scholarly journals KARAKTERISTIK PASIEN TUBERKULOSIS PARU DENGAN MULTIDRUG-RESISTANT (TB MDR) DI RSUD DR. M. HAULUSSY AMBON TAHUN 2014-2018

2021 ◽  
Vol 2 (2) ◽  
pp. 90-102
Author(s):  
Nadhirrafie Ardiadi Albaihaqi ◽  
Burhanuddin Burhanuddin ◽  
Vina Z. Latuconsina
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Multidrug Resistant ◽  
Microsoft Excel ◽  
Cross Sectional

Tuberkulosis (TB) merupakan penyakit menular yang disebabkan oleh bakteri Mycobacterium tuberculosis. Beberapa dekade terakhir muncul permasalahan lain yang berkaitan dengan TBC yaitu TB MDR (Tuberkulosis dengan multidrug-resistant) yang sangat meluas. Pengobatan TB MDR membutuhkan waktu 2 tahun dan dengan obat yang 100 kali lebih mahal jika dibandingkan pengobatan lini pertama. Tujuan penelitian ini adalah untuk mengetahui karakteristik pasien tuberkulosis paru dengan multidrug-resistant (TB MDR) di RSUD Dr. M. Haulussy Ambon tahun 2014-2018. Penelitian ini merupakan penelitian deskriptif observasional dengan pendekatan cross sectional. Teknik pengambilan sampel adalah dengan menggunakan metode total sampling. Sampel dalam penelitian ini berjumlah 113 orang. Data rekam medik paseisn TB MDR yang diperoleh kemudian dianalisis menggunakan microsoft excel. Hasil penelitian menunjukkan bahwa pada RSUD Dr. M. Haulussy Ambon penderita TB MDR paling banyak terdapat pada usia dewasa 26 – 45 tahun yaitu 61 kasus (54%), pasien TB MDR berjenis kelamin laki-laki yaitu 69 kasus (61%), tipe pasien kambuh sebanyak 67 kasus (59%), 39 kasus (34,51%) dengan lama pengobatan 0-5, pasien resisten rifampisin sebanyak 79 kasus (69,9%), pasien yang meninggal sebanyak 32 kasus (28,3%) dan terdapat 8 kasus (7,1%) pasien TB MDR positif HIV.

scholarly journals Trends of Mycobacterium Tuberculosis and Rifampicin resistance in Adigrat General Hospital, Eastern zone, Tigray Region, Northern Ethiopia

2020 ◽  
Author(s):  
Getachew Kahsu Abay ◽  
Bahlibi Hailay
Keyword(s):  
Mycobacterium Tuberculosis ◽  
General Hospital ◽  
Data Extraction ◽  
Multidrug Resistant ◽  
Rifampicin Resistance ◽  
Northern Ethiopia ◽  
Drug Resistant ◽  
Cross Sectional ◽  
Eastern Zone ◽  
Previously Treated

Abstract Background: Tuberculosis is an infectious disease usually caused by Mycobacterium tuberculosis bacteria. The global emergence of mono- or multidrug-resistant tuberculosis and extensively drug-resistant forms of tuberculosis poses a considerable challenge to tuberculosis control programs. There has been no reliable and organized data on trends and drug resistance of Mycobacterium tuberculosis in the study area. Therefore, this study aimed to determine the trends of Mycobacterium tuberculosis and Rifampicin resistance in the Adigrat General Hospital, eastern zone, Tigray, Northern Ethiopia.Methods: A hospital-based retrospective cross-sectional study was conducted at Adigrat General Hospital from January 2015 to 2018. Data were collected retrospectively from the GenexpertTM TB registration books using a data extraction format. Data was entered into Epi-Info 3.1 and subsequently exported and analyzed using SPSS Version 20. The results were summarized using descriptive statistics, tables, and figures. P values < 0.05 were considered statistically significant.Result: A total of 5,944 Mycobacterium tuberculosis presumptive patients were included in the study. The majority of the study participants were male (58.1%) with participants’ median age of 40.0 (IQR 57, 26) years, the majority were 30-44 years. The overall positive cases of Mycobacterium tuberculosis was 24.3% (1446) with a total of 132 (9.1%) found to be resistant to rifampicin. Within the total Rifampicin resistant sub-group, 129/132 (97.7 %) were newly identified cases and the rest were previously treated, tuberculosis patients. Age, the reason for diagnosis, site of presumptive tuberculosis, and/or being HIV infected showed significant association with our dependent variable; however, only age and being HIV infected were associated with rifampicin resistance.Conclusion: In our study, the overall trends of Mycobacterium tuberculosis and rifampicin resistance were found to be high and gradually increasing. HIV co-infected and previously treated patients were more likely to develop rifampicin resistance. Therefore, maximizing early detection of drug-resistant Mycobacterium tuberculosis and strengthening tuberculosis infection control activities are recommended to reduce the burden of this contagious and potentially deadly disease.

