scholarly journals GENOTYPE-SYMPTOMATOLOGY CORRELATION STUDIES IN PATIENTS WITH ANXIETY

2020 ◽  
Vol 5 (12) ◽  
pp. 1-9
Author(s):  
Chen Shengdong ◽  
Mingjun He ◽  
Xiaoli Zhu ◽  
Wei Niu ◽  
Lingming Kong ◽  
...  
Keyword(s):  
Roc Curve ◽  
Gene Microarray ◽  
Altered Expression ◽  
Somatic Anxiety ◽  
Correlation Studies ◽  
High Expression Group ◽  
Auc Value ◽  
Relationship Of ◽  
The Relationship ◽  
Low Expression

Projects: To explore the relationship of lncRNAs with altered expression in peripheral blood with symptomatogy in anxiety patients. Methods: Gene microarray was carried on to screen the lncRNAs with altered expressions between anxiety patients (GAD) and healthy people (NC), and qPCR was performed to validate these screened lncRNAs. GAD was assessed by HAMA to analyze differently-expressed lncRNAs and its relationship with symptomatology. Results: 1. The expression levels of PR1-PR10 were positively relayed to psychic anxiety and the total score of HAMA (r=0.187~0.253，P< 0.01 or P< 0.05), the expression level of PR7 was positively related to somatic anxiety (r=0.171，P< 0.05); 2. ROC curve combined analysis showed that the AUC value of ten lncRNAs arrived at 0.808, at chic YI=YImax, sensitivity and specificity was 66.3%, 90.5% respectively; 3. High expression group of PR7 (NONHSAG049179) was significantly higher than that in low expression group accounting for psychic anxiety, aromatic anxiety and total score of HAMA. Conclusion: lncRNA with altered expression may be involved in MDD, and NONHSAG049179 is closely associated with psychic anxiety and somatic anxiety.

Impact of CKLF-like MARVEL Transmembrane Domain Containing 6 (CMTM6) Expression in Gastric Cancer

2020 ◽  
Author(s):  
M Nishi ◽  
Mitsuo Shimada ◽  
Kozo Yoshikawa ◽  
Jun Higashijima ◽  
Takuya Tokunaga ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Transmembrane Domain ◽  
Disease Free Survival ◽  
University Hospital ◽  
High Expression ◽  
High Expression Group ◽  
Group 5 ◽  
Relationship Of ◽  
The Relationship ◽  
Low Expression

Abstract Background: CKLF-like MARVEL transmembrane domain containing 6 (CMTM6) is the master regulator of programmed cell death-ligand 1(PD-L1). We aimed to clarify the significance of CMTM6 expression in gastric cancer (GC). Methods: A total of 105 patients who had undergone curative surgical resection for stage II/III GC at Tokushima University Hospital were included in this study. The expression of CMTM and PD-L1 was examined by immunohistochemistry. Additionally, the relationship of each expression level to several prognostic factors was examined using univariate and multivariate analyses. Results: CMTM6 was not positively correlated with any of the factors examined. The overall survival (OS) rates were significantly poorer in the CMTM6 high-expression group than in the CMTM low-expression group (5-year OS: 57.2% vs. 79.2%, respectively; p<0.05). Disease-free survival (DFS) was significantly poorer in the CMTM high-expression group than in the CMTM6 low-expression group (5-year DFS: 52.8% vs. 72.4%, respectively; p=0.20). Multivariate analysis confirmed CMTM6 expression as an independent prognostic factor in DFS (p<0.05). CMTM6 expression tended to be correlated with PD-L1 expression (p=0.07), and PD-L1 expression was positively correlated with PD-1 expression (p<0.05).Conclusions: CMTM6 is associated with a poor prognosis and immunotolerance through PD-L1 in GC.

scholarly journals Down-Regulation of LncRNA DGCR5 Correlates with Poor Prognosis in Hepatocellular Carcinoma

2016 ◽  
Vol 40 (3-4) ◽  
pp. 707-715 ◽  
Author(s):  
Ruyi Huang ◽  
Xiaochen Wang ◽  
Wenjie Zhang ◽  
Guangyan Zhangyuan ◽  
Kangpeng Jin ◽  
...  
Keyword(s):  
Roc Curve ◽  
Cox Regression ◽  
Cancer Specific Survival ◽  
Term Survival ◽  
Diagnosis And Prognosis ◽  
Kaplan Meier ◽  
High Expression Group ◽  
Negative Prognostic Factor ◽  
Potential Biomarker ◽  
Low Expression

