scholarly journals Study of some toxicological aspects of Alfa-cypermethrin in rabbits

2010 ◽  
Vol 9 (3) ◽  
pp. 82
Author(s):  
Dh. R.H. Al-Fetly And N. K. M. Al-Nakeeb
Keyword(s):  
Biochemical Study ◽  
Liver Parenchyma ◽  
Blood Parameters ◽  
Bile Secretion ◽  
Control Group ◽  
Histopathological Study ◽  
Dependent Manner ◽  
Petechial Hemorrhage ◽  
Hb Concentration ◽  
And Control

This study was conducted to evaluate the immediate alterations that occur in rabbitsafter acute toxicity with single oral dose of cypermethrin. Twenty one rabbits were randomlydivided into three equal groups: treated groups (A1), (A2) and control group used in thisstudy. Groups (A1), (A2) received orally cypermethrin in dose of (25, 50 mg/kg body weight)respectively, While control group received normal saline at same time. Most obvious clinicalsings in the treated groups were Restlessness, salivation, licking of legs and face, frequenturination, muscular tremor, incoordination, and ataxia appeared in dose dependent manner. Inaddition, significantly increased in respiratory rate and heart rate in treated groups comparedwith control group and appeared petechial hemorrhage and congestion in the conjunctiva intreated groups. The blood samples were taking to evaluate some of blood parameters includes(RBC counts, WBC counts, PLT counts, Hb concentration, PCV, RBCs indices (MCV, MCH,MCHC, RDW -CV and RDW - SD), PDW, MPV, P-LCR and some biochemical study asALT and AST. Two rabbits from each group were killed to evaluate the histopathologicalalteration in liver. The statistical analysis revealed that there were significant decreased inRBC counts and Hb concentration (P<0.05) in treated groups (A1), (A2) as compared withcontrol group. The PCV percentage, platelet counts and MCHC values revealed significantdecreased (P<0.05) between group (A2) and control group. The RDW-SD, RDW-CV valveswere significantly increased (p<0.05) between group (A1) and control group. Other parameterstudied did not show significant differences between treated groups and control group. Thestatistical analysis revealed that the levels of ALT and AST were significantly elevated(P<0.05) in (A1 and A2) groups as compared with control group. In gross appearance therewere petechial hemorrhage and erosion of liver parenchyma. Histopathological study revealedthat there were engorgement of hepatic vein with presence of extravasated RBCs between thehepatocytes in group (A1), while group (A2) the hepatocytes undergo atrophy and severenecrosis and destruction with infiltration of polymorphnuclear leukocytes and engorgement ofsome portal trait with bile secretion

scholarly journals Safety and effectiveness evaluation of a two-handed technique combining harmonic scalpel and laparoscopic Peng’s multifunction operative dissector in laparoscopic hemihepatectomy

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Jingwei Cai ◽  
Guixing Jiang ◽  
Yuelong Liang ◽  
Yangyang Xie ◽  
Junhao Zheng ◽  
...  
Keyword(s):  
Blood Loss ◽  
Operative Time ◽  
Harmonic Scalpel ◽  
Peak Level ◽  
Bile Leakage ◽  
Liver Parenchyma ◽  
Control Group ◽  
Case Group ◽  
Intraoperative Blood Loss ◽  
And Control

Abstract Objectives This study was designed to evaluate the safety and effectiveness of a two-hand technique combining harmonic scalpel (HS) and laparoscopic Peng’s multifunction operative dissector (LPMOD) in patients who underwent laparoscopic hemihepatectomy (LHH). Methods We designed and conducted a case-control study nested in a prospectively collected laparoscopic liver surgery database. Patients who underwent LHH for liver parenchyma transection using HS + LPMOD were defined as cases (n = 98) and LPMOD only as controls (n = 47) from January 2016 to May 2018. Propensity score matching (1:1) between the case and control groups was used in the analyses. Results The case group had significantly less intraoperative blood loss in milliliters (169.4 ± 133.5 vs. 221.5 ± 176.3, P = 0.03) and shorter operative time in minutes (210.5 ± 56.1 vs. 265.7 ± 67.1, P = 0.02) comparing to the control group. The conversion to laparotomy, postoperative hospital stay, resection margin, the mean peak level of postoperative liver function parameters, bile leakage rate, and others were comparable between the two groups. There was no perioperative mortality. Conclusions We demonstrated that the two-handed technique combing HS and LPMOD in LHH is safe and effective which is associated with shorter operative time and less intraoperative blood loss compared with LPMOD alone. The technique facilitates laparoscopic liver resection and is recommended for use.