scholarly journals Evaluation of gene mutations in resistant strains of Mycobacterium tuberculosis isolated from pulmonary tuberculosis patients in Mazandaran and Golestan provinces of Iran - a 2-year study

2020 ◽  
Author(s):  
Ahmad Alikhani ◽  
Elnaz Amini ◽  
Mohsen Arabi ◽  
Hamid Reza Goli
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Gene Mutations ◽  
Multidrug Resistant ◽  
Cross Sectional Study ◽  
Proteinase K ◽  
Resistant Isolate ◽  
Ratio Method ◽  
Mazandaran Province ◽  
Northern Iran ◽  
Cross Sectional

Abstract Background: Due to the significant prevalence of tuberculosis (TB) in Mazandaran and Golestan provinces in northern Iran, we aimed to investigate the gene mutations in resistant Mycobacterium tuberculosis isolated from pulmonary TB patients in these provinces of Iran. Methods: In this cross-sectional study, sputum of patients with suspected tuberculosis were evaluated in the central TB laboratory of Golestan in a period of two years from 2017 to 2019. After growing the isolates on Lowenstein-Jensen medium, the antibiotic-resistant cases identified using the resistance ratio method. Then, the DNAs of the resistant isolates were extracted manually by the CTAB-Proteinase K method and investigated for gene mutations using PCR test and sequencing.Results: The mean age of 26 patients was 52 years, while smoking, addiction, and diabetes were more common risk factors. However, 4 isolates (15.38%) were resistant to antibiotics, while one (3.84%) of them was resistant to rifampin, and two isolates (7.69%) were resistant against isoniazid, whereas one other isolate (3.84%) exhibited a multidrug-resistant (MDR) phenotype. The MDR isolate had a mutation in codon 315 of the KatG gene resulting in the conversion of serine to threonine, and a mutation in the codon 450 of the rpoB gene, causing the alteration of serine to leucine. In the rifampin-resistant isolate, a mutation occurred at the same site converting serine to leucine. Conclusions: The low prevalence of antibiotic resistance in clinical isolates of Mycobacterium tuberculosis in this study indicates the appropriate treatment of the patients in this area, however, the prevalence of resistance to isoniazid was higher than rifampin. The more important point was that the single MDR isolate was identified in Mazandaran province.

scholarly journals Trends of Mycobacterium Tuberculosis and rifampicin Resistance in Adigrat General Hospital, Eastern zone of Tigrai, North Ethiopia

2020 ◽  
Author(s):  
Getachew Kahsu Abay ◽  
Bahlibi Hailay
Keyword(s):  
Mycobacterium Tuberculosis ◽  
General Hospital ◽  
Data Extraction ◽  
Multidrug Resistant ◽  
Cross Sectional Study ◽  
Rifampicin Resistance ◽  
Drug Resistant ◽  
Cross Sectional ◽  
Eastern Zone ◽  
Previously Treated