Background/Aims: Long non-coding RNAs (lncRNAs) have been reported to play pivotal roles in multiple tumors and can act as tumor biomarkers. In this study, we explored the association of the expression of an lncRNA, DGCR5 with clinicopathological features and prognosis in HCC. Methods: Expression levels of DGCR5 were detected by quantitative real-time PCR (qRT-PCR) and the clinical data was obtained, including basic information, data of clinicopathology and cancer specific survival rate. Receiver operating characteristic (ROC) curve, Kaplan-Meier methods and multivariable Cox regression models were used to analyze predictive efficiency, long-term survival outcomes and risk factors. Results: DGCR5 was found down-regulated in HCC tissues (P<0.001) and serum (P = 0.0035) and low expression of DGCR5 was correlated with a poor cancer specific survival (CSS) (P = 0.0019), as the overall 5-year CSS rates were 10.3% (low expression group) and 36.6% (high expression group), respectively. A stratified analysis demonstrated that low DGCR5 expression was an independent negative prognostic factor for HCC. In addition, the area under the ROC curve was 0.782 with a sensitivity of 0.633 and a specificity of 0.833. Conclusions: Our results suggest that DGCR5 may be a participator in HCC and can serve as potential biomarker for the diagnosis and prognosis in HCC.

scholarly journals Expression of miR-210, miR-137, and miR-153 in Patients with Acute Cerebral Infarction

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Hongtao Tian ◽  
Yan Zhao ◽  
Chao Du ◽  
Xiao Zong ◽  
Xiuping Zhang ◽  
...  
Keyword(s):  
Cerebral Infarction ◽  
Roc Curve ◽  
Area Under Curve ◽  
Diagnostic Value ◽  
Acute Cerebral Infarction ◽  
High Expression ◽  
Control Group ◽  
Observation Group ◽  
High Expression Group ◽  
Low Expression

Aim. To explore the expression levels of miR-210, miR-137, and miR-153 in patients with acute cerebral infarction. Material and Methods. 76 patients with acute cerebral infarction treated in our hospital from April 2016 to October 2017 were enrolled as the observation group. Another 64 normal patients were selected as the control group. The patients were divided into the death and survival groups based on 1-year mortality of patients. qRT-PCR was used to detect the expression of miR-210, miR-137, and miR-153 in the serum of each group. Receiver operating characteristic (ROC) curve was employed to analyze the diagnostic value and predictive value of miR-210, miR-137 and miR-153 death in patients. The correlation between miR-210, miR-137, and miR-153 in the serum of the observation group was analyzed by Pearson’s test. Results. Levels of miR-210 and miR-137 in the observation group were significantly lower than those in the control group, while levels of miR-153 in the observation group were significantly higher than those in the control group (all P < 0.05 ). The ROC curve of diagnosis of acute cerebral infarction showed that the area under curve of miR-210 was 0.836, that of miR-137 was 0.843, and that of miR-153 was 0.842. The 1-year survival rate was 71.05%. The 1-year survival of the low-expression group of miR-210 and miR-137 was significantly lower than that of the high-expression group, while the 1-year survival of the low-expression group of miR-153 was significantly higher than that of the high-expression group (all P < 0.05 ). The ROC curve for predicting death showed that the area under curve of miR-210 was 0.786, that of miR-137 was 0.824, and that of miR-153 was 0.858. Pearson’s correlation analysis showed that the expression of miR-210 was positively correlated with that of miR-137, while miR-137 was negatively correlated with that of miR-153 and miR-210 was negatively correlated with that of miR-153. Conclusion. miR-210, miR-137, and miR-153 have a certain value in the diagnosis and prediction of 1-year death of acute cerebral infarction and may be potential diagnostic and predictive indicators.

scholarly journals ERCC1 expression and platinum chemosensitivity in patients with ovarian cancer: A meta-analysis

2020 ◽  
Vol 35 (4) ◽  
pp. 12-19
Author(s):  
Chunjie Zhang ◽  
Shan Gao ◽  
Jingwen Hou
Keyword(s):  
Ovarian Cancer ◽  
Excision Repair ◽  
Meta Analysis ◽  
Effective Rate ◽  
High Expression ◽  
High Expression Group ◽  
Significant Difference ◽  
Ercc1 Expression ◽  
The Relationship ◽  
Low Expression