Hemostatic Efficacy of Nanofibrous Matrix in Rat Liver Injury Model

2016 ◽  
Vol 24 (1) ◽  
pp. 23-28 ◽  
Author(s):  
Amit K. Jaiswal ◽  
Hemlata Chhabra ◽  
Sandipan Narwane ◽  
Nirmala Rege ◽  
Jayesh R. Bellare
Keyword(s):  
Rat Liver ◽  
Histopathological Examination ◽  
Test Group ◽  
Control Group ◽  
Histopathological Study ◽  
Fibrinogen Concentration ◽  
Quick Recovery ◽  
Electrospinning Method ◽  
Hemostatic Efficacy ◽  
And Control

This present study examined the hemostatic efficacy of nanofibrous matrix in a rat liver model. The nanofibrous matrix comprising gelatin and polycaprolactone was prepared by electrospinning method. Twelve animals underwent surgery and were followed-up for a month. Time taken to cease bleeding, activated partial thromboplastin time, prothrombin time, and fibrinogen concentration were measured. Histopathological examination of liver was also done of treated and control animals. All test animals showed very rapid hemostasis after application of electrospun sheet. Histopathological study showed quick recovery of liver wound in the test group as compared to the control group. The nanofibrous matrix has proven to be not only safe and effective as hemostat but has also shown its potential for liver regeneration.

scholarly journals Relationship between serum iron level and febrile convulsion in children

2021 ◽  
Vol 62 (2) ◽  
pp. 112-118
Author(s):  
Ayşe Tuğba Kartal ◽  
Zeynep Çağla Mutlu
Keyword(s):  
Serum Iron ◽  
Febrile Convulsion ◽  
Blood Parameters ◽  
Control Group ◽  
Iron Level ◽  
Control Groups ◽  
Serum Iron Level ◽  
Cross Sectional ◽  
Reinforcing Factors ◽  
And Control

The aim of the present study was to evaluate the relationship between febrile convulsion, serum iron levels and whole blood parameters. This cross-sectional case-control study included patients aged 6 months-6 years-old brought to the department of pediatrics of Kütahya ParkHayat Hospital with febrile convulsions between January 2015 and December 2019. The patients were divided into two groups as: febrile with convulsions (study group; n= 47) and febrile without convulsions (control group; n= 35). Both groups were age and sex-matched. Some blood parameters such as mean serum iron, ferritin, Hb and MCV levels were used to compare the groups. Mean serum iron levels of the study and control groups were 33.7 ± 2.1 μg/dL and 56.3 ± 7.4 μg/dL (p<0.05), and serum ferritin levels were 27.3 ± 6.2 ng/mL and 31.1 ± 2.1 ng/ mL (p>0.05), respectively. Mean hemoglobin levels of the study and control groups were 10.6 ± 1.7 g/dL and 11.1 ± 1.4 g/dL (p <0.05), and mean MCV levels were 71.1 ± 1.2 fL and 73.2 ± 1.1 fL (p>0.05), respectively. In the light of the findings of this study, the low serum iron and ferritin levels may be reinforcing factors for developing febrile convulsion. However, multicentre studies with more patients are needed to reach a precise conclusion.

scholarly journals Investigation of Health Hazards in Vehicle Refueling Stations Attendants at Malakand, Khyber Pakhtunkhwa, Pakistan

2013 ◽  
Vol 4 (1) ◽  
Author(s):  
Imran Khan ◽  
Saleem Ur Rahman ◽  
Muhammad Ilyas ◽  
Ayaz Ali Khan
Keyword(s):  
Biochemical Parameters ◽  
Blood Parameters ◽  
Control Group ◽  
Blood Biochemical Parameters ◽  
Khyber Pakhtunkhwa ◽  
Blood Biochemical ◽  
Large Size ◽  
Routine Work ◽  
Size Population ◽  
And Control

