INFLAMMATORY PARODONTIC DISEASES. CLASSICAL TRADITIONS OF MEDICAMENTAL THERAPY AND CONTEMPORANEITY

Dental pathology is represented by a wide range of diseases of hard and soft tissues of these organs, various types of injuries, anomalies of shape, number, location, periodontitis. Inflammatory periodontal diseases are one of the most common human diseases, which lead to significant socio-economic losses and reduced quality of life. At the beginning of the XXI century, prevention and treatment of inflammatory periodontal diseases remains an urgent problem of medicine. The high frequency of periodontal lesions is largely due to the peculiarities of its structure and function, general human health, the constant influence of microorganisms, among which the dominant role is played by opportunistic and pathogenic bacteria. The microflora in inflammatory periodontal diseases differs from the microflora of the oral cavity of a healthy person by the presence of peculiar symbiotic associations with a specific dominant species of the pathogen. The main element of the modern protocol of medical care for periodontal disease is the systemic or local use of antimicrobials. Modern antibiotics and chemotherapeutics used in dental practice for the treatment of CPD, totally affect all parts of the biocenosis of the oral cavity and lead to its undesirable changes. In addition, even a short-term positive effect of the use of these drugs can be combined with a selective increase in the resistance of pathogens to antibacterial drugs, which generally reduces the expected effectiveness of traditional therapy. Inflammatory periodontal diseases, prospects of their treatment by classical methods and with the use of modern medical technologies were studied in the work. For the objectification of the study used archival materials and their own work over the past 15 years. The purpose of the study: to identify promising areas of integrated use of traditional and innovative treatments for inflammatory periodontal disease. The subject of the study was to clarify the issues of antibacterial, antifungal activity of hop products, the rate of formation of resistance in microorganisms, the adequacy of physical, physicochemical properties of gel compositions. Particular attention was paid to the use of antibacterial properties of gel compositions based on hop products. It is established that the use of antibiotics and chemotherapeutics in modern medical practice for the treatment of inflammatory periodontal diseases has a number of significant limitations due to the short duration of their therapeutic effect, negative impact on human microbiocenosis and the formation of acquired resistance of pathogenic microflora to widely used drugs. The results of previous studies have demonstrated the prospects of herbal medicines, namely, created on the basis of hop products for the prevention and treatment of diseases of microbial origin. It was found that the antibacterial and antifungal action of gel preparations of optimal composition with EHV 0.5% significantly exceeds the specified indicators of such known and currently used drugs. Therefore, it is clear the scientific and practical meaning of the use in protocols for the treatment of inflammatory periodontal diseases (as drugs for local therapy) phytomedicine based on hop herbal substance. Thus, a clear prospect of using new compositions of drugs with high antibacterial properties based on plant raw materials (including hops) for the treatment and prevention of periodontal disease. Solving this problem is a timely and socially appropriate fact.

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The occurrence of Entamoeba gingivalis among patients with periodontal disease

Current Issues in Pharmacy and Medical Sciences ◽

10.1515/cipms-2016-0017 ◽

2016 ◽

Vol 29 (2) ◽

pp. 86-89 ◽

Cited By ~ 2

Author(s):

Joanna Luszczak ◽

Michal Bartosik ◽

Jolanta Rzymowska ◽

Agnieszka Sochaczewska-Dolecka ◽

Ewa Tomaszek ◽

...

Keyword(s):

Oral Cavity ◽

Periodontal Disease ◽

Periodontal Diseases ◽

Age Groups ◽

Healthy People ◽

Gingival Tissue ◽

Pathological Changes ◽

Oral Diseases

AbstractAccording to some studies, the Entamoeba gingivalis colonizing the gingival tissue is an important agent in bringing about periodontitis. Other studies, however, deem it an opportunist that is able to survive in the medium induced by periodontal disease. The aim of this study was to investigate the prevalence of Entamoeba gingivalis infection in patients from the Department of Periodontology, and compare this population with that of healthy people, so as to analyze the relationships between infection and patient sex and age. The result of this work is that in both groups, a correlation (p = 0,19) has been noted between the occurrence of amoebae and other diseases in the oral cavity. Indeed, 81,4% of all patients with some periodontal disease showed the presence of amoeba. Among those who are not afflicted with oral diseases, the presence of amoeba was indicated in 62,5% of the total. In addition, a correlation between the person's age and the presence of protozoa (p = 0,15) was strongly marked among women (p = 0,19). In the three age groups of women in this study (40-49, 60-69, and above 80 years), we observed a 100% presence of protozoa.Our study leads us to the conclusion that infections with Entamoeba gingivalis should be regarded as an factor that is associated with the pathological changes occurring in patients with periodontal diseases.