Abstract Background: Tuberculosis is an infectious disease usually caused by Mycobacterium tuberculosis bacteria. The global emergence of mono- or multidrug-resistant tuberculosis and extensively drug-resistant forms of tuberculosis poses a considerable challenge to tuberculosis control programs. There has been no reliable and organized data on trends and drug Resistance of Mycobacterium tuberculosis in the study area. Therefore, this study aimed to determine the trends of Mycobacterium tuberculosis and rifampicin Resistance in the Adigrat General Hospital, eastern zone of Tigrai, North Ethiopia.Methods: A hospital-based retrospective cross-sectional study was conducted at Adigrat General Hospital from January 2015 to 2018. Data were collected retrospectively from the GenexpertTM TB registration book using a data extraction format. Data was entered into Epi-Info 3.1 and subsequently exported and analyzed using SPSS Version 20. The results were summarized using descriptive statistics, tables, and figures. Bivariate and multi-variant regression analysis were employed to measure the association between dependent and independent variables. P values < 0.05 were considered statistically significant.Result: A total of 5,944 Mycobacterium tuberculosis presumptive patients were included in the study. The majority of the study participants were male (58.1%) with participants’ median age of 40.0 (IQR 26-57) years, the majority were 30-44 years. The overall positive cases of Mycobacterium tuberculosis was 24.3% (1446) with a total of 132 (9.1%) found to be resistant to Rifampicin. Within the total Rifampicin resistant sub-group, 129/1385 (9.3 %) were newly identified cases and the rest were previously treated, tuberculosis patients. Age, the reason for diagnosis, site of presumptive tuberculosis, and/or being HIV infected showed significant association with our dependent variable; however, only age and being HIV infected were associated with Rifampicin Resistance.Conclusion: In our study, the overall trends of Mycobacterium tuberculosis and rifampicin Resistance were found to be constant. HIV co-infected and previously treated patients were more likely to develop Rifampicin Resistance. Therefore, maximizing early detection of drug-resistant Mycobacterium tuberculosis and strengthening tuberculosis infection control activities are recommended to reduce the burden of this contagious and potentially deadly disease.

scholarly journals Trends in Mycobacterium Tuberculosis and prevalence of Rifampicin Resistance in Eastern zone, Tigray Region, Northern Ethiopia

2020 ◽  
Author(s):  
Getachew Abay Kahsu ◽  
Bahlibi Hailay
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Data Extraction ◽  
Multidrug Resistant ◽  
Cross Sectional Study ◽  
Rifampicin Resistance ◽  
Northern Ethiopia ◽  
Drug Resistant ◽  
Cross Sectional ◽  
Resistant Tuberculosis ◽  
Eastern Zone

Abstract Background Tuberculosis (TB) is an infectious disease usually caused by Mycobacterium tuberculosis (MTB) bacteria. The emergence of Mono or multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis (XDR-TB), poses a considerable challenge to Mycobacterium tuberculosis control programs in the worldwide; however, there has been no reliable and organized data on trends and prevalence drug resistance of Mycobacterium tuberculosis in study area; Therefore, aim of this study to determine the trends of Mycobacterium tuberculosis and prevalence of Rifampicin resistance in eastern zone, Tigray, Northern Ethiopia. Methods Hospital based retrospective cross-sectional study was conducted at Adigrat General Hospital from June 01 to August 30, 2019.Data was collected retrospectively from the registration books using data extraction format commence January 01, 2015, December 30, 2018. Data was entered into Epi-Info 3.1 and exported and analyzed using SPSS Version 20. The results were summarized using descriptive statistics, tables, and figures. P values < 0.05 would be considered statistically significant. Result A total of 5,944 Mycobacterium tuberculosis presumptive patients were included in the study. The majority of the study participants were male (58.1%). The median age of the participants was 40.0 (IQR 57, 26) years, the majority age-group was 30-44 years. The overall prevalence of Mycobacterium tuberculosis was 1446 (24.3%). Of the total confirmed cases, 132 (9.1%) were resistant to rifampicin. From total Rifampicin resistant 129 (97.7%) new cases and the rest were previously treated tuberculosis patients. Age, reason for diagnosis, site of presumptive tuberculosis, being HIV infected was found a significant association with our dependent variable; however, only Age and being HIV infected associated with rifampicin resistance. Conclusion In our study, the overall trends of Mycobacterium tuberculosis and prevalence of rifampicin resistance were found high and increased; therefore, maximizing early detection of drug-resistant Mycobacterium tuberculosis and strengthening TB infection control activities and proper implementation of directly observed treatment are recommended reducing the burden of this contagious disease.

scholarly journals Prevalence of Mycobacterium tuberculosis infection and rifampicin resistance among presumptive tuberculosis cases visiting tuberculosis clinic of Adare General Hospital, Southern Ethiopia

