scholarly journals Analysis of Optical Properties of Posterior Surface of Cornea in Patients after Anterior Radial Keratotomy

2019 ◽  
Vol 4 (4) ◽  
pp. 24-29
Author(s):  
E. K. Tsyrenzhapova ◽  
O. I. Rozanova ◽  
N. N. Seliverstova
Keyword(s):  
Optical Properties ◽  
Careful Analysis ◽  
Radius Of Curvature ◽  
Control Group ◽  
Posterior Surface ◽  
Anterior Surface ◽  
Radial Keratotomy ◽  
Age Related ◽  
Anatomical Properties ◽  
Posterior Cornea

Taking into account the constant increase in patients with age-related cataracts after radial keratotomy, a careful analysis of both the optical and anatomical properties of the cornea with the examination of the posterior surface is of particular importance.Aim. To analyze the optical properties of the posterior surface of the cornea in patients after anterior radial keratotomy. Materials and methods. An examination of 24 patients (48 eyes) with age-related cataracts of varying degrees of density, myopia and the presence of a previous anterior radial keratotomy or radial-tangential keratotomy in history. The average age of patients was 59.5 years (from 47 to 68), there were 19 women and 5 men.Results. The radius of curvature of the anterior surface in patients after anterior radial keratotomy was 9.45 ± 0.91 mm on average along the meridians, which is significantly more in comparison with these indices in control patients – 7.70 ± 0.19 mm (p = 0.0001). The ratio of the radii of the posterior cornea curvature to the anterior radius on average along the meridians in patients after anterior radial keratotomy was 1.07 ± 0.70, and in control patients – 1.20 ± 0.02 (p = 0.0001). The keratometric index in patients after anterior radial keratotomy was 1.3538 ± 0.0239, and in the control group – 1.3372 ± 0.0003 (p = 0.23).Conclusion. In patients after anterior radial keratotomy, keratometry of the posterior surface of the cornea is significantly higher than in the control. The ratio of the radius of curvature of the posterior cornea to the radius of curvature of the anterior cornea varies significantly after anterior radial keratotomy, which is due to a more pronounced flattening of the posterior cornea. The standard keratometric index (1.3375) is invalid for patients after anterior radial keratotomy and must be calculated individually for each patient when deciding on the operative treatment of cataracts.

scholarly journals Relief-topography of anterior and posterior corneal surfaces in myopic patients in the long-term follow-up period after anterior radial keratotomy

2021 ◽  
pp. 22-28
Author(s):  
E.K. Tsyrenzhapova ◽  
◽  
O.I. Rozanova ◽  
O.I. Mikova ◽  
A.A. Ivanov ◽  
...  
Keyword(s):  
Anterior Part ◽  
Posterior Part ◽  
Control Group ◽  
Average Deviation ◽  
Radial Keratotomy ◽  
Age Related ◽  
Peripheral Area ◽  
Long Term Follow Up ◽  
History Of

Purpose. To analyze the topographical features of the relief of anterior and posterior corneal surfaces in patients with myopia in the long-term period after anterior radial keratotomy (ARK). Material and methods. We examined 132 patients with age-related cataracts of varying degrees of density and a history of myopia with previously performed ARK. Mean age of patients was 59.67±6.09 (from 47 to 76). In the control group, 30 patients of the same age group with myopia were examined. A comprehensive examination was performed, including optical biometry, keratotopography on the Pentacam HR device with the determination of the elevation points of the anterior and posterior corneal surfaces. Results. The corneal profile differed from the correct spherical configuration in the control group. The average deviation of the profile of the anterior part of the cornea from the BFS was (–)1.41±5.10 µm, the posterior part was (–)5.12±12.25 µm (p=0.0001). The profile of the posterior corneal surface had a pronounced prolapse in the paracentral area with positive elevation values in the lower-outer segment. Negative values were found in the upper and lower sectors in the peripheral area and positive values were found in the inner and outer sectors. The corneal profile was deformed in patients after ARK. Negative elevation values in the central and paracentral area and positive elevation values in the peripheral segments corresponding to its protrusion were noted. At the same time, the relief of anterior and posterior surfaces of the cornea was not regular. Prolapse from the posterior surface of the cornea in the peripheral area was more pronounced than its anterior surface (p=0.0001). Conclusion. The relief of anterior and posterior corneal surfaces in patients of the control group differs in the degree and topography of elevation. In patients after ARK, obvious topographic deformities of the anterior and posterior corneal profiles were detected. Key words: anterior radial keratotomy, corneal elevation, myopia.

