The Effect of Chicken (Gallus gallus domesticus) Eggshell’s Powder towards Wound Healing of Incision Wound  on Male Swiss-Webster Mice

Domestic chicken eggshells contain calcium and protein that could be useful in wound healing process. This research was conducted to determine whether domestic chicken eggshells can accelerate wound healing. Twenty one male Swiss-Webster mice with 2 cm incision were divided into 3 groups. Negative control group were given Carboxymethyl cellulose 1% (CMC), positive control group were given feracrylum 1% (FER), and the eggshells group given domestic chicken eggshells powder (KT). Treatment and data mesurement was measured every day until the 7th day. On the 7th day the average length of the wound were analyzed and the skin tissue is taken for microscopic examination. Data analyzed using one-way ANOVA followed by Post Hoc Least Significant Difference (LSD) with p=0,05. On macroscopic examination, there were highly significant differences between KT compared to CMC and highly significant differences between KT compared to FER. the average length of wound on the 7th day on KT 0,63 cm shorter than CMC 1,07 (p=0,000) and FER 0,81 cm (p=0,003). On microscopic examination, the degree of reepithelization on KT groups are severe, moderate for collagen density, fibroblasts density, subepithelial neutrophil density, degree of edema, and mild for angiogenesis. We conclude domestic chicken eggshells powder can accelerate wound healing. Key words: domestic chicken eggshells, incision wound, wound healing

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Ellagic Acid Activity in Healing Process of Incision Wound on Male Albino Rats (Rattus norvegicus)

KnE Life Sciences ◽

10.18502/kls.v3i6.1131 ◽

2017 ◽

Vol 3 (6) ◽

pp. 224

Author(s):

Hardany Primarizky ◽

Wiwik Misaco Yuniarti ◽

Bambang Sektiari Lukiswanto

Keyword(s):

Wound Healing ◽

Treatment Group ◽

Ellagic Acid ◽

Healing Process ◽

Control Group ◽

Albino Rats ◽

Wound Healing Process ◽

Treatment Groups ◽

Significant Difference ◽

Incision Wound

This study was conducted to prove whether ellagic acid can be used as a regulator of incision wound healing process in male albino rats as experimental animals. A total of 24 male healthy rats based on physical examination, aged at 3 months old and weight at 150-180 grams used in this study. Rats were divided into three groups and each group has 8 replications, group of control (P0) has no incision wound and no medication, treatment group (P1) has incision wound and treated with Betadine® and (P2) has incision wound and treated with 2,5 % ellagic acid. The variable that observed are histopathology changes (collagen, PMN, angiogenesis and fibrosis) from the male albino rats. The samples collection was taken at day 15 and data were collected and analyzed by Analysis of Variance (ANOVA) test. The result of collagen and PMN cells score in the control group (P0) were 1.80 ± 0.16 and 1.6 ± 0.08 with mild angiogenesis and no fibrosis. The results in the treatment (P2) group, where the collagen and PMN scores were 1.60 ± 0.08 and 1.5 ± 0.8, accompanied by mild angiogenesis and fibrosis. Meanwhile, in the treatment (P1) group, the results of scoring of collagen and PMN were lower than the other groups, 0, 80 ± 0.08 and 0.6 ± 0.16 accompanied by moderate angiogenesis and fibrosis. There was a significant difference of collagen scoring, PMN cells number, fibrosis and angiogenesis among the treatment groups (p<0.05). P1 treatment group has significant different with treatment groups P0 and P2 (p<0.05), but there is no significant difference between treatment groups P0 and P2 (p>0.05). From the results, it can be concluded that the topical application of ellagic acid ointment was proved to provide healing process on incision wound. Topical administration of ellagic acid ointment for 14 days was able to improve the skin condition and promoted the wound healing.Keywords: Ellagic acid ; wound healing ; collagen ; angiogenesis ; fibrosis ; anti-inflammatory ; antioxidant ; antibacterial.

