Chemical composition, antioxidant activity, standardization and kinetics of production of water-propylene glycol extracts of medicinal plants

2020 ◽  
Vol 86 (8) ◽  
pp. 12-22
Author(s):  
V. A. Volkov ◽  
M. V. Voronkov ◽  
V. M. Misin ◽  
E. S. Fedorova ◽  
I. A. Rodin ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Medicinal Plants ◽  
Propylene Glycol ◽  
Hypericum Perforatum ◽  
Raw Materials ◽  
Salvia Officinalis ◽  
Visible Range ◽  
Spectrometric Method ◽  
Matricaria Chamomilla ◽  
Dpph Method

Water-propylene glycol extracts of medicinal plants are widely used as active components in therapeutic and cosmetic products for external use. However, sparse data on the extracting efficiency of water-propylene glycol mixtures and chemical composition of water-propylene glycol extracts of plant raw materials are available in the scientific literature. Usually the manufacturer documentation also provides information about characteristics of the products that are not related to their biological activity. The results of HPLC/MS/MS study of Matricaria chamomilla L. flowers have shown that water-propylene glycol and water-ethanol extracts are similar in the composition of phenolic compounds: the dominant compounds of water-propylene glycol extract of Matricaria chamomilla L. flowers are apigenin and its glycosides (apigenin-7-glucoside, apigenin-7-O-6-O-malonyl-D-glycoside, apigenin-7-acetylglycoside, acetyl-malonyl-apigenin-7-O-glycoside), as well as 5,4’-dioxy-3,6,7,3’-tetramethoxyflavone, cis- and trans-forms of 2-O-glucopyranoside 2-hydroxy-4-methoxycoric acid, 7-methoxycumarin. Spectral and analytical characteristics in the UV-visible range of the spectra of water-propylene glycol extracts of a number of medicinal plants most often used in the cosmetic industry were studied to reveal extracts with the highest protective properties against UV radiation in A and B areas (extracts of Salvia officinalis L. leaves, Matricaria chamomilla L. flowers, Achillea millefolium L. grass), free radicals (extracts of Camellia sinensis L. leaves, Hypericum perforatum L. herb), and the highest content of flavonoids (extracts of Hypericum perforatum L. herb, leaves of Salvia officinalis L.) were revealed. When extracting raw materials from the same batch, the optical density at a wavelength of 270 nm is associated with the content of flavonoids, antioxidants and dry matter by a functional relationship, which is very convenient for rapid control of extraction processes in order to obtain a product with reproducible characteristics. Formulas for calculating the content of antioxidants in extracts using the DPPH method in comparison with standard samples of rutin and gallic acid are derived. Interpretation of data on the antioxidant content in different extracts in comparison with other analytical parameters are also presented. Demonstrated high repeatability of the shape of the spectral curves of Matricaria chamomilla L. flowers extract, observed regardless of the source of raw materials can be used in combination with the individuality of the curve shape of the extracts of raw materials of different types as one of the authenticity criteria. The proposed UV-spectrometric method was used to study the dynamics of Matricaria chamomilla L. flower extraction under different process parameters (temperature, propylene glycol/water ratio in the extractant). It is shown that extraction of raw materials with 50% water-propylene glycol for 4 h at a temperature of 50°C is optimal.

scholarly journals VITAMINS AND ALKALOIDS IN SOME MEDICINAL PLANTS (ACHILLEA MILLEFOLIUM L., CAPPARIS SPINOSA L., HYPERICUM PERFORATUM L.) AND THEIR EFFECTS ON HUMAN HEALTH

2022 ◽  
Author(s):  
EditorJournals and Conferences
Keyword(s):  
Chemical Composition ◽  
Medicinal Plants ◽  
Human Health ◽  
Hypericum Perforatum ◽  
The Body ◽  
Biologically Active ◽  
Physiological Characteristics ◽  
Achillea Millefolium ◽  
Capparis Spinosa ◽  
Hypericum Perforatum L