Objective: This study aimed to comprehensively investigate the correlation of ERCC1 expression and chemosensitivity of ovarian cancer. Methods: The literature on the relationship between the excision repair cross complementary gene 1 (ERCC1) and the chemosensitivity of ovarian cancer published in PubMed, Web of Science, EMBASE, CNKI, and the China Wanfang database from the establishment of the databases to June 2020 were searched. Chemosensitivity is evaluated by clinical effective rate (complete remission plus partial remission). Statistical analysis was carried out by using Stata 15.1 software. Results: A total of 11 articles met the inclusion criteria, consisting of 758 patients with ovarian cancer. The results showed a significant difference in chemosensitivity between the low expression group and the high expression group of ERCC1 (odds ratio 4.23; 95% confidence interval 2.96, 6.06; P < 0. 01). The same result was shown in the ethnicity subgroup. Conclusion: The chemosensitivity of ovarian cancer patients with a low expression of ERCC1 is better than that of patients with a high expression.

scholarly journals Expression of Coiled-Coil Domain Containing Family mRNA and prognostic value in hepatocellular carcinoma

2021 ◽  
Author(s):  
Sina Zhang ◽  
Chen Jin ◽  
Yan Yang ◽  
Haoqi Li ◽  
Jun Ma ◽  
...  
Keyword(s):  
Prognostic Value ◽  
Prognostic Markers ◽  
Malignant Tumors ◽  
Prognostic Significance ◽  
Family Members ◽  
High Expression ◽  
Rank Test ◽  
High Expression Group ◽  
The Relationship ◽  
Low Expression

Abstract Background: The CCDC family plays a significant role in the development and progression of malignant tumors. However, the relationship between CCDC family members and HCC progression is incompletely known. This study used bioinformatics analysis to investigate the expression as well as clinical prognostic value of CCDC family members in HCC and to predict the role of CCDCs family in the development and progression of HCC. Methods: This study utilized the data from two platforms databases to explore the diagnostic value and prognostic significance of CCDC family members by Cox proportional hazards regression analysis, Kaplan-Meier curve and log-rank test, ROC and nomogram diagnostic and prognostic analysis methods. GSEA and tumor microenvironment analysis were employed to investigate the underlying mechanisms and cell-cell interactions of CCDCs family in the development and progression of HCC. The relationship between mutational signatures and CCDCs family were evaluated in HCC patients with somatic mutation. Results: Five CCDC family members (CCDC34, CCDC137, CCDC77, CCDC93 and CCDC21) mRNA expression showed significantly higher in HCC tissues than in normal tissues and high expression levels of these genes predicted poor prognosis in HCC patients. The combined effect analysis of five CCDCs family prognostic markers suggests that the prognosis difference for CCDC family members combination was more significant than that for any individual CCDC family genes. We then developed a risk score model that could predict the prognosis of HCC, and nomogram gene expression was visualized with the probability of predicting the prognosis of HCC by clinical factors. GSEA revealed that, while five CCDCs family combined high expression was associated with increased cell cycle progression and low expression was associated with complement activation pathway. Mutation analysis showed that the combined high expression group had a higher TP53 mutation rate than the combined low expression group, and the high expression group showed higher TMB, which was associated with a better prognosis than high TMB. Conclusions: Our data suggest that the expression of CCDC34, CCDC137, CCDC77, CCDC93 and CCDC21 may be potential prognostic markers in HCC and in combination have a strong interaction and better predictive value for HCC prognosis.

Visceral Adiposity Index was a useful Predictor of Prediabetes

2017 ◽  
Vol 126 (10) ◽  
pp. 596-603 ◽  
Author(s):  
Dongfeng Gu ◽  
Yanan Ding ◽  
Yunfeng Zhao ◽  
Qingshan Qu
Keyword(s):  
Epidemiological Survey ◽  
Visceral Adiposity ◽  
Visceral Adiposity Index ◽  
Roc Curve Analysis ◽  
Cross Sectional ◽  
Adiposity Index ◽  
Logistic Analysis ◽  
Auc Value ◽  
Relationship Of ◽  
The Relationship

