scholarly journals EFEK HEPATOTOKSIK PEMBERIAN SUBAKUT TRITERPEN TOTAL DARI Centella asiatica Linn. PADA TIKUS PUTIH JANTAN DEWASA GALUR WISTAR

2021 ◽  
Vol 8 (1) ◽  
pp. 43
Author(s):  
Erjon Erjon ◽  
Kamaluddin Kamaluddin ◽  
Theodorus Theodorus
Keyword(s):  
Pearson Correlation ◽  
Centella Asiatica

<p>Senyawa aktif utama dari <em>Centella asiatica</em> Linn. adalah triterpen total. <em>Centella asiatica</em> dilaporkan dapat menyebabkan nekrosis sel hati. Telah diteliti efek hepatotoksik pemberian subakut triterpen total dari <em>Centella asiatica</em> pada tikus putih jantan dewasa galur Wistar. Tujuan penelitian ini adalah untuk mengevaluasi pemberian dosis tunggal triterpen total dari <em>Centella asiatica</em> terhadap gambaran histopatologi dan fungsi hati tikus.</p><p>Dari hasil penelitian menunjukkan adanya peningkatan aktivitas SGOT dan SGPT yang berbeda bermakna (<em>ANOVA one way</em>, p&lt;0,05) pada setiap kelompok perlakuan. Peningkatan dosis pemberian triterpen total menunjukkan korelasi positif yang bermakna (<em>Pearson Correlation</em>, p &lt;0,05) dengan peningkatan aktivitas SGOT dan SGPT. Peningkatan aktivitas SGOT dan SGPT tidak melebihi pada batas rentang normal.  Dari gambaran histopatologi, pada kelompok kontrol dan perlakuan tidak ditemukan kerusakan histopatologi sel hati.</p>Dari hasil penelitian disimpulkan bahwa pemberian subakut triterpen total pada dosis  21, 42, 84 mg/kgBB/hari selama 6 minggu dapat meningkatkan aktivitas SGOT dan SGPT dan belum ditemukan kelainan histopatologi sel hati

scholarly journals Interrelationship between secondary metabolites and antioxidant capacities of Centella asiatica using bivariate and multivariate correlation analyses

2021 ◽  
Vol 64 (1) ◽  
Author(s):  
Hyun Young Shin ◽  
Hoon Kim ◽  
Soontag Jung ◽  
Eun-Jin Jeong ◽  
Kyung-Haeng Lee ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Antioxidant Activities ◽  
Pearson Correlation ◽  
Principal Component ◽  
Centella Asiatica ◽  
Multivariate Correlation ◽  
Antioxidant Capacities ◽  
Whole Plant ◽  
Freeze Dried ◽  
Ethanol Extracts

AbstractCentella asiatica L. Urban (CA) is a valuable medicinal herb that contains various bioactive secondary metabolites. In the present study, the harvested CA was divided into whole plant and leaf parts, and were heated-air-dried or freeze-dried. The dried CA was extracted under various extraction conditions to obtain 16 extracts, and their antioxidant activities were examined. Twelve types of secondary metabolites (five polyphenolic acids, four triterpenoids, and three flavonoids) were quantified in each extract. Finally, the intercorrelations between secondary metabolites and antioxidant activities were analyzed through statistical analyses, such as Pearson correlation coefficient, scatter plotting, and principal component analysis. The antioxidant capacities of CA might be primarily influenced by major triterpenoids such as madecassoside and asiaticoside, which showed high content in the ethanol extracts of freeze-dried leaf parts. The present study provides a valuable groundwork for the development of optimal extraction processes for C. asiatica L. as an antioxidant material.

scholarly journals Accelerated Stability Studies on Dried Extracts of Centella asiatica Through Chemical, HPLC, HPTLC, and Biological Activity Analyses

2016 ◽  
Vol 21 (4) ◽  
pp. NP127-NP137 ◽  
Author(s):  
Ishtdeep Kaur ◽  
Nancy Suthar ◽  
Jasmeen Kaur ◽  
Yogita Bansal ◽  
Gulshan Bansal
Keyword(s):  
Pearson Correlation ◽  
Herbal Product ◽  
Centella Asiatica ◽  
Total Phenolic ◽  
Type I ◽  
Asiatic Acid ◽  
Stability Studies ◽  
Herbal Products ◽  
Type Iii ◽  
Accelerated Stability

Regulatory guidelines recommend systematic stability studies on a herbal product to establish its shelf life. In the present study, commercial extracts (Types I and II) and freshly prepared extract (Type III) of Centella asiatica were subjected to accelerated stability testing for 6 months. Control and stability samples were evaluated for organoleptics, pH, moisture, total phenolic content (TPC), asiatic acid, kaempherol, and high-performance thin layer chromatography fingerprints, and for antioxidant and acetylcholinesterase inhibitory activities. Markers and TPC and both the activities of each extract decreased in stability samples with respect to control. These losses were maximum in Type I extract and minimum in Type III extract. Higher stability of Type III extract than others might be attributed to the additional phytoconstituents and/or preservatives in it. Pearson correlation analysis of the results suggested that TPC, asiatic acid, and kaempferol can be taken as chemical markers to assess chemical and therapeutic shelf lives of herbal products containing Centella asiatica.