Vehicles refueling station workers are a class of labors prone to long term petroleum product toxicity due to their routine work at vehicles refueling stations. Health problems posed by the pollutants at the work environment of an individual are closely linked to the nature and level of exposure to these hazardous chemicals. The adverse effect of the toxicants in such environment is a common phenomenon in all the developing countries. The awareness about this problem is lacking in Pakistan, particularly in Khyber Pakhtunkhwa. In present study, blood biochemical parameters like calcium, cholesterol, glucose, magnesium, potassium, phosphorus and triglyceride levels were determined among workers and control individuals. The results of the workers showed an increase in glucose, cholesterol and phosphorus level; while significant decrease was observed in calcium and potassium level as compared to the control group of individuals. While the level of magnesium and triglyceride level was same in both groups. In comparative picture, the blood biochemical parameters were normal in control as that of workers. Further study may be conducted to investigate the effect of such environment on other blood parameters and large size population may be included in the study.

HEPATOPROTECTIVE ACTIVITY OF WHOLE FLOWER OF HIBISCUS ROSA-SINENSIS LINN EXTRACTS IN WISTAR RATS

INDIAN DRUGS ◽  
2020 ◽  
Vol 57 (05) ◽  
pp. 65-70
Author(s):  
Krishna Kumar Agrawal ◽  
Keyword(s):  
Carbon Tetrachloride ◽  
Biochemical Markers ◽  
Hepatoprotective Activity ◽  
Hepatic Damage ◽  
Control Group ◽  
Dependent Manner ◽  
Aqueous Extracts ◽  
Sleeping Time ◽  
Hibiscus Rosa Sinensis ◽  
And Control

The aim of the present study was to evaluate the hepatoprotective effect of ethanolic and aqueous extracts of Hibiscus rosa-sinensis Linn flowers..Carbon tetrachloride-induced hepatic injury in rats and pentobarbitone induced hypnosis methods were used to evaluate the hepatoprotective activity. Alteration in biochemical parameters of hepatic damage, such as alanine transminase (ALT), aspartate transminase (AST), alkaline phosphatase (ALP), triglycerides (TG), cholesterol, total bilirubin, direct bilirubin and pentobarbitone induced sleeping time were tested in different groups of study. Carbon tetrachloride (1mL/kg i.p.) enhances the level of biochemical markers of hepatic damage and increases the sleeping time in mice. Treatment with ethanolic and aqueous extracts of H. rosa-sinensis flowers (200mg/kg and 400mg/kg) has significantly brought back the altered levels of biochemical markers to near normal levels in a dose dependent manner, as compared to silyamarin (100mg/kg) and control group (1% w/V CMC).The result indicaes that the hepatoprotective activity shown may be due to the presence of flavonoids, mucilage, tannins or alkaloids, which justify its folkloric use.

scholarly journals A cluster-randomized trial determining the efficacy of caterpillar cereal as a locally available and sustainable complementary food to prevent stunting and anaemia

2015 ◽  
Vol 18 (10) ◽  
pp. 1785-1792 ◽  
Author(s):  
Melissa Bauserman ◽  
Adrien Lokangaka ◽  
Justin Gado ◽  
Kelly Close ◽  
Dennis Wallace ◽  
...  
Keyword(s):  
Democratic Republic ◽  
Democratic Republic Of Congo ◽  
Controlled Trial ◽  
Cluster Randomized Trial ◽  
Control Group ◽  
Republic Of Congo ◽  
High Prevalence ◽  
Cluster Randomized ◽  
Hb Concentration ◽  
And Control

AbstractObjectiveWe conducted a cluster-randomized controlled trial to assess the efficacy of a cereal made from caterpillars, a micronutrient-rich, locally available alternative animal-source food, on reducing stunting and anaemia in infants in the Democratic Republic of Congo.DesignSix-month-old infants were cluster randomized to receive either caterpillar cereal daily until 18 months of age or the usual diet. At 18 months of age, anthropometric measurements and biological samples were collected.SettingThe rural Equateur Province in the Democratic Republic of Congo.SubjectsOne hundred and seventy-five infants followed from 6 to 18 months of age.ResultsStunting was common at 6 months (35 %) and the prevalence increased until 18 months (69 %). There was no difference in stunting prevalence at 18 months between the intervention and control groups (67 % v. 71 %, P=0·69). Infants in the cereal group had higher Hb concentration than infants in the control group (10·7 v. 10·1 g/dl, P=0·03) and fewer were anaemic (26 v. 50 %, P=0·006), although there was no difference in estimates of body Fe stores (6·7 v. 7·2 mg/kg body weight, P=0·44).ConclusionsSupplementation of complementary foods with caterpillar cereal did not reduce the prevalence of stunting at 18 months of age. However, infants who consumed caterpillar cereal had higher Hb concentration and fewer were anaemic, suggesting that caterpillar cereal might have some beneficial effect. The high prevalence of stunting at 6 months and the lack of response to this micronutrient-rich supplement suggest that factors other than dietary deficiencies also contribute to stunting.

