ACUTE MYOCARDIAL INFARCTION;

Objective: To determine the frequency of family history of IHD and related risk factors in the first degree relatives of patients suffered from acute myocardial infarction (AMI). Study Design: Descriptive study. Setting: PMRC Research Centre, Nishtar Medical College, Multan, Cardiology unit Nishtar Hospital Multan and Chaudhry Pervez Elahi Institute of Cardiology, Multan. Duration: One year from July 2011 to June 2012. Material and methods: In this descriptive study 331 patients of AMI of either sex and age ≥ 20 years admitted in Cardiology unit of Nishtar Hospital Multan and Chaudhary Pervez Elahi Institute of Cardiology Multan were registered. For data collection non-probability convenient sampling technique was used. Informed consent was taken from each patient. The information were recorded in a pre-designed questionnaire. The data were analyzed through SPSS-11. Results: Mean age of the study cases was 54.99±11.25 years (Minimum age was 20 years and maximum was 90 years). Two hundred sixty four (79.8%) were male and 67 (20.2%) were female patients and male to female ratio was 3.9:1. Out of these 331 patients 111 (33.6 %) were having positive family history of IHD. In these 111 (33.6 %) cases history of diabetes was seen in 45 (40.5 %), 43(38.8 %) had history of hypertension and history of hyper-cholesterolemia was present in 23 (20.7 %) of cases. Conclusions: The family history of IHD in addition to traditional risk factors such as hypertension, hyperlipidemia, diabetes mellitus and smoking is itself an important risk factor for IHD. Relatives of the young patients with IHD should be considered as high risk group and it calls for close surveillance of their first degree relatives and early intervention. All their family members should be advised life style modification, appropriate management of risk factors and regular follow up of even apparently healthy descendents.

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Levels of anxiety, depression and denial in patients with myocardial infarction

European Psychiatry ◽

10.1016/s0924-9338(97)80204-0 ◽

1997 ◽

Vol 12 (3) ◽

pp. 149-151 ◽

Cited By ~ 4

Author(s):

D Sarantidis ◽

A Thomas ◽

K Iphantis ◽

N Katsaros ◽

J Tripodianakis ◽

...

Keyword(s):

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

Intensive Care Unit ◽

Family History ◽

Positive Family History ◽

Anxiety And Depression ◽

Previous Myocardial Infarction ◽

History Of ◽

Seeking Help ◽

Anxiety Depression

SummaryIn this study we investigated 1) the changes in anxiety, depression and denial from admission to discharge in patients admitted to the intensive care unit following an acute myocardial infarction and 2) the effect of smoking habits, time lapsed from the appearance of symptoms to seeking help behavior, presence of a person that motivated the patient to seek help, previous myocardial infarction (MI) and family history of MI, on these changes. The results indicated that 1) the levels of both anxiety and depression increased from admission to discharge, while denial decreased; 2) positive family history of MI was associated with lower difference of denial between admission and discharge.

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Serum Uric Acid as a Prognostic Factor of Acute Myocardial Infarction in Hospitalized Patients

TAJ Journal of Teachers Association ◽

10.3329/taj.v34i1.54902 ◽

2021 ◽

Vol 34 (1) ◽

pp. 26-32

Author(s):

Md Amzad Hossain Sardar ◽

Md Khalilur Rahman ◽

Md Mahidul Alam ◽

Md Aminul Hasan ◽

Ashoke Sarker ◽

...

Keyword(s):

Risk Factors ◽

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

Uric Acid ◽

Family History ◽

Serum Uric Acid ◽

Acid Level ◽

Serum Uric Acid Level ◽

High Serum ◽

History Of

Background: Among non-communicable diseases, acute myocardial infarction (AMI) is a common killer of people in the world. The management of AMI patients is one of the major challenges in the field of cardiology. Uric acid has several effects of potential interest in cardiovascular disease. There are some markers indicating an unfavorable prognosis in AMI patients. Uric acid is one of the markers that have been evaluated in research. Objective: The aim of this study was to assess the association between serum uric acid level and in-hospital outcomes of AMI patients. Patients and methods: This longitudinal descriptive study was conducted over 115 AMI patients in the Cardiology Unit of Rajshahi Medical College Hospital during the period of January 2015 to December 2016. Baseline characteristics such as age, sex, BMI, BP, RBS, risk factors (hypertension, DM, smoking, family history of IHD, dyslipidemia), and outcomes of AMI patients (acute LVF, arrhythmia, conduction block, cardiogenic shock, death) were recorded. We measured the serum uric acid of this patient at admission. Results: The mean age of patients was 52.83±10.71 years. Out of 115 patients, 83.5% were male, and 16.5% were female. Among the risk factors, 65.2% of patients had HTN, 20.9% DM, 64.3% smoking, 16.5% family history of IHD, and 47.8% dyslipidemia. Out of 115, 35.7% of patients demonstrated high serum uric acid. In outcomes of AMI patients, acute LVF 24.4% (p=0.031) and death 12.2% (p=0.041) were significantly higher in patients with high serum uric acid levels. Conclusion: Significant association was found between high serum uric acid level and in-hospital outcomes of AMI patients. So, estimation of serum uric acid may offer an inexpensive, quick, and non-invasive method for identifying such high-risk patients. TAJ 2021; 34: No-1: 26-32

