DEVELOPMENT OF TECHNOLOGY AND RESEARCH OF WATER-SOLUBLE FILMS OF MEDICINAL ANTI-INFLAMMATORY ACTION

2021 ◽  
pp. 80-86
Author(s):  
Pletneva I.V. ◽  
Petrukhina D.A. ◽  
Pokrovskaya Y.S.
Keyword(s):  
Wound Healing ◽  
Salt Lake ◽  
Wide Spectrum ◽  
Water Soluble ◽  
Biologically Active ◽  
Application Site ◽  
Adhesive Properties ◽  
Lipid Complex ◽  
Anti Inflammatory ◽  
And Storage

Salt Lake Elton is one of the most valuable natural objects of the Volgograd region. Therapeutic muds are characterized by a wide spectrum of pharmacological activity, a positive effect on cellular humoral nonspecific immunity in terms of initiating prooxidant processes contribute to the restoration of balanced functioning of the system of lipid peroxidation and the antioxidant system. However, the use of native therapeutic mud in therapy has a number of contraindications and limitations. Native therapeutic mud is not stable, biologically active substances of therapeutic mud are destroyed under the influence of environmental factors, losing their properties during transportation and storage. The development of technology of dosage forms based on extracts from native therapeutic mud that do not have the disadvantages inherent in native mud, convenient for use, transportation and storage is an urgent task of pharmacy. So, the technology allowing to receive an oil solution of the lipid complex "Elton"is patented. The product" Elton " has an analgesic, anti-inflammatory, wound healing, keratoplastic, antioxidant, membrane-stabilizing effect. The aim of the study was to develop a technology of biodegradable drug film containing an oil solution of the lipid complex "Elton". The oil solution has a low adhesive ability, drains from the application site, which negatively affects the effectiveness of treatment. The development of the drug film technology will eliminate the listed disadvantages of the oil solution of the lipid complex "Elton", will provide a prolonged and local action at the application site. In the development of medicinal films, we used gelatin as a base-forming component, which has a high ability to gel, physiological indifference, good adhesive properties, hemostatic and wound-healing effect.

A biologically active delivery material with dried-rehydrated vesicles containing the anti-inflammatory diclofenac for potential wound healing

2015 ◽  
Vol 26 (4) ◽  
pp. 269-275 ◽  
Author(s):  
Helena Ferreira ◽  
Raquel Silva ◽  
Teresa Matamá ◽  
Carla Silva ◽  
Andreia C. Gomes ◽  
...  
Keyword(s):  
Wound Healing ◽  
Biologically Active ◽  
Anti Inflammatory

scholarly journals A Review on the Ethnobotanical Uses, Phytochemistry and Pharmacology Effect of Luffa cylindrica

2021 ◽  
Author(s):  
Kazeeem Akinyinka Akinwumi ◽  
Oluwole Olusoji Eleyowo ◽  
Omolara Omowunmi Oladipo
Keyword(s):  
Wound Healing ◽  
Methyl Ester ◽  
Whooping Cough ◽  
Wide Spectrum ◽  
Luffa Cylindrica ◽  
Upset Stomach ◽  
Anti Inflammatory ◽  
Ethnobotanical Uses ◽  
Black Seeds ◽  
Different Parts