This article provides information on the morpho-physiological characteristics, chemical composition, especially the amount of alkaloids and vitamins, and their function in the body, as well as thorn bushes, hole field, yarrow plants, which are considered medicinal plants.The article deals with the botanical and morpho-physiological characteristics of the plant Achillea Millefolium L., one of the medicinal plants used in scientific medicine, systematics, some biologically active substances in the chemical composition, especially vitamins and alkaloids, their function in the body and their role in human health. details are given.The following article describes the role of Capparis spinosa L. in modern taxonomy, its distribution, the structure and properties of the most common alkaloids and vitamins in the plant, and its biochemical functions in the human body.The article concludes with a detailed description of the morpho-physiological characteristics of the plant Hypericum Perforatum L., its chemical composition, especially the amount of alkaloids and vitamins and their function in the body and their role in human health.

scholarly journals Hypericum Perforatum Grass: Chemical Composition, Properties, Use

2021 ◽  
pp. 57-63
Author(s):  
И.Ю. Постраш
Keyword(s):  
Chemical Composition ◽  
Hypericum Perforatum ◽  
Raw Materials ◽  
Extraction Process ◽  
Pharmaceutical Products ◽  
The Body ◽  
Biologically Active ◽  
Quantitative Relation ◽  
Resource Saving ◽  
Two Phase

Трава зверобоя является ценным лекарственным растением, так как содержит большое число разнообразных биологически активных соединений, важнейшими из которых являются флавоноиды (1,5–5%), нафтодиантроны, дубильные вещества (10–13%), эфирное масло (0,1–0,33%) и др. Препараты, содержащие зверобой, комплексно воздействуют на организм, они оказывают противовоспалительное, антимикробное, антидепрессивное, противовирусное, кровоостанавливающее действие. Трава зверобоя применяется в виде чаёв, отваров, водных настоев, спиртовых и масляных настоек, мазей, сухих экстрактов. В ветеринарной медицине широко применяют настои и отвары травы зверобоя при заболеваниях ЖКТ: диспепсиях, гастроэнтеритах, острых и хронических колитах (КРС, овцы, козы, свиньи, собаки и др.), а также при лечении смешанных инвазий. Настои и настойку применяют также наружно при стоматитах, гингивитах, фарингитах. Несмотря на перечисленный выше ассортимент лекарственных форм зверобоя, активно ведутся научные исследования по оптимизации способов извлечения биологически активных веществ (БАВ) из травы зверобоя продырявленного. В ходе экспериментов исследователи варьируют различные параметры процесса экстракции: химический состав экстрагентов (монофазная и двухфазная экстракция), время и температуру экстракционного процесса, количественное соотношение сырья и экстрагентов, степень измельчения сырья, последовательность технологических операций, возможность применения излучения и др. Разработки новых ресурсосберегающих технологий переработки зверобоя продырявленного будут способствовать снижению себестоимости фармацевтической продукции и улучшению её фармакологических свойств. Hypericum perforatum grass is a valuable medicinal plant, since it contains a large number of various biologically active compounds, the most important of which are flavonoids (1.5–5%), naphthodianthrones, tannins (10–13%), aethereal oil (0.1–0.33%), etc. Preparations containing Hypericum perforatum have a complex effect on the body, they have an anti-inflammatory, antimicrobial, antidepressant, antiviral, hemostatic effect. Hypericum perforatum grass is used in the form of teas, apozems, water infusions, alcohol and oil tinctures, ointments, dry extracts. In veterinary medicine, infusions and decoctions of Hypericum perforatum grass are widely used in diseases of the gastrointestinal tract: dyspeptic disorder, gastroenteritis, acute and chronic colitis (cattle, sheep, goats, pigs, dogs, etc.), as well as in the treatment of mixed invasions. Infusions and tincture are also used externally for stomatitis, gingivitis, blennisthmia. Despite the above range of dosage forms of Hypericum perforatum, researches are actively conducted to optimize methods of extracting biologically active substances (BAS) from Hypericum perforatum grass. During the experiments, researchers vary various parameters of the extraction process: the chemical composition of extragents (monophasic and two-phase extraction), the time and temperature of the extractive process, the quantitative relation of raw materials to extragents, the dispersity of raw materials, the sequence of technological operations, the possibility of using radiation, etc. The development of new resource-saving technologies for processing Hypericum perforatum will help reduce the cost of pharmaceutical products and improve its pharmacological properties.