Oral and Oropharyngeal Sensory Function in Adults With Chronic Obstructive Pulmonary Disease

2020 ◽  
Vol 29 (2) ◽  
pp. 864-872
Author(s):  
Fernanda Borowsky da Rosa ◽  
Adriane Schmidt Pasqualoto ◽  
Catriona M. Steele ◽  
Renata Mancopes
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Oral Cavity ◽  
Pulmonary Disease ◽  
Thermal Sensation ◽  
Sensory Function ◽  
Control Group ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Age Related ◽  
Copd Patients

Introduction The oral cavity and pharynx have a rich sensory system composed of specialized receptors. The integrity of oropharyngeal sensation is thought to be fundamental for safe and efficient swallowing. Chronic obstructive pulmonary disease (COPD) patients are at risk for oropharyngeal sensory impairment due to frequent use of inhaled medications and comorbidities including gastroesophageal reflux disease. Objective This study aimed to describe and compare oral and oropharyngeal sensory function measured using noninstrumental clinical methods in adults with COPD and healthy controls. Method Participants included 27 adults (18 men, nine women) with a diagnosis of COPD and a mean age of 66.56 years ( SD = 8.68). The control group comprised 11 healthy adults (five men, six women) with a mean age of 60.09 years ( SD = 11.57). Spirometry measures confirmed reduced functional expiratory volumes (% predicted) in the COPD patients compared to the control participants. All participants completed a case history interview and underwent clinical evaluation of oral and oropharyngeal sensation by a speech-language pathologist. The sensory evaluation explored the detection of tactile and temperature stimuli delivered by cotton swab to six locations in the oral cavity and two in the oropharynx as well as identification of the taste of stimuli administered in 5-ml boluses to the mouth. Analyses explored the frequencies of accurate responses regarding stimulus location, temperature and taste between groups, and between age groups (“≤ 65 years” and “> 65 years”) within the COPD cohort. Results We found significantly higher frequencies of reported use of inhaled medications ( p < .001) and xerostomia ( p = .003) in the COPD cohort. Oral cavity thermal sensation ( p = .009) was reduced in the COPD participants, and a significant age-related decline in gustatory sensation was found in the COPD group ( p = .018). Conclusion This study found that most of the measures of oral and oropharyngeal sensation remained intact in the COPD group. Oral thermal sensation was impaired in individuals with COPD, and reduced gustatory sensation was observed in the older COPD participants. Possible links between these results and the use of inhaled medication by individuals with COPD are discussed.

scholarly journals The impact of vascular risk factors on the thickness and volume of the choroid in AMD patients

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Elżbieta Krytkowska ◽  
Aleksandra Grabowicz ◽  
Katarzyna Mozolewska-Piotrowska ◽  
Zofia Ulańczyk ◽  
Krzysztof Safranow ◽  
...  
Keyword(s):  
Risk Factors ◽  
Vascular Risk Factors ◽  
Age Related Macular Degeneration ◽  
Control Group ◽  
Vascular Risk ◽  
Average Volume ◽  
Central Ring ◽  
Age Related ◽  
The Impact ◽  
Wet Amd

AbstractDisturbances in choroidal microcirculation may lead to the onset and progression of age-related macular degeneration (AMD). We aimed to assess changes in the choroidal volume and thickness in the macular region in AMD eyes and to investigate whether coexisting vascular risk factors alter choroidal status. We enrolled 354 AMD patients (175 dry, 179 wet AMD) and 121 healthy controls. All participants underwent a complete ophthalmologic examination and assessment of choroidal thickness and volume. A multivariate analysis adjusted for age, sex, and smoking status revealed that wet AMD was an independent factor associated with higher average thickness of the central ring area (ATC) and average volume of the central ring area (AVC) and lower choroidal vascularity index (CVI) compared to controls (β =  + 0.18, p = 0.0007, β =  + 0.18, p = 0.0008, respectively) and to dry AMD (β =  + 0.17, p = 0.00003 for both ATC and AVC and β =  − 0.30 p < 0.0001 for CVI). ATC, AVC and average volume (AV) were lower in AMD patients with hypertension and ischaemic heart disease (IHD). The duration of hypertension was inversely correlated with ATC, AVC and AV (Rs =  − 0.13, p < 0.05; Rs =  − 0.12; p < 0.05, Rs =  − 0.12; p < 0.05, respectively) while IHD duration negatively correlated with AV (Rs =  − 0.15, p < 0.05). No such associations were observed in the control group. Our findings show that the choroidal vascular system in eyes with AMD is much more susceptible to damage in the presence than in the absence of systemic vascular disease.