Luffa cylindrica, popularly known as sponge gourd is a tropic and sub-tropical fibrous plant with fruits containing black seeds. The fruit is consumed by humans as a vegetable in many parts of Asia, while different parts of the plant are used for cosmetics and as medicine in many parts of the globe. The plant has been used in the treatment of many ailments including nose cancer, snake venom, wound healing, edema, enterobiasis, filaria, whooping cough, stomach upset, stomach pain and malaria. Many health-promoting compounds such as flavonoids (apigenin-7- glucuronide luteolin-7-O-β-D-glucuronide methyl ester, -O-feruloyl-β-D-glucose, luteolin-7-O-β-D-glucuronide methyl ester), phenolics acids (p-Coumaric, gallic, caffeic, chlorogenic), triterpenoids (oleanolic acid and echinocystic acid), saponins (Lucyoside A-M), tannins (catechin), ribosome-inactivating proteins (α- luffin), carotenoids (9 -cis neoxanthin, all-trans-lutein, all-trans-β-carotene), chlorophylls (chlorophyll a and b, pheophytin), cucurbitacin B and gypsogenin have been detected or isolated from different parts of the plants. Extracts of the plant and isolated compounds have wide spectrum pharmacological activities and have been shown to possess antiemetic, antidiabetic, antiviral, wound healing, anticancer, antipyretic, anti-inflammatory, antifungal, anti-bacteria, anthelmintic, hypoglycemic and antihyperglycemic, anti-inflammatory, antioxidant activity, and hepato-protective effects in animal models. However, further information is needed on its safety and mechanisms of action. The present article is an updated review of the ethnobotanical uses, pharmacological actions, phytochemistry, safety, and future application of Luffa cylindrica in translational medicine.

scholarly journals Oat β-glucan: physico-chemical characteristics in relation to its blood-glucose and cholesterol-lowering properties

2014 ◽  
Vol 112 (S2) ◽  
pp. S4-S13 ◽  
Author(s):  
Qi Wang ◽  
Peter R. Ellis
Keyword(s):  
Blood Glucose ◽  
Plasma Cholesterol ◽  
Chemical Properties ◽  
Water Soluble ◽  
Biologically Active ◽  
Metabolic Effects ◽  
Cholesterol Lowering ◽  
Solution Rheology ◽  
And Storage

The water-soluble, mixed-linkage β-glucan, a form of soluble dietary fibre, is considered the main biologically active component responsible for the capacity of many oat products to lower postprandial glycaemia and fasting plasma cholesterol in human subjects. The present review discusses the physical and chemical properties of oat β-glucan that are considered important predictors of these beneficial metabolic effects.In vitromodelling and animal and human studies have provided compelling evidence showing that the ability of oat β-glucan to increase the viscosity of digesta in the gastrointestinal tract (GIT) is a primary determinant of its blood-glucose and cholesterol-lowering properties. Therefore, the chemical structure, molecular weight (MW), the rate and extent of dissolution and solution rheology of oat β-glucan are key factors in determining the physiological function of oat-containing foods. The structure and properties of oat β-glucan vary between species and varieties of oats, and are also affected by the growing and storage conditions and processing of oat grain. In addition, the extraction and analysis methods may also contribute to the variations in the structure, MW, hydration and solution rheology of β-glucan obtained from different laboratories. Recent work has demonstrated that β-glucan solubility in foods depends on the source of the material and processing conditions; solubility may also be subject to changes during food preparation and storage (such as freezing). In conclusion, both the amount and MW of β-glucan that are solubilised in the GIT need to be considered when assessing the blood-glucose and cholesterol-lowering properties of oat-containing foods.

scholarly journals Growth factor functionalized biomaterial for drug delivery and tissue regeneration

2017 ◽  
Vol 32 (6) ◽  
pp. 568-581 ◽  
Author(s):  
Alex Leonard ◽  
Piyush Koria
Keyword(s):  
Drug Delivery ◽  
Wound Healing ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Tissue Regeneration ◽  
Chronic Wounds ◽  
Biologically Active ◽  
Application Site ◽  
Epidermal Growth ◽  
And Migration

Elastin-like polypeptides are a class of naturally derived and non-immunogenic biomaterials that are widely used in drug delivery and tissue engineering. Elastin-like polypeptides undergo temperature-mediated inverse phase transitioning, which allows them to be purified in a relatively simple manner from bacterial expression hosts. Being able to genetically encode elastin-like polypeptides allows for the incorporation of bioactive peptides, thereby functionalizing them. Here, we report the synthesis of a biologically active epidermal growth factor–elastin-like polypeptide fusion protein that could aid in wound healing. Epidermal growth factor plays a crucial role in wound healing by inducing cell proliferation and migration. The use of exogenous epidermal growth factor has seen success in the treatment of acute wounds, but has seen relatively minimal success in chronic wounds because the method of delivery does not prevent it from diffusing away from the application site. Our data show that epidermal growth factor–elastin-like polypeptide retained the biological activity of epidermal growth factor and the phase transitioning property of elastin-like polypeptide. Furthermore, the ability of the epidermal growth factor–elastin-like polypeptide to self-assemble near physiological temperatures could allow for the formation of drug depots at the wound site and minimize diffusion, increasing the bioavailability of epidermal growth factor and enhancing tissue regeneration.

