scholarly journals GRANTING OF EDUCATION STRUCTURED NUTRITION AND ELECTROLYTE (ESNE) ON CHANGING INTERDIALYTIC WEIGHT GAIN IN CHRONIC CALCULATION FAILURE PATIENTS

2019 ◽  
Vol 3 (2) ◽  
pp. 89-99
Author(s):  
Lutfi Wahyuni ◽  
Ika Ainur Rofiah ◽  
Mochammad Achwandi
Keyword(s):  
Chronic Kidney Disease ◽  
Renal Failure ◽  
Weight Gain ◽  
Chronic Renal Failure ◽  
Kidney Disease ◽  
Kidney Function ◽  
The Body ◽  
Artificial Kidney ◽  
Fluid Restriction ◽  
Interdialytic Weight Gain

ABSTRACT   GRANTING OF EDUCATION STRUCTURED NUTRITION AND ELECTROLYTE (ESNE) ON CHANGING INTERDIALYTIC WEIGHT GAIN IN CHRONIC CALCULATION FAILURE PATIENTS By Lutfi Wahyuni, Ika Ainur rofiah, Mochammad Achwandi Chronic kidney disease is a condition when kidney function begins to decline gradually. The condition of the decline in kidney function occurs due to many factors, one of which is because the kidney damage that has occurred intensely for many years. Patients with chronic renal failure need a management or hemodialysis therapy, which is the cleansing process of blood from waste substances, through a screening process outside the body using an artificial kidney in the form of a dialysis machine. Hemodialysis therapy is needed in the management of patients with chronic renal failure who cannot be treated again (terminal). The success of hemodialysis is based on various elements, one of which is compliance with fluid restrictions. Limitation of fluid intake in patients with chronic renal failure is very important. The provision of structured education can be given to patients with chronic kidney failure who are undergoing hemodialysis therapy. Education structured nutrition and electrolyte (ESNE) is a structured health education on nutrition and electrolyte management for chronic renal failure patients undergoing hemodialysis. ESNE is done to improve patients' understanding of diet and electrolyte compliance to prevent an increase in IDWG and to improve patient compliance with fluid restrictions. The stages of service activities that have been carried out are to explain fluid requirements and fluid restriction in patients with chronic renal failure using the Education structured nutrition and electrolyte (ESNE) method, the next recourse is an evaluation after continuous or ESNE administration of respondents given treatment and respondents who were not treated. Keywords: Diet, Chronic Kidney Disease, Hemodialysis 

scholarly journals Evaluation of the Usage of Erythropoietin in Patients with End-Stage Chronic Kidney Disease Dialysis Cycle in Hanoi Nephrology Hospital

2020 ◽  
Vol 36 (1) ◽  
Author(s):  
Do Thi Hoa ◽  
Nguyen Thi Tuyet Trinh ◽  
Nguyen Thi Lien Huong ◽  
Phan Tung Linh
Keyword(s):  
Chronic Kidney Disease ◽  
Renal Failure ◽  
Chronic Renal Failure ◽  
Kidney Disease ◽  
General Hospital ◽  
Renal Dialysis ◽  
The United States ◽  
Artificial Kidney ◽  
Health Official ◽  
End Stage