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Effect of haruan (Channa striata) extract on fibroblast cells count in wound healing

Journal of Dentomaxillofacial Science ◽

10.22208/jdmfs.1.2.2016.226-231 ◽

2016 ◽

Vol 1 (2) ◽

pp. 226

Author(s):

Ardi Siswanto ◽

Nurdiana Dewi ◽

Lisda Hayatie

Keyword(s):

Wound Healing ◽

Healing Process ◽

Negative Control ◽

Control Group ◽

Wound Healing Process ◽

Fibroblast Cells ◽

Control Group Design ◽

Treatment Groups ◽

Accelerate Wound Healing ◽

Significant Difference

Haruan is Kalimantan’s indigenous fish which has the potency to accelerate wound healing. Haruan extract has substantial properties such as albumin, Zn, Cu, and Fe to accelerate wound healing. The purpose of this study is to assess the effect of haruan extract on wistar rat’s buccal mucosa wound healing on day 3, 5, and 7 histopathologically. This study was experimental with post-test with control group design. Samples were consisted of 4 treatment groups, 25%, 50%, 100% haruan extract treatment groups and negative control treated with aquadest for 7 days. Mean fibroblast cells count reached its peak on day 7. Mean fibroblast cells count in each group was 26.995; 40.500; 49.165; 24.495 respectively. Two way ANOVA and Post Hoc Least Significant Difference tests indicated there was a significant difference (p<0.05) between haruan extract treatment group and negative control. In conclusion, haruan extract treatment significantly increase fibroblast cells count in wound healing process.

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Ekstrak ikan haruan (Channa striata) meningkatkan jumlah neokapiler pada penyembuhan luka (Extract of haruan (Channa striata) increases neocapillaries count in wound healing process )

Journal of Dentomaxillofacial Science ◽

10.22208/jdmfs.v14i1.1 ◽

2015 ◽

Vol 14 (1) ◽

pp. 1

Author(s):

Muhammad Reza Setiawan ◽

Nurdiana Dewi ◽

Ika Kustiyah Oktaviyanti

Keyword(s):

Wound Healing ◽

Healing Process ◽

Negative Control ◽

Control Group ◽

Wound Healing Process ◽

Treatment Groups ◽

Accelerate Wound Healing ◽

Significant Difference ◽

Channa Striata ◽

Post Hoc

Haruan is Kalimantan’s indigenous fish which has the potency to accelerate wound healing. Haruan extract has substantial properties suchas albumin, Zn,Cu, andFeto accelerate wound healing. The purposeof this study is to assess the effect of haruan extract on wistar rats buccal mucosa wound healing on day 1, 3, 5, and 7 histopathologically. This study was purely experimental with pretest-posttest with control group design. Samples were divided into 4 treatment groups, haruan extract 25%, 50%, 100% treatment groups and aquadest treatment group as negative control, each treatment wasperformed for 7 days. Neocapillariescount reached its peak on day 5. Mean neocapillaries scoring of each group was 12, 16.5, 18.5, 6 respectively. Two way Anova and post hoc LSD tests presented a significant difference between negative control and haruan extract groups. In conclusion, haruan extract treatment significantly increased neocapillaries count in wound healing process.Haruan adalah ikankhas Kalimantan yangberpotensi mempercepat penyembuhanluka. Ekstrak ikan haruan mengandung zat penting seperti albumin, Zn , Cu, dan Fe untuk mempercepat penyembuhan luka. Penelitian ini dimaksudkan untuk mengetahui pengaruh ekstrak ikan haruan pada proses penyembuhan luka pada mukosa bukal tikus wistar hari ke-1, 3, 5, dan 7 secara histopatologi. Penelitian eksperimental murni dengan pretest-posttest with control group ini, meliputi 4 kelompok,yaitu kelompok hewan yang diberi ekstrak haruan selama7 hari dengan konsentrasi berturut-turut 25%, 50%, 100%, dan kelompok kontrol negatif diberi akuades. Hasilnya menunjukkan bahwa jumlah neokapiler mencapai puncak pada hari ke-5. Rerata jumlah neokapiler pada tiap kelompok berturut adalah 12; 16,5; 18,5; dan 6. Uji Anova 2-jalur dan uji post hoc LSDmenunjukkan adanya perbedaan bermakna antara kontrol negatif dan ekstrak ikan haruan. Berdasarkan hasil penelitian, disimpulkan bahwa pemberian ekstrak ikan haruan secara bermakna meningkatkan jumlah neokapiler pada proses penyembuhan luka.