Reliability of the Minimum Masking Level as Outcome Variable in Tinnitus Clinical Research

2020 ◽  
Vol 29 (3) ◽  
pp. 429-435
Author(s):  
Patricia C. Mancini ◽  
Richard S. Tyler ◽  
Hyung Jin Jun ◽  
Tang-Chuan Wang ◽  
Helena Ji ◽  
...  
Keyword(s):  
Standard Deviation ◽  
High Frequency ◽  
Pearson Correlation ◽  
Correlation Coefficients ◽  
Outcome Variable ◽  
Reliable Estimate ◽  
Moderate Correlation ◽  
Trained Subjects ◽  
The Relationship ◽  
Minimum Intensity

Purpose The minimum masking level (MML) is the minimum intensity of a stimulus required to just totally mask the tinnitus. Treatments aimed at reducing the tinnitus itself should attempt to measure the magnitude of the tinnitus. The objective of this study was to evaluate the reliability of the MML. Method Sample consisted of 59 tinnitus patients who reported stable tinnitus. We obtained MML measures on two visits, separated by about 2–3 weeks. We used two noise types: speech-shaped noise and high-frequency emphasis noise. We also investigated the relationship between the MML and tinnitus loudness estimates and the Tinnitus Handicap Questionnaire (THQ). Results There were differences across the different noise types. The within-session standard deviation averaged across subjects varied between 1.3 and 1.8 dB. Across the two sessions, the Pearson correlation coefficients, range was r = .84. There was a weak relationship between the dB SL MML and loudness, and between the MML and the THQ. A moderate correlation ( r = .44) was found between the THQ and loudness estimates. Conclusions We conclude that the dB SL MML can be a reliable estimate of tinnitus magnitude, with expected standard deviations in trained subjects of about 1.5 dB. It appears that the dB SL MML and loudness estimates are not closely related.

Mutational breeding of Centella asiatica (L.) urban for medicinal purposes

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
T Kaensaksiri ◽  
P Soontornchainaksaeng ◽  
N Soonthornchareonnon ◽  
S Prathanturarug
Keyword(s):  
Centella Asiatica

Evaluation of Regional and Seasonal Variations of Triterpene and Flavonoid Contents in Centella asiatica by HPLC-DAD

Planta Medica ◽  
2011 ◽  
Vol 77 (05) ◽  
Author(s):  
A Alqahtani ◽  
W Tongkao-on ◽  
KM Li ◽  
V Razmovski-Naumovski ◽  
B Kimble ◽  
...  
Keyword(s):  
Seasonal Variations ◽  
Centella Asiatica

Centella asiatica Protects Against the Toxic Effects of Intracellular beta-amyloid Accumulation

Planta Medica ◽  
2013 ◽  
Vol 79 (10) ◽  
Author(s):  
N Gray ◽  
J Morré ◽  
J Kelley ◽  
C Maier ◽  
F Stevens ◽  
...  
Keyword(s):  
Centella Asiatica ◽  
Beta Amyloid ◽  
Toxic Effects ◽  
Amyloid Accumulation

FACTORS ASSOCIATED WITH SCHOOL REFUSAL BEHAVIOUR IN PRIMARY SCHOOL STUDENTS

2019 ◽  
pp. 1-13
Keyword(s):  
Primary School ◽  
Primary Schools ◽  
Pearson Correlation ◽  
School Refusal ◽  
Self Report ◽  
Primary School Students ◽  
School Students ◽  
School Factors ◽  
School Refusal Behavior ◽  
Factors Associated

The aim of this study was to identify the factors associated with school refusal behavior in primary school students. Student’s self-report and teacher’s measures were implemented; and students were recruited from 20 primary schools in six districts in Selangor, Malaysia. The survey was conducted at the end of school term in 2016, with a total of 915 students from Year 4 and Year 5 participating. The sample of students had been absent from school for more than 15% of school days in the current year. Pearson correlation shows a significant relationship between academic achievement and school satisfaction toward school refusal behavior. The findings of this study suggest that academic difficulties and dissatisfaction towards school environment could be the important risk factors for school refusal behavior. The present study underscores the importance of early detection and intervention as measures to reduce school refusal. Finally, the findings imply that the role of school factors should always be taken into account in connection with school refusal behaviour.

Pengaruh Kotbah, Musik Gereja Dan Fasilitas Gereja Terhadap Tingkat Kehadiran Jemaat

2016 ◽  
Vol 1 (1) ◽  
pp. 1-15
Author(s):  
Frederich Oscar Lontoh
Keyword(s):  
Regression Analysis ◽  
Multiple Regression Analysis ◽  
Church Music ◽  
Pearson Correlation ◽  
Descriptive Analysis ◽  
Target Population ◽  
The Other ◽  
Pearson Correlation Coefficient ◽  
Christian Church ◽  
The City

This research is titled " The influence of sermon, church music and church facilities on the level of attendance”. The purpose of research is to identify and analyze whether sermon, church music and church facilities have influence on the the level of attendance. The target population in this study is a Christian church members who live in the city of Surabaya.. Sample required is equal to 47 respondents. Through sampling stratified Random techniques.These influence was measured using Pearson correlation coefficient and multiple regression analysis, t-test and analysis of variance. Descriptive  analysis  were taken to analyze the level of attendance according to demographic groups.The hypothesis in this study are the sermon, church music and church facilities have positive and significant on the level of attendance. The results showed that collectively, there are positive and significant correlation among the sermon, church music and church facilities on the level of attendance  96,2%. It means that 96,2 % of level of attendance influenced by sermon, church music and church facilities and the other 28,9% by others. All of the variable partially have significant correlation to level of attendance.

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