2021 ◽  
Vol 9 ◽  
pp. 205031212110455
Author(s):  
Degineh Belachew Andarge ◽  
Tariku Lambiyo Anticho ◽  
Getamesay Mulatu Jara ◽  
Musa Mohammed Ali
Keyword(s):  
Mycobacterium Tuberculosis ◽  
General Hospital ◽  
Data Entry ◽  
Multidrug Resistant ◽  
Cross Sectional Study ◽  
Southern Ethiopia ◽  
P Value ◽  
Mycobacterium Tuberculosis Infection ◽  
Cross Sectional ◽  
Logistic Regression Models

Objective: Multidrug-resistant Mycobacterium tuberculosis is a public health threat in resource-limited countries where it is easily disseminated and difficult to control. The aim of this study was to determine the prevalence of tuberculosis, rifampicin-resistant/multidrug-resistant Mycobacterium tuberculosis, and associated factors among presumptive tuberculosis cases attending the tuberculosis clinic of Adare General Hospital located in Hawassa city. Methods: A hospital-based cross-sectional study was conducted among 321 tuberculosis suspected patients from April to July 2018. Socio-demographic, environmental, and behavioral data were collected using a structured questionnaire. Sputum specimens were analyzed using GeneXpert. Data entry was made using Epi info version 7 and analyzed by SPSS version 20. Logistic regression models were used to determine the risk factors. A p-value less than 0.05 was taken as a cut point. Results: In this study, the prevalence of Mycobacterium tuberculosis was 98 (30.5%) with 95% confidence interval (25.5–35.8), and the prevalence of rifampicin-resistant/multidrug-resistant Mycobacterium tuberculosis among the 98 Mycobacterium tuberculosis confirmed cases was 4 (4.1%). The prevalence of rifampicin-resistant/multidrug-resistant Mycobacterium tuberculosis among the tuberculosis suspected patients was 1.24%. Participants who had a history of treatment with anti-tuberculosis drugs were more likely to develop rifampicin-resistant/multidrug-resistant Mycobacterium tuberculosis. Conclusions: This study identified relatively high rifampicin-resistant/multidrug-resistant Mycobacterium tuberculosis among tuberculosis suspected patients in the study area. Early detection of drug-resistant Mycobacterium tuberculosis should be given enough attention to strengthen the management of tuberculosis cases and improve direct observation therapy short-course and eventually minimize the spread of rifampicin-resistant tuberculosis strain in the community.

scholarly journals Prevalence of Multidrug Resistance Mycobacterium Tuberculosis (MDR-TB) Using GeneXpert Assay in Northern Sudan, How Serious is the Situation?

2021 ◽  
Author(s):  
Sufian Khalid Noor ◽  
Mohamed Osman Elamin ◽  
Ziryab Imad Mahmoud ◽  
Mohammed Salah ◽  
Taqwa Anwar ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Multidrug Resistant ◽  
World Health ◽  
River Nile ◽  
Cross Sectional ◽  
Resistant Tuberculosis ◽  
Multidrug Resistant Tuberculosis ◽  
Mdr Tb ◽  
History Of ◽  
Health Organization

Background: World Health Organization (WHO) estimates that there were 558000 new cases with resistance to Rifampicin, of which 82% had multidrug-resistant tuberculosis (MDR-TB). Objectives: We aimed to identify the prevalence of MDR-TB in River Nile state, Sudan, and the risk factors contributing to its occurrence. Methods: This was a descriptive cross-sectional hospital-based study involved 200 specimens taken from patients suspected of having MDR-TB tested using an automated GeneXpert assay. Results: Results of GeneXpert assay showed that the presence of Mycobacterium tuberculosis in 81 (40.5%), and out of 81 positive test results there were 13 (16%) had MDR-TB. Additionally, 7 cases of MDR-TB were previously treated which represented about (53%) of MDR patients, the remaining 6 MDR-TB patients were new cases and represented (47%) of MDR-TB patients. Moreover, there were 4 MDR-TB patients who had a history of contact with MDR-TB patients. Conclusion: Prevalence of MDR-TB in River Nile State, Sudan was 16%, which is greater than WHO estimation for Sudan (10.1%). The results revealed that the main risk factor to develop MDR-TB was a history of contact with MDR-TB, so adherence to treatment and social awareness about the spread of MDR-TB are crucial preventive measures.

