THE STUDY OF THE IMPACT OF THE SINGLE-POINT MILL CUTTING UNIT GEOMETRY ON ITS CUTTING PROPERTIES

2019 ◽  
Keyword(s):  
Single Point ◽  
The Impact ◽  
Cutting Unit

scholarly journals OP0277-PARE METABERN, THE EUROPEAN REFERENCE NETWORK FOR RARE HEREDITARY DISEASES: STRUCTURE, OBJECTIVES, METABOLIC RMDS AND THE ROLES OF EUROPEAN PATIENT ADVOCACY GROUPS (EPAGS)

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 168.2-168
Author(s):  
L. Wagner ◽  
S. Sestini ◽  
C. Brown ◽  
A. Finglas ◽  
R. Francisco ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Health Care ◽  
Social Science ◽  
Metabolic Pathways ◽  
Metabolic Disorders ◽  
Clinical Care ◽  
Single Point ◽  
Link Type ◽  
The Impact

Background:Inborn metabolic disorders (IMDs) currently encompass more than 1,500 diseases with new ones still to be identified1. Each of them is characterised by a genetic defect affecting a metabolic pathway. Only few of them have curative treatments, that target the respective metabolic pathway. Commonly, treatment examples include diet, substrate reduction therapies, enzyme replacement therapies, gene therapy and biologicals, enabling IMD-patient now to survive to adulthood. About 30 % of all IMDs involve the musculoskeletal system and are here referred to as rare metabolic RMDs. Generally, IMDs are very heterogenous with respect to symptoms and severity, often being systemic and affecting more children than adults. Thus, challenges include certified advanced training of adult metabolic experts, standardised transition plans, social support and development of therapies for diseases that do not have any cure yet.Objectives:Introduction of MetabERN, its structure and objectives, highlighting on the unique features and challenges of metabolic RMDs and describing the involvement of patient representation in MetabERN.Methods:MetabERN is stratified in 7 subnetworks (SNW) according to the respective metabolic pathways and 9 work packages (WP), including administration, dissemination, guidelines, virtual counselling framework, research/clinical trials, continuity of care, education and patient involvement. The patient board involves a steering committee and single point of contacts for each subnetwork and work package, respectively2. Projects include identifying the need of implementing social science to assess the psycho-socio-economic burden of IMDs, webinars on IMDs and their transition as well as surveys on the impact of COVID-193 on IMD-patients and health care providers (HCPs), social assistance for IMD-patients and analysing the transition landscape within Europe.Results:The MetabERN structure enables bundling of expertise, capacity building and knowledge transfer for faster diagnosis and better health care. Rare metabolic RMDs are present in all SNWs that require unique treatments according to their metabolic pathways. Implementation of social science to assess the psycho-socio-economic burden of IMDs is still underused. Involvement of patient representatives is essential for a holistic healthcare not only focusing on clinical care, but also on the quality of life for IMD-patients. Surveys identified unmet needs of patient care, patients having little information on national support systems and structural deficits of healthcare systems to ensure HCP can provide adequate clinical care during transition phases. These results are collected by MetabERN and forwarded to the Directorate-General for Health and Food Safety (DG SANTE) of the European Commission (EC) to be addressed further.Conclusion:MetabERN offers an infrastructure of virtual healthcare for patients with IMDs. Thus, in collaboration with ERN ReCONNET, MetabERN can assist in identifying rare metabolic disorders of RMDs to shorten the odyssey of diagnosis and advise on their respective therapies. On the other hand, MetabERN can benefit from EULAR’s longstanding experience regarding issues affecting the quality of life, all RMD patients are facing, such as pain, stiffness, fatigue, rehabilitation, maintaining work and disability claims.References:[1]IEMbase - Inborn Errors of Metabolism Knowledgebase http://www.iembase.org/ (accessed Jan 29, 2021).[2]MetabERN: European Refence Network for Hereditary Metabolic Disorders https://metab.ern-net.eu/ (accessed Jan 29, 2021).[3]Lampe, C.; Dionisi-Vici, C.; Bellettato, C. M.; Paneghetti, L.; van Lingen, C.; Bond, S.; Brown, C.; Finglas, A.; Francisco, R.; Sestini, S.; Heard, J. M.; Scarpa, M.; MetabERN collaboration group. The Impact of COVID-19 on Rare Metabolic Patients and Healthcare Providers: Results from Two MetabERN Surveys. Orphanet J. Rare Dis.2020, 15 (1), 341. https://doi.org/10.1186/s13023-020-01619-x.Acknowledgements:The authors thank the MetabERN collaboration group, the single point of contacts (SPOC) of the MetabERN patient board and the Transition Project Working Group (TPWG)Disclosure of Interests:None declared