Treatment and control of anemia plays an important role in improving the quality and effectiveness of artificial kidney. The study was conducted on 61 patients who met the selection and were not included in the excluded criteria group. Collecting data from medical records using retrospective, descriptive, vertical follow-up method for 6 months. Data were processed using Microsoft Excel Office 2010 and R. The results showed that patients used both EPO alpha and EPO beta simultaneously. Rate of usage’s EPO beta accounted for 23%, alpha EPO was 77%. Lyophilized form (EPO alpha) is most commonly used. Starting from T3, Hb. averages treat. There were no abnormalities in blood pressure, white blood cell, platelets, and electrolytes. Keywords Hanoi Kidney Hospital, EPO (erythropoietin), Hb, efficacy and safety. References [1] L.A. Szczech, W. Harmon, T.H. Hostetter et al, World Kidney Day 2009: Problem and Challenges in the Emering Epidemic of Kidney Disease, J Am Soc Nephrol 20 (2009) 453-455. https://doi.org/10.1681/ASN.2009010041.[2] D.T. Gilbertson, J. Liu et al, Projecting the Number of Patient with End Stage Renal Disease in the United States to the Year 2015, J Am Soc Nephrol 16 (2005) 3736-3741. https://doi.org/10.1681/ASN.2005010112.[3] A.E. Gaweda, G.R. Aronoff et al, Individualized anemia management reduces hemoglobin variability in hemodialysis patients, J Am Soc Nephrol 25(1) (2014) 159-66. https://doi.org/10.1681/ASN.2013010089.[4] Do Thi Thu Hien, Evaluation of the usage of erythropoietin in the treatment of anemia in patients with chronic renal failure on dialysis at Thai Binh Provincial General Hospital, Master of Pharmacy thesis, Hanoi University of Pharmacy, 2015 (in Vietnamese).[5] Trieu Thi Tuyet Van, Evaluation of the usage of erythropoietin in the treatment of anemia in patients with chronic renal failure on dialysis at the artificial kidney department - Bach Mai Hospital, Master of Pharmacy thesis, Hanoi University of Pharmacy, 2009 (in Vietnamese).[6] Nguyen Thi Uyen, Investigating the effectiveness and safety of Erythropoietin use in dialysis patients at artificial kidney monotherapy Sanit Paul Hospital, Graduation thesis of Pharmacist, Hanoi University of Pharmacy, 2016 (in Vietnamese).[7] Bui Thi Tam, Evaluation the effectiveness of anemia treatment with Erythropoietin in patients with chronic renal failure receiving dialysis at Dien Bien Provincial General Hospital, Graduation thesis of Pharmacist Specialist 2, Hanoi University of Pharmacy, 2011 (in Vietnamese).[8] Drug Administration of Vietnam - Ministry of health, Official dispatch number 4764/QLD-ĐK, 2014 (in Vietnamese).[9] The Vietnam Urology & Nephrology Association, Guidelines for treatment of anemia in chronic kidney disease, The Vietnam Urology & Nephrology Association, 2013 (in Vietnamese).[10] KDIGO, KDIGO 2012 Clinical practice guideline for the evaluation and management of chronic kidney disease, Kidney International Supplement, 2013, pp.1-150.[11] Lam Thanh Vung, Study on the characteristics of anemia and the effectiveness of Erythropoietin β combination with intravenous iron in patients with chronic renal dialysis by dialysis, Thesis Specialized level 2 Medical and Pharmaceutical University, Hue University, 2013.  

scholarly journals Factores que incrementan el peso interdialisis de pacientes sometidos a hemodiálisis

Más Vita ◽  
2020 ◽  
Vol 2 (1) ◽  
pp. 16-20
Author(s):  
Iván Román López ◽  
Roberto Iván Basurto-Quilligana
Keyword(s):  
Chronic Kidney Disease ◽  
Renal Failure ◽  
Weight Gain ◽  
Chronic Disease ◽  
Chronic Renal Failure ◽  
Kidney Disease ◽  
Education Program ◽  
Kidney Failure ◽  
Dry Weight ◽  
The Self

Introducción: Los pacientes con insuficiencia renal crónica se realizan hemodiálisis 3 veces a la semana. Una de las principales situaciones que se da, es la ganancia de peso o sobrecarga hídrica entre una diálisis y otra, ocasionando una serie de complicaciones que ponen en riesgo la vida del paciente. Objetivo: Determinar los factores que incrementan el peso interdialisis de pacientes sometidos a hemodiálisis. Método: El diseño de la investigación que se empleó fue cuantitativo, de tipo no experimental, transversal y descriptivo. La muestra estuvo representada por 14 pacientes adultos con enfermedad renal crónica. El análisis de los resultados se realizó a través del programa de IBM SPSS Statistcs versión 22. Resultados: A pesar de que el centro de diálisis tiene un programa de educación continua con temas de alimentación orientada hacia los pacientes, estos no siguen las recomendaciones ingiriendo líquidos a libre demanda provocando sobre peso al realizarse las hemodiálisis generalmente ocasionando dificultad en su tratamiento de hemodiálisis Conclusión: Los conocimientos de autocuidado que posee cada paciente, que presenta una enfermedad crónica como la insuficiencia renal, son esenciales porque puedenevitar las repetidas hospitalizaciones. Palabras Claves: Peso seco, Hemodiálisis, interdialisis, intradialisis. AbstractIntroduction: Patients with chronic renal failure are performed hemodialysis 3 times a week. One of the main situations that occurs is the weight gain or water overload between one dialysis and another, causing a series of complications that put the patient’s life at risk. Objective: To determine the factors that increase the interdialisis weight of patients undergoing hemodialysis. Method: Theresearch design was quantitative, non-experimental, transversal and descriptive. And14 adult patients with chronic kidney disease represented the sample. The analysis of the results was carried out through the IBM SPSS Statistcs version 22 program. Results:Even though the dialysis center has a continuous education program with patient-oriented feeding issues, they do not follow the recommendations, and ingest liquids on free demand, causing overweight at hemodialysis usually causing difficulty in hemodialysis treatment. Conclusion: The self-care knowledge that each patient has, which represents a chronic disease such as kidney failure, are essential because can avoid repeated hospitalizations. Keywords: Dry weight, Hemodialysis, interdialisis, intradialisis