Abstract Aim To study the relationship of visceral adiposity index (VAI) and prediabetes and the power of which in predicting of prediabetes. Methods A cross-sectional epidemiological survey was conducted. All participants were divided into four groups: VAI and WC (both are normal), VAI↑ and WC (postcritical VAI and normal WC), VAI and WC↑ (Normal VAI and postcritical WC), and VAI↑ and WC↑ (postcritical VAI and postcritical WC). A multivariate logistic analysis was used to analyze the relationship between the four groups and prediabetes, and diabetes. A receiver operating characteristic (ROC) curve analysis was used to evaluate the accuracy of predictions for prediabetes and diabetes. Results Both VAI and WC were independent risk factors of Prediabetes. The ORs for Prediabetes in the VAI↑&WC group were 1.641 (95%CI 1.146–2.349), P=0.007, in males, in Model 2. The ORs for Prediabetes in the VAI&WC↑ group were 1.454 (95%CI 1.055–2.005), P=0.022, in males, in Model 2. The ORs for Prediabetes in the VAI↑&WC group were 2.305 (95%CI 1.623–3.273), P=0.000, in females, in Model 2. The ORs for Prediabetes in the VAI&WC↑ group were 1.997 (95%CI 1.529–2.608), P=0.000, in females, in Model 2. The AUC value of VAI were 0.601 (95%CI 0.568–0.634), P=0.000, in prediabetes of men; which were 0.645 (95%CI 0.618–0.672), P=0.000, in prediabetes women. WC had the highest AUC value of 0.605 (95%CI 0.571–0.638), P=0.000, in prediabetes of men, also had the highest of AUC value of 0.673 (95%CI 0.648–0.697), P=0.000, in prediabetes of women. Conclusion VAI was positively associated with prediabetes, and also a usefulindicator of prediabetes.

scholarly journals Evaluation of the Therapeutic Effect of Adjuvant Transcatheter Arterial Chemoembolization Based on Ki67 After Hepatocellular Carcinoma Surgery

2021 ◽  
Vol 11 ◽  
Author(s):  
Yu-Fei Zhao ◽  
Xiu Xiong ◽  
Kai Chen ◽  
Wei Tang ◽  
Xu Yang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Transcatheter Arterial Chemoembolization ◽  
Tumor Resection ◽  
High Expression ◽  
Ki67 Expression ◽  
High Expression Group ◽  
Significant Difference ◽  
The Relationship ◽  
Low Expression ◽  
Arterial Chemoembolization

Background and aimsThis study aimed to determine the relationship between Ki67 expression and the efficacy of postoperative adjuvant transcatheter arterial chemoembolization (PA-TACE) in patients with hepatocellular carcinoma.MethodsThe Kaplan-Meier method was used to analyze the recurrence-free survival (RFS) and overall survival (OS) rates between the sub-groups in the ki67 low expression group and the ki67 high expression group and analyze the relationship between the expression of Ki67 and the efficacy of TACE.ResultsAfter PSM, there was no significant difference in the RFS and OS between the surgery + TACE and surgery subgroups after 1, 2, or 3 years (RFS: 63.9%, 55.6%, and 42.9% vs. 83.3%, 63.9%, and 55.6%, respectively, P = 0.279; OS: 91.7%, 83.3%, and 74.3% vs. 91.7%, 88.9%, and 71.4%, respectively, P = 0.890) in the Ki67 low-expression group. The RFS and OS were higher in the surgery + TACE subgroup than the surgery subgroup after 1, 2, and 3 years (RFS: 80.0%, 77.5%, and 69.2% vs. 53.5%, 39.5%, and 32.6%, respectively, P&lt;0.001; OS: 97.5%, 85.0%, and 79.5% vs. 79.1%, 48.8%, and 42.9%, respectively, P = 0.001) in the Ki67 high expression group. The RFS was higher in the Ki67 high-expression subgroup than the low-expression subgroup after 1, 2, and 3 years, and OS had no significant difference (RFS: 80.0%, 79.5%, and 69.2% vs. 67.4%, 56.5%, and 46.7%, respectively, P = 0.035; OS: 97.5%, 85.0%, and 79.5% vs. 93.5%, 82.6%, and 75.6%, respectively, P = 0.665) in the surgery + TACE group.ConclusionsFor patients with hepatocellular carcinoma and high expression of Ki67 (Ki67≥20%), adjuvant hepatic artery chemoembolization after radical liver tumor resection effectively reduced the probability of tumor recurrence after surgery and prolonged the OS of patients. High Ki67 expression during the post-operative follow-up evaluation of hepatocellular carcinoma patients is an indicator for adjuvant TACE therapy.