scholarly journals EFFECTS OF CERTAIN ALKALOIDS FOUND IN THE HYPERICUM PERFORATUM L PLANT ON HUMAN HEALTH

2022 ◽  
Author(s):  
EditorJournals and Conferences
Keyword(s):  
Chemical Composition ◽  
Medicinal Plants ◽  
Human Health ◽  
Hypericum Perforatum ◽  
The Body ◽  
Physiological Characteristics ◽  
Hypericum Perforatum L

This article provides detailed information on the morpho-physiological characteristics, chemical composition, especially the amount of alkaloids and their function in the body and their role in human health, as one of the medicinal plants Hypericum Perforatum L.

scholarly journals Rare medicinal plants of the flora of Donbass in the collection of Public Institution «Donetsk Botanical Garden»

2020 ◽  
Vol 19 (2) ◽  
pp. 052-055
Author(s):  
N. V. Shpilevaya
Keyword(s):  
Chemical Composition ◽  
Medicinal Plants ◽  
Raw Materials ◽  
Botanical Garden ◽  
Public Institution ◽  
The Public

The paper presents the rarity species of medicinal plants in the flora of Donbass, included in the Red Bookof Donetsk region and rare for this area. The article gives information on their distribution in the region, condition ofpopulations, introduction research in the Public Institution «Donetsk Botanical Garden», their growing prospects as thesource of medicinal raw materials of the herbal origin, chemical composition and pharmaceutical effects.

scholarly journals CERTAIN FLAVONOIDS IN THE PLANT HYPERICUM PERFORATUM L. AND THEIR EFFECTS ON HUMAN HEALTH

2021 ◽  
Author(s):  
EditorJournals and Conferences
Keyword(s):  
Chemical Composition ◽  
Medicinal Plants ◽  
Human Health ◽  
Hypericum Perforatum ◽  
The Body ◽  
Physiological Characteristics ◽  
Hypericum Perforatum L

This article provides detailed information on the morpho-physiological characteristics, chemical composition, especially the amount of flavonoids and their function in the body and their role in human health, as one of the medicinal plants Hypericum Perforatum L.At the beginning of the article we will discuss in detail the role and distribution of the plant Hypericum Perforatum L. in modern taxonomy. The article describes the properties of rutin flavonoid, one of the most common flavonoids in this plant, and its biochemical functions in plants and humans.

scholarly journals Application of Autofluorescence for Analysis of Medicinal Plants

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Victoria V. Roshchina ◽  
Andrei V. Kuchin ◽  
Valerii A. Yashin
Keyword(s):  
Confocal Microscopy ◽  
Medicinal Plants ◽  
Secondary Compounds ◽  
Humulus Lupulus ◽  
Salvia Officinalis ◽  
Secretory Cells ◽  
Matricaria Chamomilla ◽  
Luminescence Microscopy ◽  
Berberis Vulgaris

Autofluorescence of secondary compounds contained in plant secretory cells may be applied to the analysis of medicinal plants for pharmacy. Emission and prevailing fluorescent pharmaceuticals have been estimated in several models of species such as Salvia officinalis, Berberis vulgaris, Humulus lupulus, and Matricaria chamomilla, by luminescence microscopy, microspectrofluorimetry, and confocal microscopy.

scholarly journals PREPARATION OF MEDICINAL PLANT RAW MATERIALS WITH A GIVEN CHEMICAL COMPOSITION AND ANTIBACTERIAL ACTIVITY