Avaliação da Resiliência em Pacientes com Insuficiência Renal Crônica Submetidos à Hemodiálise / Assessment of Resilience in Patients With Chronic Kidney Disease Undergoing Hemodialysis

1970 ◽  
Vol 6 (1) ◽  
pp. 5-13
Author(s):  
Renata Izabel dos Santos ◽  
Otávia Regina Souza Costa
Keyword(s):  
Chronic Kidney Disease ◽  
Renal Failure ◽  
Health Status ◽  
Chronic Renal Failure ◽  
Kidney Disease ◽  
Renal Insufficiency ◽  
Social Economic ◽  
Descriptive Study ◽  
Psychological Resilience ◽  
Resilience Scale

RESUMOObjetivo: Avaliar o nível de resiliência dos portadores de insuficiência renal crônica em tratamento de hemodiálise. Materiais e Métodos: Estudo prospectivo, quantitativo e de abordagem descritiva. A amostra foi constituída por 61 pacientes em tratamento dialítico. Para obtenção dos resultados, foi utilizada a escala de resiliência, desenvolvida por Wagnild e Young (1993) e adaptada por Pesce et al., (2005). Foi aplicado, também, um questionário para caracterização pessoal, familiar, social, econômica e de saúde do grupo. Resultados: Foi constatado que 61% dos pacientes apresentaram tendência à resiliência. O gênero masculino obteve maior pontuação, sugerindo maior tendência à resiliência, bem como os pacientes que são praticantes de uma religião.  Conclusão: Os resultados assinalam que os pacientes em tratamento dialítico no hospital apresentam capacidade à resiliência, o que sugere melhor adaptação ao tratamento.Palavras-chave: Avaliação, Resiliência psicológica, Insuficiência renal crônica.ABSTRACTObjective: To evaluate de the level of resilience in patients with chronic renal failure undergoing dialysis. Materials and Methods: Prospective, quantitative and descriptive study. The sample consisted of 61 patients on dialysis. To obtain the results we used Resilience Scale developed by Wagnild and Young (1993) and adapted by Pesce et al., (2005). A questionnaire to characterize personal, familiar, social, economic and health status was applied. Results: It was found that 61% of patients showed trend to resilience. Males had higher scores, suggesting more likelihood to resilience, as well as patients who were practitioners of a religion. Conclusion: The results indicate that the majority of patients on dialysis have capability of resilience, which suggests better adaptation to treatment.Keywords: Evaluation, Psychological resilience, Chronic renal insufficiency.

scholarly journals CONDITION AFTER HEMOLYTIC-UREMIC SYNDROME IN A CHILD WITH 3RD STAGE CHRONIC KIDNEY DISEASE (case report)

2017 ◽  
Vol 4 (3) ◽  
pp. 136-138
Author(s):  
M.O. Gonchar ◽  
T.B. Ishenko ◽  
N.V. Orlova ◽  
G.R. Muratov ◽  
T.F. Kolibaeva ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Renal Failure ◽  
Case Report ◽  
Chronic Renal Failure ◽  
Kidney Disease ◽  
Hemolytic Uremic Syndrome ◽  
Clinical Case ◽  
Disease Case ◽  
Uremic Syndrome ◽  
The Given