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Surveillance survey of family history in children with neural tube defects

Journal of Neurosurgery Pediatrics ◽

10.3171/2016.12.peds1668 ◽

2017 ◽

Vol 19 (6) ◽

pp. 690-695 ◽

Cited By ~ 8

Author(s):

Esther B. Dupépé ◽

Daxa M. Patel ◽

Brandon G. Rocque ◽

Betsy Hopson ◽

Anastasia A. Arynchyna ◽

...

Keyword(s):

Risk Factors ◽

Family History ◽

Neural Tube ◽

Neural Tube Defects ◽

Positive Family History ◽

Cns Disorders ◽

Paternal Lineage ◽

First Degree Relatives ◽

The Family ◽

History Of

OBJECTIVE Although there are known risk factors for the development of neural tube defects (NTDs), little is known regarding the role of family history. The authors' goal in this study is to describe the family history in their population of patients with NTDs. METHODS Surveys were completed for 254 patients who were accompanied by their biological mother during their annual visit to the multidisciplinary Spina Bifida Clinic at Children's of Alabama. An NTD has been diagnosed in all patients who are seen in this clinic (myelomeningocele, lipomeningocele, split cord malformation, and congenital dermal sinus tract). Each mother answered questions regarding known NTD risk factors and their pregnancy, as well as the family history of NTDs, other CNS disorders, and birth defects. RESULTS The overall prevalence of family history of NTDs in children with an NTD was 16.9% (n = 43), of which 3.1% (n = 8) were in first-degree relatives. In patients with myelomeningocele, 17.7% (n = 37) had a positive family history for NTDs, with 3.8% in first-degree relatives. Family history in the paternal lineage for all NTDs was 8.7% versus 10.6% in the maternal lineage. Twenty-two patients (8.7%) had a family history of other congenital CNS disorders. Fifteen (5.9%) had a family history of Down syndrome, 12 (4.7%) had a family history of cerebral palsy, and 13 (5.1%) patients had a family history of clubfoot. Fourteen (5.5%) had a family history of cardiac defect, and 13 (5.1%) had a family history of cleft lip or palate. CONCLUSIONS The family history of NTDs was 16.9% in children with NTD without a difference between maternal and paternal lineage. This high rate of positive family history suggests that genetics and epigenetics may play a larger role in the pathogenesis of NTD in the modern era of widespread folate supplementation.

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Clinical and paraclinical characteristics of young patients with myocardial infarction from Northeast of Romania

10.22514/sv.2021.255 ◽

2021 ◽

Keyword(s):

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

Family History ◽

Cardiovascular Diseases ◽

Older Patients ◽

Positive Family History ◽

Young Patients ◽

Study Results ◽

History Of ◽

Case Outcome

The aim of this study was to evaluate the clinical and paraclinical features in young patients (18–40 years) with acute myocardial infarction (AMI) in the Northeast of Romania. We have considered all patients admitted between the 1st of January 2017 through the 31st of December 2019 at a tertiary care Cardiology Institute with the primary discharge diagnosis of AMI. These patients have been split into 2 groups depending on their age: the first group consisting of patients with an age equal to or lower than 40 years old and the second group consisting of patients with an age greater than 40 years old. After this, we have randomly selected a representative sample from each of the two groups. A total of 99 patients were ultimately enrolled in the study: 42 in the first group and 57 in the second group. Data collected included age, gender, medical history, laboratory tests, echocardiography parameters, coronarography study results, and case outcome. Most young patients with myocardial infarction were male, more likely to smoke (69% vs 35.1%, p = 0.001), and with a positive family history of cardiovascular diseases (35.7% vs 1.8%, p < 0.001) in comparison to their older counterparts. Also, they had fewer comorbidities, such as diabetes mellitus, hypertension, or a positive history of stroke or atrial fibrillation. Mean ejection fraction was significantly higher in young patients (43.4 ± 10.65 vs 37.16 ± 10.77, p = 0.005) and both tricuspid and mitral valve regurgitations were less severe. Coronary lesions were more severe in the older patients (p = 0.009), usually with more coronary arteries involved. No significant difference was recorded in the number of hospitalization days or in the case outcome. Acute myocardial infarction in young patients typically occurs more in men who smoke, those who are more than 30 years old, and those who have a positive family history of cardiovascular diseases. Echocardiographic parameters seem to be better than in the case of older patients and the coronary involvement is usually less severe.

