ANTIOXIDANT ACTIVITY OF SELECTED FORMULA Spirulina platensis TROCHES BASED ON PYSICAL CHARACTERISTICS
<p><strong><em>ABSTRACT</em></strong><strong><em></em></strong></p> <p><em>Spirulina</em><em> contain</em><em>s</em><em> </em><em>complete nutrition</em><em> and bioactive components as a source of antioxidants. The aims of this research were to determine </em><em>a</em><em> formula</em><em> of </em><em>troche from </em><em>Spirulina </em><em>platensis </em><em>according to</em><em> the physical characteristic</em><em> </em><em>standard of</em><em> the Indonesian Health Ministry, and </em><em>to determine </em><em>the</em><em> antioxidant activity of the </em><em>selected troche from</em><em> </em><em><span style="text-decoration: underline;">Spirulina</span></em><em> <span style="text-decoration: underline;">platensis</span></em><em>. This research was conducted in three stages. The first stage was troche</em><em>s</em><em> formulation</em><em>. The second stage was troche</em><em>s</em><em> physical analys</em><em>e</em><em>s, including weight uniformity</em><em>, friability, hardnes</em><em>,</em><em> </em><em>and</em><em> disintegration time. The third stage was to determine the antioxidant activity of the selected formula of troche</em><em> from </em><em><span style="text-decoration: underline;">Spirulina</span></em><em> <span style="text-decoration: underline;">platensis</span></em><em>. There were five formulas of troches i</em><em>.e.,</em><em> FTS 1, FTS 2, FTS 3, FTS 4, and FTS 5. The troche consist</em><em>e</em><em>d of</em><em> Spirulina platensis powder, carrageenan, gelatin, corn flour, sugarleaf</em><em>,</em><em> </em><em>and</em><em> mint powder. Based on the weight uniformity of the troche, all formulas met the standard. However, according to friability aspect</em><em>,</em><em> the best formula was FTS 1 with rate of 1.7%. The hardness of five formula ranged from 0.65 to 2.3 Kp, and none met the standard. The best formula based on disintegration time measurement was FTS 1</em><em> </em><em>(24:47 minutes). Based on the physical characteristics of the troches, the selected formula was FTS 1. The antioxidant activity (IC<sub>50</sub> of the selected formula (FTS 1) was 288,68 ppm.<strong></strong></em></p> <p> </p> <strong>Keywords</strong>: <em>antioxidant, troches, physical</em><em> characteristics of troches, Spirulina platensis</em>