Gonchar M.O., Ishchenko T.B., Orlova N.V., Muratov G., Kolibaeva T., Khmara N., Podvalnaya N.Currently, hemolytic-uremic syndrome is one of the frequent causes of acute kidney failure in children, so the timeliness of diagnosis and treatment determines the outcome of the disease. In the given clinical case, a set of certain factors that lead to an unfavorable outcome of the disease and the progression of chronic renal failure are presented. Clinical case of a 14-year-old child K., who was admitted to the nephrology department of the Regional Children's Clinical Hospital with the diagnosis: 3rd stage CKD, subcompensated stage of chronic renal failure and condition after hemolytic-uremic syndrome.KeyWords: hemolytic-uremic syndrome in children, chronic kidney disease. СТАН ПЫСЛЯ ПЕРЕНЕСЕНОГО ГЕМОЛІТИКО-УРЕМІЧНОГО СИНДРОМУ У ДИТИНИ З III СТАДІЄЮ ХРОНІЧНОГО ЗАХВОРЮВАННЯ НИРОК (КЛІНІЧНЕ СПОСТЕРЕЖЕННЯ)Гончарь М.О., Іщенко Т.Б., Орлова Н.В., Муратов Г.Р., Колібаєва Т.Ф., Хмара Н.В., Підвальна Н.А. В даний час гемолітико-уремічний синдром є однією з найчастіших причин гострої ниркової недостатності у дітей, тому своєчасність постановки діагнозу і лікування визначає результат захворювання. На наведеному клінічному випадку, представлено сукупність певних факторів, які привели до несприятливого результату захворювання і прогресування хронічної ниркової недостатності. Клінічний випадок дитини К. 14 років, який знаходився в нефрологічному відділенні Обласної дитячої клінічної лікарні з діагноз: ХХН III ст. Хронічна ниркова недостатність субкомпенсированная стадія. Стан після перенесеного гемолітико-уремічного синдрому.Ключові слова: гемолітико-уремічний синдром, діти, клінічний випадок, хронічне захворювання нирок. СОСТОЯНИЕ ПОСЛЕ ПЕРЕНЕСЕННОГО ГЕМОЛИТИКО-УРЕМИЧЕСКОГО СИНДРОМА У РЕБЕНКА С III СТАДИЕЙ ХРОНИЧЕСКОГО ЗАБОЛЕВАНИЯ ПОЧЕК (КЛИНИЧЕСКОЕ НАБЛЮДЕНИЕ)Гончарь М.А., Ищенко Т.Б., Орлова Н.В., Муратов Г.Р., Колибаева Т.Ф., Хмара Н.В., Подвальная Н.А. В настоящее время гемолитико-уремический синдром является одной из частых причин острой почечной недостаточности у детей, поэтому своевременность постановки диагноза и лечения определяет исход заболевания. На приведенном клиническом случае, представлено совокупность определенных факторов, которые привели к неблагоприятному исходу заболевания и прогрессированию хронической почечной недостаточности. Клинический случай ребенка К. 14 лет, который находился в нефрологическом отделении Областной детской клинической больнице с диагноз: ХБП III ст. Хроническая почечная недостаточность субкомпенсированная стадия. Состояние после перенесенного гемолитико-уремического синдрома.Ключевые слова: гемолитико-уремический синдром, дети, клинический случай, хроническое заболевание почек.

Anaesthesia of the patient with chronic kidney disease

2020 ◽  
Vol 25 (11) ◽  
pp. 268-276
Author(s):  
Oscar Bautista Díaz-Delgado ◽  
Briony Alderson
Keyword(s):  
Blood Pressure ◽  
Chronic Kidney Disease ◽  
Renal Failure ◽  
Cardiac Output ◽  
Kidney Disease ◽  
The Body ◽  
Renal Physiology ◽  
Successful Management ◽  
Emergency Procedures ◽  
Routine Procedures

Chronic kidney disease is common, particularly in geriatric animals. General anaesthesia is usually required for routine procedures (dental prophylaxis, ovariohysterectomy or castration) and emergency procedures, which may have profound effects on the body, especially on cardiac output, subsequent blood pressure and on the perfusion of different vital organs. It is essential to understand the effects of renal dysfunction on the patient, as well as the effects that anaesthesia and surgery may have on the kidneys. The understanding of renal physiology, along with the effect of drug choices, is key to successful management of chronic renal failure.

scholarly journals Faktor yang berhubungan dengan tingkat depresi pada pasien gagal ginjal kronis yang menjalani tindakan hemodialisa

2020 ◽  
Vol 14 (1) ◽  
pp. 101-109
Author(s):  
Indra Maulana ◽  
Iwan Shalahuddin ◽  
Taty Hernawaty
Keyword(s):  
Chronic Kidney Disease ◽  
Renal Failure ◽  
Chronic Renal Failure ◽  
Kidney Disease ◽  
Psychosocial Factors ◽  
Health Workers ◽  
Depression Score ◽  
Cross Sectional ◽  
Depression Level ◽  
The Impact