The relationship of the scleractinian corals to the rugose corals

Paleobiology ◽  
1980 ◽  
Vol 6 (02) ◽  
pp. 146-160 ◽  
Author(s):  
William A. Oliver
Keyword(s):  
Critical Points ◽  
Scleractinian Corals ◽  
Convincing Evidence ◽  
Early Triassic ◽  
Rugose Corals ◽  
History Of ◽  
The Subject ◽  
Relationship Of ◽  
The Relationship ◽  
Biologic Factors

The Mesozoic-Cenozoic coral Order Scleractinia has been suggested to have originated or evolved (1) by direct descent from the Paleozoic Order Rugosa or (2) by the development of a skeleton in members of one of the anemone groups that probably have existed throughout Phanerozoic time. In spite of much work on the subject, advocates of the direct descent hypothesis have failed to find convincing evidence of this relationship. Critical points are:(1) Rugosan septal insertion is serial; Scleractinian insertion is cyclic; no intermediate stages have been demonstrated. Apparent intermediates are Scleractinia having bilateral cyclic insertion or teratological Rugosa.(2) There is convincing evidence that the skeletons of many Rugosa were calcitic and none are known to be or to have been aragonitic. In contrast, the skeletons of all living Scleractinia are aragonitic and there is evidence that fossil Scleractinia were aragonitic also. The mineralogic difference is almost certainly due to intrinsic biologic factors.(3) No early Triassic corals of either group are known. This fact is not compelling (by itself) but is important in connection with points 1 and 2, because, given direct descent, both changes took place during this only stage in the history of the two groups in which there are no known corals.

Skeletal elements of crinoid echinoderms: High-resolution structural and microanalytical results

1983 ◽  
Vol 41 ◽  
pp. 194-195
Author(s):  
D. F. Blake ◽  
L. F. Allard ◽  
D. R. Peacor
Keyword(s):  
High Resolution ◽  
Marine Invertebrates ◽  
Sea Urchins ◽  
Structural Features ◽  
Sea Stars ◽  
High Resolution Tem ◽  
Relationship Of ◽  
The Relationship ◽  
Insight Into

Echinodermata is a phylum of marine invertebrates which has been extant since Cambrian time (c.a. 500 m.y. before the present). Modern examples of echinoderms include sea urchins, sea stars, and sea lilies (crinoids). The endoskeletons of echinoderms are composed of plates or ossicles (Fig. 1) which are with few exceptions, porous, single crystals of high-magnesian calcite. Despite their single crystal nature, fracture surfaces do not exhibit the near-perfect {10.4} cleavage characteristic of inorganic calcite. This paradoxical mix of biogenic and inorganic features has prompted much recent work on echinoderm skeletal crystallography. Furthermore, fossil echinoderm hard parts comprise a volumetrically significant portion of some marine limestones sequences. The ultrastructural and microchemical characterization of modern skeletal material should lend insight into: 1). The nature of the biogenic processes involved, for example, the relationship of Mg heterogeneity to morphological and structural features in modern echinoderm material, and 2). The nature of the diagenetic changes undergone by their ancient, fossilized counterparts. In this study, high resolution TEM (HRTEM), high voltage TEM (HVTEM), and STEM microanalysis are used to characterize tha ultrastructural and microchemical composition of skeletal elements of the modern crinoid Neocrinus blakei.

Studies on Leukemogenic and Sarcomagenic Viruses

1970 ◽  
Vol 28 ◽  
pp. 156-157
Author(s):  
Leon Dmochowski
Keyword(s):  
Electron Microscopy ◽  
Electron Microscope ◽  
Morphological Properties ◽  
Mode Of Development ◽  
Relationship Of ◽  
The Relationship

Electron microscopy has proved to be an invaluable discipline in studies on the relationship of viruses to the origin of leukemia, sarcoma, and other types of tumors in animals and man. The successful cell-free transmission of leukemia and sarcoma in mice, rats, hamsters, and cats, interpreted as due to a virus or viruses, was proved to be due to a virus on the basis of electron microscope studies. These studies demonstrated that all the types of neoplasia in animals of the species examined are produced by a virus of certain characteristic morphological properties similar, if not identical, in the mode of development in all types of neoplasia in animals, as shown in Fig. 1.

Sign in / Sign up

Export Citation Format

Share Document