scholarly journals Factores asociados a la no adherencia al tratamiento anti tuberculosis

2015 ◽  
Vol 12 (2) ◽  
pp. 26
Author(s):  
Laura Inés Plata-Casas
Keyword(s):  
Risk Factors ◽  
Mycobacterium Tuberculosis ◽  
Adverse Effects ◽  
Demographic Data ◽  
Cross Sectional Study ◽  
Health Staff ◽  
Microsoft Excel ◽  
Cross Sectional ◽  
Modifiable Factors ◽  
Factores De Riesgo

Objetivo: describir los factores de riesgo asociados a la no adherencia al tratamiento en los pacientes adscritos al programa de tuberculosis en el Municipio de Villavicencio, cohorte 2012. Materiales y Métodos: se ha realizado un estudio descriptivo de corte transversal con enfoque cuantitativo.  Se obtuvieron datos de caracterización sociodemográfica sobre factores de riesgo de personas que abandonaron el tratamiento para la enfermedad- cohorte 2012- mediante la aplicación de un instrumento diseñado por el investigador y revisado por expertos.  Los datos fueron tabulados y analizados mediante la herramienta Microsoft Excel® 2007 y Epi-info 7.0. Resultados: el 75% de los pacientes pertenecen al género masculino; el promedio de edad es de 30 años, el 63% pertenecen al régimen subsidiado de salud. Las principales causas de abandono fueron: efectos adversos a los medicamentos (58%), inadecuada atención del personal de salud (43%), dificultad de acceso al servicio (32%). Los factores sociales encontrados fueron hacinamiento 67% y desempleo 62%. Conclusiones: algunos factores no modificables como la edad y  el  género, así como factores modificables como estilos de vida inadecuados y efectos adversos; cuyo control mejoraría el cumplimiento; contribuyen al abandono del tratamiento. Las variables psicológicas y sociales deben ser evaluadas para que se conviertan en  predictores de probables abandonos o irregularidades en el tratamiento antituberculoso. PALABRAS CLAVE: mycobacterium tuberculosis, negativa del paciente al tratamiento, tuberculosis.Factors associated with non-adherence to anti-tuberculosis treatmentABSTRACT  Goal: to describe the risk factors associated with non-adherence to the treatment in patients enrolled in the tuberculosis program in Villavicencio city, cohort 2012. Materials and Methods: a descriptive cross-sectional study with quantitative approach. Socio-demographic data and characterization of risk factors for people who discontinued treatment for the disease. Datawere obtained by applying 2012 cohort instrument designed by the researcher and reviewed by experts.  Data were tabulated and analyzed using Microsoft Excel 2007 and Epi-info 7.0 tool. Results: 75% of patients are male; the average age is 30 years, 63% of them belong to the subsidized health system. The main causes of abandonment were: adverse effects to medicines (58%),an  inadequate  health staff care (43%),some  difficulties to access to the service (32%). The social factors were overcrowding found 67% and 62% unemployment. Conclusions: non-modifiable factors such as age and gender, as well as modifiable factors such as inadequate lifestyle and adverse effects; People in charge of the control would improve compliance; contribute to cessation of therapy. The psychological and social variables should be evaluated to become predictors of probable dropouts or irregularities in TB treatment.KEY WORDS: mycobacterium tuberculosis, the patient refused treatment, tuberculosis. Fatores associados à não-adesão ao tratamento anti-tuberculose  RESUMO Objetivo: descrever os fatores de risco associados à não-adesão ao tratamento em participar do programa de tuberculose na cidade de Villavicencio paciente coorte de 2012. Materiais e Métodos: um estudo descritivo transversal, com abordagem quantitativa. dados sócio-demográficos e caracterização dos fatores de risco para as pessoas que interromperam o tratamento para a doença foram obtidos através da aplicação de coorte 2012 instrumento concebido pelo investigador e revisados por especialistas. Os dados foram tabulados e analisados usando o Microsoft Excel 2007 e Epi-info 7.0 ferramenta. Resultados: 75% dos pacientes são masculinos; a média de idade é de 30 anos, 63% pertencem ao sistema de saúde subsidiado. As principais causas de abandono foram: efeitos adversos a medicamentos (58%), profissionais de saúde inadequada (43%), dificuldade de acesso ao serviço (32%). Os fatores sociais foram encontrados superlotação 67% e% de desemprego 62. Conclusões: os fatores não modificáveis, como idade e sexo, bem como fatores modificáveis, tais como estilos de vida inadequados e efeitos adversos; cujo controle seria melhorar o cumprimento; contribuir para a interrupção da terapia. variáveis psicológicas e sociais devem ser avaliados para se tornar preditores de abandono prováveis ou irregularidades no tratamento da TB.PALAVRAS-CHAVE: mycobacterium tuberculosis, o paciente recusou o tratamento, a tuberculose.