Megavitamin Therapy for Childhood Psychoses and Learning Disabilities

PEDIATRICS ◽  
1976 ◽  
Vol 58 (6) ◽  
pp. 910-912
Author(s):  
Lewis A. Barness ◽  
Alvin M. Mauer ◽  
Arnold S. Anderson ◽  
Peter R. Dallman ◽  
Gilbert B. Forbes ◽  
...  
Keyword(s):  
Wide Spectrum ◽  
Daily Intake ◽  
Normal Diet ◽  
Water Soluble ◽  
Biologically Active ◽  
National Academy Of Sciences ◽  
Inborn Errors ◽  
Normal Children ◽  
Disease States ◽  
Fat Soluble Vitamins

Vitamins have long been recognized for their unique role in human nutrition. Most of these low-molecular weight, organic substances are precursors of coenzymes, and adequate amounts to meet the known nutritional needs of healthy persons of all ages have been defined by the Food and Nutrition Board of the National Academy of Sciences as the "Recommended Dietary Allowances" (RDA). The consistent opinion of the Committee on Nutrition of the American Academy of Pediatrics has been that normal children receiving a normal diet do not need vitamin supplementation1 over and above RDA levels. However, there are a variety of clinical entities in which the daily intake of vitamins needs to be significantly increased. This is true, for example, with the fat-soluble vitamins A, D, E, and K in the steatorrhoeas2 and in the autosomally recessive selective malabsorption of vitamin B12.3 Rarely, children treated with isoniazid require increased pyridoxine; and, when treated with diphenylhydantoin sodium (Dilantin), they need increased folic acid and vitamin D.4 Finally, there are a number of rare inborn errors of metabolism affecting the apoenzyme at the cofactor binding site or involving the metabolism of the vitamin itself to its biologically active derivative.5 In these so-called dependency syndromes, the metabolic defect may completely or partially be overcome by greatly increasing vitamin or cofactor availability. Set against a background of wide public belief in the benefits of vitamins, the accounts of dramatic amelioration of deficiency states, the easy and relatively inexpensive availability of these substances, and the occasional, remarkable benefit of large doses (both in the dependency syndromes and in certain other clinical situations), it is not surprising that a cult developed in the use of large doses of water-soluble vitamins to treat a wide spectrum of disease states.

scholarly journals Efficacy of Water-Soluble Pearl Powder Components Extracted by a CO2 Supercritical Extraction System in Promoting Wound Healing

Materials ◽  
2021 ◽  
Vol 14 (16) ◽  
pp. 4458
Author(s):  
Minting Liu ◽  
Junjun Tao ◽  
Hongchen Guo ◽  
Liang Tang ◽  
Guorui Zhang ◽  
...  
Keyword(s):  
Wound Healing ◽  
High Efficiency ◽  
Extraction Process ◽  
Water Soluble ◽  
Biologically Active ◽  
Supercritical Extraction ◽  
Extraction System ◽  
Collagen Formation

Pearl powder is a biologically active substance that is widely used in traditional medicine, skin repair and maintenance. The traditional industrial extraction processes of pearl powder are mainly based on water, acid or enzyme extraction methods, all of which have their own drawbacks. In this study, we propose a new extraction process for these active ingredients, specifically, water-soluble components of pearl powder extracted by a CO2 supercritical extraction system (SFE), followed by the extraction efficiency evaluation. A wound-healing activity was evaluated in vitro and in vivo. This demonstrated that the supercritical extraction technique showed high efficiency as measured by the total protein percentage. The extracts exhibited cell proliferation and migration-promoting activity, in addition to improving collagen formation and healing efficiency in vivo. In brief, this study proposes a novel extraction process for pearl powder, and the extracts were also explored for wound-healing bioactivity, demonstrating the potential in wound healing.