Psychosocial factors: The depression level  in patients with chronic kidney disease maintained on dialysisBackground: Chronic renal failure undergoing hemodialysis therapy in the world is almost 1.5 million people, and in Indonesia there are approximately 0.2 people with chronic renal failure undergoing hemodialysis therapy. The impact of hemodialysis on the physical that will occur in patients become weak tired in living their daily lives, against the psychological impact that will occur on sleep problems, impurity and depression, the impact on social and economic conditions that will occur to patients on social relationships, and on the environment the client will also have an impact on the social environment in which he lives. Therefore hemodialysis therapy will have an impact on the quality of life of patients.Purpose: To determine Psychosocial factors: the depression level  in patients with chronic kidney disease maintained on dialysisMethod: A descriptive correlational study by a cross sectional design approach. The sample used was 40 respondents, data collection techniques using questionnaires and direct observation with results calculated based on the total answers to questions given by respondents with criteria: score <17 = no sign of depression, score 18-24 = mild depression, score 25-34 = moderate depression and a score of 35-51 = severe depression, while the bivariate test used chi-squareResults: There was a relationship among factors such as: age, educational, sex, duration of maintaine of hemodialysis therapy and sleep patterns with the depression level in patients with chronic kidney disease under maintained on dialysis at Garut dr. Slamet Hospital.Conclusion: Health workers (nurses) to provide motivational and therapeutic informing in implementing hemodialysis therapy so that patients are more excited and better understand the importance of hemodialysis and to reduce the level of depression.Keywords: Depression level; Patients; Chronic kidney disease; DialysisPendahuluan: Penyakit gagal ginjal kronik yang menjalani terapi hemodialisis di dunia hampir sekitar 1,5 juta orang, dan di indonesi hampitr sekitar 0,2 jiwa penderita gagal ginjal kronik yang menjalani terapi hemodialisis. Dampak hemodialisis terhadap fisik yang akan terjadi pada pasien menjadi lemah lelah dalam menjalani kehidupan sehari-hari, terhadap psikologis dampak yang akan terjadi pada masalah tidur, kecemasaan dan depresi, dampak terhadap sosial dan ekonomi yang akan terjadi pada pasien pada hubungan sosialnya, dan pada lingkungan klien juga akan berdampak pada sosial lingkungan dimana dia tinggal. Maka dari itu terapi hemodialisis akan berdampak pada kualitas hidup pasien.Tujuan: Mengetahui faktor-faktor yang berhubungan dengan tingkat depresi pada pasien gagal ginjal kronis yang menjalani tindakan HemodialisaMetode: Menggunakan rancangan deskriptif korelasional dengan pendekatan desain cross sectional dengan sampel sebanyak 40 responden, teknik pengambilan data menggunakan kuesioner dan observasi langsung dengan hasil dihitung berdasarkan  total jawaban dari pertanyaan yang diberikan responden dengan kriteri skor <  17 = tidak ada depresi,  skor 18-24 = depresi ringan,  skor 25-34= depresi sedang dan skor 35-51= depresi berat                        sedangkan uji bivariat menggunakan chi-square.Hasil: Menunjukan adanya hubungan antara faktor : usia, pendidikan, jenis kelamin, lamanya periode menjalani terapi hemodialisa dan pola tidur. Semua faktor tersebut sangat  berhubungan dengan tingkat depresi pada pasien gagal ginjal kronik yang menjalani tindakan hemodialisa di Ruang Hemodialisa RSUD dr. Slamet Garut.Simpulan: Petugas kesehatan (perawat) agar memberikan motivasi dan terapeutik informing dalam pelaksanaan terapi hemodialisa agar pasien lebih bersemangat dan lebih memahami pentingnya hemodialisa serta untuk mengurangi tingkat depresi.

scholarly journals Gambaran tingkat depresi terhadap kejadian peningkatan interdialytic weight gain pada pasien Penyakit Ginjal Kronik yang menjalani hemodialisis di Rumah Sakit Umum Dr. Zainal l Abidin, Banda Aceh

