MYASTHENIA GRAVIS
Objectives: To determine the frequency of different clinical features of myastheniagravis in patients presenting to a tertiary care hospital, Karachi. Study Design: Cross sectionalstudy. Setting: Neurology ward, JPMC, Karachi. Period: 23rd January 2013 to 22nd July 2013.Patients and Methods: A total of 71 diagnosed patients of Myasthenia Gravis (MG) betweenthe age 15 and 70 years were recruited. Structured questionnaire was used to collect the dataregarding most common clinical manifestations of MG. Data were entered and analyzed inSPSS version 17. Chi-Square test was used as test of significance. Results: Mean age + S.Dof patients was 34.11 ± 10.42 years. The mean ± SD of duration of symptoms among thesepatients was 5.23 ± 3.52 months. Most of the patients (21%) belong to age between 21 to30 years. Regarding clinical features in these patients of myasthenia gravis it was noted thatptosis and diplopia were most common symptoms, 62% and 54.9%, respectively. Conclusion:Myasthenia gravis, a chronic neuromuscular disorder leads to various degrees of neurologicdysfunction which manifest as different clinical features. The current study found that ocularsymptoms are commonest presenting features.