The effects of corporate brand symbolism on consumer satisfaction and loyalty

2016 ◽  
Vol 28 (3) ◽  
pp. 481-498 ◽  
Author(s):  
Tatiana Anisimova
Keyword(s):  
Social Life ◽  
Consumer Satisfaction ◽  
Single Point ◽  
Social Aspects ◽  
Consumer Loyalty ◽  
Cross Sectional ◽  
Corporate Brand ◽  
Content Type ◽  
Strategic Role ◽  
The Impact

Purpose – The purpose of this paper is to test the effects of corporate brand symbolism on consumer satisfaction and loyalty on a sample of Australian automobile consumers. Design/methodology/approach – Survey research was employed to test the study hypotheses. The regression analysis was used to evaluate the relationships between an independent variable (corporate brand symbolism) and dependent variables (consumer satisfaction and loyalty). Findings – Support was found for all hypotheses formulated in this study. Regression results reveal consistent favourable and significant effects of corporate brand symbolism on both consumer satisfaction and loyalty. Research limitations/implications – Although this paper makes contributions in international marketing, the cross-sectional nature of the data collection method limits the information gained to the single point in time. This research studied the impact of corporate brand symbolism on consumers of one original equipment manufacturers (OEM). Having a larger number of participating car manufacturers/OEMs would have provided a wider insight. However, time and resources limitation did not allow to study a larger sample. In the future, practitioners are recommended to further understand the relationship between self and social aspects of brand symbolism in order to formulate more targeted communication strategies. Practical implications – The findings of this study point to the strategic role of the brand in generating both satisfaction and loyalty. In the light of increasing advertising costs and decreasing consumer loyalty, strengthening corporate brand symbolism makes a lot of economic sense. The findings suggest that managers need to take into account consumer need for identity expression and consider this in their branding strategies. Social implications – Humans are social beings by nature. However, international brand research has paid relatively little attention to how products are used by consumers in everyday life, including their social life. Consumer behaviours increasingly depend on social meanings they imbue brands with beyond products’ functional utility. It is argued the focus of symbolic consumption needs to be broadened and integrated more with social science concepts. Originality/value – This study captures a construct of corporate brand symbolism by including self and social aspects of symbolism. The current study also comprehensively measures consumer loyalty, including cognitive, affective and behavioural types of loyalty.

Resolving the Unique Invariant Slip-Direction in Rigid Three-Dimensional Multi-Point Impacts at Stick-Slip Transitions

2018 ◽  
Author(s):  
Abhishek Chatterjee ◽  
Alan Bowling
Keyword(s):  
Single Point ◽  
Three Dimensional ◽  
Impact Behavior ◽  
Slip Direction ◽  
Stick Slip ◽  
Impact Forces ◽  
Post Impact ◽  
Impact Problems ◽  
Slip Transition ◽  
The Impact

This work presents a new approach for resolving the unique invariant slip direction at Stick-Slip Transition during impact. The solution method presented in this work is applicable to both single-point and multi-point impact problems. The proposed method utilizes rigid body constraints to resolve the impact forces at all collision points in terms of a single independent impact forces parameter. This work also uses an energetic coefficient of restitution to terminate impact events, thereby yielding energetically consistent post-impact behavior.