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MYOCARDIAL INFARCTION IN YOUNG ADULTS: ITS, CLINICAL PRESENTATION AND RISK FACTORS.

International Journal of Medical and Biomedical Studies ◽

10.32553/ijmbs.v3i10.776 ◽

2019 ◽

Vol 3 (10) ◽

Author(s):

Dr. Umesh Teltumbadr

Keyword(s):

Risk Factors ◽

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

Risk Factor ◽

Family History ◽

Physical Inactivity ◽

Clinical Presentation ◽

Golden Hour ◽

History Of ◽

Premature Cad

INTRODUCTION: Coronary heart disease (CHD) is the leading cause of death in the Western countries. Acute myocardial infarction (AMI) in young is relatively uncommon but it is of great concern for the physician as these patients present with the different clinical presentation, risk factors and better prognosis than the older patients. In younger patients and the first onset of angina which rapidly progresses to fully evolved MI is often the case in patients less than 45 years of age. In a young patient presenting with MI care full history should be taken and risk factors such as smoking, obesity, diabetes and history of recurrent venous and arterial thrombosis should also be noted. MATERIAL AND METHODS: 34 patients of age >18 years and <45 years were included in the study who presented with the acute myocardial infarction. Informed consent was obtained from all the patients who were included in the study. Clinical presentation and risk factors were recorded in the prescribed format. Anthropometric and clinical examination was carried out for each patient. Body weight and height were measured and Body mass index (BMI) was calculated using Quetlet’s formula as weight in kg/square of the height in meters. RESULTS: Mean age of the patients presenting with acute MI was 32± 6.21years. The youngest patient was 27 years old while the most common age group was 35-40 with 17(50%) patients. Out of 34 patients 33 (97.05%) were male while only 1 (2.95%) was female. Maximum patients were from urban area 22 (64.70%) while 12 (35.29%) were from the rural area. Smoking and physical inactivity was the most common associated risk factor in MI patients 29(85.29%). All smokers were male. Second most common risk factor was obesity and stressful life 18(52.94%) followed Hypertension in 13(38.24%) cases. In 12(35.29%) cases diabetes was associated as a risk factor. Family history of premature CAD, and dyslipidemia was seen in 11(32.35%) and 8(23.53%) cases respectively. CONCLUSION: Smoking, Physical inactivity, family history of premature CAD, and obesity were the most common risk factors. Early stabilisation in golden hour should be followed by risk stratification, and early revascularisation.

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(P2-89) Investigation, the Association of Cardiac Risk Factors and the Risk of Acute Myocardial Infarction, in ED Patients with Non-Diagnostic ECG

Prehospital and Disaster Medicine ◽

10.1017/s1049023x11005346 ◽

2011 ◽

Vol 26 (S1) ◽

pp. s165-s165

Author(s):

P. Kashani

Keyword(s):

Risk Factors ◽

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

Positive Family History ◽

Final Diagnosis ◽

Cardiac Risk ◽

Clinical Value ◽

Cardiac Risk Factors ◽

The Past ◽

History Of

ObjectiveTo investigate the association of cardiac Risk factors and the risk of Acute myocardial infarction, in ED patients with non-diagnostic ECG. Methods:Results474 patients were enrolled,150 had non diagnostic ECG In this study HTN with p-value = 0/012 (> 0/05), HIP with p-value = 0/0001 (> 0/001), FH with p-value = 0/001(> 0/01) was significantly more prevalent in those who ruled in for AMI.ConclusionIn the past studies in patients with non-diagnostic ECG only hypertension Was significantly more prevalent in those who ruled in for AMI and cardiac risk factors have limited clinical value in diagnosing of AMI in ED patients. In this study HLP, HTN, FH was significantly more prevalent in those who ruled in for AMI An observational study is conducted in an educational hospital in Shahid Beheshti university during a period of two years. In this study, patients with symptoms suggestive of AMI including. chest pain, Dyspnea, palpitation, syncope, cerebrovascular accident, nausea, vomiting, vertigo, loss of consciousness were enrolled. Demographic, historical feature and risk factors, such as age, sex, diabetes, hypertension, hyper lipidemia, renal failure, positive family history of CAD, smoking, substance abuse, Alcohol use in the past 24 hours, cocaine use in the past 48 h were recorded. Nondiagnost ECG including these categories: Normal, non specific, early Repolarization, abnormal without signs of ischemia such as old bundle branch block, LVH, … A final diagnosis of Acute myocardial infarction was determined by CK - MB and Troponin - 1.