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Effect of haruan (channa striata) extract on fibroblast cells count in wound healing

Journal of Dentomaxillofacial Science ◽

10.15562/jdmfs.v1i2.3 ◽

2016 ◽

Vol 1 (2) ◽

pp. 89

Author(s):

Ardi Siswanto ◽

Nurdiana Dewi ◽

Lisda Hayatie

Keyword(s):

Wound Healing ◽

Healing Process ◽

Negative Control ◽

Control Group ◽

Wound Healing Process ◽

Fibroblast Cells ◽

Control Group Design ◽

Treatment Groups ◽

Accelerate Wound Healing ◽

Significant Difference

Haruan is Kalimantan’s indigenous fish which has the potency to accelerate wound healing. Haruan extract has substantial properties such as albumin, Zn, Cu, and Fe to accelerate wound healing. The purpose of this study is to assess the effect of haruan extract on wistar rat’s buccal mucosa wound healing on day 3, 5, and 7 histopathologically. This study was experimental with post-test with control group design. Samples were consisted of 4 treatment groups, 25%, 50%, 100% haruan extract treatment groups and negative control treated with aquadest for 7 days. Mean fibroblast cells count reached its peak on day 7. Mean fibroblast cells count in each group was 26.995; 40.500; 49.165; 24.495 respectively. Two way ANOVA and Post Hoc Least Significant Difference tests indicated there was a significant difference (p<0.05) between haruan extract treatment group and negative control. In conclusion, haruan extract treatment significantly increase fibroblast cells count in wound healing process.

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EFFECT OF WOUND CARE ON WOUND HEALING PROCESS OF POST OPERATION IN PATIENTS APENDEKTOMY IN RS DUSTIRA CIMAHI

Jurnal Persatuan Perawat Nasional Indonesia (JPPNI) ◽

10.32419/jppni.v4i1.60 ◽

2021 ◽

Vol 4 (1) ◽

Author(s):

Marlin Sutrisna ◽

Vega M Tusyanawati

Keyword(s):

Wound Healing ◽

Wound Care ◽

Healing Process ◽

Intervention Group ◽

Lower Abdominal Pain ◽

Control Group ◽

Wound Healing Process ◽

P Value ◽

Ablative Surgery ◽

Significant Difference

ABSTRACTVega M. Tusyanawati1, Marlin Sutrisna2, Tonika Tohri3 Sekolah Tinggi Ilmu Kesehatan Rajawali Bandung IndonesiaEmail : [email protected]: Appendicitis is one of the emergency cases in the abdominal area with a major complaint of persistent lower abdominal pain that develops and increased pain. An appendectomy is a surgical intervention that has the purpose of ablative surgery or removal of body parts that contain problems or have disease. One of the postoperative treatments of apendectomy is with wound care. The current wound care treatment is modern and conventional wound care. Objective: This study was to investigate the effect of treatment of postoperative wound healing apendectomy. Methodology: The design used in this research is Quasi Experiment, with posttest-only design approach. The number of samples taken is 18 respondent. Taking sampling with accidental sampling technique. Result: The result shows that p-value 0.001, with mean value in intervention group was 5.50 and in control group 13.50. Conclusion: There is a significant difference in the wound healing process using conventional and modern wound care.Keywords : type of wound care, post operative apendectomy