Risk Analysis of Live Fire Shoot House Containment Systems Against Multiple Projectile Impacts

2020 ◽  
Author(s):  
Steven D. Andreen ◽  
Brad G. Davis
Keyword(s):  
Normal Distribution ◽  
Numerical Models ◽  
Single Point ◽  
Experimental Results ◽  
Risk Level ◽  
Triangular Distribution ◽  
Repeated Impact ◽  
Steel Panels ◽  
The Impact ◽  
Projectile Impacts

Abstract Many analytical and numerical models exist that can describe the effect of single projectile impacts on steel targets. These models are not adequate for the evaluation of live fire shoot house containment systems, which are subjected to repeated impact loading from small caliber projectiles over the lifetime of the structure. Models assuming perfectly rigid projectiles over-predict penetration depths. Models assuming rigid targets cannot predict any penetration, and hydrodynamic models are best suited to high velocity impacts well above the ranges of conventional ordinance. Development of sufficient analytical or numerical tools using traditional techniques would be either intractable, empirically based and unique to a given scenario, require unique material properties that are not commonly available, or require significant computational effort. Due to the limited amount of empirical data on multiple impact failure, classical reliability methods are not suitable for assessing the probability of containment system perforation. Using existing experimental results of .223 caliber ammunition against AR500 steel panels with 2-inch ballistic rubber, a commonly found protective system in these facilities, the cumulative effects of multiple projectiles were quantified to estimate the number of impacts required to perforate the target material. Impacts were simulated from normal distributions of the x and y coordinates describing the impact point using a cartesian coordinate plane. The impact resistance of the steel was also simulated from a triangular distribution to account for the variability of the experimental results. Monte Carlo Simulation was then used to estimate the expected number of impacts to cause failure at a single point on the target. Using this collective model, it was possible to determine that the distribution of the number of rounds to cause target failure approached a normal distribution. The results indicated that the mean impacts at failure was 11800 with a standard deviation of 800 impacts. Finally, targeting the allowable risk level for structural failure from the JCSS probabilistic model code from the simulated normal distribution, it was determined that the safe number of impacts was approximately 7996. Decision makers can utilize the safe number of impacts to inform training guidance for the future use of facilities and to develop effective inspection requirements. This model can also be adapted to evaluate similar training facilities and to assess how other small caliber projectile impacts would affect live fire shoot house containment systems, providing a useful tool for the design and analysis of future and the assessment of existing facilities for use with ammunition that did not exist during its design.

scholarly journals The Impact of COVID-19 on Epilepsy Care: A Survey of the American Epilepsy Society Membership

2020 ◽  
Vol 20 (5) ◽  
pp. 316-324
Author(s):  
Dara V. F. Albert ◽  
Rohit R. Das ◽  
Jayant N. Acharya ◽  
Jong Woo Lee ◽  
John R. Pollard ◽  
...  
Keyword(s):  
Elective Surgery ◽  
Clinical Care ◽  
Single Point ◽  
The United States ◽  
Prior History ◽  
Delivery Of Care ◽  
History Of ◽  
Almost All ◽  
The Impact ◽  
New Onset

The COVID-19 pandemic has impacted the delivery of care to people with epilepsy (PWE) in multiple ways including limitations on in-person contact and restrictions on neurophysiological procedures. To better study the effect of the pandemic on PWE, members of the American Epilepsy Society were surveyed between April 30 and June 14, 2020. There were 366 initial responses (9% response rate) and 337 respondents remained for analysis after screening out noncompleters and those not directly involved with clinical care; the majority were physicians from the United States. About a third (30%) of respondents stated that they had patients with COVID-19 and reported no significant change in seizure frequency. Conversely, one-third of respondents reported new onset seizures in patients with COVID-19 who had no prior history of seizures. The majority of respondents felt that there were at least some barriers for PWE in receiving appropriate clinical care, neurophysiologic procedures, and elective surgery. Medication shortages were noted by approximately 30% of respondents, with no clear pattern in types of medication involved. Telehealth was overwhelmingly found to have value. Among the limitation of the survey was that it was administered at a single point in time in a rapidly changing pandemic. The survey showed that almost all respondents were affected by the pandemic in a variety of ways.

scholarly journals Impacts Assessments without True Baselines: Assessing the Relative Effects of Training on the Performance of Water User Associations in Southern Tajikistan

2018 ◽  
Vol 04 (03) ◽  
pp. 1850007 ◽  
Author(s):  
Soumya Balasubramanya ◽  
Joseph P. G. Price ◽  
Theodore M. Horbulyk
Keyword(s):  
Structural Changes ◽  
Propensity Scores ◽  
Single Point ◽  
Water User Associations ◽  
Water User ◽  
The Difference ◽  
Synthetic Controls ◽  
New Institutions ◽  
Time Invariant ◽  
The Impact

