scholarly journals Effect of Dracocephalum polychaetum Burnm, aqueous extract on acetic acid-induced ulcerative colitis in adult male rats

2016 ◽  
Vol 14 (1) ◽  
pp. 9-17
Author(s):  
saeedeh ahmadinejad
Keyword(s):  
Ulcerative Colitis ◽  
Acetic Acid ◽  
Aqueous Extract ◽  
Adult Male ◽  
Male Rats

scholarly journals Effects of Age and Sex on the Healing of Acetic-Acid Induced Ulcerative Colitis in Adult Wistar Rats

2021 ◽  
pp. 63-73
Author(s):  
Serah F. Ige ◽  
Waliyat O. Aremu ◽  
Bolade S. Olateju ◽  
Victor A. Oladipupo ◽  
Adedayo T. Adekola
Keyword(s):  
Ulcerative Colitis ◽  
Superoxide Dismutase ◽  
Acetic Acid ◽  
Adult Female ◽  
Adult Male ◽  
Wistar Rats ◽  
Female Rats ◽  
Male Rats ◽  
Cell Numbers ◽  
Age And Sex

Aims: Ulcerative colitis is a disease of the bowel that occurs in all ages and affects both males and females. This research study was designed to investigate the effect of age and sex on the healing of colitis in rats. Methodology: Twenty - eight rats were randomly distributed into four groups of seven animals per group; adult male rats, mid age male rats, adult female rats and mid age female rats. Mid age and adult Wistar rats were 7- 8weeks and 14 weeks old respectively. Colitis was induced through a single intra-colonic instillation of 7% acetic acid (1mL/100g body weight) and allowed to heal for 14 days. Blood samples were obtained for analysis. Colon samples were also obtained for histomorphological study and biochemical assays (Myeloperoxidase activities, Superoxide dismutase, Glutathione, Catalase and Malondialdehyde) levels. Results: There was no significant difference in Malondialdehyde concentration, catalase, Superoxide dismutase, Myeloperoxidase, Platelet Distribution Width, Platelet Count, Basophil cell numbers, Eosinophil cell numbers, platelet cells, Mean Platelet Volume , Mean Cell Volume and white blood cells across the groups. The Glutathione concentration in mid age male rats was significantly increased when compared with adult male rats. The haemoglobin , Lymphocytes and Mean Cell Haemoglobin levels were increased while neutrophils and monocyte levels were decreased in the younger female rats. The histomorphological study revealed poorly preserved surface epithelia layer of the colon in adult male rats while mid age male and female rats showed moderately preserved surface epithelia layer, adult female rats showed normal surface epithelia layer. Conclusion: Mid age rats heal faster than adult rats while in terms of sex, female rats tends to heal faster than male rats.

scholarly journals Effect of aqueous extract of aloe vera leaves on gut-brain axis response following acetic acid -induced gastric ulcer in male rats

2014 ◽  
Vol 6 (2) ◽  
pp. 347-357
Author(s):  
M Sabaghian ◽  
Z Keshavarzi ◽  
B Bibak ◽  
M Vatanchian ◽  
T Mohammad Rezapour
Keyword(s):  
Acetic Acid ◽  
Gastric Ulcer ◽  
Aqueous Extract ◽  
Aloe Vera ◽  
Male Rats

Effects of jujube fruit extract on acetic acid-induced colitis in adult male rats

2016 ◽  
Vol 15 (1) ◽  
pp. 19 ◽  
Author(s):  
El SayedAly Mohamed Metwally ◽  
FardousSoror Karawya
Keyword(s):  
Acetic Acid ◽  
Adult Male ◽  
Male Rats ◽  
Fruit Extract ◽  
Jujube Fruit

Myrtle berry seed aqueous extract inhibits human neutrophil myeloperoxidase in vitro and attenuates acetic acid-induced ulcerative colitis in rats

RSC Advances ◽  
2015 ◽  
Vol 5 (80) ◽  
pp. 64865-64877 ◽  
Author(s):  
Mohamed-Amine Jabri ◽  
Kais Rtibi ◽  
Haifa Tounsi ◽  
Karim Hosni ◽  
Abdelaziz Souli ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Acetic Acid ◽  
Protective Effect ◽  
Aqueous Extract ◽  
Human Neutrophil ◽  
Myrtus Communis

We aimed in the present study to investigate the protective effect of a myrtle (Myrtus communisL.) berry seed aqueous extract (MBSAE) on acetic acid (AA)-induced colitis in rats as well as the mechanism implicated in this coli-protection.

Prophylactic effect of aquatic extract of stevia on acetic acid induced-ulcerative colitis in male rats: a possible role of Nrf2 and PPARγ

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Abeer F. Mostafa ◽  
Mahmoud M. Elalfy ◽  
Ahmed Shata ◽  
Mona G. Elhadidy
Keyword(s):  
Ulcerative Colitis ◽  
Acetic Acid ◽  
Inflammatory Diseases ◽  
Histopathological Examination ◽  
Antioxidant Properties ◽  
Thiobarbituric Acid ◽  
Serum Levels ◽  
Rectal Administration ◽  
Male Rats ◽  
Tnf Α