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HE EFFECT OF BINJAI LEAVES EXTRACT (Mangifera caesia) ON INCISIONAL BACK WOUND OF MICE (Mus musculus) TO THE NUMBER OF NEUTROPHIL CELLS (Preliminary Study of Drug Preparations for Wound Healing)

Dentino : Jurnal Kedokteran Gigi ◽

10.20527/dentino.v5i1.8116 ◽

2020 ◽

Vol 5 (1) ◽

pp. 21

Author(s):

Desty Ayu Dwiyanti ◽

Irham Taufiqurrahman ◽

Didit Aspriyanto

Keyword(s):

Wound Healing ◽

Healing Process ◽

Negative Control Group ◽

Negative Control ◽

Control Group ◽

Wound Healing Process ◽

Control Group Design ◽

Group Design ◽

Inflammatory Phase ◽

Significant Difference

Background: Ethanol extract of binjai leaves contain bioactive compounds in the form of flavonoid and saponin which is potential as anti-inflammatory, so it will be able to control the wound healing process. Binjai leaves extract can affect the number of neutrophil on inflammatory phase, as it is characterized by neutrophil cells infiltration to the wound tissue, so its number will increase at the beginning of inflammatory phase and decrease on the 3rd day. Objective: To prove the effect of binjai leaves extract in 1 mg/mL, 2 mg/mL, and 3 mg/mL which given topically to the number of neutrophil in day 1, 3, and 5 of wound incision on the back of male mice. Methods: The study design was a pure laboratory experimental study with post-test only with control group design which involved 36 mice divided into 4 groups: negative control group design which was given BR2 feed, treatment group which was given binjai leaves extract in 1 mg/mL, 2 mg/mL, and 3 mg/mL. Results: The result of One-way ANOVA showed that there was significant difference of all groups in day 1 (p=0.000), day 3 (p=0.001), and day 5 (p=0.000). Post-Hoc LSD test showed that there was significant difference (p<0.05) between the negative control group and treatment groups. Conclusion: Binjai leaves extract has an effect to increase the number of neutrophil in day 1 and decrease the number of neutrophil in day 3 and 5 on the healing of back wound incision in mice.

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Ekstrak ikan haruan (Channa striata) meningkatkan jumlah neokapiler pada penyembuhan luka (Extract of haruan (Channa striata) increases neocapillaries count in wound healing process )

Journal of Dentomaxillofacial Science ◽

10.15562/jdmfs.v14i1.416 ◽

2015 ◽

Vol 14 (1) ◽

pp. 1

Author(s):

Muhammad Reza Setiawan ◽

Nurdiana Dewi ◽

Ika Kustiyah Oktaviyanti

Keyword(s):

Wound Healing ◽

Healing Process ◽

Negative Control ◽

Control Group ◽

Wound Healing Process ◽

Control Group Design ◽

Treatment Groups ◽

Accelerate Wound Healing ◽

Channa Striata ◽

Post Hoc

Haruan is Kalimantan’s indigenous fish which has the potency to accelerate wound healing. Haruan extract hassubstantial properties such as albumin, Zn,Cu, and Feto accelerate wound healing. The purpose of this study is to assessthe effect of haruan extract on wistar rats buccal mucosa wound healing on day 1, 3, 5, and 7 histopathologically. Thisstudy was purely experimental with pretest-posttest with control group design. Samples were divided into 4 treatmentgroups, haruan extract 25%, 50%, 100% treatment groups and aquadest treatment group as negative control, eachtreatment wasperformed for 7 days. Neocapillariescount reached its peak on day 5. Mean neocapillaries scoring of eachgroup was 12, 16.5, 18.5, 6 respectively. Two way Anova and post hoc LSD tests presented a significant differencebetween negative control and haruan extract groups. In conclusion, haruan extract treatment significantly increasedneocapillaries count in wound healing process.