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CONDITIONS OF THE ORAL CAVITY STATUS IN YOUTH WITH ALIMENTARY-CONSTITUTIONAL FORM OF OBESITY

The Medical and Ecological Problems ◽

10.31718/mep.2019.23.1-2.04 ◽

2019 ◽

Vol 23 (1-2) ◽

pp. 17-21

Author(s):

M. Skrypnyk ◽

T. Petrushanko ◽

T. Kryvoruchko ◽

K. Neporada

Keyword(s):

Oral Cavity ◽

Periodontal Disease ◽

Periodontal Diseases ◽

Young Patients ◽

Overweight And Obesity ◽

Obesity Prevalence ◽

Periodontal Tissues ◽

Mild Degree ◽

Inflammatory Processes ◽

Second Degree

Obesity prevalence has significantly increased especially in young adults, which is caused by a particular lifestyle, food quality and dietary behavior. Obesity leads to development of huge array of comorbid conditions such as arterial hypertonia, heart stroke, arthritis and other diseases. We conducted standard clinical examination of oral cavity of 154 young patients (18-21 years old) – all of them were students of Ukrainian Medical Stomatological Academy. It has been determined that the majority of patients with BMI >30 kg/cm2 have aggravated family heredity, in 66,2% cases one parent of obese students had obesity and 32,43% patients have both parents with obesity that is significantly higher compared with persons with normal BMI and overweight. There was a high prevalence of periodontal diseases about 74% and carious lesions of teeth - 97.4% among young people despite the age and contingent of examined patients - medical students. In patients with BMI >30 kg/cm2 prevalence of generalized forms of gingivitis and periodontitis was by three times higher compared with individuals with normal BMI. The values of oral hygienic indexes were poor in all examined groups, but their values were slightly lower in patients with normal BMI than in those with overweight and obesity. The prevalence of inflammatory changes in gums was higher in persons with obesity: all of them had a mild degree of lesions in periodontal tissues. Inflammatory processes in the gums were the most intense in patients with the second degree of obesity. According to the results of the study, the presence of the first and the second degree of obesity should be considered as a risk factor triggering periodontal tissues diseases. For persons with BMI >30 kg/cm2 with periodontal disease measures for the secondary prevention of inflammatory and inflammatory dystrophic periodontal diseases should be carried out and in persons without periodontal disease on the background of obesity measures primary prevention should be done.

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CONDITION OF PERIODONTAL TISSUES IN PATIENTS WITH DERMATOSES

The actual problems in dentistry ◽

10.18481/2077-7566-2018-14-4-54-57 ◽

2018 ◽

Vol 14 (4) ◽

pp. 54-57

Author(s):

Н. Чернышева ◽

N. Chernyshova ◽

Сергей Чуйкин ◽

Sergey Chuykin ◽

Гузель Акмалова ◽

...

Keyword(s):

Oral Cavity ◽

Periodontal Disease ◽

Lichen Planus ◽

Oral Lichen Planus ◽

Periodontal Diseases ◽

Complex Treatment ◽

Adequate Treatment ◽

Periodontal Tissues ◽

Periodontal Index ◽

Oral Lichen

Background. Periodontal disease is one of the most common and complex pathologies in dentistry. It is known frequently damage to the tissues of the periodontal complex with dermatoses. The most relevant among the dermatoses of the mucous membrane of the mouth and the red border of the lips is oral lichen planus. Among the six clinical forms of red flat oral lichen planus and the red border of the lips, the exudative-hyperemic and erosive-ulcerous forms occur most often. Atypical form is much less common than other forms and is often diagnosed by dentists as an inflammatory periodontal disease. At the same time, the pathogenetic mechanisms of inflammatory processes in the gums, which are different in oral lichen planus, are not taken into account, which, accordingly, complicates adequate treatment. Objectives. The aim of the study was to analyze the periodontal status in patients with exudative-hyperemic, erosive-ulcerative and atypical forms of oral lichen planus. Methods. Under our supervision there were 181 patients with oral lichen planus, in whom a simplified Green-Vermillion hygiene index was determined. To assess the state of periodontal used periodontal index according to Russell. Results. When assessing the hygienic condition of the oral cavity, high values were observed in individuals with severe forms of the disease: erosive-ulcerative, exudative-hyperemic. The highest values of the periodontal index were found in patients with atypical, erosive and ulcerative forms of oral lichen planus. Conclusions. The results of the clinical examination of patients with oral lichen planus dictate, first of all, to include in the scheme of complex treatment of it the sanitization of oral cavity and complex treatment of inflammatory periodontal diseases as well.