AbstractObjectivesUlcerative colitis (UC) is a non-specific intestinal inflammatory disease. Several studies demonstrated that inflammation and oxidative stress play significant role in the pathogenesis of this disease. This study aimed to determine the protective effect and possible mechanism by which stevia affects the course of experimentally induced colitis.MethodsMale rats were received stevia 20, 40, 80 mg/kg/day before induction of colitis by intra-rectal administration of 2 mL of 4% acetic acid, AA. Macroscopic and histopathological examination of the colon were done. Colonic content of catalase (CAT), superoxide dismutase (SOD), reduced glutathione (GSH), myeloperoxidase (MPO) and thiobarbituric acid reactive substances (TBARS) activities and serum levels of interleukin (IL)1- β and tumor necrosis factor (TNF)-α were assessed. Real time-PCR (RT-PCR) was done to determine the expression of NF-κB, Nrf2 and PPARγ genes. Spontaneous contraction and effects of increasing concentrations of acetylcholine and stevia have been studied on the isolated colonic segments.ResultsStevia ameliorated colitis not only histopathologically but also it decreased the level of TNF-α, IL-1β, TBARS, MPO and the expression of NF-κB which were significantly increased in the AA group. The concentration of GSH, SOD, CAT and expression of Nrf2 and PPARγ were significantly increased with stevia. Moreover, stevia showed a relaxant effect on the colonic contractility which was increased in AA group. These all effects of stevia were more prominent with its highest dose.ConclusionOur results explored that, stevia acts protectively against UC by its anti-inflammatory and antioxidant properties which mediated by up-regulation of Nrf2 and PPARγ with downregulation of NF-κB. We suggest that stevia has the potential for treatment of chronic inflammatory diseases, such as UC.

scholarly journals Eurycoma longifolia Root Aqueous Extract Augments the Testosterone Level and Spermatogenesis in Adult Male Rats

2020 ◽  
Vol 18 (3) ◽  
Author(s):  
Hamoud H. Al-Faqeh ◽  
Mohammed Imad AMM
Keyword(s):  
Aqueous Extract ◽  
Adult Male ◽  
Testosterone Level ◽  
Male Rats ◽  
Control Group ◽  
Distilled Water ◽  
Sprague Dawley ◽  
Testosterone Levels ◽  
Eurycoma Longifolia ◽  
Healthy Adult Male

Introduction The Eurycoma longifolia (EL) root aqueous extract has long been used as an enhancer of male sexual performance. However, data from previous studies in both human males and experimental male animals on the testosterone level in those given the EL extract orally were at best insufficiently conclusive. Materials and Method Sixty-four healthy adult male Sprague Dawley rats were acclimatized, and randomized into six test groups and one control group. All rats where given either the aqueous EL extract or distilled water via metal gavage needle. The first three test groups received the low (50mg/kg bw), medium (100mg/ kg bw) and high (200mg/kg bw) doses respectively of the EL daily for 15 days only. The second three test groups continued receiving the same daily treatment doses for 30 days. The controls were given distilled water only. At the end of each of the study period, blood samples were collected via cardiac puncture and the rats were euthanized. The testicles were obtained, weighed, and processed for histological examination. Results The sera testosterone levels were higher in animals which received the medium and high doses for both treatment duration. Rats which received medium and high oral doses of EL showed an increase of spermatogenesis and mature spermatozoa. Conclusion The optimal enhancing effect on sera testosterone levels and testicular spermatogenesis of EL treatment in adult male rats was observed with the medium dose of 100mg/kg bw given once daily for both 15 and 30 days.

scholarly journals Analgesic and Antipyretic Activities of Ethyl Acetate Fraction Tablet of Andrographis paniculata in Animal Models

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Hilkatul Ilmi ◽  
Irfan Rayi Pamungkas ◽  
Lidya Tumewu ◽  
Achmad Fuad Hafid ◽  
Aty Widyawaruyanti
Keyword(s):  
Body Weight ◽  
Acetic Acid ◽  
Animal Models ◽  
Ethyl Acetate ◽  
Adult Male ◽  
Ethyl Acetate Fraction ◽  
Andrographis Paniculata ◽  
Male Rats ◽  
Antipyretic Effect ◽  
Antipyretic Activity

Objectives. To determine the analgesic and antipyretic activities of a tablet derived from Andrographis paniculata ethyl acetate fraction (AS201-01) in animal models. Methods. The tablet derived from AS201-01 contains an equivalent of 35 mg andrographolide per tablet. Analgesic activity was determined using an acetic acid-induced writhing test on adult male mice. A writhe was recorded by a stopwatch and was defined as the stretching of the abdomen and/or stretching of at least one hind limb. For the determination of antipyretic activity, pyrexia was induced by subcutaneous injection of 15% w/v Brewer’s yeast into adult male rats. Rectal temperature was monitored at 1, 2, 3, and 4 hours after treatment. Results. The results showed that the AS201-01 tablet had analgesic and antipyretic activity. In the acetic acid-induced writhing model, AS201-01 tablet exhibited significant analgesic effect with a 66.73% reduction in writhing response at a dose of 50 mg andrographolide/kg body weight compared to the negative control group. The tablet also showed a significant antipyretic effect. The maximum antipyretic effect was observed after the third hour of administration of the AS201-01 tablet at a dose of 100 mg andrographolide/kg body weight. Conclusion. Tablet of Andrographis paniculata ethyl acetate fraction (AS201-01) exhibited analgesic and antipyretic activities.

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