Conducting rigorous evaluations of whether the process of creating new institutions affects their performance of mandated duties presents several challenges. Not only is assignment to process often not random, but when the process of creating new institutions starts, outcomes and other performance-influencing covariates are not measurable because the yet-to-be created institutions are not functioning at baseline. This paper compares the performance of 74 ‘treated’ water user associations (WUAs) in Tajikistan that were created using a longer training process with 67 ‘control’ WUAs that were created using shorter training, to assess the impact of training on WUA performance of mandated duties. First, propensity scores were constructed to estimate the probabilities of being ‘treated’ by treatment status. These results guided the application of the difference-in-difference technique with right-hand side covariates in a context where field measures of outcomes and other performance-influencing covariates were made after the new institutions were created and functioning. The first measures were taken within 12–18 months of the new institutions being functional and the second measures were taken 24 months after the first. This choice of methods introduces a bias due to measurement error causing an underestimate of the treatment effects, while controlling for biases due to time-invariant and time-varying unobservables. An alternative method that only compared the differences in outcomes at a single point in time after the new institutions were created would have provided an inaccurate estimate of the effects of the intervention. This is a context in which methods such as synthetic controls are impossible to employ due to the nature of the intervention, other macroeconomic structural changes, and severe data restrictions. The methodology employed here generates evidence that, while biased toward generating an underestimate of effect, can still be useful and informative for policy and management purposes, and for evaluating the impact of process on the functioning of new institutions in transition settings.

scholarly journals EP.FRI.1023 Clinical Portal: a clinician-led IT solution to the ‘surgical list’

2021 ◽  
Vol 108 (Supplement_7) ◽  
Author(s):  
Cait Bleakley ◽  
Chloe Wright ◽  
Rola Salem ◽  
Kirk Bowling
Keyword(s):  
Patient Information ◽  
Single Point ◽  
Direct Consequence ◽  
Direct Access ◽  
Accurate Information ◽  
Junior Doctors ◽  
Post Intervention ◽  
It Systems ◽  
The Creation ◽  
The Impact

Abstract Aim Burnout amongst junior doctors is an emotive topic, with time pressures during busy on-call shifts negatively impacting efficiency and morale. Historically, within busy surgical firms the most junior team members commonly worked beyond scheduled hours. It has been highlighted within our trust that our IT systems significantly contributed to this. Thus leading to the creation of a clinician-led IT solution, enabling direct access to accurate information at a single point.  This study aims to measure the impact of the systems introduction on efficiency and shift experience of our junior doctors.  Methods 'Clinical Portal’ was introduced in August 2019. This IT system enables all patient information to be collated in one place, with the added benefit of simplifying the creation of patient lists. Number and duration of Exception Reports (ER) by on-call surgical juniors were measured for two months pre and post intervention. A qualitative survey was also distributed to this cohort to measure satisfaction and experience during on-call shifts within this period.  Results Following introduction of 'Clinical Portal', the total length of time included in ERs reduced. Surgical juniors expressed an improvement in their on-call experience, most notably dedicating less time to collating patient information and ward list formation. The overall experience improved despite time required to become proficient at using the new system.  Conclusions Streamlining of IT systems used during on-call shifts demonstrates improved efficiency amongst juniors reflected in a reduction of ERs. A direct consequence of these implemented changes is significant improvement in morale amongst our juniors. 

scholarly journals How sensitive are modeled contemporary subsea permafrost thaw and thickness of the methane clathrates stability zone in Eurasian Arctic to assumptions on Pleistocene glacial cycles?