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Antioxidant-Rich Natural Raw Materials in the Prevention and Treatment of Selected Oral Cavity and Periodontal Diseases

Antioxidants ◽

10.3390/antiox10111848 ◽

2021 ◽

Vol 10 (11) ◽

pp. 1848

Author(s):

Jolanta Pytko-Polończyk ◽

Magdalena Stawarz-Janeczek ◽

Agata Kryczyk-Poprawa ◽

Bożena Muszyńska

Keyword(s):

Oral Cavity ◽

Raw Materials ◽

Periodontal Diseases ◽

Salivary Secretion ◽

Biologically Active ◽

Quantitative Composition ◽

Oral Diseases ◽

Treatment And Prevention ◽

Prevention And Treatment ◽

Materials Used

Antioxidant-rich natural raw materials have been used for thousands of years in traditional medicine. In the past decade, there has been increasing interest in naturotherapy, which is a practice of using products with a natural origin. Natural products can be effective in the treatment and prevention of oral and dental diseases, among others. Such raw materials used in dentistry are characterized by antioxidant, anti-inflammatory, antibacterial, antiviral, antiedematous, astringent, anticoagulant, dehydrating, vitaminizing, and—above all—regenerative properties. Reports have shown that a relationship exists between oral diseases and the qualitative and quantitative composition of the microbiota colonizing the oral cavity. This review aimed to analyze the studies focusing on the microbiome colonizing the oral cavity in the context of using natural raw materials especially herbs, plant extracts, and isolated biologically active compounds as agents in the prevention and treatment of oral and periodontal diseases such as dental caries as well as mucosal changes associated with salivary secretion disorder. The present work discusses selected plant ingredients exhibiting an antioxidant activity with potential for the treatment of selected oral cavity and periodontal diseases.

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CORECTION OF ENZYMATIC AND MICROELEMENT IMBALANCE IN THE ORAL CAVITY DURING THE ENT DISEASES

The actual problems in dentistry ◽

10.18481/2077-7566-2014-0-4-11-14 ◽

2014 ◽

Vol 10 (4) ◽

pp. 11-14

Author(s):

Н. Гурцкая ◽

N. Gurtskaya

Keyword(s):

Oral Cavity ◽

Structural Changes ◽

Periodontal Diseases ◽

Herbal Medicines ◽

Upper Respiratory Tract ◽

Sod Activity ◽

Calcium Phosphorus ◽

Mda Content ◽

Upper Respiratory ◽

Immunoglobulin Levels

<p>The result of research 50 patients with upper respiratory tract finds out immune deficiency, which developed in the organs and tissues of the oral cavity of the examined patients. When conducting clinical and laboratory studies have established intensive increase MDA level and decrease the level and SOD activity in the saliva of the examined patients suffering from concomitant ENT pathologies and periodontal diseases. Thus, it should be noted that deficiency and imbalance of calcium, phosphorus in saliva in patients with studied pathology may result serious pathogenic metabolic and structural changes in tissues and organs of the oral cavity. This confirms a significant increase secretors Immunoglobulin levels in saliva at the early stages of treatment when using herbal medicines. MDA content more pronounced, respectively decreased after treatment and preventive measures at the use of combined herbal preparation «Faqolin» as compared with the other groups of patients. </p>

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Prevalence of periodontal disease in children and adolescents

Kazan medical journal ◽

10.17816/kazmj65184 ◽

1999 ◽

Vol 80 (1) ◽

pp. 71-72

Author(s):

V. Y. Khitrov ◽

L. S. Ageeva ◽

N. K. Khamitova ◽

E. V. Mamaeva ◽

N. V. Berezina ◽

...

Keyword(s):

Oral Cavity ◽

Periodontal Disease ◽

Children And Adolescents ◽

Oral Hygiene ◽

Soft Tissues ◽

Periodontal Diseases ◽

Poor Oral Hygiene ◽

Facial Skeleton

Periodontal diseases in children and adolescents are quite common, as a result of various reasons: geographic conditions, diet, poor oral hygiene, occlusion pathology, anomalies in the attachment of soft tissues of the oral cavity to the facial skeleton, etc.

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METHODS FOR TREATMENT OF CHRONIC GENERALIZED PERIODONTITIS (LITERATURE REVIEW)

UZBEK MEDICAL JOURNAL ◽

10.26739/2181-0664-2021-5-6 ◽

2021 ◽

Vol 2 (5) ◽

pp. 30-33

Author(s):

Saloma Avezova ◽

Keyword(s):

Literature Review ◽

Oral Cavity ◽

Periodontal Disease ◽

Oral Mucosa ◽

Periodontal Diseases ◽

Pathological Changes ◽

Urgent Task ◽

Immunological Changes

The article provides data on the methods used for the treatment of generalized periodontitis. Most researchers believe that periodontitis is a polyetiological disease, the development of which is based on a complex of pathological changes occurring in the oral cavity associated with microbiological and immunological changes. Improving the effectiveness of treatment of inflammatory periodontal diseases is an urgent task in modern dentistry.Keywords:dentistry, diseases of the oral mucosa, periodontal disease, chronic generalized periodontitis, etiology, treatment