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27. The Effectiveness Of High Protein Nutrient To The Post Sectio Caesarea Healing Process

Jurnal Medika Veterinaria ◽

10.21157/j.med.vet..v13i2.14090 ◽

2019 ◽

Vol 13 (2) ◽

Author(s):

Darmawati Darmawati ◽

Cut Husna ◽

Aida Fitri ◽

Dahrul Munira

Keyword(s):

Wound Healing ◽

Cesarean Section ◽

Treatment Time ◽

Healing Process ◽

Intervention Group ◽

High Protein ◽

Sectio Caesarea ◽

Control Group ◽

Wound Healing Process ◽

Significant Difference

The prevalence of cesarean section (SC) continues to increase along with the quality of technical facilities improvement. Failure to recover the surgical wounds after cesarean section is one of the possible SC complications that should be taken seriously. Proper nutrition greatly affect to wound healing. This study aims to found the effectiveness of high protein nutrients intake for post SC wound healing process at dr. Zainoel Abidin Hospital Banda Aceh. Design: This study is an experimental research with post test for intervention and control group design and using purposive sampling with the observation format as the measuring instrument. A total of 30 mother with post sectio caesarea participated in this study. There was a significant difference between post-SC wound healing in the intervention group (46.7%) compare to the control group (6.7%) (0.000). The mean of wound healing in the proliferation phase in the intervention group was faster than the control group respectively (10.47; 7.93). The hospital should provide information and evaluate high protein intake especially in post-SC patients during the treatment time, so that the patient is able to apply the information until they are going back home.

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COMPARISON OF THE EFFECTIVENESS OF GIVING BINAHONG LEAF (Anredera cordifolia (Ten) Steenis) AND PAPAYA LEAF (Carica papaya) ON SKIN WOUND HEALING IN WHITE RAT (Rattus novergicus)

Journal Widya Medika Junior ◽

10.33508/jwmj.v3i2.3181 ◽

2021 ◽

Vol 3 (2) ◽

pp. 78-85

Author(s):

Givenchy Winarjo ◽

◽

Fransiscus Arifin ◽

Dave Oenarta ◽

◽

...

Keyword(s):

Wound Healing ◽

Leaf Extract ◽

Healing Process ◽

Control Group ◽

Wound Healing Process ◽

P Value ◽

World Population ◽

White Rats ◽

Significant Difference ◽

The World

Introduction: The incidence of acute and chronic injuries increases every year. Most injuries in the world population, as many as 48%, are caused by trauma or surgery. the highest incidence of wounds in the world based on the etiology was from surgery, which was 110.30 million cases. One of the handlings of wounds on the skin can be done by giving herbal medicines, which can be easily accessed by the public, such as binahong leaves and papaya leaves. Purpose: To analyze the effectiveness of giving 40% binahong leaf extract cream and 40% papaya leaf extract cream on the wound distance in the white rat wound healing process. Method: this study is an experimental study with post-test only control group design approach. The sampling technique used in this study was a random sampling method where the number of samples was calculated using the Federer formula, with a total sample of 28 white rats. The distance of the wound was measured using a micrometer. Results: Twenty-eight wound distance on rats were measured as subjects of the study and then treated with binahong leaf extract cream and papaya leaf extract cream, then the wound distance of each treatment was measured using a micrometer. According to the results, 40% binahong leaf extract cream and 40% papaya leaf extract cream showed better effectiveness in reducing the wound distance of white rat incision than the negative control group (cream base) and positive control group (gentamicin ointment). According to the Mann Whitney test comparing the P1 group (40% binahong leaf extract cream) and P2 (40% papaya leaf extract cream), p-value >0.05, which is 0.543, which means that P1 has no significant mean difference with P2. Conclusion: There was no significant difference in effectiveness between the treatment of 40% binahong leaf extract cream and 40% papaya leaf extract cream.

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