemotherapy for palliative treatment intent, and discuss the role of nursing in caring for patients who are receiving palliative surgery and chemotherapy.

scholarly journals ICT & Online Education – Factors affecting Employees’ preference for Online Education

2019 ◽  
Vol 8 (9) ◽  
pp. 994-1000
Keyword(s):  
Online Education ◽  
Rural Areas ◽  
Key Factors ◽  
Factors Affecting ◽  
Knowledge Enhancement ◽  
Education Market ◽  
E Learning ◽  
Teaching Learning

The potential of ICTs in promoting the development and reach of educational avenues in India is unambiguously clear in the light of the challenges facing the country. Role of ICTs with enhanced focus on development of content and the applications to provide enhanced quality of education must be synchronized with the various initiatives for using ICT for education and should be guided by adequate guidelines and framework. Provisioning of ICT is limited by the Infrastructure especially in the rural areas, where Internet and electrification are major issues of concern. It is well known that higher penetration of mobile phone, radio and TV implies increased development and delivery of innovative content via these media. This paper is focussed on the necessity to incorporate ICT as a part of the curriculum and also use it to strengthen the teaching learning process. The paper explores the key factors that drive the growth in the E-Learning sector. The authors undertook a research for identifying the various factors that may affect the choice and preference of employees for opting for online education as a measure for career/knowledge enhancement. The study indicates that online education market in India is currently booming. The growth of the market is dependent on the field of study, the willingness to pay, the credibility of the offering organization and the acceptability of the learning in the Corporate sector.

scholarly journals Role of gastrointestinal inflammations in the development and treatment of depression

2011 ◽  
Vol 152 (37) ◽  
pp. 1477-1485 ◽  
Author(s):  
János Fehér ◽  
Illés Kovács ◽  
Corrado Balacco Gabrieli
Keyword(s):  
Treatment Modalities ◽  
Depression Symptoms ◽  
Low Grade ◽  
Omega 3 ◽  
Neuropsychiatric Manifestation ◽  
Treatment Of Depression ◽  
Inflammatory Syndrome ◽  
Low Grade Inflammation

Recent studies have revealed that inflammation, among other factors, may be involved in the pathogenesis of depression. One line of studies has shown that depression is frequently associated with manifest gastrointestinal inflammations and autoimmune diseases as well as with cardiovascular diseases, neurodegenerative diseases, type 2-diabetes and also cancer, in which chronic low-grade inflammation is a significant contributing factor. Thus depression may be a neuropsychiatric manifestation of a chronic inflammatory syndrome. Another line of studies has shown that the primary cause of inflammation may be the dysfunction of the “gut-brain axis”. Although, this is a bidirectional mechanism, life style factors may primarily affect the symbiosis between host mucous membrane and the microbiota. Local inflammation through the release of cytokines, neuropeptides and eicosanoids may also influence the function of the brain and of other organs. Role of metabolic burst due to inflammation represents a new aspect in both pathophysiology and treatment of the depression. Finally, an increasing number of clinical studies have shown that treating gastrointestinal inflammations with probiotics, vitamin B, D and omega 3 fatty acids, through attenuating proinflammatory stimuli to brain, may also improve depression symptoms and quality of life. All these findings justify an assumption that treating gastrointestinal inflammations may improve the efficacy of the currently used treatment modalities of depression and related diseases. However, further studies are certainly needed to confirm these findings. Orv. Hetil., 2011, 152, 1477–1485.

scholarly journals Defining Characteristics of Democracy in the 21st Century

2021 ◽  
Author(s):  
Amanda Lenhardt
Keyword(s):  
Gender Inequality ◽  
21St Century ◽  
Freedom Of Expression ◽  
Emerging Trends ◽  
Regime Types ◽  
Recent Trends ◽  
Key Indicators ◽  
Civic Space

This report offers a brief overview of the literature on the defining characteristics of democracy in the 21st century. This report seeks to map out a range of conceptual approaches to understanding democracy, evidence on emerging trends in democratisation, and challenges to realising democracy in its varied forms. The report begins with a discussion on definitions of democracy that have emerged in recent decades (Section 2), highlighting a range of qualifiers that are widely used to differentiate and analyse different democratic regime types. Section 3 summarises trends in key indicators of democracy from widely cited observers – The Economist Intelligence Unit and the V-Dem Institute - and recent trends in public opinion towards democracy, according to World Values and Pew Centre surveys. Section 4 gives a very brief overview of three leading challenges to democracy discussed widely in the literature – gender inequality; the role of media and social media; and declining quality of elections, freedom of expression and civic space.

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