2020 ◽  
Vol 20 (2) ◽  
Author(s):  
Maryatun Hasan
Keyword(s):  
Chronic Kidney Disease ◽  
Weight Gain ◽  
Kidney Disease ◽  
Public Hospital ◽  
Rating Scale ◽  
P Value ◽  
Cross Sectional ◽  
Interdialytic Weight Gain ◽  
Hamilton Rating Scale ◽  
Banda Aceh

Abstrak. Penyakit ginjal kronis (PGK) merupakan penyakit yang dapat mengakibatkan penderitanya mengalami stress jangka panjang dan akhirnya bermanifestasi menjadi depresi. Depresi yang ditimbulkan dapat mempengaruhi perilaku pasien dalam hal pengaturan cairan sehingga dapat berakibat terhadap peningkatan Interdialytic Weight Gain (IDWG). Jika IDWG meningkat maka akan menimbulkan komplikasi yang dapat menghambat keberhasilan terapi hemodialisis.  Penelitian ini bertujuan untuk mengetahui gambaran tingkat depresi terhadap terjadinya peningkatan Interdialytic Weight Gain pada pasien PGK yang menjalani hemodialisis di RSUDZA Banda Aceh. Jenis penelitian ini adalah deskriptif analitik dengan pendekatan cross sectional. Pengumpulan data dilakukan pada bulan Desember 2019 menggunakan teknik accidental sampling dengan responden adalah pasien di unit hemodialisis RSUDZA Banda Aceh. Pengumpulan data dilakukan dengan menggunakan kuesioner Hamilton Rating Scale for Depression kemudian dilakukan analisis univariat untuk mengatahui gambaran dari penelitian dan bivariat dengan menggunakan uji korelasi Spearman. Berdasarkan hasil analisis statistik dengan menggunakan uji Spearman, didapatkan p value sebesar 0,000 (p0,05) dengan koefisien korelasi Spearman sebesar 0,729. Hal ini menunjukkan adanya hubungan yang signifikan antara tingkat depresi dengan peningkatan IDWG pada pasien PGK yang menjalani hemodialisis di RSUDZA Banda Aceh.Kata Kunci: Penyakit Ginjal Kronis, Hemodialisis, Depresi, Interdialytic Weight GainAbstract. Chronic kidney diasease (CKD) might cause stress which generally leads to depression. Depression is correlated to significant impairment in a patient's daily life, such as excessive Interdialytic Weight Gain (IDWG) caused by an overload of fluids. Excessive Interdialytic Weight Gain might also cause other complications that are able to interfere the process of hemodialysis therapy. The objective of this research was to identify the overview of and the correlation between depression types and Interdialytic Weight Gain (IDWG) of the chronic kidney disease patients undergoing hemodialysis therapy in dr. Zainoel Abidin Regional Public Hospital of Banda Aceh. This descriptive analytical research was conducted by means of a cross-sectional study approach. The data were collected in December 2019 by using an accidental sampling technique. The data were collected by distributing the Hamilton Rating Scale for Depression. Those data were then analyzed by using a univariate data analysis and a bivariate data analysis, especially the Spearman Correlation Coefficient. Based on the statistical analysis with the Spearman test, p-value of 0.000 (p0.05) with a Spearmen Correlation Coefficient of 0.729 was found. Hence, a significant correlation between depression levels or types and IDWG in chronic kidney disease patients undergoing hemodialysis in dr. Zainoel Abidin Regional Public Hospital of Banda Aceh was indicated.Keywords: Chronic Kidney Disease, hemodialysis, Depression, Interdialytic Weight Gain

scholarly journals Nonsteroidal Anti-Inflammatory Drugs (NSAIDS) Induced Acute Kidney Injury (AKI): Patient Profile and Outcome in Bangladesh Armed Forces

2015 ◽  
Vol 10 (2) ◽  
pp. 39-43
Author(s):  
Azizun Nessa ◽  
Md Amzad H Fakir
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Kidney Injury ◽  
Physical Exertion ◽  
Armed Forces ◽  
Complete Recovery ◽  
The Body ◽  
Military Hospital ◽  
Fluid Restriction ◽  
Patient Profile