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Restorative dentistry 1: periodontology

Oxford Handbook of Clinical Dentistry ◽

10.1093/med/9780198832171.003.0005 ◽

2020 ◽

pp. 173-224

Keyword(s):

Periodontal Disease ◽

Periodontal Diseases ◽

Anaesthetic Techniques ◽

Aggressive Periodontitis ◽

Mucogingival Surgery ◽

Prevention And Treatment ◽

Flap Design ◽

Recent Classification ◽

Key Aspects ◽

Suturing Techniques

This chapter covers the fundamentals of the diagnosis, prevention, and treatment of periodontal disease, alongside the most recent classification system. The epidemiology of periodontal disease is discussed before the key aspects of clinical examination are explained. The relevance and implications of plaque and calculus are detailed including their composition and pathological effects. The chapter includes the clinical features of periodontal diseases, including aggressive periodontitis, necrotizing periodontal diseases, and periodontal abscesses, as well as periodontitis associated with endodontic lesions. The principles of periodontal surgery are described, covering local anaesthetic techniques, flap design, and suturing techniques, as well as regenerative techniques and mucogingival surgery.

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The Promising Role of Antioxidant Phytochemicals in the Prevention and Treatment of Periodontal Disease via the Inhibition of Oxidative Stress Pathways: Updated Insights

Antioxidants ◽

10.3390/antiox9121211 ◽

2020 ◽

Vol 9 (12) ◽

pp. 1211

Author(s):

Thi Thuy Tien Vo ◽

Pei-Ming Chu ◽

Vo Phuoc Tuan ◽

Joyce Si-Liang Te ◽

I-Ta Lee

Keyword(s):

Oxidative Stress ◽

Oral Cavity ◽

Periodontal Disease ◽

Inflammatory Disease ◽

Therapeutic Agents ◽

Future Prospects ◽

Pharmacological Activities ◽

Current Review ◽

Prevention And Treatment

There is growing evidence on the involvement of oxidative stress, which is simply described as the imbalance between oxidants and antioxidants in favor of the former, in the development of periodontal disease that is the most common inflammatory disease in the oral cavity. Thus, the potential of antioxidant phytochemicals as adjunctively preventive and therapeutic agents against the initiation and progression of periodontal disease is a topic of great interest. The current review firstly aims to provide updated insights about the immuno-inflammatory pathway regulated by oxidative stress in periodontal pathology. Then, this work further presents the systemic knowledge of antioxidant phytochemicals, particularly the pharmacological activities, which can be utilized in the prevention and treatment of periodontal disease. Additionally, the challenges and future prospects regarding such a scope are figured out.

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Proanthocyanidins and Flavan-3-ols in the Prevention and Treatment of Periodontitis—Immunomodulatory Effects, Animal and Clinical Studies

Nutrients ◽

10.3390/nu13010239 ◽

2021 ◽

Vol 13 (1) ◽

pp. 239

Author(s):

Izabela Nawrot-Hadzik ◽

Adam Matkowski ◽

Paweł Kubasiewicz-Ross ◽

Jakub Hadzik

Keyword(s):

Periodontal Disease ◽

Clinical Studies ◽

Antibacterial Properties ◽

Immunomodulatory Effects ◽

Grape Seeds ◽

Periodontal Tissues ◽

Major Response ◽

Prevention And Treatment ◽

Black Other

This paper continues the systematic review on proanthocyanidins and flavan-3-ols in the prevention and treatment of periodontal disease and covers the immunomodulatory effects, and animal- and clinical studies, while the other part discussed the direct antibacterial properties. Inflammation as a major response of the periodontal tissues attacked by pathogenic microbes can significantly exacerbate the condition. However, the bidirectional activity of phytochemicals that simultaneously inhibit bacterial proliferation and proinflammatory signaling can provide a substantial alleviation of both cause and symptoms. The modulatory effects on various aspects of inflammatory and overall immune response are covered, including confirmed and postulated mechanisms of action, structure activity relationships and molecular targets. Further, the clinical relevance of flavan-3-ols and available outcomes from clinical studies is analyzed and discussed. Among the numerous natural sources of flavan-3-ols and proanthocyanidins the most promising are, similarly to antibacterial properties, constituents of various foods, such as fruits of Vaccinium species, tea leaves, grape seeds, and tannin-rich medicinal herbs. Despite a vast amount of in vitro and cell-based evidence of immunomodulatory there are still only a few animal and clinical studies. Most of the reports, regardless of the used model, indicated the efficiency of these phytochemicals from cranberries and other Vaccinium species and tea extracts (green or black). Other sources such as grape seeds and traditional medicinal plants, were seldom. In conclusion, the potential of flavan-3-ols and their derivatives in prevention and alleviation of periodontal disease is remarkable but clinical evidence is urgently needed for issuing credible dietary recommendation and complementary treatments.

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