Immunosenescence: potential causes and strategies for reversal

2000 ◽  
Vol 28 (2) ◽  
pp. 250-254 ◽  
Author(s):  
R. Aspinall ◽  
D. Andrew
Keyword(s):  
T Cell ◽  
Immune Dysfunction ◽  
Careful Analysis ◽  
Experimental Therapy ◽  
Thymic Involution ◽  
Interleukin 7 ◽  
Cell Pool ◽  
Age Related ◽  
Peripheral T Cells ◽  
Laboratory Investigations

Age-related deterioration in immune function has been recognized in many species. In humans the clinical manifestation of such immune dysfunction is age-related increases in the susceptibility to certain infections and in the incidence of some autoimmune disease and certain cancers. Laboratory investigations reveal age-related changes in the peripheral T cell pool, in the predominant phenotype, cytokine production profiles, signalling function and in replicative ability following stimulus with antigen, mitogens or anti-CD3 antibody. These changes in the properties of peripheral T cells are thought to be causally linked to an age-associated involution in the thymus. Our analysis reveals that thymic involution is due to a change in the thymic microenvironment linked to a reduction in the level of available interleukin 7. Treatment with interleukin 7 leads to a reversal of thymic atrophy with increased thymopoiesis. This provides the potential to reverse the immune dysfunction seen in the peripheral T cell pool by replacing old cells with new output generated in the thymus. Problems to overcome in order for such an experimental therapy to be successful require careful analysis in order to provide an optimal strategy to ensure that new T cell emigrants from the thymus have a broad range of specificities and are able to enter the peripheral T cell pool.

scholarly journals Perilla Seed Oil Enhances Cognitive Function and Mental Health in Healthy Elderly Japanese Individuals by Enhancing the Biological Antioxidant Potential

Foods ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 1130
Author(s):  
Michio Hashimoto ◽  
Kentaro Matsuzaki ◽  
Shahdat Hossain ◽  
Tomoko Ito ◽  
Harumi Wakatsuki ◽  
...  
Keyword(s):  
Mental Health ◽  
Cognitive Function ◽  
Plasma Membranes ◽  
Seed Oil ◽  
Antioxidant Potential ◽  
Control Group ◽  
Healthy Elderly ◽  
Age Related ◽  
Elderly Japanese ◽  
Perilla Seed

Oxidative stress plays an important role in age-associated cognitive decline. We recently reported that dietary intake of perilla seed oil (PO), a rich source of α-linolenic acid (LNA, C18:3, ω-3), helps in maintaining good mental health in adults. This study aimed to investigate the impacts of dietary PO intake on cognitive functions and mental health in healthy, elderly Japanese individuals. Seventy-five healthy volunteers aged 64–84 years were randomly divided into two groups: a control group and a PO-administered group. At baseline and at 12 months of intervention, cognitive function, mental health condition, fatty acid profile of the red blood cell plasma membranes (RBC-PM), and serum biochemical parameters were evaluated. Results showed that serum biological antioxidant potential and LNA levels in the RBC-PM at 12 months after the trial were significantly higher in the PO group compared to the control group. Further, both the cognitive function measures, as evaluated by the Frontal Assessment Battery test and the apathy scores, tended to be improved after 12 months in the PO group. Our results demonstrate that dietary PO intake enhances the antioxidant potential and prevents the age-related cognitive and mental decline in healthy elderly individuals by enhancing the blood LNA levels.