scholarly journals PREVALENCE AND RISK FACTORS OF MULTI DRUG RESISTANT TUBERCULOSIS AMONG REFUGEES IN THE RESETTLEMENT CAMPS OF ADJUMANI, MOYO AND YUMBE DISTRICTS WEST NILE REGION

2020 ◽  
Author(s):  
◽  
Laurent Nshizirungu ◽  
Denish Olet ◽  
Doreen Amulen ◽  
Michael Oming ◽  
...  
Keyword(s):  
Risk Factors ◽  
Mycobacterium Tuberculosis ◽  
Statistical Tests ◽  
Multidrug Resistant ◽  
West Nile ◽  
Cross Sectional ◽  
P Values ◽  
Factors Associated ◽  
Resistant Tuberculosis ◽  
Mdr Tb

Background: Multidrug-resistant tuberculosis (MDR-TB) is a name given to tuberculosis agents when the bacteria are resistant to at least isoniazid and rifampicin, two of the most effective TB drugs. The study aimed to determine the prevalence and risk factors of MDR-TB among the refugees in the resettlement camps of Adjumani, Yumbe, and Moyo districts, West Nile region. Method: This was a cross-sectional study where questionnaires were used to capture risk factors associated with MDR-TB and sputum samples (n=223) collected were examined using the gene expert machine. P values and corresponding 95% CI were calculated. All statistical tests were two-tailed and P-values less than 0.05 were considered significant. Results: From the study,143(64.1%) were males while 80 (35.9%) were females, with the age range of 3- 64 years and mean age of 32 years, out of 223 sputum samples analyzed on GeneXpert machine; 178 (79.8%) tested negative for Mycobacterium tuberculosis (MTB) while 45 (20.2%) tested positive for Mycobacterium tuberculosis. Of the 45 samples that tested positive for MTB; 39 (17.5%) were rifampicin sensitive and 6 (2.7%) were rifampicin-resistant. Of the 39 case MTB cases detected in the refugee resettlement camps of Bidibidi, Itula, and Mungula, 17 (43.6%), 14 (35.9%), and 8 (20.5%) were from each mentioned camp respectively; whereas of the 6 MDR-TB cases detected; Mungula camp had the majority cases 3 (50%), Bidibidi camp had 2 (33.3%) cases and Itula had 1 (16.7%) cases. The Risk factors associated with MDR-TB among refugees was overcrowding 5 (83.3%) and not enrolled on DOTs, 5 (66.7%). There was no significant association between MDR-TB and age (P=0.43; 95%CI=0.163-0.233) Conclusions and recommendations: The general prevalence of Mycobacterium tuberculosis is 20.2% and MDR-TB is 2.7%.

scholarly journals Persepsi dan Sikap Keluarga terhadap Perilaku Keluarga dalam Mencegah Penularan TB Paru

2019 ◽  
Vol 2 (1) ◽  
pp. 12-18
Author(s):  
Suarnianti Suarnianti ◽  
Sri Angriani
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Microsoft Excel ◽  
Chi Square ◽  
Cross Sectional ◽  
Purposive Sampling ◽  
Continuity Correction