Introduction: In military environment where musculoskeletal injury is more common, NSAIDs abuse and subsequent AKI carries a special risk. This study of NSAIDs induced AKI was carried out to highlight this issue.Objective: To find out the incidence, risk factors, diagnostic approach, clinical course, management and outcome of patients of Bangladesh Armed Forces.Methods: This longitudinal study was carried out in nephrology centre, combined military hospital (CMH) Dhaka from July 2010 to Jun 2013. Total 59 patients of NSAIDs induced AKI were included in this study. Any patient having pre existing renal pathology or chronic kidney disease was excluded from the study.Results: Total 59 patients were included in this study. Mean age of the patient was 36±7.12 yrs. Forty five patients (76.27%) took NSAIDs at their own and 14 patients (23.73%) were prescribed by physician. Fifty one patients (86.44%) took NSAIDs because of musculoskeletal pain. Dehydration due to physical exertion (30.50%), gastroenteritis (15.25%) and nil per os (NPO) (5.08%) were the common predisposing factors. Common symptoms were swelling of the body (40.67%), headache (32.20%), fatigue (27.11%) and vomiting (13.55%). Oedema was the most common sign (40.67%). Blood urea and serum creatinine were raised in all patients. Treatment includes drug withdrawl (100%), fluid resuscitation (86.44%), fluid restriction (61.01%), short course of steroid (13.55%) and haemodialysis (10.16%). Forty seven patients (79.66%) had complete recovery within two weeks of therapy whereas nine patients (15.25%) required more than two weeks to one month for complete recovery. Three patients (5.09%) developed chronic kidney disease (CKD).Conclusion: NSAIDs induced AKI carries a good prognosis with early diagnosis and proper management and it can be prevented by limiting the availability of over the counter drugs and creating awareness both in physicians and patients.Journal of Armed Forces Medical College Bangladesh Vol.10(2) 2014

scholarly journals Shen Shuai II Recipe Attenuates Renal Interstitial Fibrosis by Improving Hypoxia via the IL-1β/c-Myc Pathway

2021 ◽  
Vol 2021 ◽  
pp. 1-13
Author(s):  
Liuyi Yang ◽  
Meng Wang ◽  
Yuan Zhou ◽  
Jing Yang ◽  
Chaoyang Ye ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Renal Failure ◽  
Renal Function ◽  
Chronic Renal Failure ◽  
Kidney Disease ◽  
Protein Expression ◽  
Interstitial Fibrosis ◽  
Renal Interstitial Fibrosis ◽  
Related Factors

Background. Renal interstitial fibrosis is a pathological manifestation of progression of chronic kidney disease induced by various factors. Shen Shuai II Recipe (SSR) has been used in clinical practice for more than 20 years, and clinical studies have confirmed that SSR significantly improves the renal function of patients with chronic kidney disease. However, the specific mechanisms underlying its efficacy require further research. This study aims to explore the influencing factors of renal interstitial fibrosis in the context of hypoxia via the IL-1β/c-Myc pathway and the potential molecular mechanisms of SSR intervention in vivo and in vitro. Methods. A rat model of chronic renal failure was developed by performing 5/6 (ablation/infarction, A/I) surgery on randomly selected, male Sprague Dawley rats. Thirty-six successfully modeled rats were randomly divided into three groups: 5/6 (A/I), 5/6 (A/I) + SSR, and 5/6 (A/I) + losartan. Another 12 rats were used as the sham group. After 8 weeks of the corresponding intervention, renal function, liver function, and protein expression of renal-fibrosis-related factors, HIF-1α, IL-1β, and c-Myc, were detected. In vitro analysis was performed using hypoxia-induced rat renal tubular epithelial cells (NRK-52E) and IL-1β-stimulated rat renal interstitial fibroblasts (NRK-49F). IL-1β concentration in the culture medium and IL-1β protein expression in hypoxic NRK-52E treated with different concentrations of SSR were investigated. Furthermore, we also studied the changes in protein expression of c-Myc and fibrosis-related factors after c-Myc gene silencing in IL-1β-stimulated NRK-49F treated with SSR. Results. Shen Shuai II Recipe significantly reduced RIF and downregulated the expression of HIF-1α, c-Myc, and IL-1β proteins in 5/6 (A/I) rats with chronic renal failure. It also inhibited IL-1β secretion from NRK-52E induced by hypoxia, which in turn inhibited fibroblast activation mediated by the IL-1β/c-Myc pathway, and finally reduced the overproduction of the extracellular matrix. Conclusion. The renoprotective effects of SSR in rats with chronic renal failure may be related to its inhibition of hypoxia via the IL-1β/c-Myc pathway. Thus, SSR is a potentially effective drug for delaying the progression of renal interstitial fibrosis.

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