2021 ◽  
pp. 309-318
Author(s):  
Lyudmila Ivanovna Tikhomirova ◽  
Lyudmila Vladimirovna Shcherbakova ◽  
Tat'yana Nikolayevna Ilyicheva ◽  
Natal'ya Grigor'yevna Bazarnova ◽  
Dmitriy Alekseyevich Karpitsky
Keyword(s):  
Antibacterial Activity ◽  
Chemical Composition ◽  
Medicinal Plant ◽  
Salmonella Typhimurium ◽  
Bacillus Pumilus ◽  
Raw Materials ◽  
Salvia Officinalis ◽  
Origanum Vulgare ◽  
Plant Raw Materials ◽  
Extractive Substances

A significant effect on the amount of hydroxycinnamic acids was not an increase in the content of bap from BA 1.0 to 10.0 μM, but the introduction of auxins of NAA 1.0 μM + IBA 0.1 μM. Auxins in combination with cytokinin BA increased the amount of acids by an average of 20% in alcoholic (1.9±0.2%) and aqueous (1.46±0.06%) extracts from Iris sibirica raw materials. The maximum yield of extractive substances, including tannins (4.4±0.3%) was observed when growing raw materials on media with a BA content of 2.5–5.0 μM, the lowest value was obtained with a BA of 10.0 μM. The introduction of auxins (NAA 1.0 μM + IBA 0.1 μM) did not significantly affect the dynamics of the accumulation of tannins. Screening of the chemical composition of medicinal plant raw materials Origanum vulgare and Salvia officinalis obtained by biotechnology methods showed the presence of flavonoids of 1.6±0.1% and 3.2±0.04%, hydroxycinnamic acids of 7.4% and 13.4% at a.s.s., respectively. Antibacterial activity with a minimum inhibitory concentration of 0.02-0.04 mg/ml against Sporosarcina ureae, Bacillus pumilus, Salmonella typhimurium, Staphylococcus aureus was pronounced in the hexane extract of Salvia officinalis. Ethanol extract of sage was active against Salmonella typhimurium. Ethanol extracts of Iris sibirica and Salvia officinalis showed antibacterial activity against Salmonella typhimurium, MIC-0.35 and 0.16 mg / ml, respectively. Siberian iris suppressed Bacillus pumilus at MIC-0.7 mg / ml. The largest amount of extractive substances was extracted from the raw materials of Origanum vulgare with an aqueous-glycerol mixture – 21.5±0.2 % per a. s. s. Against Salmonella typhimurium, the extracts showed antibiotic activity with MIC – 1.2 mg/ml.

Study of Acute Toxicity of Phytopreparation Parodonfit

2020 ◽  
pp. 7-9
Author(s):  
Zhuraeva Aziza Alisherovna ◽  
S. A. Saidov ◽  
B.S. Tulyaganov
Keyword(s):  
Chemical Composition ◽  
Medicinal Plants ◽  
Acute Toxicity ◽  
Oral Mucosa ◽  
Dosage Form ◽  
Salvia Officinalis ◽  
Alcoholic Extract ◽  
Calendula Officinalis ◽  
Traditional Use ◽  
Liquid Extract

The object of the study is a liquid alcoholic extract under the code name "Parodonfit" -containing medicinal plants, such as Salvia officinalis, Matricariachamomilla, Calendula officinalis, Hypericumper for atum. The chemical composition of this phytocomposition was previously studied. Moreover, alkaloids, flavonoids, saponins and tannins were found in the composition of the liquid extract. Given the traditional use of this phytocomposition in dentistry, it is of undoubted interest to develop a dental dosage form based on it for the treatment of diseases of the oral mucosa. The article presents the results of a study of acute toxicity of the Parodonfit liquid extract.

Chemical composition of essential oils from leaves and twigs with leaves of two new varieties of common sage (Salvia officinalis L.)

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
A Aprotosoaie ◽  
E Gille ◽  
A Spac ◽  
M Gonceariuc ◽  
M Hancianu ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Essential Oils ◽  
Salvia Officinalis ◽  
New Varieties ◽  
Salvia Officinalis L
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