Tuberculosis (TB) paru merupakan penyakit infeksi menular yang disebabkan Mycobacterium tuberculosis yang menyerang paru-paru dan hampir seluruh organ tubuh lainnya. Lima negara dengan insiden kasus tertinggi adalah Indonesia. Prevelensi kejadian tuberkulosis ini terus meningkat tiap tahunnya. Salah satu penyebabnya adalah persepsi keluarga dan sikap keluarga. Tujuan penelitian ini adalah untuk mengetahui pengaruh persepsi berisiko dan sikap keluarga terhadap perilaku keluarga dalam mencegah penularan TB paru di Puskesmas Bara Baraya Makassar. Penelitian ini merupakan jenis penelitian Deskriptif Analitik dengan desain/rancangan Cross Sectional Study. Populasi dalam penelitian ini adalah keluarga dari 41 pasien yang menderita TB paru di Puskesmas Bara Baraya Makassar. Pengambilan sampel menggunakan Purposive Sampling yaitu dimana sampel yang di gunakan hanya 37 orang. Pengumpulan data dilakukan dengan menggunakan lembar observasi, kuesioner, program Microsoft Excel dan program Statistic (SPSS). Analisis data mencakup analisis univariat dengan mencari distribusi frekuensi, analisis bivariat dengan uji stastistik Chi Square (α=0.05) dengan korelasi Continuity Correction untuk mengetahui pengaruh antar variabel. Hasil analisis bivariat didapatkan persepsi berisiko mempengaruhi perilaku keluarga dalam mencegah penularan TB paru (ρ=0.004) dan sikap keluarga mempengaruhi perilaku keluarga dalam mencegah penularan TB paru (ρ=0.004). Kesimpulan dalam penelitian ini adalah ada pengaruh antara persepsi berisiko dan sikap keluarga terhadap perilaku keluarga dalam mencegah penularan TB paru.

scholarly journals Trends of Mycobacterium Tuberculosis and rifampicin resistance in Adigrat General Hospital, Eastern Zone of Tigrai, North Ethiopia

2020 ◽  
Author(s):  
Getachew Kahsu Abay ◽  
Bahlibi Hailay
Keyword(s):  
Drug Resistance ◽  
Mycobacterium Tuberculosis ◽  
General Hospital ◽  
Data Extraction ◽  
Multidrug Resistant ◽  
Cross Sectional Study ◽  
Rifampicin Resistance ◽  
Drug Resistant ◽  
Cross Sectional ◽  
Eastern Zone

Abstract Background: Tuberculosis is an infectious disease usually caused by Mycobacterium tuberculosis bacteria. The global emergence of mono- or multidrug-resistant tuberculosis and extensively drug-resistant forms of tuberculosis pose a considerable challenge to tuberculosis control programs. There has been no reliable and organized data on trends and drug resistance of Mycobacterium tuberculosis in the study area. Therefore, this study aimed to determine the trends of Mycobacterium tuberculosis and rifampicin resistance in the Adigrat General Hospital, eastern Zone of Tigrai, North Ethiopia.Methods: A hospital-based retrospective cross-sectional study was conducted at Adigrat General Hospital from January 2015 to 2018.Data was collected retrospectively from the GeneXpertTM TB registration book using a data extraction format. Data was entered into Epi-Info 3.1 and subsequently exported and analyzed using SPSS Version 20.The results were summarized using descriptive statistics, tables, and figures. Bivariate and multi-variant regression analysis was employed to measure the association between dependent and independent variables. P values < 0.05 were considered statistically significant.Result: A total of 5,944 Mycobacterium tuberculosis presumptive patients were included in the study. The majority of the study participants were male (58.1%) with participants’ median age of 40.0 (IQR 26-57) years, the majority were 30-44 years. The overall positive cases of Mycobacterium tuberculosis was 24.3% (1446) with a total of 132 (9.1%) found to be resistant to rifampicin. Of the total confirmed positive cases 8.7 % (103/1188) and 11.2 % (29/258) were rifampicin resistance of presumptive tuberculosis and presumptive drug resistance tuberculosis patients respectively. Age, the reason for diagnosis, site of presumptive tuberculosis, and/or being HIV infected showed significant association with our dependent variable; however, only age and being HIV infected were associated with rifampicin resistance.Conclusion: In our study, the overall trends of Mycobacterium tuberculosis and rifampicin resistance were found to be high. Rifampicin resistance is more common in patients with HIV and presumptive drug resistance tuberculosis individuals. Therefore, maximizing early detection of drug-resistant and strengthening tuberculosis infection control activities are recommended to reduce the burden of this contagious and potentially deadly disease.

Sign in / Sign up

Export Citation Format

Share Document