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Cardiovascular family history increases the risk of disease recurrence after a first myocardial infarction

European Heart Journal ◽

10.1093/ehjci/ehaa946.2979 ◽

2020 ◽

Vol 41 (Supplement_2) ◽

Author(s):

A Wahrenberg ◽

P Magnusson ◽

R Kuja-Halkola ◽

H Habel ◽

K Hambraeus ◽

...

Keyword(s):

Risk Factors ◽

Myocardial Infarction ◽

Family History ◽

Cardiovascular Events ◽

Cardiovascular Death ◽

Funding Source ◽

History Of ◽

First Time ◽

Early Family

Abstract Background Despite recent advances in secondary prevention, recurrent cardiovascular events are common after a myocardial infarction (MI). It has been reported that genetic risk scores may predict the risk of recurrent cardiovascular events. Although patient-derived family history is a composite of both genetic and environmental heritability of atherosclerotic cardiovascular disease (ASCVD), it is an easily accessible information compared to genetically based risk models but the association with recurrent events is unknown. Purpose To evaluate whether a register-verified family history of ASCVD is associated with recurrent cardiovascular events (rASCVD) in patients after a first-time MI. Methods We included patients with a first-time MI during 2005 – 2014, registered in the SWEDEHEART SEPHIA registry and without prior ASCVD. Follow-up was available until Dec 31st, 2018. Data on relatives, diagnoses and prescriptions were extracted from national registers. A family history of ASCVD was defined as a register-verified hospitalisation due to MI, angina with coronary revascularization procedures, stroke or cardiovascular death in any parent. Early history was defined as such an event before the age of 55 years in fathers and 65 years in mothers. The association between family history and a composite outcome including recurrent MI, angina requiring acute revascularization, ischaemic stroke and cardiovascular death during follow-up was studied with Cox proportional hazard regression with time from SEPHIA registry completion as underlying time-scale, adjusted for age with splines, gender and year of SEPHIA registry. Regression models were then further adjusted for hypertension, diabetes, smoking and for a subset of patients, LDL-cholesterol (LDL_C) at time of first event. Results Of 25,615 patients, 2.5% and 32.1% had an early and ever-occurring family history of ASCVD, respectively. Patients with early family history were significantly younger than other patients and were more likely to be current smokers and have a higher LDL-C (Median (IQR) 3.5 (1.1) vs 3.3 (1.1) mmol/L). In total, 3,971 (15.5%) patients experienced the outcome. Early family history of ASCVD was significantly associated with rASCVD (Hazard ratio (HR) 1.52, 95% confidence interval (CI) 1.23–1.87), and the effect was sustained when adjusted for cardiovascular risk factors (HR 1.48, 95% CI 1.20–1.83) and LDL-C (HR 1.35, 95% CI 1.04–1.74). Ever-occurring family history was weakly associated with ASCVD (HR 1.09, 95% CI 1.02 – 1.17) and the association remained unchanged with adjustments for risk factors. Conclusions Early family history of cardiovascular disease is a potent risk factor for recurrent cardiovascular events in a secondary prevention setting, independent of traditional risk factors including LDL-C. This is a novel finding and these patients may potentially benefit from intensified secondary preventive measures after a first-time MI. Funding Acknowledgement Type of funding source: Private grant(s) and/or Sponsorship. Main funding source(s): This work was funded by grants from The Swedish Heart and Lung Association

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Metabolic Risk Factors and Outcomes in Acute Coronary Syndrome

Journal of Advances in Medicine and Medical Research ◽

10.9734/jammr/2020/v32i130349 ◽

2020 ◽

pp. 46-50

Author(s):

Ritu Attri ◽

Harsimran Kaur ◽

Raminderpal Singh Sibia ◽

Mandip Singh Bhatia

Keyword(s):