IV. Postscript to a paper “On the ganglia and nerves of the heart.”

1849 ◽  
Vol 139 ◽  
pp. 47-48
Keyword(s):  
Nervous System ◽  
Left Ventricle ◽  
Blood Vessels ◽  
Coronary Arteries ◽  
Royal Society ◽  
Posterior Surface ◽  
Anterior Surface ◽  
Entire Surface ◽  
Naked Eye ◽  
Nervous Structure

Since the communication above referred to was presented to the Royal Society, I have made a very minute dissection in alcohol of the whole nervous system of the young heifer’s heart. The distribution of the ganglia and nerves over the entire surface of the heart, and the relations of these structures to the blood-vessels and muscular substance, are far more fully displayed in these preparations than in any of my former dissections. On the anterior surface, there are distinctly visible to the naked eye ninety ganglia or ganglionic enlargements on the nerves, which pass obliquely across the arteries and the muscular fibres of the ventricles from their base to the apex. These ganglionic enlargements are observed on the nerves, not only where they are crossing the arteries, but where they are ramifying on the muscular substance without the blood-vessels. On the posterior surface, the principal branches of the coronary arteries plunge into the muscular substance of the heart near the base, and many nerves with ganglia accompany them throughout the walls to the lining membrane and columnse carneæ. From the sudden disappearance of the chief branches of the coronary arteries on the posterior surface, the nervous structure distributed over a consider­ able portion of the left ventricle is completely isolated from the blood-vessels, and on these, numerous ganglionic enlargements are likewise observed, but smaller in size than the chains of ganglia formed over the blood-vessels on the anterior surface of the heart. In the accompanying beautiful drawings, Mr. West has depicted with the greatest accuracy and minuteness the whole nervous structures demon­strable in these preparations on the surface of the heart. But the ganglia and nerves represented in these drawings constitute only a small portion of the nervous system of the heart, numerous ganglia being formed in the walls of the heart which no artist can represent. It can be clearly demonstrated that every artery distributed throughout the walls of the Uterus and Heart, and every muscular fasciculus of these organs, is supplied with nerves upon which ganglia are formed.

Application of 25-National Eye Institute Visual Function Questionnaire in ophthalmological patients

2020 ◽  
Vol 2 (3) ◽  
pp. 1-8
Author(s):  
Luciano Mesquite Simmo ◽  
Carissa Fouad Ibrahim ◽  
Senice Alvarenga Rodrigues Silva ◽  
Thai Nunes Andrade ◽  
Doora Faleiros Leite ◽  
...  
Keyword(s):  
Visual Function ◽  
Peripheral Vision ◽  
Statistical Significance ◽  
Eye Diseases ◽  
Age Related Macular Degeneration ◽  
Control Group ◽  
Ischemic Optic Neuropathy ◽  
Age Related ◽  
Visual Function Questionnaire ◽  
The Impact

Objective: To compare the vision-targeted health related quality of life (HRQOL) between neuro-ophthalmological patients and other eye diseases by the National Eye Institute 25-Item Visual Function Questionnaire. Methods: Cross sectional study with a control group and patients with the following pathologies: primary open-angle glaucoma (POAG), diabetic retinopathy (DR), age-related macular degeneration (ARMD), non-arteritic ischemic optic neuropathy (NAION), intracranial hypertension (IH), optic neuritis (ON), ptosis and cataract. Results: All comparisons of the subscales scores among the control group and the patient groups were statistically significant (p<0.05) except for “ocular pain” (p=0.160), “social functioning” (p=0.052) and “peripheral vision” (p=0.112). The control group had the best scores across all dimensions of the NEI VFQ-25. Interestingly, the ARMD and cataract groups presented the best and worst total scores of NEI VFQ-25, respectively. The lowest subscales scores were found in the cataract, in the NAION/ON, and in the POAG groups. Finally, the comparison between the NAION/ON/IH patients and the other eye diseases did not show statistical significance in any subscale. Conclusion: The NEI VFQ-25 showed the impact of various eye conditions in vision-targeted HRQOL, and no difference was measured between neuro-ophthalmological patients and other eye diseases

Teachers’ Conversational Style and Children’s Language Development in German Childcare Centers: A Culture-Sensitive Intervention