scholarly journals Histopathological and Biochemical study of the effect of Citrullus colocynthis on the heart and liver of mature male rabbits: as a model for mammals

2012 ◽  
Vol 36 (0E) ◽  
pp. 322-330
Author(s):  
Saad S. Al-Dujaily
Keyword(s):  
Biochemical Study ◽  
Portal Tract ◽  
Inflammatory Cells ◽  
Mature Male ◽  
Control Group ◽  
Histopathological Study ◽  
Histopathological Changes ◽  
Citrullus Colocynthis ◽  
Serum Glutamate ◽  
Low Dosage

The aim of the present work is to found out if there are histopathological and enzymatic effects on the heart and liver after oral administration of Citrullus colocynthis (CC) fruit (bitter apple) for mature male rabbits, as a model for mammals. Two experiments were performed for sixty mature male rabbits that equally and randomly divided into six groups each containing five animals .In the two experiments ,independently, three groups in each one were considered as treated groups and represented as T1, T2 and T3 groups .These rabbits groups were orally administrated with low dosage of CC (4.8mg/kg/day,experiment No.1 ) and double dosage of CC extract (9.6mg /kg /day , experiment No2 ) for three intervals 2, 4 and 8 weeks ,respectively. The other three groups in each experiment were considered control and represented as C1, C2 and C3 groups, respectively. All the rabbits in control groups were given orally distilled water (DW) at the same periods of treated groups. Histopathological changes of the heart and liver with related enzymes namely; serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT) and creatinine kinase (SCK) were studied.The histopathological study revealed no changes in rabbit’s heart tissue particularly after treatment with 4.8mg/kg/day of CC for 2 and 4 weeks. While no histopathological changes were observed in the heart of rabbit groups treated with 9.6mg/kg/day of CC extract after 2 weeks. The results of the treatment with the two dosages of the CC for 8 weeks indicated a mild degenerative changes and mild necrosis of the myocardial cells. There was swelling of the hepatocytes and perivascular cuffing of mononuclear inflammatory cells after two weeks of daily treatment with 4.8mg/kg/day of CC exposure. After four weeks with the low dosage of the CC extract, caused initiation of necrosis, more inflammation picture of liver portal tract with sinusoid All rabbit groups showed statistically a significant gradual increase (P<0.05) in the value of serum enzyme GOT, GPT and CK levels after treatment with the two dosages of CC at the end of each different period compared with before treatment and control group. Concluded from this study that the dosage 4.8mg/Kg/day of CC plant resulted in simple histopathological effects on the heart and mild histopathological changes on the liver during the entire period of the study, instead of serum enzymatic elevation of SGOT ,SGPT and SCK. Further studies are recommended to found out the possibility to use and effects of CC on animal hygiene and reproduction

scholarly journals Qualitative Diagnosis of Liver Tumors Based on Ultrasound-Guided Automatic Biopsy

2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Bin Peng
Keyword(s):  
Liver Tumors ◽  
Liver Parenchyma ◽  
Lesion Size ◽  
Control Group ◽  
Ultrasound Images ◽  
Ultrasound Guided ◽  
Significant Difference ◽  
Conventional Ultrasound ◽  
The Difference ◽  
And Control

The goal of this study was to see if automatic biopsy guided by ultrasound could be used to provide a qualitative diagnosis of a liver tumor. Methods. A total of 40 patients (101 focuses) were treated with automatic liver parenchyma biopsy under ultrasound guidance, and the correlation between pathological outcomes and ultrasound images was investigated. The lesion size in the observation group was compared to that in the control group using conventional ultrasound ( P  > 0.05), and there was no significant difference. Under contrast-enhanced ultrasound (CEUS), there was no statistically significant difference in lesion size between the observation and control groups ( P  > 0.05). The difference in lesion size between the conventional ultrasonography and CEUS observation groups was statistically significant ( P 0.05). Conclusion. Ultrasound-guided automated biopsy of the liver parenchyma is a simple and effective procedure with fewer problems and a high diagnostic rate, and it deserves to be promoted clinically.