Risk Factors ◽

Acute Coronary Syndrome ◽

Positive Family History ◽

Developed Countries ◽

P Value ◽

Health Crisis ◽

Female Ratio ◽

Medical College ◽

Coronary Syndrome ◽

History Of

Introduction: CAD is the most common cause of mortality in India. It is a common multifarious public health crisis today and a leading cause of morbidity and mortality in both developing and developed countries. Hence, understanding the predominant risk factors among the Indian population is important. Materials and Methods: This was a hospital based age and sex matched case control study, carried out at Government Medical College and Rajindra Hospital Patiala. A total of 100 patients of Acute coronary syndrome were studied. Patients and controls were enquired about the presence of cardiometabolic risk factors and the significance of association of these risk factors with the occurrence of Acute coronary syndrome was given by p value of <0.05. Results: Majority of the cases were in the age group 61-70 years (32%) with male to female ratio of 1.25:1. Significant association was found between ACS and risk factors like smoking, positive family history of IHD, hypertension, diabetes, dyslipidemia, waist hip ratio and body mass index. Overall, most common outcome of ACS in the present study was NSTEMI (45%) followed by STEMI (35%) followed by Unstable angina (20%). Conclusion: Significant association was found between smoking and occurrence of STEMI and significant association was found between Hypertension and occurrence of NSTEMI.

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Study of risk factors and its correlation with constraint induced movement therapy for atherosclerosis in patients of coronary artery disease and their offspring

International Journal of Advances in Medicine ◽

10.18203/2349-3933.ijam20200656 ◽

2020 ◽

Vol 7 (3) ◽

pp. 446

Author(s):

Venugopal Margekar ◽

Shweta Thakur ◽

O. P. Jatav ◽

Pankaj Yadav

Keyword(s):

Risk Factors ◽

Family History ◽

Positive Family History ◽

Surrogate Marker ◽

Control Group ◽

Medical College ◽

Constraint Induced Movement Therapy ◽

Group Data ◽

History Of ◽

Artery Disease

Background: A significant percent of cardiovascular event occurs without well-known modifiable risk. A new tool for early identification for atherosclerosis is required for early intervention. Aims and objectives of the study was to study the risk factors for CAD and its correlation with CIMT.Methods: One hundred and forty subjects were studied for the risk factors of CAD in Department of Medicine of G.R. Medical College, Gwalior from 2012 to 2013. Out of 140 subjects, 100 were patients having CAD and 40 age matched subjects were included as control group. Data was also recorded from their offspring. High resolution B mode ultrasonography was performed to assess CIMT of carotid arteries. The maximum CIMT of any one side of carotid artery was taken for study.Results: CAD was more prevalent among males (78%). Majority of the offspring of cases had age between 28-42 years and majority were male (73%). Most common risk factors for CAD was dyslipidemia (48%), hypertension (24%), diabetes (12%) and smoking (21%), whereas in offspring’s of CAD patients, dyslipidemia was seen in 28%, hypertension in 3%, diabetes and tobacco smoking in 12% and 24% respectively. The CIMT of CAD patients was significantly increased with increasing the number of risk factors and the same pattern was also seen in controls. The CIMT of asymptomatic offspring’s having positive family history was significantly more than the asymptomatic offspring without positive family history of CAD.Conclusions: CIMT measurements can be used as a surrogate marker of atherosclerosis as it has showed a direct link with number of risk factors of CAD.

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Characteristics of Acute Myocardial Infarction Patients

STRADA JURNAL ILMIAH KESEHATAN ◽

10.30994/sjik.v9i2.414 ◽

2020 ◽

Vol 9 (2) ◽

pp. 1017-1026

Author(s):

Desi Natalia Trijayanti Idris ◽

Dian Taviyanda ◽

Srinalesti Mahanani

Keyword(s):

Diabetes Mellitus ◽

Myocardial Infarction ◽

Blood Pressure ◽

Acute Myocardial Infarction ◽

Family History ◽

Frequency Distribution ◽

Pulse Frequency ◽

Education History ◽

Male And Female ◽

History Of

Acute myocardial infarction (AMI) is a disease that has a high mortality. Usually happens to anyone and regardless of age, both male and female. The purpose of this study was to describe the characteristics of acute myocardial infarction patients hospitalized. This study uses a descriptive design. The variables used in this study were the characteristics of acute myocardial infarction patients consisting of gender, age, education, history of hypertension, history of diabetes mellitus, family history of acute myocardial infarction, blood pressure and pulse frequency. The number of samples used was 35 respondents who analyzed the data using a frequency distribution. The results showed that the characteristics of 35 respondents showed that the majority of AMI patients occurred in men, namely 60%, the majority were aged 56-60, namely 34.3%, the majority had a history of hypertension, diabetes mellitus and also a family history of having AMI.

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