2018 ◽  
Vol 50 (2) ◽  
pp. 164-184 ◽  
Author(s):  
Lisa Schröder ◽  
Anna Dintsioudi ◽  
Marit Kristine List ◽  
Heidi Keller
Keyword(s):  
Language Development ◽  
Intervention Group ◽  
Control Group ◽  
Childcare Centers ◽  
Language Programs ◽  
Age Related ◽  
Limited Effectiveness ◽  
Conversational Style ◽  
Psychological Autonomy ◽  
Instructional Language

Instructional language programs in German childcare centers have shown limited effectiveness. Two reasons may be that (a) the training is unconnected with everyday situations in which children typically acquire language and (b) the programs adopt a cultural model of psychological autonomy, a model that may be inconsistent with some children’s background. In the present study, we implemented an everyday-based language intervention in four German childcare centers. In a prepost design, teachers ( N = 37, M = 32.97 years) were first trained to adopt an elaborative, socially oriented style. Their language behavior, videotaped and analyzed during daily routines over 1 year, demonstrated significant changes (e.g., asking more open-ended questions, referring to social content and decontextualized content more often). Independent of their families’ cultural orientation. children’s ( N = 85, M = 3.42 years) language competencies significantly increased beyond age-related development norms. In comparison with a control group of children who visited childcare centers implementing instructional language programs, children of the intervention group performed significantly better in nonword repetition (an indicator of lexical knowledge) after 1 year. The results demonstrate that, in a brief intervention, teachers’ conversational style could be effectively changed toward promoting language development in a culture-sensitive way. Although the direct link to children’s language development remains to be proven, results indicate that children with different cultural backgrounds could profit from this everyday-based approach without using extra settings, materials, or instructions.

Processing gender stereotypes in dementia patients and older healthy adults: a self-paced reading study

2019 ◽  
Vol 5 (s2) ◽  
Author(s):  
Daniel Müller-Feldmeth ◽  
Katharina Ahnefeld ◽  
Adriana Hanulíková
Keyword(s):  
Older Adults ◽  
Young Adults ◽  
Sentence Processing ◽  
Gender Stereotypes ◽  
Time Course ◽  
Healthy Adults ◽  
Control Group ◽  
Healthy Older Adults ◽  
Dementia Patients ◽  
Age Related

AbstractWe used self-paced reading to examine whether stereotypical associations of verbs with women or men as prototypical agents (e.g. the craftsman knits a sweater) are activated during sentence processing in dementia patients and healthy older adults. Effects of stereotypical knowledge on language processing have frequently been observed in young adults, but little is known about age-related changes in the activation and integration of stereotypical information. While syntactic processing may remain intact, semantic capacities are often affected in dementia. Since inferences based on gender stereotypes draw on social and world knowledge, access to stereotype information may also be affected in dementia patients. Results from dementia patients (n = 9, average age 86.6) and healthy older adults (n = 14, average age 79.5) showed slower reading times and less accuracy in comprehension scores for dementia patients compared to the control group. While activation of stereotypical associations of verbs was visible in both groups, they differed with respect to the time-course of processing. The effect of stereotypes on comprehension accuracy was visible for healthy adults only. The evidence from reading times suggests that older adults with and without dementia engage stereotypical inferences during reading, which is in line with research on young adults.

Rorschach Indices of Children Classified as Hyperactive

1981 ◽  
Vol 52 (3) ◽  
pp. 703-707 ◽  
Author(s):  
Michael Gordon ◽  
Harvey Oshman
Keyword(s):  
Conceptual Framework ◽  
Reaction Times ◽  
Control Group ◽  
Age Related ◽  
Underlying Dimension

The Rorschach protocols of 20 boys (6 to 11 yr.) rated by their teachers as hyperactive and those of 20 nonhyperactive boys were compared along 16 indices, including R, P, M, FM, C, CF, FC, Sum C, A%, H%, F+%, Sum Shading, and the reaction times. The results suggested that children classified as hyperactive produce fewer movement ( M) and Human ( H) responses but a far greater percentage of Animal ( A) responses than the matched clinic control group. Age-related effects occurred within the hyperactive group such that younger hyperactives produced a higher Sum C, a lower H% and F +%, and had shorter reaction times than the older hyperactives. Findings were discussed in terms of the assessment of hyperactivity within a conceptual framework which regards impulsivity as a major underlying dimension.

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