scholarly journals Influence of Sodium Humate on the Growth Performance, Diarrhea Incidence, Blood Parameters, and Fecal Microflora of Pre-Weaned Dairy Calves

Animals ◽  
2022 ◽  
Vol 12 (1) ◽  
pp. 123
Author(s):  
Dong Wang ◽  
Zhendong You ◽  
Yuanyi Du ◽  
Duo Zheng ◽  
Haotian Jia ◽  
...  
Keyword(s):  
Growth Performance ◽  
Basal Diet ◽  
Blood Parameters ◽  
Dairy Calves ◽  
Milk Replacer ◽  
Control Group ◽  
Sodium Humate ◽  
Fecal Microflora ◽  
Diarrhea Incidence ◽  
And Control

This study aimed to evaluate the effects of the administration of sodium humate (NaH) on the growth performance, diarrhea incidence, and fecal microflora of pre-weaned Holstein calves. In a 53-day experiment, forty healthy newborn female calves were randomly allocated to the following four treatment groups: (1) control (basal diet); (2) 1-gram NaH (basal diet extra orally supplemented with 1 g of NaH dissolved in 100 mL of milk or milk replacer daily); (3) 3-gram NaH (basal diet extra orally supplemented with 3 g of NaH dissolved in 100 mL of milk or milk replacer daily); and (4) 5-gram NaH (basal diet extra orally supplemented with 5 g of NaH dissolved in 100 mL of milk or milk replacer daily). NaH was mixed with milk (d 2–20) or milk replacer (d 21–53). Calves in the 5-gram NaH group had a higher ADG during d 1 to 21 and d 21 to 53 than the other groups did (p < 0.05). Fecal scores and diarrheal incidence were significantly lower in the 3-gram and 5-gram NaH groups than the 1-gram NaH and control groups during d 1 to 20 (p < 0.05). The serum IgA, IgG and IL-4 concentrations, and T-SOD and T-AOC activities were higher, and the serum IL-6, TNF-α, D-lactic acid, and MDA concentrations were lower in the 5-gram NaH group than the control group (p < 0.05). Furthermore, NaH supplementation increased the abundances of Bifidobacterium and Lactobacillus but decreased the abundance of Escherichia coli in feces (p < 0.05). These encouraging findings indicated that supplementation with 5 g of NaH effectively improved the immune status, antioxidant capacity, and intestinal beneficial bacteria, and further improved the growth performance and reduced the diarrhea incidence of the pre-weaned dairy calves.

Reye's Syndrome and Salicylate Use

PEDIATRICS ◽  
1980 ◽  
Vol 66 (6) ◽  
pp. 859-864
Author(s):  
Karen M. Starko ◽  
C. George Ray ◽  
Lee B. Dominguez ◽  
Warren L. Stromberg ◽  
Dora F. Woodall
Keyword(s):  
Influenza A ◽  
Control Group ◽  
Dependent Manner ◽  
Reye's Syndrome ◽  
Medication Usage ◽  
Cough Headache ◽  
Control Subjects ◽  
Gastrointestinal Complaints ◽  
And Control ◽  
Dose Dependent

During an outbreak of influenza A, seven patients with Reye's syndrome and 16 ill classmate control subjects were evaluated for characteristics of the patients' prodromal illness and the control subjects illness and for medication usage. Patients during the prodrome and control subjects had similar rates of sore throat, coryza, cough, headache, and gastrointestinal complaints except for documented fever which occurred significantly more often in patients than in control subjects (P = .05). While medications which did not contain salicylate were taken as frequently by patients as control subjects, patients took more salicylate-containing medications than did control children (P &lt; .01). All seven patients took salicylate whereas only eight of 16 control subjects did so (P &lt; .05). Patients took larger doses of salicylate than did the entire control group (P &lt; .01). When the eight control subjects who took salicylate were compared with the patients, the patients still tended to take larger doses (P = .08). Patients with fever took salicylate more frequently than control subjects with fever (P &lt; .01). In addition, salicylate consumption was correlated with severity of Reye's syndrome (P &lt; .05). It is postulated that salicylate, operating in a dose-dependent manner, possibly potentiated by fever, represents a primary causative agent of Reye's syndrome.

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