2016 ◽  
Author(s):  
Valentina V. Malakhova ◽  
Alexey V. Eliseev
Keyword(s):  
Time Scales ◽  
Thermal State ◽  
Initial Conditions ◽  
Single Point ◽  
Ice Core ◽  
Oceanic Water ◽  
Stability Zone ◽  
Glacial Cycles ◽  
The Impact ◽  
Subsea Permafrost

Abstract. Single-point simulations with a model for thermal state of subsea sediments driven by the forcing constructed from the ice core data show that the impact of initial conditions is lost after ~ 100 kyr. The time scales of temperature propagation in sediments and respective permafrost response are ~ 10–20 kyr which is longer than the present interglacial. The timings of shelf exposure during oceanic regressions and flooding during transgressions are important for representation of sediment thermal state and hydrates stability zone (HSZ). These timings should depend on the contemporary shelf depth (SD). During glacial cycles temperature at the top of sediments is a major driver of HSZ vertical boundaries change for SD of few tens of meters, while the pressure exerted by oceanic water becomes more important for larger SD. Thus, even the existence of HSZ and its disappearance might not be easily tied to oceanic transgressions and regressions.

scholarly journals EFFECT OF FORMING TOOLS NOSE ON THE FORMABILITY OF SINGLE POINT INCREMENTAL SHEET FORMING.

2021 ◽  
Vol 21 (1) ◽  
pp. 1-14
Author(s):  
Entesar Nayyef Farhan
Keyword(s):  
Metal Forming ◽  
Room Temperature ◽  
Fe Simulation ◽  
Contact Region ◽  
Single Point ◽  
Spring Back ◽  
Incremental Sheet Metal Forming ◽  
Aluminum 7075 ◽  
Forming Tools ◽  
The Impact

In this paper the FE simulation and experimental equipment and design of the system for deformation by single point incremental sheet metal forming are presented. The formability is executed at room temperature and needs the milling machine, the tool of hemispherical head and toroidal head applied to deform the sheet, whereas translates from the peripheral of the sheet to its focus that additionally driving the sheet down. The blank is distorted increment by increment into the required shape via hemispherical or toroidal nose instrument going along a circular way. In the present investigation, the deformation’s analyses were down on the aluminum 7075 compound with thickness (0.9mm) and various device nose are enormously impact on the contact region and its observed that the hemispherical apparatus gives the best outcome. Close to this investigation consequence of the impact of shaping instrument nose on the formability is displayed. The ANSYS results are comparison with results obtained experimentally and it's discovered the deviation about 8% and this is expected to the criteria of spring-back.

scholarly journals CARACTERIZACIÓN AMBIENTAL DE LA ENSENADA DE PLAYA GRANDE, ESTADO SUCRE, VENEZUELA

2016 ◽  
Author(s):  
J. Castañeda ◽  
William James Senior ◽  
Arístide Márquez ◽  
Ángel González
Keyword(s):  
Single Point ◽  
Coastal Region ◽  
Fecal Coliforms ◽  
Trade Winds ◽  
Human Contact ◽  
Hydrographic Conditions ◽  
Chemical Conditions ◽  
Set Up ◽  
The Impact

The hydrographic conditions and sanitary quality of the waters of the coastal region of Playa Grande Baywere studied during May 2003. We set up 21 stations to collect surface and bottom samples and three current meters – anupward-mounted hydroacoustic profiler and two single-point Doppler current sensors that operated for 14 days. Samples werecollected in 5-L Niskin bottles equipped with a lid-closing device operated through a cable. The samples were studied accordingto established methods for seawater analysis. The pH ranged between 7.93 and 8.31; the temperature, between 22.0 and 24.0ºC; the salinity, between 36.56 and 37.17 units; the color, between 15 and 30 Pt-Co units. The biochemical oxygen demandranged between 4.05 and 68.96 mg/L; and total nitrogen, between 0.53 and 1.27 mg/L. Total phosphate fluctuated between0.02 and 0.16 mg/L; lipids, between 0.08 and 0.39 mg/L; aliphatic hydrocarbons, between 0.01 and 0.12 mg/L. Detergents didnot exceed the value of 0.02 mg/L. In some cases, total and fecal coliforms reached values beyond the limit of 1000 NMP/100ml for total coliforms set by the Ministry of the Environment for type 4 waters (partial and total human contact). Thequality of these waters shows the impact of effluents, running mostly from east to west, in the sector of Campo Ajuro. Thephysical and chemical conditions of the waters of this bay may vary throughout the year as a consequence of the dynamicconditions prevailing in the region. It is recommended that these studies be carried out at least twice a year: during the dryseason (December to May), when the trade winds increase, and during the rainy season (June to November).

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