Investigation on the use of graphene as a unique drug delivery platform for dissimilar anticancer drugs
This study examines the performance of 5-flurouracil (5-FU) and cisplatin (CDDP) loaded graphene nanocarrier, which were prepared using nano precipitation technique to investigate the loading nature of two anti-cancer drugs. Initially, the graphite was exfoliated under ultrasonication method. The exfoliated sheets characterized and a single layer of carbon atoms like graphene sheets was confirmed. 5-FU and CDDP as an anti-cancer model drugs were entrapped on to the surface of the graphene sheets via electrostatic and π-π staking interactions. The prepared graphene nanocarrier have been thoroughly characterized by using various microscopic techniques, including Fourier transform infrared (FT-IR) spectroscopy, scanning electron microscopy (SEM), and X-ray diffraction(XRD).The encapsulation efficiency and in-vitro drug releasing behavior of the nanocarrier were investigated by UV-Vis spectrometry the wavelength of λmax 265nm and 267nm. Aromatic 5-FU anti-cancer drug have higher encapsulation efficacy and sustained releasing nature. Since graphene is good platform for the entrapment of 5-FU anti-cancer drug then CDDP for chemotherapy.