An in vitro model for investigation of vitamin A effects on wound healing

2021 ◽  
pp. 1-6
Author(s):  
Hoda Keshmiri Neghab ◽  
Mohammad Hasan Soheilifar ◽  
Gholamreza Esmaeeli Djavid
Keyword(s):  
Wound Healing ◽  
Endothelial Cell ◽  
Vitamin A ◽  
In Vitro Model ◽  
Cellular Proliferation ◽  
Endothelial Cell Migration ◽  
Normal Fibroblast ◽  
Anti Inflammatory ◽  
Vitro Model

Abstract. Wound healing consists of a series of highly orderly overlapping processes characterized by hemostasis, inflammation, proliferation, and remodeling. Prolongation or interruption in each phase can lead to delayed wound healing or a non-healing chronic wound. Vitamin A is a crucial nutrient that is most beneficial for the health of the skin. The present study was undertaken to determine the effect of vitamin A on regeneration, angiogenesis, and inflammation characteristics in an in vitro model system during wound healing. For this purpose, mouse skin normal fibroblast (L929), human umbilical vein endothelial cell (HUVEC), and monocyte/macrophage-like cell line (RAW 264.7) were considered to evaluate proliferation, angiogenesis, and anti-inflammatory responses, respectively. Vitamin A (0.1–5 μM) increased cellular proliferation of L929 and HUVEC (p < 0.05). Similarly, it stimulated angiogenesis by promoting endothelial cell migration up to approximately 4 fold and interestingly tube formation up to 8.5 fold (p < 0.01). Furthermore, vitamin A treatment was shown to decrease the level of nitric oxide production in a dose-dependent effect (p < 0.05), exhibiting the anti-inflammatory property of vitamin A in accelerating wound healing. These results may reveal the therapeutic potential of vitamin A in diabetic wound healing by stimulating regeneration, angiogenesis, and anti-inflammation responses.

In vitro anti-inflammatory and wound healing activities of Citrus auraptene

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
F Epifano ◽  
S Genovese ◽  
L Zhao ◽  
V Dang La ◽  
D Grenier
Keyword(s):  
Wound Healing ◽  
Anti Inflammatory

The effects and use of negative pressure wound therapy – a set of case reports

2020 ◽  
Vol 99 (4) ◽  
pp. 183-188
Keyword(s):  
Wound Healing ◽  
High Risk ◽  
Negative Pressure ◽  
Negative Pressure Wound Therapy ◽  
Chronic Wounds ◽  
Wide Spectrum ◽  
Case Reports ◽  
Modern Medicine ◽  
Wound Therapy ◽  
Basic Set

Modern medicine offers a wide spectrum of wound healing resources for acute or chronic wounds. Negative pressure wound therapy (NPWT) is a very effective method, allowing complicated defects and wounds to heal. The basic set is usually provided with various special accessories to facilitate the use and support safe application of NPWT to high-risk tissue. Selected case reports are presented herein to document the special use and combinations of materials in negative pressure wound therapy.

Diverse chemical and biological potentials of various pyridazine and pyridazinone derivatives

2019 ◽  
Author(s):  
Chem Int
Keyword(s):  
Heterocyclic Compounds ◽  
Biological Activities ◽  
Wide Spectrum ◽  
Biological Properties ◽  
Industrial Chemical ◽  
Anti Inflammatory ◽  
Pyridazinone Derivatives

A series of heterocyclic compounds incorporating pyridazine moiety were for diverse biological activities. Pyridazines and pyridazinones derivatives showed wide spectrum of biological activities such as vasodialator, cardiotonic, anticonvulsant, antihypertensive, antimicrobial, anti-inflammatory, analgesic, anti-feedant, herbicidal, and various other biological, agrochemical and industrial chemical activities. The results illustrated that the synthesized pyridazine/pyridazine compounds have diverse and significant biological activities. Mechanistic insights into the biological properties of pyridazinone derivatives and various synthetic techniques used for their synthesis are also described.

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